Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GBG2_HUMAN

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in GBG2_HUMAN
GO:0043169 cation binding 37.2881 4 no
GO:0004930 G protein-coupled receptor activity 35.5932 4 no
GO:0000166 nucleotide binding 27.1186 4 no
GO:0001664 G protein-coupled receptor binding 27.1186 4 no
GO:0017076 purine nucleotide binding 27.1186 5 no
GO:0032555 purine ribonucleotide binding 27.1186 4 no
GO:0035639 purine ribonucleoside triphosphate binding 27.1186 4 no
GO:0043168 anion binding 27.1186 4 no
GO:0046872 metal ion binding 27.1186 5 no
GO:0016462 pyrophosphatase activity 25.4237 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.4237 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.4237 6 no
GO:0003924 GTPase activity 23.7288 7 no

Biological process

Term Name % Distance from top the of the tree Annotated in GBG2_HUMAN
GO:0010646 regulation of cell communication 64.4068 4 no
GO:0048523 negative regulation of cellular process 52.5424 4 no
GO:0048522 positive regulation of cellular process 50.8475 4 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 47.4576 4 yes
GO:0051049 regulation of transport 45.7627 4 no
GO:0009966 regulation of signal transduction 44.0678 4 no
GO:0010647 positive regulation of cell communication 38.9831 5 no
GO:0023056 positive regulation of signaling 38.9831 4 no
GO:0031323 regulation of cellular metabolic process 35.5932 4 no
GO:0010648 negative regulation of cell communication 32.2034 5 no
GO:0023057 negative regulation of signaling 32.2034 4 no
GO:0009893 positive regulation of metabolic process 32.2034 4 no
GO:0048584 positive regulation of response to stimulus 32.2034 4 no
GO:0060255 regulation of macromolecule metabolic process 32.2034 4 no
GO:0009967 positive regulation of signal transduction 30.5085 5 no
GO:0051240 positive regulation of multicellular organismal process 30.5085 4 no
GO:0050804 modulation of chemical synaptic transmission 30.5085 5 no
GO:0099177 regulation of trans-synaptic signaling 30.5085 4 no
GO:0080090 regulation of primary metabolic process 28.8136 4 no
GO:1902531 regulation of intracellular signal transduction 28.8136 5 no
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 27.1186 5 yes
GO:0042127 regulation of cell population proliferation 27.1186 4 no
GO:0044057 regulation of system process 25.4237 4 no
GO:0051046 regulation of secretion 25.4237 5 no
GO:0051241 negative regulation of multicellular organismal process 25.4237 4 no
GO:1903530 regulation of secretion by cell 25.4237 4 no
GO:0009889 regulation of biosynthetic process 25.4237 4 no
GO:0031325 positive regulation of cellular metabolic process 25.4237 5 no
GO:0051128 regulation of cellular component organization 25.4237 4 no
GO:0010243 response to organonitrogen compound 23.7288 4 yes
GO:0071310 cellular response to organic substance 23.7288 4 yes
GO:0048585 negative regulation of response to stimulus 23.7288 4 no
GO:0051050 positive regulation of transport 23.7288 4 no
GO:0031326 regulation of cellular biosynthetic process 23.7288 5 no
GO:0031399 regulation of protein modification process 23.7288 6 no
GO:0034762 regulation of transmembrane transport 23.7288 4 no
GO:0051246 regulation of protein metabolic process 23.7288 5 no
GO:1902533 positive regulation of intracellular signal transduction 23.7288 6 no
GO:1901701 cellular response to oxygen-containing compound 22.0339 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 22.0339 5 no
GO:0010604 positive regulation of macromolecule metabolic process 22.0339 5 no
GO:0051094 positive regulation of developmental process 22.0339 4 no
GO:2000026 regulation of multicellular organismal development 22.0339 4 no
GO:0009892 negative regulation of metabolic process 22.0339 4 no
GO:0043269 regulation of monoatomic ion transport 22.0339 5 no
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 22.0339 5 no
GO:0033993 response to lipid 20.3390 4 yes
GO:0001932 regulation of protein phosphorylation 20.3390 7 no
GO:0010468 regulation of gene expression 20.3390 6 no
GO:0019220 regulation of phosphate metabolic process 20.3390 6 no
GO:0042325 regulation of phosphorylation 20.3390 7 no
GO:0051174 regulation of phosphorus metabolic process 20.3390 5 no
GO:0007268 chemical synaptic transmission 20.3390 7 no
GO:0098916 anterograde trans-synaptic signaling 20.3390 6 no
GO:0099536 synaptic signaling 20.3390 4 no
GO:0099537 trans-synaptic signaling 20.3390 5 no
GO:0010959 regulation of metal ion transport 20.3390 6 no
GO:0051051 negative regulation of transport 20.3390 4 no
GO:0014070 response to organic cyclic compound 18.6441 4 yes
GO:0071417 cellular response to organonitrogen compound 15.2542 4 yes
GO:0097305 response to alcohol 15.2542 4 yes
GO:1901699 cellular response to nitrogen compound 15.2542 4 yes
GO:0071396 cellular response to lipid 13.5593 5 yes
GO:0032870 cellular response to hormone stimulus 11.8644 4 yes
GO:0071407 cellular response to organic cyclic compound 10.1695 5 yes
GO:1901654 response to ketone 10.1695 4 yes
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway 8.4746 4 yes
GO:0097306 cellular response to alcohol 8.4746 5 yes
GO:0071867 response to monoamine 6.7797 5 yes
GO:0071868 cellular response to monoamine stimulus 6.7797 5 yes
GO:0071869 response to catecholamine 6.7797 4 yes
GO:0071870 cellular response to catecholamine stimulus 6.7797 5 yes
GO:1901655 cellular response to ketone 6.7797 5 yes
GO:0034694 response to prostaglandin 5.0847 4 yes
GO:0034695 response to prostaglandin E 5.0847 5 yes
GO:0071379 cellular response to prostaglandin stimulus 5.0847 5 yes
GO:0071380 cellular response to prostaglandin E stimulus 5.0847 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GALR2_HUMAN [view interactions] Low throughput no yes
CX3C1_HUMAN [view interactions] Low throughput no yes
GALR1_HUMAN [view interactions] Low throughput no no
SPXN_HUMAN [view interactions] Low throughput no no
NMUR2_HUMAN [view interactions] Low throughput no yes
SMS_HUMAN [view entry] [view interactions] Low throughput yes no
SSR2_HUMAN [view interactions] Low throughput no yes
SSR4_HUMAN [view interactions] Low throughput no no
TSHR_HUMAN [view interactions] Low throughput no no
P2Y12_HUMAN [view interactions] Low throughput no no
PDYN_HUMAN [view interactions] Low throughput no yes
GPR12_HUMAN [view interactions] Low throughput no no
GPR17_HUMAN [view interactions] Low throughput no no
PYY_HUMAN [view interactions] Low throughput no no
KCNK2_HUMAN [view entry] [view interactions] Low throughput yes no
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACM4_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI1_HUMAN [view entry] [view interactions] Low throughput yes yes
SMO_HUMAN [view entry] [view interactions] Low throughput yes yes
OPRM_HUMAN [view entry] [view interactions] Low throughput yes no
5HT1B_HUMAN [view interactions] Low throughput no no
NTR1_HUMAN [view interactions] Low throughput no no
GRM2_HUMAN [view entry] [view interactions] Low throughput yes yes
WDR26_HUMAN [view interactions] Low throughput no yes
PKHG2_HUMAN [view interactions] Low throughput no no
RACK1_HUMAN [view interactions] Low throughput no yes
GBB2_HUMAN [view entry] [view interactions] Low throughput yes yes
GBB3_HUMAN [view interactions] Low throughput no yes
GNB5_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARBK1_HUMAN [view entry] [view interactions] Low throughput yes yes
BTK_HUMAN [view interactions] Low throughput no no
GNA13_HUMAN [view entry] [view interactions] Low throughput yes yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI2_HUMAN [view entry] [view interactions] Low throughput yes yes
GABR1_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAQ_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAZ_HUMAN [view entry] [view interactions] Low throughput yes yes
GNA11_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
KCD12_HUMAN [view entry] [view interactions] Low throughput yes no
KCTD5_HUMAN [view interactions] Low throughput no no
PI3R5_HUMAN [view interactions] Low throughput no no
PK3CG_HUMAN [view interactions] Low throughput no yes
ADRB2_HUMAN [view entry] [view interactions] Low throughput yes no
V2R_HUMAN [view interactions] Low throughput no no
ADA2A_HUMAN [view entry] [view interactions] Low throughput yes no
MRGX1_HUMAN [view interactions] Low throughput no no
TA2R_HUMAN [view interactions] Low throughput no no
ADCY2_HUMAN [view interactions] Low throughput no yes
CALCR_HUMAN [view interactions] Low throughput no no
GLP1R_HUMAN [view interactions] Low throughput no no
RAMP1_HUMAN [view interactions] Low throughput no no
CALRL_HUMAN [view interactions] Low throughput no yes
CNR2_HUMAN [view entry] [view interactions] Low throughput yes yes
CNR1_HUMAN [view interactions] Low throughput no yes
IL8_HUMAN [view interactions] Low throughput no no
CXCR2_HUMAN [view interactions] Low throughput no no
GPR52_HUMAN [view interactions] Low throughput no no
GLR_HUMAN [view interactions] Low throughput no no
GLUC_HUMAN [view interactions] Low throughput no no
PACR_HUMAN [view interactions] Low throughput no no
PACA_HUMAN [view interactions] Low throughput no no
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
ACM2_HUMAN [view entry] [view interactions] Low throughput yes yes
FPR2_HUMAN [view interactions] Low throughput no yes
CRF_HUMAN [view interactions] Low throughput no no
CRFR1_HUMAN [view entry] [view interactions] Low throughput yes yes
TRPM1_HUMAN [view interactions] Low throughput no no
ADML_HUMAN [view interactions] Low throughput no no
RAMP2_HUMAN [view interactions] Low throughput no no
RAMP3_HUMAN [view interactions] Low throughput no no
ADM2_HUMAN [view interactions] Low throughput no no
VIPR1_HUMAN [view interactions] Low throughput no yes
SECR_HUMAN [view interactions] Low throughput no no
SCTR_HUMAN [view interactions] Low throughput no no
MC4R_HUMAN [view interactions] Low throughput no yes
NEU2_HUMAN [view interactions] Low throughput no no
GPBAR_HUMAN [view interactions] Low throughput no no
DRD1_HUMAN [view entry] [view interactions] Low throughput yes no
PE2R2_HUMAN [view interactions] Low throughput no no
AGRG3_HUMAN [view interactions] Low throughput no no
PE2R4_HUMAN [view interactions] Low throughput no yes
GRM4_HUMAN [view interactions] Low throughput no no
GNAI3_HUMAN [view entry] [view interactions] Low throughput yes yes
GABR2_HUMAN [view entry] [view interactions] Low throughput yes yes
GPR88_HUMAN [view interactions] Low throughput no no
S1PR1_HUMAN [view interactions] Low throughput no no
AGRD1_HUMAN [view interactions] Low throughput no yes
FZD7_HUMAN [view interactions] Low throughput no yes
S1PR5_HUMAN [view interactions] Low throughput no no
S1PR3_HUMAN [view interactions] Low throughput no no
CCKN_HUMAN [view interactions] Low throughput no yes
CCKAR_HUMAN [view interactions] Low throughput no no
CCR5_HUMAN [view interactions] Low throughput no no
GASR_HUMAN [view interactions] Low throughput no no
OREX_HUMAN [view interactions] Low throughput no no
OX2R_HUMAN [view interactions] Low throughput no no
GHSR_HUMAN [view entry] [view interactions] Low throughput yes no
GHRL_HUMAN [view entry] [view interactions] Low throughput yes no
GIPR_HUMAN [view interactions] Low throughput no yes
X3CL1_HUMAN [view interactions] Low throughput no yes
TKN1_HUMAN [view interactions] Low throughput no yes
NK1R_HUMAN [view entry] [view interactions] Low throughput yes no
MRGX2_HUMAN [view interactions] Low throughput no yes
AGRG1_HUMAN [view interactions] Low throughput no yes
S1PR2_HUMAN [view entry] [view interactions] Low throughput yes no
GP183_HUMAN [view interactions] Low throughput no yes
IAPP_HUMAN [view interactions] Low throughput no no
CALC_HUMAN [view interactions] Low throughput no no
CORT_HUMAN [view interactions] Low throughput no no
NPY1R_HUMAN [view interactions] Low throughput no no
NPY_HUMAN [view interactions] Low throughput no yes
LT4R1_HUMAN [view interactions] Low throughput no yes
CCR1_HUMAN [view interactions] Low throughput no no
CCL15_HUMAN [view interactions] Low throughput no no
NMU_HUMAN [view interactions] Low throughput no no
NMS_HUMAN [view interactions] Low throughput no no
AGRF1_HUMAN [view interactions] Low throughput no no
AGRG2_HUMAN [view interactions] Low throughput no no
FPR1_HUMAN [view interactions] Low throughput no no
5HT2C_HUMAN [view interactions] Low throughput no no
OPRK_HUMAN [view entry] [view interactions] Low throughput yes yes
VIP_HUMAN [view interactions] Low throughput no no
ACM3_HUMAN [view entry] [view interactions] Low throughput yes yes
PLCB3_HUMAN [view entry] [view interactions] Low throughput yes no
COLI_HUMAN [view interactions] Low throughput no no
KNG1_HUMAN [view interactions] Low throughput no no
BKRB2_HUMAN [view interactions] Low throughput no yes
O51E2_HUMAN [view interactions] Low throughput no no
GAST_HUMAN [view interactions] Low throughput no no
PTHY_HUMAN [view interactions] Low throughput no no
PTH1R_HUMAN [view interactions] Low throughput no no
PTHR_HUMAN [view interactions] Low throughput no yes
NEUT_HUMAN [view interactions] Low throughput no no
GPR84_HUMAN [view interactions] Low throughput no no
CD69_HUMAN [view interactions] Low throughput no no
GPR35_HUMAN [view interactions] Low throughput no no
EDNRB_HUMAN [view interactions] Low throughput no no
EDNRA_HUMAN [view interactions] Low throughput no yes
EDN1_HUMAN [view interactions] Low throughput no no
AA2BR_HUMAN [view interactions] Low throughput no no
GPR21_HUMAN [view interactions] Low throughput no no
C5AR1_HUMAN [view interactions] Low throughput no yes
CO5_HUMAN [view interactions] Low throughput no no
FSHB_HUMAN [view interactions] Low throughput no no
FSHR_HUMAN [view interactions] Low throughput no no
GLHA_HUMAN [view interactions] Low throughput no no
HCAR2_HUMAN [view interactions] Low throughput no yes
C3AR_HUMAN [view interactions] Low throughput no no
CO3_HUMAN [view entry] [view interactions] Low throughput yes no
FFAR4_HUMAN [view interactions] Low throughput no no
GP156_HUMAN [view interactions] Low throughput no no
AGRE5_HUMAN [view interactions] Low throughput no no
PF2R_HUMAN [view interactions] Low throughput no no
TAAR9_HUMAN [view interactions] Low throughput no no
GP174_HUMAN [view interactions] Low throughput no no
FFAR3_HUMAN [view interactions] Low throughput no yes
FFAR2_HUMAN [view interactions] Low throughput no yes
GRM3_HUMAN [view entry] [view interactions] Low throughput yes no
PENK_HUMAN [view interactions] Low throughput no yes
FZD6_HUMAN [view interactions] Low throughput no yes
GNAS1_HUMAN [view entry] [view interactions] Low throughput yes yes
FZD3_HUMAN [view interactions] Low throughput no yes
