Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RAB14_HUMAN

Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes . Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in RAB14_HUMAN
GO:0043168 anion binding 34.4444 4 yes
GO:0000166 nucleotide binding 33.3333 4 yes
GO:0017076 purine nucleotide binding 33.3333 5 yes
GO:0032555 purine ribonucleotide binding 32.2222 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 31.1111 4 yes
GO:0016462 pyrophosphatase activity 25.5556 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.5556 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.5556 6 yes
GO:0043169 cation binding 24.4444 4 no
GO:0046872 metal ion binding 22.2222 5 no
GO:0005525 GTP binding 18.8889 5 yes
GO:0019001 guanyl nucleotide binding 18.8889 6 yes
GO:0032561 guanyl ribonucleotide binding 18.8889 5 yes
GO:0003924 GTPase activity 17.7778 7 yes
GO:0019003 GDP binding 11.1111 5 yes
GO:0017022 myosin binding 2.2222 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RAB14_HUMAN
GO:0048522 positive regulation of cellular process 55.5556 4 no
GO:0008104 protein localization 52.2222 4 yes
GO:0051128 regulation of cellular component organization 44.4444 4 no
GO:0022607 cellular component assembly 43.3333 4 yes
GO:0006996 organelle organization 42.2222 4 yes
GO:0048523 negative regulation of cellular process 42.2222 4 no
GO:0010646 regulation of cell communication 41.1111 4 no
GO:0060255 regulation of macromolecule metabolic process 40.0000 4 no
GO:0009966 regulation of signal transduction 38.8889 4 no
GO:0071702 organic substance transport 36.6667 4 yes
GO:0009893 positive regulation of metabolic process 36.6667 4 no
GO:0048584 positive regulation of response to stimulus 35.5556 4 no
GO:0080090 regulation of primary metabolic process 35.5556 4 no
GO:0051049 regulation of transport 35.5556 4 no
GO:0010604 positive regulation of macromolecule metabolic process 34.4444 5 no
GO:0031323 regulation of cellular metabolic process 34.4444 4 no
GO:0071705 nitrogen compound transport 33.3333 4 yes
GO:0023056 positive regulation of signaling 32.2222 4 no
GO:0015031 protein transport 31.1111 4 yes
GO:0051246 regulation of protein metabolic process 30.0000 5 no
GO:0009967 positive regulation of signal transduction 28.8889 5 no
GO:0010647 positive regulation of cell communication 28.8889 5 no
GO:0044087 regulation of cellular component biogenesis 27.7778 4 no
GO:1902531 regulation of intracellular signal transduction 27.7778 5 no
GO:0009889 regulation of biosynthetic process 26.6667 4 no
GO:0033043 regulation of organelle organization 26.6667 5 no
GO:0051130 positive regulation of cellular component organization 26.6667 5 no
GO:0060341 regulation of cellular localization 25.5556 4 yes
GO:0010468 regulation of gene expression 25.5556 6 no
GO:0010556 regulation of macromolecule biosynthetic process 25.5556 5 no
GO:0031325 positive regulation of cellular metabolic process 25.5556 5 no
GO:0031326 regulation of cellular biosynthetic process 25.5556 5 no
GO:0051247 positive regulation of protein metabolic process 24.4444 6 no
GO:0042981 regulation of apoptotic process 23.3333 5 no
GO:0043067 regulation of programmed cell death 23.3333 4 no
GO:0032880 regulation of protein localization 22.2222 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.1111 5 no
GO:0031399 regulation of protein modification process 21.1111 6 no
GO:0042127 regulation of cell population proliferation 21.1111 4 no
GO:0051129 negative regulation of cellular component organization 21.1111 5 no
GO:0051240 positive regulation of multicellular organismal process 21.1111 4 no
GO:2000026 regulation of multicellular organismal development 20.0000 4 yes
GO:0006886 intracellular protein transport 18.8889 4 yes
GO:0070925 organelle assembly 15.5556 5 yes
GO:0016050 vesicle organization 13.3333 5 yes
GO:0006892 post-Golgi vesicle-mediated transport 6.6667 4 yes
GO:0007033 vacuole organization 6.6667 5 yes
GO:0032456 endocytic recycling 6.6667 4 yes
GO:0016482 cytosolic transport 5.5556 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 4.4444 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 4.4444 5 yes
GO:0007040 lysosome organization 2.2222 7 yes
GO:0008543 fibroblast growth factor receptor signaling pathway 2.2222 6 yes
GO:0042742 defense response to bacterium 2.2222 4 yes
GO:0045995 regulation of embryonic development 2.2222 5 yes
GO:0080171 lytic vacuole organization 2.2222 6 yes
GO:0090382 phagosome maturation 2.2222 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
OCRL_HUMAN [view interactions] Low throughput no yes
NISCH_HUMAN [view interactions] Low throughput no yes
AP1G1_HUMAN [view entry] [view interactions] Low throughput yes yes
EEA1_HUMAN [view entry] [view interactions] Low throughput yes yes
HGS_HUMAN [view entry] [view interactions] Low throughput yes yes
CATA_HUMAN [view entry] [view interactions] Low throughput yes no
ECHP_HUMAN [view interactions] Low throughput no no
RUFY1_HUMAN [view interactions] Low throughput no yes
OPTN_HUMAN [view interactions] Low throughput no yes
