KCD12_HUMAN
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in KCD12_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 25.7143 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 25.7143 | 4 | no |
GO:0003723 | RNA binding | 17.1429 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in KCD12_HUMAN |
---|---|---|---|---|
GO:0010646 | regulation of cell communication | 45.7143 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 42.8571 | 4 | no |
GO:0048522 | positive regulation of cellular process | 40.0000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 40.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
GO:0022607 | cellular component assembly | 37.1429 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 37.1429 | 4 | no |
GO:0009966 | regulation of signal transduction | 37.1429 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 31.4286 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 31.4286 | 5 | no |
GO:0006996 | organelle organization | 31.4286 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 28.5714 | 5 | no |
GO:0071310 | cellular response to organic substance | 28.5714 | 4 | no |
GO:0010468 | regulation of gene expression | 28.5714 | 5 | no |
GO:0043933 | protein-containing complex organization | 25.7143 | 4 | yes |
GO:0008104 | protein localization | 25.7143 | 4 | no |
GO:0051128 | regulation of cellular component organization | 25.7143 | 4 | no |
GO:0010243 | response to organonitrogen compound | 25.7143 | 4 | no |
GO:0014070 | response to organic cyclic compound | 25.7143 | 4 | no |
GO:0071417 | cellular response to organonitrogen compound | 25.7143 | 4 | no |
GO:1901699 | cellular response to nitrogen compound | 25.7143 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.7143 | 5 | no |
GO:0010941 | regulation of cell death | 25.7143 | 4 | no |
GO:0042981 | regulation of apoptotic process | 25.7143 | 6 | no |
GO:0043067 | regulation of programmed cell death | 25.7143 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.7143 | 5 | no |
GO:0031399 | regulation of protein modification process | 22.8571 | 6 | no |
GO:0033043 | regulation of organelle organization | 22.8571 | 5 | no |
GO:1901701 | cellular response to oxygen-containing compound | 22.8571 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 22.8571 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 22.8571 | 5 | no |
GO:0065003 | protein-containing complex assembly | 20.0000 | 5 | yes |
GO:0051259 | protein complex oligomerization | 14.2857 | 6 | yes |
GO:0051260 | protein homooligomerization | 11.4286 | 7 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in KCD12_HUMAN |
---|---|---|---|---|
DOID:574 | peripheral nervous system disease | 8.5714 | 3 | no |
DOID:870 | neuropathy | 8.5714 | 4 | no |
DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 5.7143 | 7 | no |
DOID:10595 | Charcot-Marie-Tooth disease | 5.7143 | 6 | no |
DOID:440 | neuromuscular disease | 5.7143 | 5 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
KCD12_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ARAP1_HUMAN | [view interactions] | Low throughput | no | yes |
GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GABR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GBRB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
GBRG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
GBRA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
RASF5_HUMAN | [view interactions] | High throughput | no | yes |
OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
PCM1_HUMAN | [view interactions] | High throughput | no | yes |
FTM_HUMAN | [view interactions] | High throughput | no | yes |
LCA5_HUMAN | [view interactions] | High throughput | no | no |
XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TF7L2_HUMAN | [view interactions] | High throughput | no | yes |
MYLK_HUMAN | [view interactions] | High throughput | no | no |
EIF1B_HUMAN | [view interactions] | High throughput | no | no |
RIPK2_HUMAN | [view interactions] | High throughput | no | yes |
ATG5_HUMAN | [view interactions] | High throughput | no | no |
CRCM_HUMAN | [view interactions] | High throughput | no | no |
HLAB_HUMAN | [view interactions] | High throughput | no | yes |
TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
ZN792_HUMAN | [view interactions] | High throughput | no | yes |
TNR1B_HUMAN | [view interactions] | High throughput | no | no |
CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
RCCD1_HUMAN | [view interactions] | High throughput | no | yes |
CEP19_HUMAN | [view interactions] | High throughput | no | no |
SMUF2_HUMAN | [view interactions] | High throughput | no | yes |
KSR1_HUMAN | [view interactions] | High throughput | no | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
SET_HUMAN | [view interactions] | High throughput | no | yes |
CLPX_HUMAN | [view interactions] | High throughput | no | yes |
CDK1_HUMAN | [view interactions] | High throughput | no | no |
PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LEG3_HUMAN | [view interactions] | High throughput | no | yes |
TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SF3A3_HUMAN | [view interactions] | High throughput | no | yes |
RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
TOM22_HUMAN | [view interactions] | High throughput | no | yes |
ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PA2G4_HUMAN | [view interactions] | High throughput | no | yes |
AKT3_HUMAN | [view interactions] | High throughput | no | yes |
ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GSTM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYRC_HUMAN | [view interactions] | High throughput | no | yes |
RAB14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EIF3I_HUMAN | [view interactions] | High throughput | no | yes |
MPIP2_HUMAN | [view interactions] | High throughput | no | no |
SOCS2_HUMAN | [view interactions] | High throughput | no | yes |
UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
CEP97_HUMAN | [view interactions] | High throughput | no | yes |
MPIP1_HUMAN | [view interactions] | High throughput | no | no |
EYA4_HUMAN | [view interactions] | High throughput | no | yes |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
ABR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MAFB_HUMAN | [view interactions] | High throughput | no | yes |
SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PD1L1_HUMAN | [view interactions] | High throughput | no | no |
DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
T2FA_HUMAN | [view interactions] | High throughput | no | yes |
CTF8_HUMAN | [view interactions] | High throughput | no | no |
NUCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PUSL1_HUMAN | [view interactions] | High throughput | no | yes |
TPD53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUD16_HUMAN | [view interactions] | High throughput | no | yes |
DUS11_HUMAN | [view interactions] | High throughput | no | no |
PIF1_HUMAN | [view interactions] | High throughput | no | yes |
LATS1_HUMAN | [view interactions] | High throughput | no | yes |
DYH14_HUMAN | [view interactions] | High throughput | no | no |
ZIC2_HUMAN | [view interactions] | High throughput | no | no |
RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARG39_HUMAN | [view interactions] | High throughput | no | yes |
CLH2_HUMAN | [view interactions] | High throughput | no | no |
YTHD1_HUMAN | [view interactions] | High throughput | no | no |
KCD16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TSR3_HUMAN | [view interactions] | High throughput | no | yes |
RL24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
P5CR3_HUMAN | [view interactions] | High throughput | no | no |
PRR5_HUMAN | [view interactions] | High throughput | no | yes |
HECD1_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GABPA_HUMAN | [view interactions] | High throughput | no | no |
DNPEP_HUMAN | [view interactions] | High throughput | no | yes |
GLCNE_HUMAN | [view interactions] | High throughput | no | yes |
SHOT1_HUMAN | [view interactions] | High throughput | no | no |
LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OSBP1_HUMAN | [view interactions] | High throughput | no | yes |
RNBP6_HUMAN | [view interactions] | High throughput | no | yes |
IMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUCL_HUMAN | [view interactions] | High throughput | no | yes |
HS12A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MAP1S_HUMAN | [view interactions] | High throughput | no | no |
EWS_HUMAN | [view interactions] | High throughput | no | yes |
TRI14_HUMAN | [view interactions] | High throughput | no | yes |
NUFP2_HUMAN | [view interactions] | High throughput | no | no |
TIA1_HUMAN | [view interactions] | High throughput | no | no |
NAA40_HUMAN | [view interactions] | High throughput | no | no |