RAB14_HUMAN
Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes . Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in RAB14_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 27.6316 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 27.6316 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 27.6316 | 4 | yes |
GO:0016462 | pyrophosphatase activity | 23.6842 | 5 | yes |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 23.6842 | 4 | yes |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 23.6842 | 6 | yes |
GO:0003924 | GTPase activity | 19.7368 | 7 | yes |
GO:0005525 | GTP binding | 19.7368 | 5 | yes |
GO:0019001 | guanyl nucleotide binding | 19.7368 | 5 | yes |
GO:0032561 | guanyl ribonucleotide binding | 19.7368 | 5 | yes |
GO:0019003 | GDP binding | 14.4737 | 4 | yes |
GO:0017022 | myosin binding | 3.9474 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in RAB14_HUMAN |
---|---|---|---|---|
GO:0008104 | protein localization | 61.8421 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 57.8947 | 4 | no |
GO:0071702 | organic substance transport | 48.6842 | 4 | yes |
GO:0071705 | nitrogen compound transport | 48.6842 | 4 | yes |
GO:0015031 | protein transport | 47.3684 | 4 | yes |
GO:0006996 | organelle organization | 46.0526 | 4 | yes |
GO:0016192 | vesicle-mediated transport | 43.4211 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 43.4211 | 4 | no |
GO:0022607 | cellular component assembly | 40.7895 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 40.7895 | 4 | no |
GO:0051049 | regulation of transport | 39.4737 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 38.1579 | 4 | no |
GO:0048523 | negative regulation of cellular process | 36.8421 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 35.5263 | 4 | no |
GO:0010646 | regulation of cell communication | 35.5263 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 34.2105 | 4 | no |
GO:0009966 | regulation of signal transduction | 32.8947 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 32.8947 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 31.5789 | 5 | no |
GO:0006886 | intracellular protein transport | 28.9474 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 27.6316 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 27.6316 | 5 | no |
GO:0060341 | regulation of cellular localization | 26.3158 | 4 | yes |
GO:0023056 | positive regulation of signaling | 26.3158 | 4 | no |
GO:0033043 | regulation of organelle organization | 26.3158 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 26.3158 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
GO:0032880 | regulation of protein localization | 23.6842 | 5 | yes |
GO:0009967 | positive regulation of signal transduction | 22.3684 | 5 | no |
GO:0010647 | positive regulation of cell communication | 22.3684 | 5 | no |
GO:0060627 | regulation of vesicle-mediated transport | 21.0526 | 4 | no |
GO:0051050 | positive regulation of transport | 21.0526 | 4 | no |
GO:0009894 | regulation of catabolic process | 21.0526 | 4 | no |
GO:0030030 | cell projection organization | 21.0526 | 4 | no |
GO:0071310 | cellular response to organic substance | 21.0526 | 4 | no |
GO:0031344 | regulation of cell projection organization | 21.0526 | 5 | no |
GO:0048193 | Golgi vesicle transport | 19.7368 | 5 | yes |
GO:0016050 | vesicle organization | 17.1053 | 5 | yes |
GO:0070925 | organelle assembly | 17.1053 | 5 | yes |
GO:0098876 | vesicle-mediated transport to the plasma membrane | 14.4737 | 4 | yes |
GO:0006892 | post-Golgi vesicle-mediated transport | 13.1579 | 6 | yes |
GO:2000026 | regulation of multicellular organismal development | 13.1579 | 4 | yes |
GO:0016197 | endosomal transport | 9.2105 | 4 | yes |
GO:0007033 | vacuole organization | 7.8947 | 5 | yes |
GO:0016482 | cytosolic transport | 7.8947 | 4 | yes |
GO:0032456 | endocytic recycling | 3.9474 | 5 | yes |
GO:0042742 | defense response to bacterium | 3.9474 | 4 | yes |
GO:0007040 | lysosome organization | 2.6316 | 7 | yes |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 2.6316 | 4 | yes |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 2.6316 | 5 | yes |
GO:0045995 | regulation of embryonic development | 2.6316 | 5 | yes |
GO:0080171 | lytic vacuole organization | 2.6316 | 6 | yes |
GO:0090382 | phagosome maturation | 2.6316 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
RBNS5_HUMAN | [view interactions] | Low throughput | no | yes |
TBCD1_HUMAN | [view interactions] | Low throughput | no | no |
TBCD4_HUMAN | [view interactions] | Low throughput | no | yes |
OCRL_HUMAN | [view interactions] | Low throughput | no | yes |
NISCH_HUMAN | [view interactions] | Low throughput | no | yes |
