ANXA2_HUMAN
Evidence for PS localization
Functions
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed, PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ANXA2_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 28.8136 | 4 | no |
| GO:0046872 | metal ion binding | 27.9661 | 4 | yes |
| GO:0019901 | protein kinase binding | 27.9661 | 5 | no |
| GO:0017076 | purine nucleotide binding | 25.4237 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 24.5763 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.5763 | 4 | no |
| GO:0003723 | RNA binding | 24.5763 | 4 | yes |
| GO:0045296 | cadherin binding | 18.6441 | 4 | yes |
| GO:0005509 | calcium ion binding | 14.4068 | 5 | yes |
| GO:0002020 | protease binding | 5.9322 | 4 | yes |
| GO:0005544 | calcium-dependent phospholipid binding | 5.9322 | 4 | yes |
| GO:0035091 | phosphatidylinositol binding | 5.0847 | 4 | yes |
| GO:0098631 | cell adhesion mediator activity | 5.0847 | 4 | yes |
| GO:0098632 | cell-cell adhesion mediator activity | 5.0847 | 5 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 5.0847 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 4.2373 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 4.2373 | 5 | yes |
| GO:0008324 | cation transmembrane transporter activity | 4.2373 | 4 | yes |
| GO:0015267 | channel activity | 4.2373 | 4 | yes |
| GO:0030414 | peptidase inhibitor activity | 3.3898 | 4 | yes |
| GO:0055102 | lipase inhibitor activity | 3.3898 | 4 | yes |
| GO:0061135 | endopeptidase regulator activity | 3.3898 | 4 | yes |
| GO:0004859 | phospholipase inhibitor activity | 3.3898 | 5 | yes |
| GO:0004866 | endopeptidase inhibitor activity | 3.3898 | 5 | yes |
| GO:0004867 | serine-type endopeptidase inhibitor activity | 3.3898 | 6 | yes |
| GO:0005216 | ion channel activity | 3.3898 | 4 | yes |
| GO:0005261 | cation channel activity | 3.3898 | 5 | yes |
| GO:0005262 | calcium channel activity | 3.3898 | 6 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 3.3898 | 6 | yes |
| GO:0019834 | phospholipase A2 inhibitor activity | 2.5424 | 6 | yes |
| GO:0098641 | cadherin binding involved in cell-cell adhesion | 2.5424 | 5 | yes |
| GO:1902936 | phosphatidylinositol bisphosphate binding | 1.6949 | 6 | yes |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 1.6949 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ANXA2_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 65.2542 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 63.5593 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 61.0169 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 61.0169 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 60.1695 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 58.4746 | 4 | yes |
| GO:0010646 | regulation of cell communication | 52.5424 | 4 | no |
| GO:0009966 | regulation of signal transduction | 49.1525 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 49.1525 | 4 | yes |
| GO:0006996 | organelle organization | 47.4576 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 46.6102 | 4 | yes |
| GO:0010468 | regulation of gene expression | 46.6102 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 45.7627 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 45.7627 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 44.0678 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 43.2203 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 41.5254 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 39.8305 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 39.8305 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 38.9831 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 38.1356 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 37.2881 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 37.2881 | 5 | no |
| GO:0022607 | cellular component assembly | 37.2881 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 36.4407 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 34.7458 | 4 | no |
| GO:0043412 | macromolecule modification | 34.7458 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 34.7458 | 5 | no |
| GO:0008104 | protein localization | 34.7458 | 4 | no |
| GO:0051049 | regulation of transport | 33.8983 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.8983 | 5 | no |
| GO:0036211 | protein modification process | 33.8983 | 4 | no |
| GO:0023056 | positive regulation of signaling | 33.8983 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 32.2034 | 6 | yes |
| GO:0010647 | positive regulation of cell communication | 32.2034 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 31.3559 | 5 | no |
| GO:0031399 | regulation of protein modification process | 31.3559 | 6 | no |