5HT6R_HUMAN [view interactions] Low throughput no yes
5HT1A_HUMAN [view interactions] Low throughput no yes
GPR34_HUMAN [view interactions] Low throughput no yes
CCR8_HUMAN [view interactions] Low throughput no no
HRH2_HUMAN [view interactions] Low throughput no no
NEU1_HUMAN [view interactions] Low throughput no no
OXYR_HUMAN [view interactions] Low throughput no no
5HT2A_HUMAN [view entry] [view interactions] Low throughput yes yes
AGRL3_HUMAN [view entry] [view interactions] Low throughput yes yes
RARR2_HUMAN [view interactions] Low throughput no no
CML1_HUMAN [view interactions] Low throughput no yes
GP161_HUMAN [view interactions] Low throughput no yes
5HT2B_HUMAN [view interactions] Low throughput no no
CASR_HUMAN [view interactions] Low throughput no no
FFAR1_HUMAN [view interactions] Low throughput no no
TSHB_HUMAN [view interactions] Low throughput no no
CUL3_HUMAN [view entry] [view interactions] Low throughput yes yes
GPR3_HUMAN [view interactions] Low throughput no no
5HT5A_HUMAN [view entry] [view interactions] Low throughput yes yes
TAAR1_HUMAN [view interactions] Low throughput no yes
GP101_HUMAN [view interactions] Low throughput no no
GP119_HUMAN [view interactions] Low throughput no no
PI2R_HUMAN [view interactions] Low throughput no no
NPY2R_HUMAN [view interactions] Low throughput no no
NPY4R_HUMAN [view interactions] Low throughput no yes
PAHO_HUMAN [view interactions] Low throughput no no
CCR3_HUMAN [view interactions] Low throughput no yes
CCR2_HUMAN [view interactions] Low throughput no yes
CCL2_HUMAN [view interactions] Low throughput no no
GALA_HUMAN [view interactions] Low throughput no no
NUFP1_HUMAN [view interactions] High throughput no yes
RRP7A_HUMAN [view interactions] High throughput no yes
ARMC1_HUMAN [view interactions] High throughput no yes
BOREA_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
FNTA_HUMAN [view interactions] High throughput no yes
SMUF2_HUMAN [view interactions] High throughput no yes
GBB4_HUMAN [view entry] [view interactions] High throughput yes yes
ATP4A_HUMAN [view entry] [view interactions] High throughput yes no
MTOR_HUMAN [view entry] [view interactions] High throughput yes yes
RICTR_HUMAN [view interactions] High throughput no yes
RPTOR_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
DGUOK_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
CD81_HUMAN [view interactions] High throughput no no
TBC24_HUMAN [view entry] [view interactions] High throughput yes yes
KCTD2_HUMAN [view interactions] High throughput no no
GNA12_HUMAN [view interactions] High throughput no no
PHLP_HUMAN [view interactions] High throughput no yes
FTO_HUMAN [view interactions] High throughput no yes
KCD16_HUMAN [view entry] [view interactions] High throughput yes yes
DCP1B_HUMAN [view interactions] High throughput no yes
KCD17_HUMAN [view interactions] High throughput no yes
MSPD2_HUMAN [view interactions] High throughput no yes
F1712_HUMAN [view interactions] High throughput no no
MOG1_HUMAN [view interactions] High throughput no yes
RHEB_HUMAN [view entry] [view interactions] High throughput yes yes
WDFY1_HUMAN [view interactions] High throughput no yes
TTBK2_HUMAN [view interactions] High throughput no yes
PKHG5_HUMAN [view interactions] High throughput no yes
STK25_HUMAN [view interactions] High throughput no no
STK26_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
GBG12_HUMAN [view entry] [view interactions] High throughput yes yes
GBG11_HUMAN [view interactions] High throughput no no
GBG3_HUMAN [view entry] [view interactions] High throughput yes no
HDAC4_HUMAN [view interactions] High throughput no yes
NDKB_HUMAN [view entry] [view interactions] High throughput yes yes