RFIP5_HUMAN
Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in RFIP5_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 40.9091 | 4 | no |
GO:0000166 | nucleotide binding | 39.3939 | 4 | no |
GO:0017076 | purine nucleotide binding | 39.3939 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 39.3939 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 39.3939 | 4 | no |
GO:0016462 | pyrophosphatase activity | 27.2727 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 27.2727 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 27.2727 | 6 | no |
GO:0003924 | GTPase activity | 22.7273 | 7 | no |
GO:0005525 | GTP binding | 22.7273 | 5 | no |
GO:0019001 | guanyl nucleotide binding | 22.7273 | 6 | no |
GO:0032561 | guanyl ribonucleotide binding | 22.7273 | 5 | no |
GO:0051020 | GTPase binding | 15.1515 | 4 | yes |
GO:0015631 | tubulin binding | 10.6061 | 4 | yes |
GO:0031267 | small GTPase binding | 10.6061 | 5 | yes |
GO:0043015 | gamma-tubulin binding | 4.5455 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in RFIP5_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 60.6061 | 4 | no |
GO:0008104 | protein localization | 53.0303 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 53.0303 | 4 | no |
GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
GO:0071702 | organic substance transport | 48.4848 | 4 | yes |
GO:0010646 | regulation of cell communication | 46.9697 | 4 | yes |
GO:0071705 | nitrogen compound transport | 45.4545 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 45.4545 | 4 | no |
GO:0051049 | regulation of transport | 43.9394 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 43.9394 | 4 | no |
GO:0006996 | organelle organization | 40.9091 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 37.8788 | 4 | no |
GO:0015031 | protein transport | 36.3636 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 36.3636 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 36.3636 | 4 | no |
GO:0009966 | regulation of signal transduction | 36.3636 | 4 | no |
GO:0010468 | regulation of gene expression | 36.3636 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 36.3636 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 36.3636 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 36.3636 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 36.3636 | 5 | no |
GO:0022607 | cellular component assembly | 34.8485 | 4 | no |
GO:0032880 | regulation of protein localization | 33.3333 | 5 | yes |
GO:0060341 | regulation of cellular localization | 33.3333 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 31.8182 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 31.8182 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 31.8182 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 28.7879 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 28.7879 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 27.2727 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 27.2727 | 5 | no |
GO:0010647 | positive regulation of cell communication | 25.7576 | 5 | no |
GO:0023056 | positive regulation of signaling | 25.7576 | 4 | no |
GO:0031399 | regulation of protein modification process | 25.7576 | 6 | no |
GO:0051130 | positive regulation of cellular component organization | 25.7576 | 5 | no |
GO:0009891 | positive regulation of biosynthetic process | 25.7576 | 5 | no |
GO:0010648 | negative regulation of cell communication | 24.2424 | 5 | yes |
GO:0023057 | negative regulation of signaling | 24.2424 | 4 | yes |
GO:0044087 | regulation of cellular component biogenesis | 24.2424 | 4 | no |
GO:0031327 | negative regulation of cellular biosynthetic process | 22.7273 | 6 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 22.7273 | 6 | no |
GO:0009967 | positive regulation of signal transduction | 22.7273 | 5 | no |
GO:0030030 | cell projection organization | 22.7273 | 4 | no |
GO:0031344 | regulation of cell projection organization | 22.7273 | 5 | no |
GO:0051248 | negative regulation of protein metabolic process | 22.7273 | 6 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 22.7273 | 6 | no |
GO:0007010 | cytoskeleton organization | 22.7273 | 5 | no |
GO:0033043 | regulation of organelle organization | 22.7273 | 5 | no |
GO:0009890 | negative regulation of biosynthetic process | 22.7273 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.7273 | 6 | no |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 22.7273 | 6 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.7273 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 21.2121 | 5 | no |
GO:0051050 | positive regulation of transport | 21.2121 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 21.2121 | 7 | no |
GO:0042325 | regulation of phosphorylation | 21.2121 | 7 | no |
GO:0060627 | regulation of vesicle-mediated transport | 21.2121 | 4 | no |
GO:0051241 | negative regulation of multicellular organismal process | 19.6970 | 4 | yes |
GO:0070201 | regulation of establishment of protein localization | 19.6970 | 6 | yes |
GO:0051046 | regulation of secretion | 18.1818 | 5 | yes |
GO:0051051 | negative regulation of transport | 18.1818 | 4 | yes |
GO:0051223 | regulation of protein transport | 18.1818 | 5 | yes |
GO:1903530 | regulation of secretion by cell | 18.1818 | 4 | yes |
GO:0046903 | secretion | 15.1515 | 4 | yes |
GO:1903828 | negative regulation of protein localization | 10.6061 | 5 | yes |
GO:0009914 | hormone transport | 9.0909 | 4 | yes |
GO:0023061 | signal release | 9.0909 | 4 | yes |
GO:0046879 | hormone secretion | 9.0909 | 5 | yes |
GO:0046883 | regulation of hormone secretion | 9.0909 | 4 | yes |
GO:0050708 | regulation of protein secretion | 9.0909 | 5 | yes |
GO:0002790 | peptide secretion | 7.5758 | 5 | yes |
GO:0009306 | protein secretion | 7.5758 | 4 | yes |
GO:0015833 | peptide transport | 7.5758 | 5 | yes |
GO:0030072 | peptide hormone secretion | 7.5758 | 6 | yes |
GO:0030073 | insulin secretion | 7.5758 | 5 | yes |
GO:0035592 | establishment of protein localization to extracellular region | 7.5758 | 4 | yes |
GO:0042886 | amide transport | 7.5758 | 5 | yes |
GO:0045055 | regulated exocytosis | 7.5758 | 4 | yes |
GO:0051048 | negative regulation of secretion | 7.5758 | 5 | yes |
GO:0051224 | negative regulation of protein transport | 7.5758 | 5 | yes |
GO:0071692 | protein localization to extracellular region | 7.5758 | 5 | yes |
GO:1903531 | negative regulation of secretion by cell | 7.5758 | 5 | yes |
GO:1904950 | negative regulation of establishment of protein localization | 7.5758 | 6 | yes |
GO:2000008 | regulation of protein localization to cell surface | 7.5758 | 6 | yes |
GO:0035773 | insulin secretion involved in cellular response to glucose stimulus | 6.0606 | 4 | yes |
GO:0046888 | negative regulation of hormone secretion | 6.0606 | 5 | yes |
GO:0071467 | cellular response to pH | 6.0606 | 4 | yes |
GO:0010447 | response to acidic pH | 4.5455 | 4 | yes |
GO:0050709 | negative regulation of protein secretion | 4.5455 | 6 | yes |
GO:0070163 | regulation of adiponectin secretion | 4.5455 | 5 | yes |
GO:0070164 | negative regulation of adiponectin secretion | 4.5455 | 5 | yes |
GO:0071468 | cellular response to acidic pH | 4.5455 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
RFIP4_HUMAN | [view interactions] | Low throughput | no | yes |
RAB25_HUMAN | [view interactions] | Low throughput | no | no |
RAB14_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SNAG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RFIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RFIP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RO52_HUMAN | [view interactions] | Low throughput | no | yes |
RFFL_HUMAN | [view interactions] | Low throughput | no | yes |
RB11A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SNX18_HUMAN | [view interactions] | Low throughput | no | no |
KIF3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RFIP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CRUM3_HUMAN | [view interactions] | Low throughput | no | no |
STYK1_HUMAN | [view interactions] | High throughput | no | yes |
STT3B_HUMAN | [view interactions] | High throughput | no | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
KCNK3_HUMAN | [view interactions] | High throughput | no | no |
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRK5_HUMAN | [view interactions] | High throughput | no | yes |
HAUS1_HUMAN | [view interactions] | High throughput | no | yes |
RHG26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPN90_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
NFKB2_HUMAN | [view interactions] | High throughput | no | yes |
RNF4_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
BRD3_HUMAN | [view interactions] | High throughput | no | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
TULP3_HUMAN | [view interactions] | High throughput | no | yes |
CC85A_HUMAN | [view interactions] | High throughput | no | yes |
HDGR2_HUMAN | [view interactions] | High throughput | no | yes |
2ABB_HUMAN | [view interactions] | High throughput | no | yes |
ISCA2_HUMAN | [view interactions] | High throughput | no | yes |
CRCM_HUMAN | [view interactions] | High throughput | no | no |
WDR47_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KLHL8_HUMAN | [view interactions] | High throughput | no | no |
ZCH10_HUMAN | [view interactions] | High throughput | no | yes |
RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
RL34_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RBM42_HUMAN | [view interactions] | High throughput | no | yes |
ATE1_HUMAN | [view interactions] | High throughput | no | yes |
KLH15_HUMAN | [view interactions] | High throughput | no | yes |
ZY11B_HUMAN | [view interactions] | High throughput | no | yes |
PIGR_HUMAN | [view interactions] | High throughput | no | no |
RFIP1_HUMAN | [view interactions] | High throughput | no | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSME3_HUMAN | [view interactions] | High throughput | no | yes |
SCAM2_HUMAN | [view interactions] | High throughput | no | no |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
DVL2_HUMAN | [view interactions] | High throughput | no | yes |
MIDN_HUMAN | [view interactions] | High throughput | no | no |
ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HAPR1_HUMAN | [view interactions] | High throughput | no | yes |
MITOS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECHM_HUMAN | [view interactions] | High throughput | no | yes |
BID_HUMAN | [view interactions] | High throughput | no | no |
GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
GAL3B_HUMAN | [view interactions] | High throughput | no | no |
CATB_HUMAN | [view interactions] | High throughput | no | yes |
DDAH2_HUMAN | [view interactions] | High throughput | no | yes |
ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FRDA_HUMAN | [view interactions] | High throughput | no | yes |
GLRX5_HUMAN | [view interactions] | High throughput | no | yes |
HINT1_HUMAN | [view interactions] | High throughput | no | yes |
JMJD8_HUMAN | [view interactions] | High throughput | no | no |
LACB2_HUMAN | [view interactions] | High throughput | no | yes |
THTM_HUMAN | [view interactions] | High throughput | no | yes |
MTPN_HUMAN | [view interactions] | High throughput | no | yes |
NOS2_HUMAN | [view interactions] | High throughput | no | yes |
PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SAP_HUMAN | [view interactions] | High throughput | no | yes |
CA198_HUMAN | [view interactions] | High throughput | no | yes |
NENF_HUMAN | [view interactions] | High throughput | no | yes |
PDP1_HUMAN | [view interactions] | High throughput | no | yes |
SORCN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBCA_HUMAN | [view interactions] | High throughput | no | yes |
TXD12_HUMAN | [view interactions] | High throughput | no | no |
JUPI1_HUMAN | [view interactions] | High throughput | no | yes |
PHP14_HUMAN | [view interactions] | High throughput | no | yes |
ANXA4_HUMAN | [view interactions] | High throughput | no | no |
CBX5_HUMAN | [view interactions] | High throughput | no | yes |
ENSA_HUMAN | [view interactions] | High throughput | no | yes |
ERH_HUMAN | [view interactions] | High throughput | no | yes |
FOXK1_HUMAN | [view interactions] | High throughput | no | yes |
GIPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HGFA_HUMAN | [view interactions] | High throughput | no | no |
AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUP93_HUMAN | [view interactions] | High throughput | no | yes |
PIMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PCNP_HUMAN | [view interactions] | High throughput | no | yes |
PDZD2_HUMAN | [view interactions] | High throughput | no | yes |
PGK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SELM_HUMAN | [view interactions] | High throughput | no | yes |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
STXB2_HUMAN | [view interactions] | High throughput | no | no |
SUMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RENT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XDH_HUMAN | [view interactions] | High throughput | no | no |
DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
ARSB_HUMAN | [view interactions] | High throughput | no | yes |
CAVN1_HUMAN | [view interactions] | High throughput | no | no |
MIPEP_HUMAN | [view interactions] | High throughput | no | yes |
RN183_HUMAN | [view interactions] | High throughput | no | no |
GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
CXAR_HUMAN | [view interactions] | High throughput | no | yes |
DEN6A_HUMAN | [view interactions] | High throughput | no | yes |
RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
LAMP3_HUMAN | [view interactions] | High throughput | no | no |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OCLN_HUMAN | [view interactions] | High throughput | no | no |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB3B_HUMAN | [view interactions] | High throughput | no | no |
RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
IFM1_HUMAN | [view interactions] | High throughput | no | no |
AMPN_HUMAN | [view interactions] | High throughput | no | no |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
IFM3_HUMAN | [view interactions] | High throughput | no | yes |
ACE2_HUMAN | [view interactions] | High throughput | no | no |
PML_HUMAN | [view interactions] | High throughput | no | yes |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RNF43_HUMAN | [view interactions] | High throughput | no | yes |
AR13B_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
TYRO3_HUMAN | [view interactions] | High throughput | no | yes |
A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MUC18_HUMAN | [view interactions] | High throughput | no | yes |
TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
2ABA_HUMAN | [view interactions] | High throughput | no | yes |
SORT_HUMAN | [view interactions] | High throughput | no | yes |
LZTS2_HUMAN | [view interactions] | High throughput | no | no |
RM12_HUMAN | [view interactions] | High throughput | no | yes |
RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SGF29_HUMAN | [view interactions] | High throughput | no | yes |
2ABD_HUMAN | [view interactions] | High throughput | no | yes |
DIK2A_HUMAN | [view interactions] | High throughput | no | yes |
HMGN1_HUMAN | [view interactions] | High throughput | no | yes |
H2BFS_HUMAN | [view interactions] | High throughput | no | yes |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
SMAD3_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMM17_HUMAN | [view interactions] | High throughput | no | yes |
KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTPRH_HUMAN | [view interactions] | High throughput | no | no |
DDR2_HUMAN | [view interactions] | High throughput | no | no |
EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
FGFR4_HUMAN | [view interactions] | High throughput | no | no |
LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
LMTK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LMTK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PGFRB_HUMAN | [view interactions] | High throughput | no | yes |