| GO:0010941 | regulation of cell death | 30.5085 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.5085 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.5085 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 30.5085 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 30.5085 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 30.5085 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 29.6610 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 29.6610 | 5 | no |
| GO:0051050 | positive regulation of transport | 27.9661 | 4 | yes |
| GO:0042325 | regulation of phosphorylation | 27.9661 | 7 | no |
| GO:0033043 | regulation of organelle organization | 27.1186 | 5 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 26.2712 | 6 | yes |
| GO:0007010 | cytoskeleton organization | 25.4237 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.4237 | 7 | no |
| GO:0071702 | organic substance transport | 25.4237 | 4 | no |
| GO:0009894 | regulation of catabolic process | 25.4237 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 24.5763 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 24.5763 | 4 | no |
| GO:0030030 | cell projection organization | 23.7288 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 23.7288 | 4 | no |
| GO:0060548 | negative regulation of cell death | 23.7288 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.7288 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 23.7288 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.8814 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.8814 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 22.0339 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 22.0339 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.1864 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 21.1864 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 21.1864 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 21.1864 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 21.1864 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.1864 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 21.1864 | 7 | no |
| GO:0051338 | regulation of transferase activity | 21.1864 | 4 | no |
| GO:0051726 | regulation of cell cycle | 21.1864 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 21.1864 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 20.3390 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 20.3390 | 4 | no |
| GO:0080134 | regulation of response to stress | 20.3390 | 4 | no |
| GO:0015031 | protein transport | 20.3390 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.3390 | 4 | no |
| GO:0043408 | regulation of MAPK cascade | 20.3390 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 20.3390 | 6 | yes |
| GO:0051129 | negative regulation of cellular component organization | 19.4915 | 5 | yes |
| GO:0030162 | regulation of proteolysis | 18.6441 | 6 | yes |
| GO:0031329 | regulation of cellular catabolic process | 17.7966 | 5 | yes |
| GO:0051051 | negative regulation of transport | 16.1017 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 16.1017 | 4 | yes |
| GO:0061024 | membrane organization | 15.2542 | 4 | yes |
| GO:0042176 | regulation of protein catabolic process | 15.2542 | 5 | yes |
| GO:0010638 | positive regulation of organelle organization | 12.7119 | 6 | yes |
| GO:0045862 | positive regulation of proteolysis | 12.7119 | 7 | yes |
| GO:0032386 | regulation of intracellular transport | 11.8644 | 5 | yes |
| GO:0009895 | negative regulation of catabolic process | 11.0169 | 5 | yes |
| GO:0030100 | regulation of endocytosis | 11.0169 | 5 | yes |
| GO:0032388 | positive regulation of intracellular transport | 10.1695 | 5 | yes |
| GO:0043393 | regulation of protein binding | 10.1695 | 4 | yes |
| GO:0051099 | positive regulation of binding | 8.4746 | 4 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 7.6271 | 6 | yes |
| GO:0045807 | positive regulation of endocytosis | 7.6271 | 5 | yes |
| GO:0016050 | vesicle organization | 6.7797 | 5 | yes |
| GO:0031330 | negative regulation of cellular catabolic process | 6.7797 | 6 | yes |
| GO:0042177 | negative regulation of protein catabolic process | 6.7797 | 6 | yes |
| GO:0032092 | positive regulation of protein binding | 5.9322 | 5 | yes |
| GO:0048260 | positive regulation of receptor-mediated endocytosis | 5.0847 | 6 | yes |
| GO:1905952 | regulation of lipid localization | 5.0847 | 4 | yes |
| GO:0002090 | regulation of receptor internalization | 5.0847 | 7 | yes |
| GO:0032368 | regulation of lipid transport | 5.0847 | 5 | yes |
| GO:0061515 | myeloid cell development | 4.2373 | 4 | yes |
| GO:0071709 | membrane assembly | 4.2373 | 5 | yes |
| GO:0048261 | negative regulation of receptor-mediated endocytosis | 3.3898 | 6 | yes |
| GO:0070613 | regulation of protein processing | 3.3898 | 7 | yes |
