Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GBG2_HUMAN

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in GBG2_HUMAN
GO:0017076 purine nucleotide binding 40.9836 4 no
GO:0032555 purine ribonucleotide binding 40.9836 4 no
GO:0035639 purine ribonucleoside triphosphate binding 40.9836 4 no
GO:0046872 metal ion binding 34.4262 4 no
GO:0003924 GTPase activity 29.5082 7 no
GO:0016462 pyrophosphatase activity 29.5082 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 29.5082 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 29.5082 6 no
GO:0001664 G protein-coupled receptor binding 26.2295 4 no
GO:0019001 guanyl nucleotide binding 24.5902 5 no
GO:0032561 guanyl ribonucleotide binding 24.5902 5 no
GO:0004930 G protein-coupled receptor activity 24.5902 4 no
GO:0005525 GTP binding 22.9508 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in GBG2_HUMAN
GO:0048522 positive regulation of cellular process 57.3770 4 no
GO:0010646 regulation of cell communication 57.3770 4 no
GO:0009966 regulation of signal transduction 54.0984 4 no
GO:0048523 negative regulation of cellular process 50.8197 4 no
GO:0051049 regulation of transport 45.9016 4 no
GO:1902531 regulation of intracellular signal transduction 44.2623 5 no
GO:0048584 positive regulation of response to stimulus 40.9836 4 no
GO:0009893 positive regulation of metabolic process 40.9836 4 no
GO:0010647 positive regulation of cell communication 40.9836 5 no
GO:0023056 positive regulation of signaling 40.9836 4 no
GO:0031323 regulation of cellular metabolic process 40.9836 4 no
GO:0060255 regulation of macromolecule metabolic process 39.3443 4 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 39.3443 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 37.7049 4 no
GO:0080090 regulation of primary metabolic process 37.7049 4 no
GO:0009967 positive regulation of signal transduction 37.7049 5 no
GO:1902533 positive regulation of intracellular signal transduction 34.4262 6 no
GO:0051050 positive regulation of transport 34.4262 4 no
GO:0043085 positive regulation of catalytic activity 34.4262 4 no
GO:0031325 positive regulation of cellular metabolic process 34.4262 5 no
GO:0051246 regulation of protein metabolic process 32.7869 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 31.1475 5 no
GO:0043269 regulation of ion transport 31.1475 5 no
GO:0010604 positive regulation of macromolecule metabolic process 31.1475 5 no
GO:0051128 regulation of cellular component organization 29.5082 4 no
GO:0071310 cellular response to organic substance 29.5082 4 yes
GO:0010468 regulation of gene expression 29.5082 5 no
GO:0051174 regulation of phosphorus metabolic process 27.8689 5 no
GO:0010648 negative regulation of cell communication 27.8689 5 no
GO:0023057 negative regulation of signaling 27.8689 4 no
GO:0009892 negative regulation of metabolic process 27.8689 4 no
GO:0019220 regulation of phosphate metabolic process 27.8689 6 no
GO:0051247 positive regulation of protein metabolic process 26.2295 6 no
GO:0048585 negative regulation of response to stimulus 26.2295 4 no
GO:0010243 response to organonitrogen compound 26.2295 4 yes
GO:0031399 regulation of protein modification process 26.2295 6 no
GO:0042127 regulation of cell population proliferation 26.2295 4 no
GO:0042325 regulation of phosphorylation 26.2295 7 no
GO:0051240 positive regulation of multicellular organismal process 24.5902 4 no
GO:0044057 regulation of system process 24.5902 4 no
GO:0080134 regulation of response to stress 24.5902 4 no
GO:0043408 regulation of MAPK cascade 24.5902 6 no
GO:0001932 regulation of protein phosphorylation 24.5902 7 no
GO:0006796 phosphate-containing compound metabolic process 24.5902 4 no
GO:0010941 regulation of cell death 24.5902 4 no
