Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACM2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ACM2_HUMAN
GO:0004930 G protein-coupled receptor activity 12.5000 4 yes
GO:0004993 G protein-coupled serotonin receptor activity 12.5000 6 yes
GO:0008227 G protein-coupled amine receptor activity 12.5000 5 yes
GO:0015464 acetylcholine receptor activity 12.5000 4 yes
GO:0016907 G protein-coupled acetylcholine receptor activity 12.5000 5 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 12.5000 4 yes
GO:0099528 G protein-coupled neurotransmitter receptor activity 12.5000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ACM2_HUMAN
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 31.2500 4 yes
GO:0048523 negative regulation of cellular process 31.2500 4 no
GO:0048522 positive regulation of cellular process 31.2500 4 no
GO:0010646 regulation of cell communication 25.0000 4 yes
GO:0008104 protein localization 25.0000 4 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0010468 regulation of gene expression 25.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0031323 regulation of cellular metabolic process 25.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 25.0000 4 no
GO:0080090 regulation of primary metabolic process 25.0000 4 no
GO:0051049 regulation of transport 25.0000 4 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 18.7500 4 yes
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 18.7500 4 yes
GO:0050804 modulation of chemical synaptic transmission 18.7500 5 yes
GO:0095500 acetylcholine receptor signaling pathway 18.7500 4 yes
GO:0099177 regulation of trans-synaptic signaling 18.7500 4 yes
GO:0006937 regulation of muscle contraction 12.5000 6 yes
GO:0006940 regulation of smooth muscle contraction 12.5000 7 yes
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 12.5000 4 yes
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 12.5000 5 yes
GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway 12.5000 5 yes
GO:0007207 phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway 12.5000 5 yes
GO:0007268 chemical synaptic transmission 12.5000 7 yes
GO:0007399 nervous system development 12.5000 4 yes
GO:0008016 regulation of heart contraction 12.5000 6 yes
GO:0044057 regulation of system process 12.5000 4 yes
GO:0090257 regulation of muscle system process 12.5000 5 yes
GO:0098916 anterograde trans-synaptic signaling 12.5000 6 yes
GO:0099171 presynaptic modulation of chemical synaptic transmission 12.5000 6 yes
GO:0099536 synaptic signaling 12.5000 4 yes
GO:0099537 trans-synaptic signaling 12.5000 5 yes
GO:1903522 regulation of blood circulation 12.5000 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
LAMP1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACM2_HUMAN [view entry] [view interactions] Low throughput yes yes
SET_HUMAN [view interactions] Low throughput no yes
RGS7_HUMAN [view entry] [view interactions] Low throughput yes yes
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
GASP1_HUMAN [view interactions] High throughput no yes
GASP2_HUMAN [view entry] [view interactions] High throughput yes yes
SH3G1_HUMAN [view entry] [view interactions] High throughput yes no
SH3G2_HUMAN [view entry] [view interactions] High throughput yes yes
SHSA4_HUMAN [view interactions] High throughput no no
TSN7_HUMAN [view entry] [view interactions] High throughput yes yes
TSN33_HUMAN [view interactions] High throughput no no
MDHC_HUMAN [view entry] [view interactions] High throughput yes yes
HERP1_HUMAN [view interactions] High throughput no yes
CXG2_HUMAN [view interactions] High throughput no no
S52A2_HUMAN [view interactions] High throughput no no
TMM8B_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
MTX2_HUMAN [view entry] [view interactions] High throughput yes yes