| GO:1903317 | regulation of protein maturation | 3.3898 | 6 | yes |
| GO:1903319 | positive regulation of protein maturation | 3.3898 | 7 | yes |
| GO:0006900 | vesicle budding from membrane | 3.3898 | 5 | yes |
| GO:0010954 | positive regulation of protein processing | 3.3898 | 8 | yes |
| GO:0045806 | negative regulation of endocytosis | 3.3898 | 5 | yes |
| GO:0098751 | bone cell development | 2.5424 | 4 | yes |
| GO:1900120 | regulation of receptor binding | 2.5424 | 5 | yes |
| GO:1900122 | positive regulation of receptor binding | 2.5424 | 6 | yes |
| GO:1905599 | positive regulation of low-density lipoprotein receptor activity | 2.5424 | 4 | yes |
| GO:1905954 | positive regulation of lipid localization | 2.5424 | 4 | yes |
| GO:0001765 | membrane raft assembly | 2.5424 | 6 | yes |
| GO:0001919 | regulation of receptor recycling | 2.5424 | 4 | yes |
| GO:0001921 | positive regulation of receptor recycling | 2.5424 | 5 | yes |
| GO:0010755 | regulation of plasminogen activation | 2.5424 | 8 | yes |
| GO:0010756 | positive regulation of plasminogen activation | 2.5424 | 9 | yes |
| GO:0010984 | regulation of lipoprotein particle clearance | 2.5424 | 4 | yes |
| GO:0010988 | regulation of low-density lipoprotein particle clearance | 2.5424 | 5 | yes |
| GO:0031338 | regulation of vesicle fusion | 2.5424 | 5 | yes |
| GO:0031340 | positive regulation of vesicle fusion | 2.5424 | 5 | yes |
| GO:0031579 | membrane raft organization | 2.5424 | 5 | yes |
| GO:0032370 | positive regulation of lipid transport | 2.5424 | 5 | yes |
| GO:0044088 | regulation of vacuole organization | 2.5424 | 6 | yes |
| GO:1905581 | positive regulation of low-density lipoprotein particle clearance | 1.6949 | 6 | yes |
| GO:1905595 | regulation of low-density lipoprotein particle receptor binding | 1.6949 | 6 | yes |
| GO:1905597 | positive regulation of low-density lipoprotein particle receptor binding | 1.6949 | 7 | yes |
| GO:1905600 | regulation of receptor-mediated endocytosis involved in cholesterol transport | 1.6949 | 6 | yes |
| GO:1905602 | positive regulation of receptor-mediated endocytosis involved in cholesterol transport | 1.6949 | 7 | yes |
| GO:2000644 | regulation of receptor catabolic process | 1.6949 | 5 | yes |
| GO:2000645 | negative regulation of receptor catabolic process | 1.6949 | 6 | yes |
| GO:0002091 | negative regulation of receptor internalization | 1.6949 | 7 | yes |
| GO:0010986 | positive regulation of lipoprotein particle clearance | 1.6949 | 5 | yes |
| GO:0032371 | regulation of sterol transport | 1.6949 | 6 | yes |
| GO:0032373 | positive regulation of sterol transport | 1.6949 | 6 | yes |
| GO:0032374 | regulation of cholesterol transport | 1.6949 | 7 | yes |
| GO:0032376 | positive regulation of cholesterol transport | 1.6949 | 7 | yes |
| GO:0032377 | regulation of intracellular lipid transport | 1.6949 | 6 | yes |
| GO:0032379 | positive regulation of intracellular lipid transport | 1.6949 | 6 | yes |
| GO:0032380 | regulation of intracellular sterol transport | 1.6949 | 7 | yes |
| GO:0032382 | positive regulation of intracellular sterol transport | 1.6949 | 7 | yes |
| GO:0032383 | regulation of intracellular cholesterol transport | 1.6949 | 8 | yes |
| GO:0032385 | positive regulation of intracellular cholesterol transport | 1.6949 | 8 | yes |
| GO:0032803 | regulation of low-density lipoprotein particle receptor catabolic process | 1.6949 | 6 | yes |
| GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process | 1.6949 | 7 | yes |
| GO:0036035 | osteoclast development | 1.6949 | 5 | yes |
| GO:0044090 | positive regulation of vacuole organization | 1.6949 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ANXA2_HUMAN |
|---|---|---|---|---|
| DOID:0050686 | organ system cancer | 3.3898 | 3 | no |
| DOID:114 | heart disease | 3.3898 | 3 | no |
| DOID:0050700 | cardiomyopathy | 2.5424 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 2.5424 | 5 | no |
| DOID:2843 | long QT syndrome | 1.6949 | 6 | no |
| DOID:120 | female reproductive organ cancer | 1.6949 | 5 | no |
| DOID:193 | reproductive organ cancer | 1.6949 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 1.6949 | 3 | no |
| DOID:6457 | Cowden syndrome | 1.6949 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PA24A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB14_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STAT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RSCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| CATB_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK9_HUMAN | [view interactions] | Low throughput | no | yes |
| PTN11_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRI59_HUMAN | [view interactions] | Low throughput | no | no |
| SAM12_HUMAN | [view interactions] | Low throughput | no | yes |
| MLH1_HUMAN | [view interactions] | Low throughput | no | yes |
| HAKAI_HUMAN | [view interactions] | Low throughput | no | yes |
| S10AA_HUMAN | [view interactions] | Low throughput | no | no |
| PCSK9_HUMAN | [view interactions] | Low throughput | no | no |
| SUMO1_HUMAN | [view interactions] | Low throughput | no | yes |
| AHNK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NHRF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ITSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCE_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYSF_HUMAN | [view interactions] | Low throughput | no | no |
| M3K4_HUMAN | [view interactions] | Low throughput | no | yes |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| UBB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RO52_HUMAN | [view interactions] | Low throughput | no | yes |
| RS27A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TFEB_HUMAN | [view interactions] | Low throughput | no | no |
| RL40_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HLTF_HUMAN | [view interactions] | Low throughput | no | no |
| CCR10_HUMAN | [view interactions] | Low throughput | no | yes |
| TRPV5_HUMAN | [view interactions] | Low throughput | no | no |
| TPA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| APOH_HUMAN | [view interactions] | Low throughput | no | no |
| TENA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MYOC_HUMAN | [view interactions] | Low throughput | no | no |
| ANGI_HUMAN | [view interactions] | Low throughput | no | no |
| ANXA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| WFDC2_HUMAN | [view interactions] | Low throughput | no | yes |
| MMP2_HUMAN | [view interactions] | Low throughput | no | no |
| MYC_HUMAN | [view interactions] | Low throughput | no | yes |
| S10A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CAV2_HUMAN | [view interactions] | Low throughput | no | no |
| PHB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STAT6_HUMAN | [view interactions] | Low throughput | no | yes |
| CD99_HUMAN | [view interactions] | Low throughput | no | no |
| SNX17_HUMAN | [view interactions] | Low throughput | no | yes |
| CATS_HUMAN | [view interactions] | Low throughput | no | no |
| RS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ZBTB4_HUMAN | [view interactions] | Low throughput | no | yes |
| ODO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CCD32_HUMAN | [view interactions] | Low throughput | no | yes |
| GLD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACTS_HUMAN | [view interactions] | Low throughput | no | no |
| CEAM1_HUMAN | [view interactions] | Low throughput | no | no |
| CDK7_HUMAN | [view interactions] | Low throughput | no | yes |
| ASB9_HUMAN | [view interactions] | High throughput | no | no |
| ERR2_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| ANX13_HUMAN | [view interactions] | High throughput | no | no |
| KS6B2_HUMAN | [view interactions] | High throughput | no | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| PEPL_HUMAN | [view interactions] | High throughput | no | yes |
| FXL12_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| KLH42_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| DC4L2_HUMAN | [view interactions] | High throughput | no | no |
| TTC23_HUMAN | [view interactions] | High throughput | no | yes |
| TEDC2_HUMAN | [view interactions] | High throughput | no | no |
| BRAF_HUMAN | [view interactions] | High throughput | no | yes |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| GALE_HUMAN | [view interactions] | High throughput | no | no |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| NEK2_HUMAN | [view interactions] | High throughput | no | no |
| K1C17_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| H2AY_HUMAN | [view interactions] | High throughput | no | yes |
| TET2_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| HAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBLN3_HUMAN | [view interactions] | High throughput | no | no |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| DOCK8_HUMAN | [view interactions] | High throughput | no | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OPHN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2AX_HUMAN | [view interactions] | High throughput | no | yes |
| STAG1_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| PDS5A_HUMAN | [view interactions] | High throughput | no | yes |
| NPHP1_HUMAN | [view interactions] | High throughput | no | yes |
| PDS5B_HUMAN | [view interactions] | High throughput | no | yes |
| NPHP4_HUMAN | [view interactions] | High throughput | no | yes |
| NIPBL_HUMAN | [view interactions] | High throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| SCC4_HUMAN | [view interactions] | High throughput | no | no |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| MAP1S_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| PLOD1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| AHNK2_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| GT251_HUMAN | [view interactions] | High throughput | no | no |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| PLOD3_HUMAN | [view interactions] | High throughput | no | yes |
| AL3A1_HUMAN | [view interactions] | High throughput | no | no |
| PLOD2_HUMAN | [view interactions] | High throughput | no | yes |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR76_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN208_HUMAN | [view interactions] | High throughput | no | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EIF3F_HUMAN | [view interactions] | High throughput | no | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| ARGI1_HUMAN | [view interactions] | High throughput | no | no |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPB12_HUMAN | [view interactions] | High throughput | no | no |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTA70_HUMAN | [view interactions] | High throughput | no | no |
| KPRP_HUMAN | [view interactions] | High throughput | no | no |
| FL2D_HUMAN | [view interactions] | High throughput | no | yes |
| XP32_HUMAN | [view interactions] | High throughput | no | no |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| FABP5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| TGM3_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| CASPE_HUMAN | [view interactions] | High throughput | no | no |
| GRN_HUMAN | [view interactions] | High throughput | no | no |
| BLMH_HUMAN | [view interactions] | High throughput | no | yes |
| POC5_HUMAN | [view interactions] | High throughput | no | yes |
| DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10AE_HUMAN | [view interactions] | High throughput | no | no |
| DSC1_HUMAN | [view interactions] | High throughput | no | no |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GGCT_HUMAN | [view interactions] | High throughput | no | yes |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10A8_HUMAN | [view interactions] | High throughput | no | no |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPR2E_HUMAN | [view interactions] | High throughput | no | no |
| AKP13_HUMAN | [view interactions] | High throughput | no | yes |
| SPB3_HUMAN | [view interactions] | High throughput | no | no |
| CYTA_HUMAN | [view interactions] | High throughput | no | no |
| NCBP3_HUMAN | [view interactions] | High throughput | no | yes |
| CALL5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCBP2_HUMAN | [view interactions] | High throughput | no | yes |
| LEG7_HUMAN | [view interactions] | High throughput | no | no |
| DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZA2G_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDSN_HUMAN | [view interactions] | High throughput | no | no |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSDMA_HUMAN | [view interactions] | High throughput | no | no |
| ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FILA2_HUMAN | [view interactions] | High throughput | no | no |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| S10A7_HUMAN | [view interactions] | High throughput | no | no |
| PKP1_HUMAN | [view interactions] | High throughput | no | no |
| AN32A_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| FILA_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSI1_HUMAN | [view interactions] | High throughput | no | no |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSI2_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| CP087_HUMAN | [view interactions] | High throughput | no | no |
| APR_HUMAN | [view interactions] | High throughput | no | yes |
| SYTL2_HUMAN | [view interactions] | High throughput | no | no |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| STC2_HUMAN | [view interactions] | High throughput | no | no |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| CAVN2_HUMAN | [view interactions] | High throughput | no | no |
| TTLL7_HUMAN | [view interactions] | High throughput | no | yes |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| UBP2_HUMAN | [view interactions] | High throughput | no | yes |
| FAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| HMGN3_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRC2_HUMAN | [view interactions] | High throughput | no | no |
| TCAL8_HUMAN | [view interactions] | High throughput | no | no |
| PALMD_HUMAN | [view interactions] | High throughput | no | no |
| MISP_HUMAN | [view interactions] | High throughput | no | no |
| MOK_HUMAN | [view interactions] | High throughput | no | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| ACM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI26_HUMAN | [view interactions] | High throughput | no | yes |