RFIP5_HUMAN [view entry] [view interactions] Low throughput yes yes
RFIP1_HUMAN [view interactions] Low throughput no yes
ANXA2_HUMAN [view entry] [view interactions] Low throughput yes no
RBNS5_HUMAN [view interactions] Low throughput no yes
ARL8B_HUMAN [view interactions] Low throughput no yes
TBCD1_HUMAN [view interactions] Low throughput no no
TBCD4_HUMAN [view interactions] Low throughput no yes
HACL2_HUMAN [view interactions] High throughput no yes
UCRI_HUMAN [view entry] [view interactions] High throughput yes yes
ILF3_HUMAN [view interactions] High throughput no yes
TACC3_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPF_HUMAN [view interactions] High throughput no yes
VATC1_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
SDHA_HUMAN [view interactions] High throughput no yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
DNM1L_HUMAN [view entry] [view interactions] High throughput yes yes
PLOD2_HUMAN [view interactions] High throughput no yes
HPRT_HUMAN [view interactions] High throughput no yes
THIO_HUMAN [view interactions] High throughput no yes
RIR1_HUMAN [view entry] [view interactions] High throughput yes yes
DNJB1_HUMAN [view entry] [view interactions] High throughput yes yes
FEN1_HUMAN [view interactions] High throughput no yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RC3H1_HUMAN [view interactions] High throughput no yes
HSDL2_HUMAN [view entry] [view interactions] High throughput yes yes
MOB2_HUMAN [view interactions] High throughput no no
M21D2_HUMAN [view interactions] High throughput no yes
RBM14_HUMAN [view interactions] High throughput no yes
ILKAP_HUMAN [view interactions] High throughput no yes
PDLI7_HUMAN [view entry] [view interactions] High throughput yes no
ADPPT_HUMAN [view entry] [view interactions] High throughput yes yes
OLA1_HUMAN [view entry] [view interactions] High throughput yes yes
AGR2_HUMAN [view interactions] High throughput no no
RFFL_HUMAN [view interactions] High throughput no yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP2_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3B_HUMAN [view interactions] High throughput no yes
NBR1_HUMAN [view interactions] High throughput no yes
CACO2_HUMAN [view interactions] High throughput no yes
H33_HUMAN [view interactions] High throughput no yes
H31_HUMAN [view interactions] High throughput no yes
RAB25_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
GLUT4_HUMAN [view interactions] High throughput no no
FTM_HUMAN [view interactions] High throughput no yes
IQCB1_HUMAN [view interactions] High throughput no no
ATF2_HUMAN [view interactions] High throughput no yes
GDIA_HUMAN [view entry] [view interactions] High throughput yes yes
RENR_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
FLNB_HUMAN [view interactions] High throughput no no
CEP43_HUMAN [view interactions] High throughput no no
ATLA3_HUMAN [view interactions] High throughput no no
PLAK_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4B_HUMAN [view entry] [view interactions] High throughput yes no
ACATN_HUMAN [view interactions] High throughput no yes
KSR1_HUMAN [view interactions] High throughput no yes
RAB2B_HUMAN [view interactions] High throughput no no
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
TAGL_HUMAN [view interactions] High throughput no no
NPC1_HUMAN [view interactions] High throughput no yes
RB39A_HUMAN [view interactions] High throughput no no
AHR_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
IKKE_HUMAN [view interactions] High throughput no yes
DUSTY_HUMAN [view interactions] High throughput no yes
HLAB_HUMAN [view interactions] High throughput no yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
CD177_HUMAN [view interactions] High throughput no no
TX101_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP3_HUMAN [view interactions] High throughput no no
EXOC5_HUMAN [view entry] [view interactions] High throughput yes yes
3BP5L_HUMAN [view interactions] High throughput no yes
GAR6_HUMAN [view interactions] High throughput no no
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
CNTRL_HUMAN [view interactions] High throughput no yes
FAKD3_HUMAN [view interactions] High throughput no yes
ASPH_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
GBA1_HUMAN [view interactions] High throughput no yes
COMT_HUMAN [view entry] [view interactions] High throughput yes yes
CCHL_HUMAN [view interactions] High throughput no yes
SMUF2_HUMAN [view interactions] High throughput no yes
SUMO3_HUMAN [view entry] [view interactions] High throughput yes yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
UBL4A_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
RFA3_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
S2541_HUMAN [view interactions] High throughput no no
HAX1_HUMAN [view interactions] High throughput no no
NUFP1_HUMAN [view interactions] High throughput no yes
DGUOK_HUMAN [view interactions] High throughput no yes
ACL6A_HUMAN [view interactions] High throughput no yes
UNK_HUMAN [view interactions] High throughput no yes
IF16_HUMAN [view interactions] High throughput no no
WDTC1_HUMAN [view interactions] High throughput no yes
DUS22_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
KCD12_HUMAN [view entry] [view interactions] High throughput yes no
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
PIHD1_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
UB2R1_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
GLP1R_HUMAN [view interactions] High throughput no no
AAPK1_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
FLCN_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
NHLC2_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
BAG6_HUMAN [view entry] [view interactions] High throughput yes yes
DUS6_HUMAN [view interactions] High throughput no yes
LMBRL_HUMAN [view interactions] High throughput no no
WWP1_HUMAN [view interactions] High throughput no yes
EMC1_HUMAN [view interactions] High throughput no yes
EMC4_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
BAP31_HUMAN [view interactions] High throughput no yes
APR_HUMAN [view interactions] High throughput no yes
WDR5_HUMAN [view interactions] High throughput no no
LSM1_HUMAN [view interactions] High throughput no no
STX17_HUMAN [view interactions] High throughput no yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
FIS1_HUMAN [view entry] [view interactions] High throughput yes yes
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
LDAF1_HUMAN [view interactions] High throughput no yes
FFAR1_HUMAN [view interactions] High throughput no no
PLCA_HUMAN [view interactions] High throughput no yes
OSGEP_HUMAN [view interactions] High throughput no yes
CR021_HUMAN [view interactions] High throughput no no
THAP8_HUMAN [view interactions] High throughput no yes
DERL2_HUMAN [view interactions] High throughput no yes
MMTA2_HUMAN [view interactions] High throughput no yes
CCR1_HUMAN [view interactions] High throughput no no
TIDC1_HUMAN [view interactions] High throughput no yes
SSUH2_HUMAN [view interactions] High throughput no no
SERB1_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
SYT6_HUMAN [view entry] [view interactions] High throughput yes no
SPRTN_HUMAN [view interactions] High throughput no yes
FSCN1_HUMAN [view entry] [view interactions] High throughput yes yes
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
CCNF_HUMAN [view interactions] High throughput no no
TM192_HUMAN [view interactions] High throughput no yes
LEG8_HUMAN [view entry] [view interactions] High throughput yes yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RAE1_HUMAN [view interactions] High throughput no yes
GDIB_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
LTOR2_HUMAN [view interactions] High throughput no yes
TOM40_HUMAN [view interactions] High throughput no yes
TFR1_HUMAN [view entry] [view interactions] High throughput yes yes
TSN6_HUMAN [view interactions] High throughput no yes
NSF_HUMAN [view entry] [view interactions] High throughput yes yes
RAE2_HUMAN [view interactions] High throughput no yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
VATB2_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
CD81_HUMAN [view interactions] High throughput no no
SC31A_HUMAN [view entry] [view interactions] High throughput yes yes
S6A15_HUMAN [view interactions] High throughput no yes
NRBF2_HUMAN [view interactions] High throughput no yes
PRP19_HUMAN [view interactions] High throughput no yes
TMCO1_HUMAN [view interactions] High throughput no yes
ENPP4_HUMAN [view interactions] High throughput no yes
VPP2_HUMAN [view interactions] High throughput no yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
VP13C_HUMAN [view interactions] High throughput no yes
BLT3A_HUMAN [view interactions] High throughput no no
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1B_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
SCAM1_HUMAN [view interactions] High throughput no no
SCAM2_HUMAN [view interactions] High throughput no no
SCAM4_HUMAN [view interactions] High throughput no yes
SEC13_HUMAN [view entry] [view interactions] High throughput yes yes
SPTC1_HUMAN [view interactions] High throughput no yes
STX12_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
TMEDA_HUMAN [view interactions] High throughput no yes
VAMP3_HUMAN [view entry] [view interactions] High throughput yes no
PLD4_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
AIMP2_HUMAN [view interactions] High throughput no yes
PI4KB_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
PJA2_HUMAN [view entry] [view interactions] High throughput yes yes
MOB3C_HUMAN [view interactions] High throughput no no
EZH2_HUMAN [view interactions] High throughput no no
PD1L1_HUMAN [view interactions] High throughput no no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
GOLI_HUMAN [view interactions] High throughput no yes
RN149_HUMAN [view interactions] High throughput no no
TRPC6_HUMAN [view interactions] High throughput no no
FAS_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
MRP2_HUMAN [view interactions] High throughput no no
LTOR3_HUMAN [view interactions] High throughput no yes