Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RFIP5_HUMAN

Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in RFIP5_HUMAN
GO:0043168 anion binding 40.9091 4 no
GO:0000166 nucleotide binding 39.3939 4 no
GO:0017076 purine nucleotide binding 39.3939 5 no
GO:0032555 purine ribonucleotide binding 39.3939 4 no
GO:0035639 purine ribonucleoside triphosphate binding 39.3939 4 no
GO:0016462 pyrophosphatase activity 27.2727 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 27.2727 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 27.2727 6 no
GO:0003924 GTPase activity 22.7273 7 no
GO:0005525 GTP binding 22.7273 5 no
GO:0019001 guanyl nucleotide binding 22.7273 6 no
GO:0032561 guanyl ribonucleotide binding 22.7273 5 no
GO:0051020 GTPase binding 15.1515 4 yes
GO:0015631 tubulin binding 10.6061 4 yes
GO:0031267 small GTPase binding 10.6061 5 yes
GO:0043015 gamma-tubulin binding 4.5455 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RFIP5_HUMAN
GO:0048522 positive regulation of cellular process 60.6061 4 no
GO:0008104 protein localization 53.0303 4 yes
GO:0051128 regulation of cellular component organization 53.0303 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0071702 organic substance transport 48.4848 4 yes
GO:0010646 regulation of cell communication 46.9697 4 yes
GO:0071705 nitrogen compound transport 45.4545 4 yes
GO:0080090 regulation of primary metabolic process 45.4545 4 no
GO:0051049 regulation of transport 43.9394 4 yes
GO:0031323 regulation of cellular metabolic process 43.9394 4 no
GO:0006996 organelle organization 40.9091 4 no
GO:0009889 regulation of biosynthetic process 37.8788 4 no
GO:0015031 protein transport 36.3636 4 yes
GO:0009892 negative regulation of metabolic process 36.3636 4 no
GO:0009893 positive regulation of metabolic process 36.3636 4 no
GO:0009966 regulation of signal transduction 36.3636 4 no
GO:0010468 regulation of gene expression 36.3636 6 no
GO:0010556 regulation of macromolecule biosynthetic process 36.3636 5 no
GO:0010605 negative regulation of macromolecule metabolic process 36.3636 5 no
GO:0031326 regulation of cellular biosynthetic process 36.3636 5 no
GO:0051246 regulation of protein metabolic process 36.3636 5 no
GO:0022607 cellular component assembly 34.8485 4 no
GO:0032880 regulation of protein localization 33.3333 5 yes
GO:0060341 regulation of cellular localization 33.3333 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 31.8182 5 no
GO:0031324 negative regulation of cellular metabolic process 31.8182 5 no
GO:1902531 regulation of intracellular signal transduction 31.8182 5 no
GO:0031325 positive regulation of cellular metabolic process 28.7879 5 no
GO:0048584 positive regulation of response to stimulus 28.7879 4 no
GO:0019220 regulation of phosphate metabolic process 27.2727 6 no
GO:0051174 regulation of phosphorus metabolic process 27.2727 5 no
GO:0010647 positive regulation of cell communication 25.7576 5 no
GO:0023056 positive regulation of signaling 25.7576 4 no
GO:0031399 regulation of protein modification process 25.7576 6 no
GO:0051130 positive regulation of cellular component organization 25.7576 5 no
GO:0009891 positive regulation of biosynthetic process 25.7576 5 no
GO:0010648 negative regulation of cell communication 24.2424 5 yes
GO:0023057 negative regulation of signaling 24.2424 4 yes
GO:0044087 regulation of cellular component biogenesis 24.2424 4 no
GO:0031327 negative regulation of cellular biosynthetic process 22.7273 6 no
GO:0031328 positive regulation of cellular biosynthetic process 22.7273 6 no
GO:0009967 positive regulation of signal transduction 22.7273 5 no
GO:0030030 cell projection organization 22.7273 4 no
GO:0031344 regulation of cell projection organization 22.7273 5 no
GO:0051248 negative regulation of protein metabolic process 22.7273 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.7273 6 no
GO:0007010 cytoskeleton organization 22.7273 5 no
GO:0033043 regulation of organelle organization 22.7273 5 no
GO:0009890 negative regulation of biosynthetic process 22.7273 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.7273 6 no
GO:0010558 negative regulation of macromolecule biosynthetic process 22.7273 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.7273 5 no
GO:0051252 regulation of RNA metabolic process 21.2121 5 no
GO:0051050 positive regulation of transport 21.2121 4 no
GO:0001932 regulation of protein phosphorylation 21.2121 7 no
GO:0042325 regulation of phosphorylation 21.2121 7 no
GO:0060627 regulation of vesicle-mediated transport 21.2121 4 no
GO:0051241 negative regulation of multicellular organismal process 19.6970 4 yes
GO:0070201 regulation of establishment of protein localization 19.6970 6 yes
GO:0051046 regulation of secretion 18.1818 5 yes
GO:0051051 negative regulation of transport 18.1818 4 yes
GO:0051223 regulation of protein transport 18.1818 5 yes
GO:1903530 regulation of secretion by cell 18.1818 4 yes
GO:0046903 secretion 15.1515 4 yes
GO:1903828 negative regulation of protein localization 10.6061 5 yes
GO:0009914 hormone transport 9.0909 4 yes
GO:0023061 signal release 9.0909 4 yes
GO:0046879 hormone secretion 9.0909 5 yes
GO:0046883 regulation of hormone secretion 9.0909 4 yes
GO:0050708 regulation of protein secretion 9.0909 5 yes
GO:0002790 peptide secretion 7.5758 5 yes
GO:0009306 protein secretion 7.5758 4 yes
GO:0015833 peptide transport 7.5758 5 yes
GO:0030072 peptide hormone secretion 7.5758 6 yes
GO:0030073 insulin secretion 7.5758 5 yes
GO:0035592 establishment of protein localization to extracellular region 7.5758 4 yes
GO:0042886 amide transport 7.5758 5 yes
GO:0045055 regulated exocytosis 7.5758 4 yes
GO:0051048 negative regulation of secretion 7.5758 5 yes
GO:0051224 negative regulation of protein transport 7.5758 5 yes
GO:0071692 protein localization to extracellular region 7.5758 5 yes
GO:1903531 negative regulation of secretion by cell 7.5758 5 yes
GO:1904950 negative regulation of establishment of protein localization 7.5758 6 yes
GO:2000008 regulation of protein localization to cell surface 7.5758 6 yes
GO:0035773 insulin secretion involved in cellular response to glucose stimulus 6.0606 4 yes
GO:0046888 negative regulation of hormone secretion 6.0606 5 yes
GO:0071467 cellular response to pH 6.0606 4 yes
GO:0010447 response to acidic pH 4.5455 4 yes
GO:0050709 negative regulation of protein secretion 4.5455 6 yes
GO:0070163 regulation of adiponectin secretion 4.5455 5 yes
GO:0070164 negative regulation of adiponectin secretion 4.5455 5 yes
GO:0071468 cellular response to acidic pH 4.5455 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RFIP4_HUMAN [view interactions] Low throughput no yes
RAB25_HUMAN [view interactions] Low throughput no no
RAB14_HUMAN [view entry] [view interactions] Low throughput yes yes
SNAG_HUMAN [view entry] [view interactions] Low throughput yes yes
RFIP2_HUMAN [view entry] [view interactions] Low throughput yes yes
RFIP5_HUMAN [view entry] [view interactions] Low throughput yes yes
ARF6_HUMAN [view entry] [view interactions] Low throughput yes yes
RO52_HUMAN [view interactions] Low throughput no yes
RFFL_HUMAN [view interactions] Low throughput no yes
RB11A_HUMAN [view entry] [view interactions] Low throughput yes yes
SNX18_HUMAN [view interactions] Low throughput no no
KIF3A_HUMAN [view entry] [view interactions] Low throughput yes yes
RFIP3_HUMAN [view entry] [view interactions] Low throughput yes no
CRUM3_HUMAN [view interactions] Low throughput no no
STYK1_HUMAN [view interactions] High throughput no yes
STT3B_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
GRK5_HUMAN [view interactions] High throughput no yes
HAUS1_HUMAN [view interactions] High throughput no yes
RHG26_HUMAN [view entry] [view interactions] High throughput yes yes
SPN90_HUMAN [view entry] [view interactions] High throughput yes no
TRI25_HUMAN [view interactions] High throughput no yes
NFKB2_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
BRD3_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
TULP3_HUMAN [view interactions] High throughput no yes
CC85A_HUMAN [view interactions] High throughput no yes
HDGR2_HUMAN [view interactions] High throughput no yes
2ABB_HUMAN [view interactions] High throughput no yes
ISCA2_HUMAN [view interactions] High throughput no yes
CRCM_HUMAN [view interactions] High throughput no no
WDR47_HUMAN [view entry] [view interactions] High throughput yes yes
KLHL8_HUMAN [view interactions] High throughput no no
ZCH10_HUMAN [view interactions] High throughput no yes
RNPS1_HUMAN [view interactions] High throughput no yes
RL34_HUMAN [view entry] [view interactions] High throughput yes yes
RBM42_HUMAN [view interactions] High throughput no yes
ATE1_HUMAN [view interactions] High throughput no yes
KLH15_HUMAN [view interactions] High throughput no yes
ZY11B_HUMAN [view interactions] High throughput no yes
PIGR_HUMAN [view interactions] High throughput no no
RFIP1_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
PSME3_HUMAN [view interactions] High throughput no yes
SCAM2_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
DVL2_HUMAN [view interactions] High throughput no yes
MIDN_HUMAN [view interactions] High throughput no no
ESYT1_HUMAN [view entry] [view interactions] High throughput yes yes
HAPR1_HUMAN [view interactions] High throughput no yes
MITOS_HUMAN [view entry] [view interactions] High throughput yes yes
ECHM_HUMAN [view interactions] High throughput no yes
BID_HUMAN [view interactions] High throughput no no
GAL3A_HUMAN [view interactions] High throughput no yes
GAL3B_HUMAN [view interactions] High throughput no no
CATB_HUMAN [view interactions] High throughput no yes
DDAH2_HUMAN [view interactions] High throughput no yes
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
FRDA_HUMAN [view interactions] High throughput no yes
GLRX5_HUMAN [view interactions] High throughput no yes
HINT1_HUMAN [view interactions] High throughput no yes
JMJD8_HUMAN [view interactions] High throughput no no
LACB2_HUMAN [view interactions] High throughput no yes
THTM_HUMAN [view interactions] High throughput no yes
MTPN_HUMAN [view interactions] High throughput no yes
NOS2_HUMAN [view interactions] High throughput no yes
PARK7_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX5_HUMAN [view entry] [view interactions] High throughput yes yes
SAP_HUMAN [view interactions] High throughput no yes
CA198_HUMAN [view interactions] High throughput no yes
NENF_HUMAN [view interactions] High throughput no yes
PDP1_HUMAN [view interactions] High throughput no yes
SORCN_HUMAN [view entry] [view interactions] High throughput yes yes
TBCA_HUMAN [view interactions] High throughput no yes
TXD12_HUMAN [view interactions] High throughput no no
JUPI1_HUMAN [view interactions] High throughput no yes
PHP14_HUMAN [view interactions] High throughput no yes
ANXA4_HUMAN [view interactions] High throughput no no
CBX5_HUMAN [view interactions] High throughput no yes
ENSA_HUMAN [view interactions] High throughput no yes
ERH_HUMAN [view interactions] High throughput no yes
FOXK1_HUMAN [view interactions] High throughput no yes
GIPC1_HUMAN [view entry] [view interactions] High throughput yes yes
HGFA_HUMAN [view interactions] High throughput no no
AINX_HUMAN [view entry] [view interactions] High throughput yes yes
NUP93_HUMAN [view interactions] High throughput no yes
PIMT_HUMAN [view entry] [view interactions] High throughput yes yes
PCNP_HUMAN [view interactions] High throughput no yes
PDZD2_HUMAN [view interactions] High throughput no yes
PGK1_HUMAN [view entry] [view interactions] High throughput yes yes
SELM_HUMAN [view interactions] High throughput no yes
STX6_HUMAN [view interactions] High throughput no yes
STXB2_HUMAN [view interactions] High throughput no no
SUMO1_HUMAN [view entry] [view interactions] High throughput yes yes
RENT1_HUMAN [view entry] [view interactions] High throughput yes yes
XDH_HUMAN [view interactions] High throughput no no
DYR1A_HUMAN [view interactions] High throughput no yes
ARSB_HUMAN [view interactions] High throughput no yes
CAVN1_HUMAN [view interactions] High throughput no no
MIPEP_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC5_HUMAN [view interactions] High throughput no yes
CAV1_HUMAN [view interactions] High throughput no no
CXAR_HUMAN [view interactions] High throughput no yes
DEN6A_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3B_HUMAN [view interactions] High throughput no no
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
VASP_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
IFM1_HUMAN [view interactions] High throughput no no
AMPN_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
IFM3_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
PML_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
RNF43_HUMAN [view interactions] High throughput no yes
AR13B_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
TYRO3_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
MUC18_HUMAN [view interactions] High throughput no yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
EGLN3_HUMAN [view interactions] High throughput no no
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
2ABA_HUMAN [view interactions] High throughput no yes
SORT_HUMAN [view interactions] High throughput no yes
LZTS2_HUMAN [view interactions] High throughput no no
RM12_HUMAN [view interactions] High throughput no yes
RB11B_HUMAN [view entry] [view interactions] High throughput yes no
SGF29_HUMAN [view interactions] High throughput no yes
2ABD_HUMAN [view interactions] High throughput no yes
DIK2A_HUMAN [view interactions] High throughput no yes
HMGN1_HUMAN [view interactions] High throughput no yes
H2BFS_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
BMI1_HUMAN [view interactions] High throughput no yes
SMAD3_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
TMM17_HUMAN [view interactions] High throughput no yes
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRH_HUMAN [view interactions] High throughput no no
DDR2_HUMAN [view interactions] High throughput no no
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR2_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
LMTK1_HUMAN [view interactions] High throughput no yes
LMTK2_HUMAN [view entry] [view interactions] High throughput yes yes
LMTK3_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
NTRK2_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
PGFRB_HUMAN [view interactions] High throughput no yes