ACM2_HUMAN
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. [View more on UniProt]
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No data found.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ACM2_HUMAN |
---|---|---|---|---|
GO:0003924 | GTPase activity | 24.0000 | 7 | no |
GO:0016462 | pyrophosphatase activity | 24.0000 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 24.0000 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 24.0000 | 6 | no |
GO:0004930 | G protein-coupled receptor activity | 20.0000 | 4 | yes |
GO:0004993 | G protein-coupled serotonin receptor activity | 12.0000 | 5 | yes |
GO:0008227 | G protein-coupled amine receptor activity | 12.0000 | 5 | yes |
GO:0015464 | acetylcholine receptor activity | 12.0000 | 4 | yes |
GO:0016907 | G protein-coupled acetylcholine receptor activity | 12.0000 | 5 | yes |
GO:0098960 | postsynaptic neurotransmitter receptor activity | 12.0000 | 4 | yes |
GO:0099528 | G protein-coupled neurotransmitter receptor activity | 12.0000 | 4 | yes |
GO:0099589 | serotonin receptor activity | 12.0000 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ACM2_HUMAN |
---|---|---|---|---|
GO:0048523 | negative regulation of cellular process | 36.0000 | 4 | no |
GO:0048522 | positive regulation of cellular process | 32.0000 | 4 | no |
GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 28.0000 | 4 | yes |
GO:0051049 | regulation of transport | 28.0000 | 4 | no |
GO:0009966 | regulation of signal transduction | 24.0000 | 4 | no |
GO:0010646 | regulation of cell communication | 24.0000 | 4 | no |
GO:0051050 | positive regulation of transport | 24.0000 | 4 | no |
GO:0010468 | regulation of gene expression | 24.0000 | 5 | no |
GO:0031323 | regulation of cellular metabolic process | 24.0000 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 24.0000 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 24.0000 | 5 | no |
GO:0060255 | regulation of macromolecule metabolic process | 24.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 24.0000 | 4 | no |
GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway | 20.0000 | 4 | yes |
GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 16.0000 | 5 | yes |
GO:0007213 | G protein-coupled acetylcholine receptor signaling pathway | 16.0000 | 4 | yes |
GO:0095500 | acetylcholine receptor signaling pathway | 16.0000 | 4 | yes |
GO:0099537 | trans-synaptic signaling | 16.0000 | 4 | yes |
GO:0006937 | regulation of muscle contraction | 12.0000 | 6 | yes |
GO:0006940 | regulation of smooth muscle contraction | 12.0000 | 7 | yes |
GO:0007187 | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | 12.0000 | 4 | yes |
GO:0007197 | adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway | 12.0000 | 5 | yes |
GO:0007207 | phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway | 12.0000 | 5 | yes |
GO:0007268 | chemical synaptic transmission | 12.0000 | 6 | yes |
GO:0007399 | nervous system development | 12.0000 | 4 | yes |
GO:0044057 | regulation of system process | 12.0000 | 4 | yes |
GO:0090257 | regulation of muscle system process | 12.0000 | 5 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 12.0000 | 5 | yes |
GO:1903522 | regulation of blood circulation | 12.0000 | 5 | yes |
GO:0008016 | regulation of heart contraction | 8.0000 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ARRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
LAMP1_HUMAN | [view interactions] | Low throughput | no | yes |
SET_HUMAN | [view interactions] | Low throughput | no | yes |
RGS7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GNAO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ANXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GASP1_HUMAN | [view interactions] | High throughput | no | yes |
GASP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SH3G2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
S52A2_HUMAN | [view interactions] | High throughput | no | no |
CXG2_HUMAN | [view interactions] | High throughput | no | no |
HERP1_HUMAN | [view interactions] | High throughput | no | yes |
MDHC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TSN33_HUMAN | [view interactions] | High throughput | no | no |
TSN7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SHSA4_HUMAN | [view interactions] | High throughput | no | no |
TMM8B_HUMAN | [view interactions] | High throughput | no | yes |
ACM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GBG8_HUMAN | [view interactions] | Computational | no | no |
UBQL2_HUMAN | [view interactions] | Computational | no | yes |
LPAR2_HUMAN | [view interactions] | Computational | no | yes |
LPAR6_HUMAN | [view interactions] | Computational | no | no |
GBB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GBG10_HUMAN | [view interactions] | Computational | no | no |
ARRB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GBG3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GBB3_HUMAN | [view interactions] | Computational | no | yes |
GBGT2_HUMAN | [view interactions] | Computational | no | no |
GBG5_HUMAN | [view interactions] | Computational | no | no |
LPAR1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
LPAR4_HUMAN | [view interactions] | Computational | no | no |
PAR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GBG13_HUMAN | [view interactions] | Computational | no | no |
GBB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GNB5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ACM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GBG7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
LPAR5_HUMAN | [view interactions] | Computational | no | yes |
LPAR3_HUMAN | [view interactions] | Computational | no | no |
GBG1_HUMAN | [view interactions] | Computational | no | no |
GBG11_HUMAN | [view interactions] | Computational | no | no |
GBG12_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GBG4_HUMAN | [view interactions] | Computational | no | no |