AP1G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EEA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HGS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CATA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ECHP_HUMAN | [view interactions] | Low throughput | no | no |
RUFY1_HUMAN | [view interactions] | Low throughput | no | yes |
OPTN_HUMAN | [view interactions] | Low throughput | no | yes |
RFIP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RFIP1_HUMAN | [view interactions] | Low throughput | no | yes |
ANXA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLP1R_HUMAN | [view interactions] | High throughput | no | no |
AAPK1_HUMAN | [view interactions] | High throughput | no | no |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
FLCN_HUMAN | [view interactions] | High throughput | no | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
TIA1_HUMAN | [view interactions] | High throughput | no | no |
BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DUS6_HUMAN | [view interactions] | High throughput | no | yes |
LMBRL_HUMAN | [view interactions] | High throughput | no | no |
WWP1_HUMAN | [view interactions] | High throughput | no | yes |
EMC1_HUMAN | [view interactions] | High throughput | no | yes |
EMC4_HUMAN | [view interactions] | High throughput | no | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
NPC1_HUMAN | [view interactions] | High throughput | no | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
BAP31_HUMAN | [view interactions] | High throughput | no | yes |
APR_HUMAN | [view interactions] | High throughput | no | yes |
WDR5_HUMAN | [view interactions] | High throughput | no | no |
LSM1_HUMAN | [view interactions] | High throughput | no | no |
STX17_HUMAN | [view interactions] | High throughput | no | yes |
GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LDAF1_HUMAN | [view interactions] | High throughput | no | yes |
FFAR1_HUMAN | [view interactions] | High throughput | no | no |
PLCA_HUMAN | [view interactions] | High throughput | no | yes |
OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
CR021_HUMAN | [view interactions] | High throughput | no | no |
THAP8_HUMAN | [view interactions] | High throughput | no | yes |
DERL2_HUMAN | [view interactions] | High throughput | no | yes |
MMTA2_HUMAN | [view interactions] | High throughput | no | yes |
CCR1_HUMAN | [view interactions] | High throughput | no | no |
TIDC1_HUMAN | [view interactions] | High throughput | no | yes |
SSUH2_HUMAN | [view interactions] | High throughput | no | no |
PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
PINK1_HUMAN | [view interactions] | High throughput | no | yes |
SYT6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CCNF_HUMAN | [view interactions] | High throughput | no | no |
TM192_HUMAN | [view interactions] | High throughput | no | yes |
LEG8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAE1_HUMAN | [view interactions] | High throughput | no | yes |
GDIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
LTOR2_HUMAN | [view interactions] | High throughput | no | yes |
TOM40_HUMAN | [view interactions] | High throughput | no | yes |
TFR1_HUMAN | [view interactions] | High throughput | no | yes |
TSN6_HUMAN | [view interactions] | High throughput | no | yes |
NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAE2_HUMAN | [view interactions] | High throughput | no | yes |
VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CD81_HUMAN | [view interactions] | High throughput | no | no |
SC31A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
S6A15_HUMAN | [view interactions] | High throughput | no | yes |
NRBF2_HUMAN | [view interactions] | High throughput | no | yes |
PRP19_HUMAN | [view interactions] | High throughput | no | yes |
TMCO1_HUMAN | [view interactions] | High throughput | no | yes |
ENPP4_HUMAN | [view interactions] | High throughput | no | yes |
VPP2_HUMAN | [view interactions] | High throughput | no | yes |
DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VP13C_HUMAN | [view interactions] | High throughput | no | yes |
URFB1_HUMAN | [view interactions] | High throughput | no | no |
RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCAM1_HUMAN | [view interactions] | High throughput | no | no |
SCAM2_HUMAN | [view interactions] | High throughput | no | no |
SCAM4_HUMAN | [view interactions] | High throughput | no | yes |
SEC13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPTC1_HUMAN | [view interactions] | High throughput | no | yes |
STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TRPC6_HUMAN | [view interactions] | High throughput | no | no |
FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MRP2_HUMAN | [view interactions] | High throughput | no | no |
LTOR3_HUMAN | [view interactions] | High throughput | no | yes |
