ACM2_HUMAN

G2C

SynGO

SynaptomeDB

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. [View more on UniProt]

Transmembrane

Phase separation

ELM

Phosphorylation

PFAM

Coiled coil

Anchor

Disordered

Interacting regions

Sequence

LOADING 55%

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

ACM2_HUMAN

GASP2_HUMAN

LOADING 67%

ACM2_HUMAN

SH3G1_HUMAN

LOADING 67%

ACM2_HUMAN

SH3G2_HUMAN

LOADING 67%

ACM2_HUMAN

LOADING 67%

ACM2_HUMAN

GBG2_HUMAN

LOADING 67%

ACM2_HUMAN

GNAO_HUMAN

LOADING 67%

ACM2_HUMAN

GBB1_HUMAN

LOADING 67%

ACM2_HUMAN has binary interactions with 15 proteins

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Show entries

Search:

Term	Name	%	Distance from the top of the tree	Annotated in ACM2_HUMAN
GO:0004930	G protein-coupled receptor activity	12.5000	4	yes
GO:0004993	G protein-coupled serotonin receptor activity	12.5000	6	yes
GO:0008227	G protein-coupled amine receptor activity	12.5000	5	yes
GO:0015464	acetylcholine receptor activity	12.5000	4	yes
GO:0016907	G protein-coupled acetylcholine receptor activity	12.5000	5	yes
GO:0098960	postsynaptic neurotransmitter receptor activity	12.5000	4	yes
GO:0099528	G protein-coupled neurotransmitter receptor activity	12.5000	4	yes

Showing 1 to 7 of 7 entries

Biological process

Show entries

Search:

Term	Name	%	Distance from top the of the tree	Annotated in ACM2_HUMAN
GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	31.2500	4	yes
GO:0048523	negative regulation of cellular process	31.2500	4	no
GO:0048522	positive regulation of cellular process	31.2500	4	no
GO:0010646	regulation of cell communication	25.0000	4	yes
GO:0008104	protein localization	25.0000	4	no
GO:0009889	regulation of biosynthetic process	25.0000	4	no
GO:0009892	negative regulation of metabolic process	25.0000	4	no
GO:0010468	regulation of gene expression	25.0000	6	no
GO:0010556	regulation of macromolecule biosynthetic process	25.0000	5	no
GO:0010605	negative regulation of macromolecule metabolic process	25.0000	5	no
GO:0031323	regulation of cellular metabolic process	25.0000	4	no
GO:0031324	negative regulation of cellular metabolic process	25.0000	5	no
GO:0031326	regulation of cellular biosynthetic process	25.0000	5	no
GO:0051246	regulation of protein metabolic process	25.0000	5	no
GO:0060255	regulation of macromolecule metabolic process	25.0000	4	no
GO:0080090	regulation of primary metabolic process	25.0000	4	no
GO:0051049	regulation of transport	25.0000	4	no
GO:0051050	positive regulation of transport	25.0000	4	no
GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	18.7500	4	yes
GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	18.7500	4	yes
GO:0050804	modulation of chemical synaptic transmission	18.7500	5	yes
GO:0095500	acetylcholine receptor signaling pathway	18.7500	4	yes
GO:0099177	regulation of trans-synaptic signaling	18.7500	4	yes
GO:0006937	regulation of muscle contraction	12.5000	6	yes
GO:0006940	regulation of smooth muscle contraction	12.5000	7	yes

Showing 1 to 25 of 39 entries

Disease

No data found.

Show entries

Search:

Uniprot ID	Details	Highest evidence	Localizing into PSD	HPA (protein expression in neurons)
ACM2_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
ANXA2_HUMAN	[view entry] [view interactions]	High throughput	yes	no
ARRB2_HUMAN	[view entry] [view interactions]	Low throughput	yes	no
CXG2_HUMAN	[view interactions]	High throughput	no	no
ELAV1_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
GASP1_HUMAN	[view interactions]	High throughput	no	yes
GASP2_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
GBB1_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
GBG2_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
GNAO_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
HERP1_HUMAN	[view interactions]	High throughput	no	yes
LAMP1_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
MDHC_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
MTX2_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
RGS7_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
S52A2_HUMAN	[view interactions]	High throughput	no	no
SET_HUMAN	[view interactions]	Low throughput	no	yes
SH3G1_HUMAN	[view entry] [view interactions]	High throughput	yes	no
SH3G2_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
SHSA4_HUMAN	[view interactions]	High throughput	no	no
TMM8B_HUMAN	[view interactions]	High throughput	no	yes
TSN33_HUMAN	[view interactions]	High throughput	no	no
TSN7_HUMAN	[view entry] [view interactions]	High throughput	yes	yes

Showing 1 to 23 of 23 entries

ACM2_HUMAN

Evidence for PS localization

Functions

Protein features

Binary interactions with known binding regions

Network

Isoforms

Disease-causing germline mutations

Linear motifs

Fingerprint

Molecular function

Biological process

Disease

All partners