GO:0042981 regulation of apoptotic process 22.9508 6 no
GO:0043067 regulation of programmed cell death 22.9508 5 no
GO:0045937 positive regulation of phosphate metabolic process 22.9508 7 no
GO:0034762 regulation of transmembrane transport 22.9508 4 no
GO:0051336 regulation of hydrolase activity 22.9508 4 no
GO:0032880 regulation of protein localization 22.9508 5 no
GO:0050804 modulation of chemical synaptic transmission 22.9508 5 no
GO:0060341 regulation of cellular localization 22.9508 4 no
GO:0099177 regulation of trans-synaptic signaling 22.9508 4 no
GO:0043410 positive regulation of MAPK cascade 22.9508 7 no
GO:1901701 cellular response to oxygen-containing compound 22.9508 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 22.9508 6 no
GO:0042327 positive regulation of phosphorylation 22.9508 8 no
GO:0044087 regulation of cellular component biogenesis 21.3115 4 no
GO:0060548 negative regulation of cell death 21.3115 5 no
GO:0034765 regulation of ion transmembrane transport 21.3115 5 no
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 21.3115 5 no
GO:0051223 regulation of protein transport 21.3115 5 no
GO:0070201 regulation of establishment of protein localization 21.3115 6 no
GO:0051046 regulation of secretion 21.3115 5 no
GO:0051241 negative regulation of multicellular organismal process 21.3115 4 no
GO:1903530 regulation of secretion by cell 21.3115 4 no
GO:0001934 positive regulation of protein phosphorylation 21.3115 8 no
GO:0031401 positive regulation of protein modification process 21.3115 7 no
GO:0014070 response to organic cyclic compound 19.6721 4 yes
GO:0071417 cellular response to organonitrogen compound 19.6721 4 yes
GO:1901699 cellular response to nitrogen compound 19.6721 4 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 18.0328 5 yes
GO:0032870 cellular response to hormone stimulus 16.3934 4 yes
GO:0033993 response to lipid 16.3934 4 yes
GO:0071407 cellular response to organic cyclic compound 13.1148 5 yes
GO:0071396 cellular response to lipid 11.4754 5 yes
GO:1901654 response to ketone 11.4754 4 yes
GO:0097305 response to alcohol 9.8361 4 yes
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway 8.1967 4 yes
GO:0071867 response to monoamine 8.1967 5 yes
GO:0071868 cellular response to monoamine stimulus 8.1967 5 yes
GO:0071869 response to catecholamine 8.1967 4 yes
GO:0071870 cellular response to catecholamine stimulus 8.1967 5 yes
GO:1901655 cellular response to ketone 8.1967 5 yes
GO:0097306 cellular response to alcohol 6.5574 5 yes
GO:0034694 response to prostaglandin 4.9180 4 yes
GO:0034695 response to prostaglandin E 4.9180 5 yes
GO:0071379 cellular response to prostaglandin stimulus 4.9180 5 yes
GO:0071380 cellular response to prostaglandin E stimulus 4.9180 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GP183_HUMAN [view interactions] Low throughput no yes
IAPP_HUMAN [view interactions] Low throughput no no
CALC_HUMAN [view interactions] Low throughput no no
CORT_HUMAN [view interactions] Low throughput no no
NPY_HUMAN [view interactions] Low throughput no yes
NPY1R_HUMAN [view interactions] Low throughput no no
LT4R1_HUMAN [view interactions] Low throughput no yes
CCR1_HUMAN [view interactions] Low throughput no no
CCL15_HUMAN [view interactions] Low throughput no no
NMU_HUMAN [view interactions] Low throughput no no
NMS_HUMAN [view interactions] Low throughput no no
AGRF1_HUMAN [view interactions] Low throughput no no
AGRG2_HUMAN [view interactions] Low throughput no no
FPR1_HUMAN [view interactions] Low throughput no no
NPY2R_HUMAN [view interactions] Low throughput no no
PAHO_HUMAN [view interactions] Low throughput no no
NPY4R_HUMAN [view interactions] Low throughput no yes
KCNK2_HUMAN [view interactions] Low throughput no no
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACM4_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI1_HUMAN [view entry] [view interactions] Low throughput yes yes
SMO_HUMAN [view interactions] Low throughput no yes
CALCR_HUMAN [view interactions] Low throughput no no
OPRM_HUMAN [view entry] [view interactions] Low throughput yes no
5HT1B_HUMAN [view interactions] Low throughput no no
NTR1_HUMAN [view interactions] Low throughput no no
GRM2_HUMAN [view entry] [view interactions] Low throughput yes yes
WDR26_HUMAN [view interactions] Low throughput no yes
PKHG2_HUMAN [view interactions] Low throughput no no
RACK1_HUMAN [view interactions] Low throughput no yes
GBB2_HUMAN [view entry] [view interactions] Low throughput yes yes
GBB3_HUMAN [view interactions] Low throughput no yes
GNB5_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARBK1_HUMAN [view entry] [view interactions] Low throughput yes yes
BTK_HUMAN [view interactions] Low throughput no no
GNA13_HUMAN [view entry] [view interactions] Low throughput yes yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI2_HUMAN [view entry] [view interactions] Low throughput yes yes
GABR1_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAQ_HUMAN [view entry] [view interactions] Low throughput yes yes
GNA11_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
KCD12_HUMAN [view entry] [view interactions] Low throughput yes no
PI3R5_HUMAN [view interactions] Low throughput no no
PK3CG_HUMAN [view interactions] Low throughput no yes
V2R_HUMAN [view interactions] Low throughput no no
ADA2A_HUMAN [view entry] [view interactions] Low throughput yes no
ADCY2_HUMAN [view interactions] Low throughput no yes
ACM2_HUMAN [view entry] [view interactions] Low throughput yes yes
RAMP3_HUMAN [view interactions] Low throughput no no
PACA_HUMAN [view interactions] Low throughput no no
CXCR2_HUMAN [view interactions] Low throughput no no
IL8_HUMAN [view interactions] Low throughput no no
CNR1_HUMAN [view interactions] Low throughput no yes
GLUC_HUMAN [view interactions] Low throughput no no
ADM2_HUMAN [view interactions] Low throughput no no
RAMP2_HUMAN [view interactions] Low throughput no no
CALRL_HUMAN [view interactions] Low throughput no yes
GLR_HUMAN [view interactions] Low throughput no no
SCTR_HUMAN [view interactions] Low throughput no no
SECR_HUMAN [view interactions] Low throughput no no
GPR52_HUMAN [view interactions] Low throughput no no
ADML_HUMAN [view interactions] Low throughput no no
FPR2_HUMAN [view interactions] Low throughput no yes
GLP1R_HUMAN [view interactions] Low throughput no no
GNAI3_HUMAN [view entry] [view interactions] Low throughput yes yes
PACR_HUMAN [view interactions] Low throughput no no
CNR2_HUMAN [view interactions] Low throughput no yes
RAMP1_HUMAN [view interactions] Low throughput no no
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
CRF_HUMAN [view interactions] Low throughput no no
CRFR1_HUMAN [view interactions] Low throughput no yes
TRPM1_HUMAN [view interactions] Low throughput no no
VIPR1_HUMAN [view interactions] Low throughput no yes
MC4R_HUMAN [view interactions] Low throughput no yes
NEU2_HUMAN [view interactions] Low throughput no no
GPBAR_HUMAN [view interactions] Low throughput no no
DRD1_HUMAN [view entry] [view interactions] Low throughput yes no
PE2R2_HUMAN [view interactions] Low throughput no no
AGRG3_HUMAN [view interactions] Low throughput no no
PE2R4_HUMAN [view interactions] Low throughput no yes
GRM4_HUMAN [view interactions] Low throughput no no
GABR2_HUMAN [view entry] [view interactions] Low throughput yes yes
GPR88_HUMAN [view interactions] Low throughput no no
S1PR1_HUMAN [view interactions] Low throughput no no
AGRD1_HUMAN [view interactions] Low throughput no yes
FZD7_HUMAN [view interactions] Low throughput no yes
S1PR5_HUMAN [view interactions] Low throughput no no
S1PR3_HUMAN [view interactions] Low throughput no no
CCKN_HUMAN [view interactions] Low throughput no yes
CCKAR_HUMAN [view interactions] Low throughput no no
CCR5_HUMAN [view interactions] Low throughput no no
GASR_HUMAN [view interactions] Low throughput no no
OX2R_HUMAN [view interactions] Low throughput no no
OREX_HUMAN [view interactions] Low throughput no no
GHSR_HUMAN [view entry] [view interactions] Low throughput yes no
GHRL_HUMAN [view entry] [view interactions] Low throughput yes no
GIPR_HUMAN [view interactions] Low throughput no yes
X3CL1_HUMAN [view interactions] Low throughput no yes
TKN1_HUMAN [view interactions] Low throughput no yes
NK1R_HUMAN [view interactions] Low throughput no no
MRGX2_HUMAN [view interactions] Low throughput no yes
AGRG1_HUMAN [view interactions] Low throughput no yes
S1PR2_HUMAN [view interactions] Low throughput no no
NUFP1_HUMAN [view interactions] High throughput no yes
RRP7A_HUMAN [view interactions] High throughput no yes
ARMC1_HUMAN [view interactions] High throughput no yes
BOREA_HUMAN [view interactions] High throughput no yes
FNTA_HUMAN [view interactions] High throughput no yes
SMUF2_HUMAN [view interactions] High throughput no yes
GBB4_HUMAN [view entry] [view interactions] High throughput yes yes
ATP4A_HUMAN [view entry] [view interactions] High throughput yes no
MTOR_HUMAN [view entry] [view interactions] High throughput yes yes
RICTR_HUMAN [view interactions] High throughput no yes
RPTOR_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
DGUOK_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
CD81_HUMAN [view interactions] High throughput no no
TBC24_HUMAN [view entry] [view interactions] High throughput yes yes
GNAZ_HUMAN [view entry] [view interactions] High throughput yes yes
KCTD2_HUMAN [view interactions] High throughput no no
GNA12_HUMAN [view interactions] High throughput no no
PHLP_HUMAN [view interactions] High throughput no yes
FTO_HUMAN [view interactions] High throughput no yes
KCD16_HUMAN [view entry] [view interactions] High throughput yes yes
DCP1B_HUMAN [view interactions] High throughput no yes
KCD17_HUMAN [view interactions] High throughput no yes
MSPD2_HUMAN [view interactions] High throughput no yes
KCTD5_HUMAN [view interactions] High throughput no no
F1712_HUMAN [view interactions] High throughput no no
MOG1_HUMAN [view interactions] High throughput no yes
RHEB_HUMAN [view entry] [view interactions] High throughput yes yes
WDFY1_HUMAN [view interactions] High throughput no yes
TTBK2_HUMAN [view interactions] High throughput no yes
PKHG5_HUMAN [view interactions] High throughput no yes
STK25_HUMAN [view interactions] High throughput no no
STK26_HUMAN [view interactions] High throughput no no
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
MRGX1_HUMAN [view interactions] High throughput no no
TA2R_HUMAN [view interactions] High throughput no no
GBG12_HUMAN [view entry] [view interactions] High throughput yes yes
GBG11_HUMAN [view interactions] High throughput no no
GBG3_HUMAN [view entry] [view interactions] High throughput yes no
HDAC4_HUMAN [view interactions] High throughput no yes
NDKB_HUMAN [view entry] [view interactions] High throughput yes yes
PI3R6_HUMAN [view interactions] Computational no yes
CXL13_HUMAN [view interactions] Computational no no
UBQL1_HUMAN [view interactions] Computational no yes
CXL10_HUMAN [view interactions] Computational no no
KAPCA_HUMAN [view entry] [view interactions] Computational yes yes
CD3Z_HUMAN [view interactions] Computational no no
KCNJ6_HUMAN [view interactions] Computational no no
LPAR5_HUMAN [view interactions] Computational no yes
KCNJ5_HUMAN [view interactions] Computational no yes