HACL2_HUMAN | [view interactions] | High throughput | no | yes |
UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ILF3_HUMAN | [view interactions] | High throughput | no | yes |
TACC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SDHA_HUMAN | [view interactions] | High throughput | no | yes |
RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGR2_HUMAN | [view interactions] | High throughput | no | no |
RFFL_HUMAN | [view interactions] | High throughput | no | yes |
AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
NBR1_HUMAN | [view interactions] | High throughput | no | yes |
CACO2_HUMAN | [view interactions] | High throughput | no | yes |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GLUT4_HUMAN | [view interactions] | High throughput | no | no |
FTM_HUMAN | [view interactions] | High throughput | no | yes |
IQCB1_HUMAN | [view interactions] | High throughput | no | no |
ATF2_HUMAN | [view interactions] | High throughput | no | yes |
GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FLNB_HUMAN | [view interactions] | High throughput | no | no |
CEP43_HUMAN | [view interactions] | High throughput | no | no |
ATLA3_HUMAN | [view interactions] | High throughput | no | no |
PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB4B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACATN_HUMAN | [view interactions] | High throughput | no | yes |
KSR1_HUMAN | [view interactions] | High throughput | no | yes |
RAB2B_HUMAN | [view interactions] | High throughput | no | no |
XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TAGL_HUMAN | [view interactions] | High throughput | no | no |
RB39A_HUMAN | [view interactions] | High throughput | no | no |
AHR_HUMAN | [view interactions] | High throughput | no | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IKKE_HUMAN | [view interactions] | High throughput | no | yes |
DUSTY_HUMAN | [view interactions] | High throughput | no | yes |
HLAB_HUMAN | [view interactions] | High throughput | no | yes |
TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CD177_HUMAN | [view interactions] | High throughput | no | no |
TX101_HUMAN | [view interactions] | High throughput | no | no |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
RYBP_HUMAN | [view interactions] | High throughput | no | no |
LAMP3_HUMAN | [view interactions] | High throughput | no | no |
EXOC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
3BP5L_HUMAN | [view interactions] | High throughput | no | yes |
FA71C_HUMAN | [view interactions] | High throughput | no | no |
ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
FAKD3_HUMAN | [view interactions] | High throughput | no | yes |
ASPH_HUMAN | [view interactions] | High throughput | no | yes |
TGON2_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GLCM_HUMAN | [view interactions] | High throughput | no | yes |
COMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCHL_HUMAN | [view interactions] | High throughput | no | yes |
SMUF2_HUMAN | [view interactions] | High throughput | no | yes |
SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
SUMO3_HUMAN | [view interactions] | High throughput | no | yes |
TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBL4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
CUL7_HUMAN | [view interactions] | High throughput | no | yes |
CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
EED_HUMAN | [view interactions] | High throughput | no | yes |
S2541_HUMAN | [view interactions] | High throughput | no | no |
HAX1_HUMAN | [view interactions] | High throughput | no | no |
NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
ACL6A_HUMAN | [view interactions] | High throughput | no | yes |
UNK_HUMAN | [view interactions] | High throughput | no | yes |
IF16_HUMAN | [view interactions] | High throughput | no | no |
WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
DUS22_HUMAN | [view interactions] | High throughput | no | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
KCD12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
RNF4_HUMAN | [view interactions] | High throughput | no | yes |
DEN6B_HUMAN | [view interactions] | Computational | no | no |
EXOC2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RALA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EXOC4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EXOC6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EXOC3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
DEN6A_HUMAN | [view interactions] | Computational | no | yes |
EXOC7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EXOC8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
LCAP_HUMAN | [view interactions] | Computational | no | yes |
EXOC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |