ANXA2_HUMAN
Evidence for PS localization
Functions
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed, PubMed, PubMed). [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 82%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Interacting regions
Canonical [ANXA2_HUMAN]
Isoform [H0YNP5] alignment
Isoform [H0YMU9] alignment
Isoform [H0YMW4] alignment
Isoform [H0YMT9] alignment
Isoform [H0YN28] alignment
Isoform [H0YN42] alignment
Isoform [H0YMM1] alignment
Isoform [H0YNA0] alignment
Isoform [H0YNB8] alignment
Isoform [H0YLV6] alignment
Isoform [H0YM50] alignment
Isoform [H0YMD0] alignment
Isoform [H0YMD9] alignment
Isoform [H0YKS4] alignment
Isoform [H0YL33] alignment
Isoform [H0YKN4] alignment
Isoform [H0YKL9] alignment
Isoform [H0YLE2] alignment
Isoform [H0YKZ7] alignment
Isoform [H0YKV8] alignment
Isoform [H0YKX9] alignment
Isoform [A0A7I2V4P4] alignment
Isoform [P07355-2] alignment
LOADING 17%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ANXA2_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 34.5070 | 4 | yes |
| GO:0000166 | nucleotide binding | 29.5775 | 4 | no |
| GO:0043169 | cation binding | 28.8732 | 4 | yes |
| GO:0046872 | metal ion binding | 28.8732 | 5 | yes |
| GO:0017076 | purine nucleotide binding | 28.8732 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 28.1690 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.4648 | 4 | no |
| GO:0003723 | RNA binding | 26.7606 | 4 | yes |
| GO:0019900 | kinase binding | 26.7606 | 4 | no |
| GO:0019901 | protein kinase binding | 26.0563 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 21.8310 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 21.1268 | 5 | no |
| GO:0005524 | ATP binding | 20.4225 | 5 | no |
| GO:0045296 | cadherin binding | 16.9014 | 4 | yes |
| GO:0005509 | calcium ion binding | 14.7887 | 6 | yes |
| GO:0002020 | protease binding | 5.6338 | 4 | yes |
| GO:0035091 | phosphatidylinositol binding | 4.9296 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 4.9296 | 5 | yes |
| GO:0005544 | calcium-dependent phospholipid binding | 4.2254 | 4 | yes |
| GO:0098631 | cell adhesion mediator activity | 3.5211 | 4 | yes |
| GO:0098632 | cell-cell adhesion mediator activity | 3.5211 | 5 | yes |
| GO:0004859 | phospholipase inhibitor activity | 2.8169 | 5 | yes |
| GO:0004866 | endopeptidase inhibitor activity | 2.8169 | 5 | yes |
| GO:0004867 | serine-type endopeptidase inhibitor activity | 2.8169 | 6 | yes |
| GO:0030414 | peptidase inhibitor activity | 2.8169 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ANXA2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.4930 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 64.7887 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 63.3803 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 61.2676 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 59.1549 | 4 | yes |
| GO:0010646 | regulation of cell communication | 54.9296 | 4 | no |
| GO:0009966 | regulation of signal transduction | 50.7042 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 48.5915 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 48.5915 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 47.8873 | 5 | yes |
| GO:0010468 | regulation of gene expression | 47.1831 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 47.1831 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 46.4789 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 45.7746 | 5 | yes |
| GO:0006996 | organelle organization | 44.3662 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 43.6620 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 42.2535 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 40.8451 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 40.1408 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 40.1408 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 39.4366 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 38.7324 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 38.0282 | 4 | yes |
| GO:0022607 | cellular component assembly | 37.3239 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| 4ET_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| ACLY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTBL_HUMAN | [view interactions] | Low throughput | no | no |
| ACTS_HUMAN | [view interactions] | Low throughput | no | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| AHNK2_HUMAN | [view interactions] | Low throughput | no | yes |
| AHNK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| AKP13_HUMAN | [view interactions] | High throughput | no | yes |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL3A1_HUMAN | [view interactions] | High throughput | no | no |
| AN32A_HUMAN | [view interactions] | High throughput | no | yes |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANGI_HUMAN | [view interactions] | Low throughput | no | no |