| CO1A1_HUMAN | [view interactions] | High throughput | no | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| NALP7_HUMAN | [view interactions] | High throughput | no | no |
| LEG8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOST_HUMAN | [view interactions] | High throughput | no | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| RANB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| HMGA1_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPM1B_HUMAN | [view interactions] | High throughput | no | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| SMN_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC8_HUMAN | [view interactions] | High throughput | no | yes |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| ANX11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRM7_HUMAN | [view interactions] | High throughput | no | yes |
| FUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| LEG1_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR3_HUMAN | [view interactions] | High throughput | no | yes |
| NCKPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOMA_HUMAN | [view interactions] | High throughput | no | no |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| PCBP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| PDCD6_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| CYTB_HUMAN | [view interactions] | High throughput | no | no |
| TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYPA1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| S10AB_HUMAN | [view interactions] | High throughput | no | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10A6_HUMAN | [view interactions] | High throughput | no | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| DC1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SATB2_HUMAN | [view interactions] | High throughput | no | yes |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| ERRFI_HUMAN | [view interactions] | High throughput | no | no |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SLN11_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SETD7_HUMAN | [view interactions] | High throughput | no | yes |
| WRP73_HUMAN | [view interactions] | High throughput | no | no |
| CSAG1_HUMAN | [view interactions] | High throughput | no | no |
| CSAG2_HUMAN | [view interactions] | High throughput | no | no |
| TIFAB_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| TERT_HUMAN | [view interactions] | High throughput | no | no |
| NOD2_HUMAN | [view interactions] | High throughput | no | yes |
| 4ET_HUMAN | [view interactions] | High throughput | no | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| MGMT_HUMAN | [view interactions] | High throughput | no | no |
| CD4_HUMAN | [view interactions] | High throughput | no | no |
| NCOA3_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3A_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO3_HUMAN | [view interactions] | High throughput | no | yes |
| SP1_HUMAN | [view interactions] | High throughput | no | yes |
| P5F1B_HUMAN | [view interactions] | High throughput | no | no |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| RD23B_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI18_HUMAN | [view interactions] | High throughput | no | no |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNF1A_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATP4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | Computational | no | no |
| AX2R_HUMAN | [view interactions] | Computational | no | no |
| FETUA_HUMAN | [view interactions] | Computational | no | no |
| ANXA6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PP13_HUMAN | [view interactions] | Computational | no | no |
| CD44_HUMAN | [view interactions] | Computational | no | yes |
| CD63_HUMAN | [view interactions] | Computational | no | no |
| SLPI_HUMAN | [view interactions] | Computational | no | no |
| LEG3_HUMAN | [view interactions] | Computational | no | yes |
| S10A2_HUMAN | [view interactions] | Computational | no | no |
| CAD17_HUMAN | [view interactions] | Computational | no | no |
| CAV1_HUMAN | [view interactions] | Computational | no | no |
| SDF1_HUMAN | [view interactions] | Computational | no | no |
| PSN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLMN_HUMAN | [view interactions] | Computational | no | no |
| BASI_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SNP23_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| STAT4_HUMAN | [view interactions] | Computational | no | yes |
| TRI72_HUMAN | [view interactions] | Computational | no | no |
| TLR4_HUMAN | [view interactions] | Computational | no | yes |
| ENOA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |