RFIP5_HUMAN
Evidence for PS localization
Functions
Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RFIP5_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 43.8596 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 43.8596 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 43.8596 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 28.0702 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 28.0702 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 28.0702 | 6 | no |
| GO:0003924 | GTPase activity | 26.3158 | 7 | no |
| GO:0005525 | GTP binding | 26.3158 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 26.3158 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 26.3158 | 5 | no |
| GO:0019900 | kinase binding | 22.8070 | 4 | no |
| GO:0019901 | protein kinase binding | 21.0526 | 5 | no |
| GO:0051020 | GTPase binding | 15.7895 | 4 | yes |
| GO:0015631 | tubulin binding | 12.2807 | 4 | yes |
| GO:0031267 | small GTPase binding | 12.2807 | 5 | yes |
| GO:0043015 | gamma-tubulin binding | 5.2632 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RFIP5_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 59.6491 | 4 | no |
| GO:0008104 | protein localization | 52.6316 | 4 | yes |
| GO:0071702 | organic substance transport | 52.6316 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 52.6316 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 49.1228 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 49.1228 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.3684 | 4 | yes |
| GO:0010646 | regulation of cell communication | 45.6140 | 4 | yes |
| GO:0051049 | regulation of transport | 45.6140 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 45.6140 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 45.6140 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 43.8596 | 4 | no |
| GO:0015031 | protein transport | 42.1053 | 4 | yes |
| GO:0006996 | organelle organization | 42.1053 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 38.5965 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 38.5965 | 4 | no |
| GO:0022607 | cellular component assembly | 36.8421 | 4 | no |
| GO:0010468 | regulation of gene expression | 36.8421 | 5 | no |
| GO:0009966 | regulation of signal transduction | 36.8421 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.5789 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.5789 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 29.8246 | 5 | no |
| GO:0032880 | regulation of protein localization | 28.0702 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 28.0702 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 28.0702 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.0702 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 28.0702 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.0702 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.0702 | 5 | no |
| GO:0007010 | cytoskeleton organization | 26.3158 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.3158 | 5 | no |
| GO:0071310 | cellular response to organic substance | 26.3158 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 26.3158 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.3158 | 5 | no |
| GO:0030030 | cell projection organization | 26.3158 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.3158 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.3158 | 5 | no |
| GO:0051050 | positive regulation of transport | 24.5614 | 4 | no |
| GO:0033043 | regulation of organelle organization | 24.5614 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 24.5614 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 24.5614 | 7 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 24.5614 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 22.8070 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 22.8070 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 22.8070 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 22.8070 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.8070 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.8070 | 5 | no |
| GO:0010941 | regulation of cell death | 22.8070 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 22.8070 | 6 | no |
| GO:0031399 | regulation of protein modification process | 22.8070 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.8070 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 22.8070 | 7 | no |
| GO:0051248 | negative regulation of protein metabolic process | 22.8070 | 6 | no |
| GO:0051046 | regulation of secretion | 21.0526 | 5 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 21.0526 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 21.0526 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 21.0526 | 5 | no |
| GO:0036211 | protein modification process | 21.0526 | 4 | no |
| GO:0043412 | macromolecule modification | 21.0526 | 4 | no |
| GO:0006886 | intracellular protein transport | 21.0526 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.0526 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 21.0526 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 21.0526 | 8 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.0526 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 21.0526 | 4 | no |
| GO:0051051 | negative regulation of transport | 19.2982 | 4 | yes |
| GO:0051223 | regulation of protein transport | 19.2982 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 19.2982 | 6 | yes |
| GO:0046903 | secretion | 17.5439 | 4 | yes |
| GO:0006887 | exocytosis | 10.5263 | 4 | yes |
| GO:0009914 | hormone transport | 10.5263 | 4 | yes |
| GO:0023061 | signal release | 10.5263 | 4 | yes |
| GO:0046879 | hormone secretion | 10.5263 | 5 | yes |
| GO:0050708 | regulation of protein secretion | 10.5263 | 5 | yes |
| GO:0002790 | peptide secretion | 8.7719 | 5 | yes |
| GO:0009306 | protein secretion | 8.7719 | 4 | yes |
| GO:0015833 | peptide transport | 8.7719 | 5 | yes |
| GO:0030072 | peptide hormone secretion | 8.7719 | 6 | yes |
| GO:0030073 | insulin secretion | 8.7719 | 5 | yes |
| GO:0035592 | establishment of protein localization to extracellular region | 8.7719 | 4 | yes |
| GO:0042886 | amide transport | 8.7719 | 5 | yes |
| GO:0045055 | regulated exocytosis | 8.7719 | 5 | yes |
| GO:0046883 | regulation of hormone secretion | 8.7719 | 4 | yes |
| GO:0051048 | negative regulation of secretion | 8.7719 | 5 | yes |
| GO:0071692 | protein localization to extracellular region | 8.7719 | 5 | yes |
| GO:1903531 | negative regulation of secretion by cell | 8.7719 | 5 | yes |
| GO:1903828 | negative regulation of protein localization | 8.7719 | 5 | yes |
| GO:0035773 | insulin secretion involved in cellular response to glucose stimulus | 7.0175 | 4 | yes |
| GO:0046888 | negative regulation of hormone secretion | 7.0175 | 5 | yes |
| GO:0051224 | negative regulation of protein transport | 7.0175 | 5 | yes |
| GO:0071467 | cellular response to pH | 7.0175 | 4 | yes |
| GO:1904950 | negative regulation of establishment of protein localization | 7.0175 | 6 | yes |
| GO:2000008 | regulation of protein localization to cell surface | 7.0175 | 6 | yes |
| GO:0010447 | response to acidic pH | 5.2632 | 4 | yes |
| GO:0050709 | negative regulation of protein secretion | 5.2632 | 6 | yes |
| GO:0070163 | regulation of adiponectin secretion | 5.2632 | 5 | yes |
| GO:0070164 | negative regulation of adiponectin secretion | 5.2632 | 5 | yes |
| GO:0071468 | cellular response to acidic pH | 5.2632 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in RFIP5_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 3.5088 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RB11A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNX18_HUMAN | [view interactions] | Low throughput | no | no |
| KIF3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CRUM3_HUMAN | [view interactions] | Low throughput | no | no |
| RFIP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RFIP4_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB25_HUMAN | [view interactions] | Low throughput | no | no |
| RAB14_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNAG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RFIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RFIP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RO52_HUMAN | [view interactions] | Low throughput | no | yes |
| RFFL_HUMAN | [view interactions] | Low throughput | no | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| SORT_HUMAN | [view interactions] | High throughput | no | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| RM12_HUMAN | [view interactions] | High throughput | no | yes |
| RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SGF29_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABD_HUMAN | [view interactions] | High throughput | no | yes |
| DIK2A_HUMAN | [view interactions] | High throughput | no | yes |
| HMGN1_HUMAN | [view interactions] | High throughput | no | yes |
| H2BFS_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD3_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRH_HUMAN | [view interactions] | High throughput | no | no |
| DDR2_HUMAN | [view interactions] | High throughput | no | no |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMTK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
| STYK1_HUMAN | [view interactions] | High throughput | no | yes |
| STT3B_HUMAN | [view interactions] | High throughput | no | yes |
| GRK5_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS1_HUMAN | [view interactions] | High throughput | no | yes |
| RHG26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPN90_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB2_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| BRD3_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| CC85A_HUMAN | [view interactions] | High throughput | no | yes |
| HDGR2_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| ISCA2_HUMAN | [view interactions] | High throughput | no | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| WDR47_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLHL8_HUMAN | [view interactions] | High throughput | no | no |
| ZCH10_HUMAN | [view interactions] | High throughput | no | yes |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| RL34_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM42_HUMAN | [view interactions] | High throughput | no | yes |
| ATE1_HUMAN | [view interactions] | High throughput | no | yes |
| KLH15_HUMAN | [view interactions] | High throughput | no | yes |
| ZY11B_HUMAN | [view interactions] | High throughput | no | yes |
| PIGR_HUMAN | [view interactions] | High throughput | no | no |
| RFIP1_HUMAN | [view interactions] | High throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSME3_HUMAN | [view interactions] | High throughput | no | yes |
| SCAM2_HUMAN | [view interactions] | High throughput | no | no |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MITOS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| BID_HUMAN | [view interactions] | High throughput | no | no |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| CATB_HUMAN | [view interactions] | High throughput | no | yes |
| DDAH2_HUMAN | [view interactions] | High throughput | no | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FRDA_HUMAN | [view interactions] | High throughput | no | yes |
| GLRX5_HUMAN | [view interactions] | High throughput | no | yes |
| HINT1_HUMAN | [view interactions] | High throughput | no | yes |
| JMJD8_HUMAN | [view interactions] | High throughput | no | no |
| LACB2_HUMAN | [view interactions] | High throughput | no | yes |
| THTM_HUMAN | [view interactions] | High throughput | no | yes |
| MTPN_HUMAN | [view interactions] | High throughput | no | yes |
| NOS2_HUMAN | [view interactions] | High throughput | no | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAP_HUMAN | [view interactions] | High throughput | no | yes |
| CA198_HUMAN | [view interactions] | High throughput | no | yes |
| NENF_HUMAN | [view interactions] | High throughput | no | yes |
| PDP1_HUMAN | [view interactions] | High throughput | no | yes |
| SORCN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCA_HUMAN | [view interactions] | High throughput | no | yes |
| TXD12_HUMAN | [view interactions] | High throughput | no | no |
| JUPI1_HUMAN | [view interactions] | High throughput | no | yes |
| PHP14_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA4_HUMAN | [view interactions] | High throughput | no | no |
| CBX5_HUMAN | [view interactions] | High throughput | no | yes |
| ENSA_HUMAN | [view interactions] | High throughput | no | yes |
| ERH_HUMAN | [view interactions] | High throughput | no | yes |
| FOXK1_HUMAN | [view interactions] | High throughput | no | yes |
| GIPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HGFA_HUMAN | [view interactions] | High throughput | no | no |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP93_HUMAN | [view interactions] | High throughput | no | yes |
| PIMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCNP_HUMAN | [view interactions] | High throughput | no | yes |
| PDZD2_HUMAN | [view interactions] | High throughput | no | yes |
| PGK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SELM_HUMAN | [view interactions] | High throughput | no | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STXB2_HUMAN | [view interactions] | High throughput | no | no |
| SUMO1_HUMAN | [view interactions] | High throughput | no | yes |
| RENT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XDH_HUMAN | [view interactions] | High throughput | no | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| ARSB_HUMAN | [view interactions] | High throughput | no | yes |
| CAVN1_HUMAN | [view interactions] | High throughput | no | no |
| MIPEP_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DEN6A_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VASP_HUMAN | [view interactions] | High throughput | no | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| AMPN_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |