KCD12_HUMAN
Evidence for PS localization
Functions
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KCD12_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 32.5581 | 4 | no |
| GO:0000166 | nucleotide binding | 30.2326 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.9070 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.5814 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.9302 | 4 | no |
| GO:0003723 | RNA binding | 16.2791 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KCD12_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 53.4884 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 48.8372 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 48.8372 | 4 | no |
| GO:0009966 | regulation of signal transduction | 46.5116 | 4 | yes |
| GO:0022607 | cellular component assembly | 44.1860 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 44.1860 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 41.8605 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 41.8605 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 37.2093 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.2093 | 5 | no |
| GO:0006996 | organelle organization | 34.8837 | 4 | no |
| GO:0043933 | protein-containing complex organization | 32.5581 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 32.5581 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 32.5581 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 30.2326 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.2326 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.2326 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.2326 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.2326 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 27.9070 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 27.9070 | 4 | no |
| GO:0008104 | protein localization | 27.9070 | 4 | no |
| GO:0031399 | regulation of protein modification process | 25.5814 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 25.5814 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.5814 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.5814 | 4 | no |
| GO:0071310 | cellular response to organic substance | 25.5814 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 23.2558 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 23.2558 | 6 | no |
| GO:0033043 | regulation of organelle organization | 23.2558 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.2558 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 23.2558 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.2558 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.2558 | 6 | no |
| GO:0051049 | regulation of transport | 23.2558 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 23.2558 | 4 | no |
| GO:0071417 | cellular response to organonitrogen compound | 23.2558 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 23.2558 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 20.9302 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 20.9302 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.9302 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.9302 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.9302 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.9302 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 20.9302 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 20.9302 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.9302 | 5 | no |
| GO:0051259 | protein complex oligomerization | 13.9535 | 6 | yes |
| GO:0051260 | protein homooligomerization | 9.3023 | 7 | yes |
| GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 6.9767 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| KCD12_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GABR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBRB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RASF5_HUMAN | [view interactions] | High throughput | no | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| LCA5_HUMAN | [view interactions] | High throughput | no | no |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TF7L2_HUMAN | [view interactions] | High throughput | no | yes |
| MYLK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| RIPK2_HUMAN | [view interactions] | High throughput | no | yes |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| ZN792_HUMAN | [view interactions] | High throughput | no | yes |
| TNR1B_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| RCCD1_HUMAN | [view interactions] | High throughput | no | yes |
| CEP19_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SMUF2_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| SET_HUMAN | [view interactions] | High throughput | no | yes |
| CLPX_HUMAN | [view interactions] | High throughput | no | yes |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SF3A3_HUMAN | [view interactions] | High throughput | no | yes |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PA2G4_HUMAN | [view interactions] | High throughput | no | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSTM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYRC_HUMAN | [view interactions] | High throughput | no | yes |
| RAB14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3I_HUMAN | [view interactions] | High throughput | no | yes |
| MPIP2_HUMAN | [view interactions] | High throughput | no | no |
| SOCS2_HUMAN | [view interactions] | High throughput | no | yes |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| CEP97_HUMAN | [view interactions] | High throughput | no | yes |
| MPIP1_HUMAN | [view interactions] | High throughput | no | no |
| EYA4_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ABR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAFB_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T2FA_HUMAN | [view interactions] | High throughput | no | yes |
| CTF8_HUMAN | [view interactions] | High throughput | no | no |
| NUCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUSL1_HUMAN | [view interactions] | High throughput | no | yes |
| TPD53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUD16_HUMAN | [view interactions] | High throughput | no | yes |
| DUS11_HUMAN | [view interactions] | High throughput | no | no |
| PIF1_HUMAN | [view interactions] | High throughput | no | yes |
| LATS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYH14_HUMAN | [view interactions] | High throughput | no | no |
| ZIC2_HUMAN | [view interactions] | High throughput | no | no |
| RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARG39_HUMAN | [view interactions] | High throughput | no | yes |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| YTHD1_HUMAN | [view interactions] | High throughput | no | no |
| KCD16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSR3_HUMAN | [view interactions] | High throughput | no | yes |
| RL24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P5CR3_HUMAN | [view interactions] | High throughput | no | no |
| PRR5_HUMAN | [view interactions] | High throughput | no | yes |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GABPA_HUMAN | [view interactions] | High throughput | no | no |
| DNPEP_HUMAN | [view interactions] | High throughput | no | yes |
| GLCNE_HUMAN | [view interactions] | High throughput | no | yes |
| SHOT1_HUMAN | [view interactions] | High throughput | no | no |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSBP1_HUMAN | [view interactions] | High throughput | no | yes |
| RNBP6_HUMAN | [view interactions] | High throughput | no | yes |
| IMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| HS12A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP1S_HUMAN | [view interactions] | High throughput | no | no |
| NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
| PDP1_HUMAN | [view interactions] | High throughput | no | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| NUFP2_HUMAN | [view interactions] | High throughput | no | no |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |