Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PRDX5_HUMAN

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PRDX5_HUMAN
GO:0003723 RNA binding 27.9412 4 no
GO:0000166 nucleotide binding 25.0000 4 no
GO:0043168 anion binding 25.0000 4 no
GO:0017076 purine nucleotide binding 23.5294 5 no
GO:0043169 cation binding 23.5294 4 no
GO:0046872 metal ion binding 23.5294 5 no
GO:0003677 DNA binding 14.7059 4 yes
GO:0003690 double-stranded DNA binding 10.2941 5 yes
GO:0043565 sequence-specific DNA binding 10.2941 5 yes
GO:0000976 transcription cis-regulatory region binding 8.8235 5 yes
GO:0001067 transcription regulatory region nucleic acid binding 8.8235 4 yes
GO:1990837 sequence-specific double-stranded DNA binding 8.8235 6 yes
GO:0008379 thioredoxin peroxidase activity 5.8824 5 yes
GO:0140824 thioredoxin-dependent peroxiredoxin activity 5.8824 4 yes
GO:0001016 RNA polymerase III transcription regulatory region sequence-specific DNA binding 2.9412 6 yes
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2.9412 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PRDX5_HUMAN
GO:0048522 positive regulation of cellular process 54.4118 4 no
GO:0048523 negative regulation of cellular process 51.4706 4 yes
GO:0010646 regulation of cell communication 45.5882 4 no
GO:0060255 regulation of macromolecule metabolic process 41.1765 4 yes
GO:0009966 regulation of signal transduction 39.7059 4 no
GO:0031323 regulation of cellular metabolic process 38.2353 4 yes
GO:0080090 regulation of primary metabolic process 36.7647 4 yes
GO:0009889 regulation of biosynthetic process 36.7647 4 yes
GO:0009893 positive regulation of metabolic process 36.7647 4 yes
GO:0010468 regulation of gene expression 36.7647 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 36.7647 5 yes
GO:0031326 regulation of cellular biosynthetic process 36.7647 5 yes
GO:0006996 organelle organization 35.2941 4 no
GO:0006796 phosphate-containing compound metabolic process 33.8235 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 32.3529 5 no
GO:1902531 regulation of intracellular signal transduction 32.3529 5 no
GO:0008104 protein localization 32.3529 4 no
GO:0051128 regulation of cellular component organization 32.3529 4 no
GO:0023056 positive regulation of signaling 30.8824 4 no
GO:0022607 cellular component assembly 30.8824 4 no
GO:0042981 regulation of apoptotic process 30.8824 5 yes
GO:0043067 regulation of programmed cell death 30.8824 4 yes
GO:0010647 positive regulation of cell communication 29.4118 5 no
GO:0031325 positive regulation of cellular metabolic process 27.9412 5 no
GO:0051246 regulation of protein metabolic process 27.9412 5 no
GO:0009891 positive regulation of biosynthetic process 27.9412 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.9412 5 yes
GO:0051252 regulation of RNA metabolic process 26.4706 5 yes
GO:0009967 positive regulation of signal transduction 26.4706 5 no
GO:0048584 positive regulation of response to stimulus 26.4706 4 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0051049 regulation of transport 25.0000 4 no
GO:0006355 regulation of DNA-templated transcription 25.0000 7 yes
GO:0009892 negative regulation of metabolic process 25.0000 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 23.5294 6 no
GO:0043412 macromolecule modification 23.5294 4 no
GO:0060341 regulation of cellular localization 23.5294 4 no
GO:0010648 negative regulation of cell communication 23.5294 5 no
GO:0023057 negative regulation of signaling 23.5294 4 no
GO:0010605 negative regulation of macromolecule metabolic process 23.5294 5 yes
GO:0043066 negative regulation of apoptotic process 23.5294 6 yes
GO:0043069 negative regulation of programmed cell death 23.5294 5 yes
GO:0036211 protein modification process 22.0588 4 no
GO:0032880 regulation of protein localization 22.0588 5 no
GO:0071702 organic substance transport 22.0588 4 no
GO:0045595 regulation of cell differentiation 22.0588 4 no
GO:0048585 negative regulation of response to stimulus 22.0588 4 no
GO:0006753 nucleoside phosphate metabolic process 22.0588 4 yes
GO:0009117 nucleotide metabolic process 22.0588 5 yes
GO:0072521 purine-containing compound metabolic process 20.5882 4 yes
GO:1902533 positive regulation of intracellular signal transduction 20.5882 6 no
GO:0009968 negative regulation of signal transduction 20.5882 5 no
GO:0051247 positive regulation of protein metabolic process 20.5882 6 no
GO:0006163 purine nucleotide metabolic process 20.5882 5 yes
GO:0031324 negative regulation of cellular metabolic process 20.5882 5 yes
GO:1901701 cellular response to oxygen-containing compound 19.1176 4 yes
GO:0009890 negative regulation of biosynthetic process 17.6471 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 16.1765 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 16.1765 6 yes
GO:0062197 cellular response to chemical stress 13.2353 4 yes
GO:0072524 pyridine-containing compound metabolic process 13.2353 4 yes
GO:0019362 pyridine nucleotide metabolic process 13.2353 5 yes
GO:0034599 cellular response to oxidative stress 13.2353 4 yes
GO:0046496 nicotinamide nucleotide metabolic process 13.2353 6 yes
GO:0043086 negative regulation of catalytic activity 11.7647 4 yes
GO:0000302 response to reactive oxygen species 10.2941 4 yes
GO:0042743 hydrogen peroxide metabolic process 10.2941 4 yes
GO:0051253 negative regulation of RNA metabolic process 8.8235 6 yes
GO:1902679 negative regulation of RNA biosynthetic process 8.8235 7 yes
GO:0045892 negative regulation of DNA-templated transcription 8.8235 8 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 8.8235 5 yes
GO:0034614 cellular response to reactive oxygen species 7.3529 5 yes
GO:0042744 hydrogen peroxide catabolic process 7.3529 4 yes
GO:0006954 inflammatory response 5.8824 4 yes
GO:0051341 regulation of oxidoreductase activity 4.4118 4 yes
GO:0006739 NADP metabolic process 4.4118 6 yes
GO:0051354 negative regulation of oxidoreductase activity 2.9412 5 yes
GO:0060785 regulation of apoptosis involved in tissue homeostasis 2.9412 6 yes
GO:0070995 NADPH oxidation 2.9412 7 yes
GO:0006359 regulation of transcription by RNA polymerase III 2.9412 8 yes
GO:0010712 regulation of collagen metabolic process 2.9412 4 yes
GO:0010714 positive regulation of collagen metabolic process 2.9412 5 yes
GO:0016480 negative regulation of transcription by RNA polymerase III 2.9412 9 yes
GO:0032965 regulation of collagen biosynthetic process 2.9412 5 yes
GO:0032967 positive regulation of collagen biosynthetic process 2.9412 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SODC_HUMAN [view interactions] Low throughput no yes
PRDX5_HUMAN [view entry] [view interactions] Low throughput yes yes
UBE2A_HUMAN [view interactions] High throughput no no
ZNRD2_HUMAN [view interactions] High throughput no yes
ANCHR_HUMAN [view interactions] High throughput no yes
PSRC1_HUMAN [view interactions] High throughput no no
DUT_HUMAN [view interactions] High throughput no yes
NDKA_HUMAN [view entry] [view interactions] High throughput yes yes
AL7A1_HUMAN [view entry] [view interactions] High throughput yes no
ALDOC_HUMAN [view entry] [view interactions] High throughput yes yes
CATA_HUMAN [view entry] [view interactions] High throughput yes no
COF1_HUMAN [view entry] [view interactions] High throughput yes no
DEST_HUMAN [view entry] [view interactions] High throughput yes yes
FUBP1_HUMAN [view interactions] High throughput no yes
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
HINT1_HUMAN [view interactions] High throughput no yes
FUBP2_HUMAN [view interactions] High throughput no yes
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD8_HUMAN [view entry] [view interactions] High throughput yes yes
NIT2_HUMAN [view interactions] High throughput no yes
NDKB_HUMAN [view entry] [view interactions] High throughput yes yes
PEBP1_HUMAN [view entry] [view interactions] High throughput yes yes
MPPB_HUMAN [view interactions] High throughput no yes
SODM_HUMAN [view entry] [view interactions] High throughput yes no
SPRE_HUMAN [view interactions] High throughput no yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
THIK_HUMAN [view entry] [view interactions] High throughput yes yes
KAD3_HUMAN [view entry] [view interactions] High throughput yes yes
COF2_HUMAN [view entry] [view interactions] High throughput yes yes
THIL_HUMAN [view entry] [view interactions] High throughput yes yes
KPYM_HUMAN [view interactions] High throughput no yes
THIM_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
MDHM_HUMAN [view entry] [view interactions] High throughput yes yes
COX17_HUMAN [view interactions] High throughput no yes
F136A_HUMAN [view interactions] High throughput no yes
NMES1_HUMAN [view interactions] High throughput no no
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
PPIA_HUMAN [view entry] [view interactions] High throughput yes yes
ICAM1_HUMAN [view interactions] High throughput no no
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
PREP_HUMAN [view interactions] High throughput no yes
TM205_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
FAH2A_HUMAN [view interactions] High throughput no yes
LEG3_HUMAN [view interactions] High throughput no yes
KAD4_HUMAN [view interactions] High throughput no yes
GAL3A_HUMAN [view interactions] High throughput no yes
GAL3B_HUMAN [view interactions] High throughput no no
CATB_HUMAN [view interactions] High throughput no yes
AATM_HUMAN [view entry] [view interactions] High throughput yes yes
MTDC_HUMAN [view interactions] High throughput no yes
MX2_HUMAN [view interactions] High throughput no yes
NUD19_HUMAN [view interactions] High throughput no no
KAD2_HUMAN [view interactions] High throughput no no
FRDA_HUMAN [view interactions] High throughput no yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
GIMA8_HUMAN [view interactions] High throughput no yes
GLRX5_HUMAN [view interactions] High throughput no yes
KGUA_HUMAN [view entry] [view interactions] High throughput yes yes
MSRB3_HUMAN [view interactions] High throughput no yes
PTRD1_HUMAN [view interactions] High throughput no yes
RFIP5_HUMAN [view entry] [view interactions] High throughput yes yes
THIOM_HUMAN [view interactions] High throughput no yes
SAP_HUMAN [view interactions] High throughput no yes
THIO_HUMAN [view interactions] High throughput no yes
TXD12_HUMAN [view interactions] High throughput no no
ARF3_HUMAN [view entry] [view interactions] High throughput yes no
RL27A_HUMAN [view entry] [view interactions] High throughput yes yes
RL4_HUMAN [view entry] [view interactions] High throughput yes yes
HSBP1_HUMAN [view interactions] High throughput no no
RL32_HUMAN [view entry] [view interactions] High throughput yes yes
B3A2_HUMAN [view interactions] High throughput no yes
EHMT1_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
DHCR7_HUMAN [view interactions] High throughput no yes
DET1_HUMAN [view interactions] High throughput no no
GLUT4_HUMAN [view interactions] High throughput no no
BABA1_HUMAN [view interactions] High throughput no yes
ICT1_HUMAN [view interactions] High throughput no yes
ATF2_HUMAN [view interactions] High throughput no yes
OTUB1_HUMAN [view interactions] High throughput no yes
SIR4_HUMAN [view interactions] High throughput no yes
SHLD3_HUMAN [view interactions] High throughput no yes
SHOC2_HUMAN [view interactions] High throughput no yes
ARHG6_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
TAGL_HUMAN [view interactions] High throughput no no
YJU2_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
SCRB2_HUMAN [view interactions] High throughput no yes
TRI55_HUMAN [view interactions] High throughput no no
PINX1_HUMAN [view interactions] High throughput no yes
IKKE_HUMAN [view interactions] High throughput no yes
LIN54_HUMAN [view interactions] High throughput no yes
HSC20_HUMAN [view interactions] High throughput no yes
CAV3_HUMAN [view interactions] High throughput no no
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
NUFP2_HUMAN [view interactions] High throughput no no
MCSP_HUMAN [view interactions] High throughput no no
CDN2D_HUMAN [view interactions] High throughput no no
CC90B_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
ERBB3_HUMAN [view interactions] High throughput no yes
ERBB4_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
TIF1A_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no
SUFU_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
WWOX_HUMAN [view interactions] High throughput no yes
PPT1_HUMAN [view interactions] High throughput no yes
MAGA1_HUMAN [view interactions] High throughput no no
EM55_HUMAN [view entry] [view interactions] High throughput yes no
MYH7_HUMAN [view interactions] High throughput no no
APC15_HUMAN [view interactions] High throughput no yes
PCDBF_HUMAN [view interactions] High throughput no yes
SLAI2_HUMAN [view interactions] High throughput no no
URP2_HUMAN [view interactions] High throughput no no
BD1L1_HUMAN [view interactions] High throughput no yes
MYH3_HUMAN [view interactions] High throughput no no
CETN2_HUMAN [view interactions] High throughput no yes
NAA10_HUMAN [view interactions] High throughput no yes
TMED2_HUMAN [view interactions] High throughput no yes
CHMP3_HUMAN [view interactions] High throughput no yes
NDC80_HUMAN [view interactions] High throughput no no
SAM50_HUMAN [view entry] [view interactions] High throughput yes yes
TRI32_HUMAN [view entry] [view interactions] High throughput yes yes
SESD1_HUMAN [view entry] [view interactions] High throughput yes no
TF3C4_HUMAN [view interactions] High throughput no no
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
DS13A_HUMAN [view interactions] High throughput no no
DUS19_HUMAN [view interactions] High throughput no yes
DUS2_HUMAN [view interactions] High throughput no no
DUS4_HUMAN [view entry] [view interactions] High throughput yes no
FACD2_HUMAN [view interactions] High throughput no no
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
PURA2_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
U5S1_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
SHRPN_HUMAN [view entry] [view interactions] High throughput yes yes
GPC1_HUMAN [view entry] [view interactions] High throughput yes no
CCND1_HUMAN [view interactions] High throughput no yes
RHG31_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KIF23_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
DCA10_HUMAN [view interactions] High throughput no no
DTX3_HUMAN [view interactions] High throughput no yes
BAG1_HUMAN [view interactions] High throughput no yes
SAR1B_HUMAN [view interactions] High throughput no yes
UBE2O_HUMAN [view interactions] High throughput no yes
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
MALT1_HUMAN [view interactions] High throughput no no
BAP1_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
RIPK2_HUMAN [view interactions] High throughput no yes
CBL_HUMAN [view interactions] High throughput no yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2H_HUMAN [view interactions] High throughput no yes
SRBP2_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
CLK1_HUMAN [view interactions] High throughput no yes
PEX5_HUMAN [view interactions] High throughput no yes
STAM1_HUMAN [view interactions] High throughput no yes
VAMP2_HUMAN [view entry] [view interactions] High throughput yes no
PRDX2_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX6_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX1_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO1_HUMAN [view entry] [view interactions] High throughput yes yes
SC24A_HUMAN [view interactions] High throughput no no
IGBP1_HUMAN [view interactions] High throughput no yes
PTN23_HUMAN [view entry] [view interactions] High throughput yes yes
SLD5_HUMAN [view interactions] High throughput no yes
RS12_HUMAN [view entry] [view interactions] High throughput yes yes
RD23B_HUMAN [view interactions] High throughput no yes
PARK7_HUMAN [view entry] [view interactions] High throughput yes yes
TOM40_HUMAN [view interactions] High throughput no yes
UBE2B_HUMAN [view interactions] High throughput no no
UBAP2_HUMAN [view interactions] High throughput no yes
PTMS_HUMAN [view interactions] High throughput no yes
MDHC_HUMAN [view entry] [view interactions] High throughput yes yes
IFT27_HUMAN [view interactions] High throughput no yes
PTGR1_HUMAN [view interactions] High throughput no yes