CD4_HUMAN [view interactions] Computational no no
GNAL_HUMAN [view interactions] Computational no yes
PLF4_HUMAN [view interactions] Computational no no
CA2D2_HUMAN [view entry] [view interactions] Computational yes yes
CAC1C_HUMAN [view entry] [view interactions] Computational yes no
PAR1_HUMAN [view entry] [view interactions] Computational yes yes
RASH_HUMAN [view entry] [view interactions] Computational yes no
KPCD_HUMAN [view entry] [view interactions] Computational yes yes
PTN6_HUMAN [view interactions] Computational no no
LPAR4_HUMAN [view interactions] Computational no no
LPAR1_HUMAN [view entry] [view interactions] Computational yes no
LPAR3_HUMAN [view interactions] Computational no no
CDC42_HUMAN [view entry] [view interactions] Computational yes yes
CXCR4_HUMAN [view interactions] Computational no no
SRC_HUMAN [view entry] [view interactions] Computational yes no
CD3G_HUMAN [view interactions] Computational no no
NOS3_HUMAN [view interactions] Computational no no
CBL_HUMAN [view interactions] Computational no yes
TGM2_HUMAN [view interactions] Computational no no
NHRF1_HUMAN [view interactions] Computational no no
CACB2_HUMAN [view interactions] Computational no yes
CAC1D_HUMAN [view interactions] Computational no yes
PLCB2_HUMAN [view interactions] Computational no no
PK3CA_HUMAN [view entry] [view interactions] Computational yes yes
AA1R_HUMAN [view entry] [view interactions] Computational yes no
PLCB3_HUMAN [view entry] [view interactions] Computational yes no
PLCB1_HUMAN [view entry] [view interactions] Computational yes yes
KCNJ3_HUMAN [view interactions] Computational no yes
HDAC5_HUMAN [view interactions] Computational no yes
LPAR6_HUMAN [view interactions] Computational no no
LPAR2_HUMAN [view interactions] Computational no yes
PAR4_HUMAN [view entry] [view interactions] Computational yes no
PAXI_HUMAN [view interactions] Computational no yes
CXCL9_HUMAN [view interactions] Computational no no
GNAS1_HUMAN [view entry] [view interactions] Computational yes yes
CXCR3_HUMAN [view interactions] Computational no no
P85A_HUMAN [view interactions] Computational no yes
CACB3_HUMAN [view entry] [view interactions] Computational yes no
RAC1_HUMAN [view entry] [view interactions] Computational yes no
CXL11_HUMAN [view interactions] Computational no no
ESR1_HUMAN [view interactions] Computational no no
MK14_HUMAN [view interactions] Computational no yes
PTH1R_HUMAN [view interactions] Computational no no
MTG1_HUMAN [view interactions] Computational no yes
PREX1_HUMAN [view entry] [view interactions] Computational yes no
CCL20_HUMAN [view interactions] Computational no no
SDF1_HUMAN [view interactions] Computational no no
TRPM3_HUMAN [view interactions] Computational no no
CAC1H_HUMAN [view entry] [view interactions] Computational yes yes
CD3D_HUMAN [view interactions] Computational no no
ANDR_HUMAN [view interactions] Computational no no
ESR2_HUMAN [view interactions] Computational no no
CXCR1_HUMAN [view interactions] Computational no yes
ACM1_HUMAN [view entry] [view interactions] Computational yes yes
CCL11_HUMAN [view interactions] Computational no no
GNA15_HUMAN [view interactions] Computational no yes
PAR3_HUMAN [view interactions] Computational no no
BCAR1_HUMAN [view interactions] Computational no yes
GNA14_HUMAN [view entry] [view interactions] Computational yes yes
MK11_HUMAN [view interactions] Computational no yes
PK3CB_HUMAN [view interactions] Computational no yes
DRB1_HUMAN [view interactions] Computational no no
DRA_HUMAN [view interactions] Computational no no
PTN11_HUMAN [view entry] [view interactions] Computational yes yes
LCK_HUMAN [view entry] [view interactions] Computational yes no
CD3E_HUMAN [view interactions] Computational no no