PRDX5_HUMAN
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PRDX5_HUMAN |
---|---|---|---|---|
GO:0003723 | RNA binding | 27.9412 | 4 | no |
GO:0000166 | nucleotide binding | 25.0000 | 4 | no |
GO:0043168 | anion binding | 25.0000 | 4 | no |
GO:0017076 | purine nucleotide binding | 23.5294 | 5 | no |
GO:0043169 | cation binding | 23.5294 | 4 | no |
GO:0046872 | metal ion binding | 23.5294 | 5 | no |
GO:0003677 | DNA binding | 14.7059 | 4 | yes |
GO:0003690 | double-stranded DNA binding | 10.2941 | 5 | yes |
GO:0043565 | sequence-specific DNA binding | 10.2941 | 5 | yes |
GO:0000976 | transcription cis-regulatory region binding | 8.8235 | 5 | yes |
GO:0001067 | transcription regulatory region nucleic acid binding | 8.8235 | 4 | yes |
GO:1990837 | sequence-specific double-stranded DNA binding | 8.8235 | 6 | yes |
GO:0008379 | thioredoxin peroxidase activity | 5.8824 | 5 | yes |
GO:0140824 | thioredoxin-dependent peroxiredoxin activity | 5.8824 | 4 | yes |
GO:0001016 | RNA polymerase III transcription regulatory region sequence-specific DNA binding | 2.9412 | 6 | yes |
GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | 2.9412 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PRDX5_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 54.4118 | 4 | no |
GO:0048523 | negative regulation of cellular process | 51.4706 | 4 | yes |
GO:0010646 | regulation of cell communication | 45.5882 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 41.1765 | 4 | yes |
GO:0009966 | regulation of signal transduction | 39.7059 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 38.2353 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 36.7647 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 36.7647 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 36.7647 | 4 | yes |
GO:0010468 | regulation of gene expression | 36.7647 | 6 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 36.7647 | 5 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 36.7647 | 5 | yes |
GO:0006996 | organelle organization | 35.2941 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 33.8235 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 32.3529 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 32.3529 | 5 | no |
GO:0008104 | protein localization | 32.3529 | 4 | no |
GO:0051128 | regulation of cellular component organization | 32.3529 | 4 | no |
GO:0023056 | positive regulation of signaling | 30.8824 | 4 | no |
GO:0022607 | cellular component assembly | 30.8824 | 4 | no |
GO:0042981 | regulation of apoptotic process | 30.8824 | 5 | yes |
GO:0043067 | regulation of programmed cell death | 30.8824 | 4 | yes |
GO:0010647 | positive regulation of cell communication | 29.4118 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 27.9412 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 27.9412 | 5 | no |
GO:0009891 | positive regulation of biosynthetic process | 27.9412 | 5 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.9412 | 5 | yes |
GO:0051252 | regulation of RNA metabolic process | 26.4706 | 5 | yes |
GO:0009967 | positive regulation of signal transduction | 26.4706 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 26.4706 | 4 | no |
GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | no |
GO:0051049 | regulation of transport | 25.0000 | 4 | no |
GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 7 | yes |
GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | yes |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.5294 | 6 | no |
GO:0043412 | macromolecule modification | 23.5294 | 4 | no |
GO:0060341 | regulation of cellular localization | 23.5294 | 4 | no |
GO:0010648 | negative regulation of cell communication | 23.5294 | 5 | no |
GO:0023057 | negative regulation of signaling | 23.5294 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 23.5294 | 5 | yes |
GO:0043066 | negative regulation of apoptotic process | 23.5294 | 6 | yes |
GO:0043069 | negative regulation of programmed cell death | 23.5294 | 5 | yes |
GO:0036211 | protein modification process | 22.0588 | 4 | no |
GO:0032880 | regulation of protein localization | 22.0588 | 5 | no |
GO:0071702 | organic substance transport | 22.0588 | 4 | no |
GO:0045595 | regulation of cell differentiation | 22.0588 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 22.0588 | 4 | no |
GO:0006753 | nucleoside phosphate metabolic process | 22.0588 | 4 | yes |
GO:0009117 | nucleotide metabolic process | 22.0588 | 5 | yes |
GO:0072521 | purine-containing compound metabolic process | 20.5882 | 4 | yes |
GO:1902533 | positive regulation of intracellular signal transduction | 20.5882 | 6 | no |
GO:0009968 | negative regulation of signal transduction | 20.5882 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 20.5882 | 6 | no |
GO:0006163 | purine nucleotide metabolic process | 20.5882 | 5 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 20.5882 | 5 | yes |
GO:1901701 | cellular response to oxygen-containing compound | 19.1176 | 4 | yes |
GO:0009890 | negative regulation of biosynthetic process | 17.6471 | 5 | yes |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 16.1765 | 6 | yes |
GO:0031327 | negative regulation of cellular biosynthetic process | 16.1765 | 6 | yes |
GO:0062197 | cellular response to chemical stress | 13.2353 | 4 | yes |
GO:0072524 | pyridine-containing compound metabolic process | 13.2353 | 4 | yes |
GO:0019362 | pyridine nucleotide metabolic process | 13.2353 | 5 | yes |
GO:0034599 | cellular response to oxidative stress | 13.2353 | 4 | yes |
GO:0046496 | nicotinamide nucleotide metabolic process | 13.2353 | 6 | yes |
GO:0043086 | negative regulation of catalytic activity | 11.7647 | 4 | yes |
GO:0000302 | response to reactive oxygen species | 10.2941 | 4 | yes |
GO:0042743 | hydrogen peroxide metabolic process | 10.2941 | 4 | yes |
GO:0051253 | negative regulation of RNA metabolic process | 8.8235 | 6 | yes |
GO:1902679 | negative regulation of RNA biosynthetic process | 8.8235 | 7 | yes |
GO:0045892 | negative regulation of DNA-templated transcription | 8.8235 | 8 | yes |
GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 8.8235 | 5 | yes |
GO:0034614 | cellular response to reactive oxygen species | 7.3529 | 5 | yes |
GO:0042744 | hydrogen peroxide catabolic process | 7.3529 | 4 | yes |
GO:0006954 | inflammatory response | 5.8824 | 4 | yes |
GO:0051341 | regulation of oxidoreductase activity | 4.4118 | 4 | yes |
GO:0006739 | NADP metabolic process | 4.4118 | 6 | yes |
GO:0051354 | negative regulation of oxidoreductase activity | 2.9412 | 5 | yes |
GO:0060785 | regulation of apoptosis involved in tissue homeostasis | 2.9412 | 6 | yes |
GO:0070995 | NADPH oxidation | 2.9412 | 7 | yes |
GO:0006359 | regulation of transcription by RNA polymerase III | 2.9412 | 8 | yes |
GO:0010712 | regulation of collagen metabolic process | 2.9412 | 4 | yes |
GO:0010714 | positive regulation of collagen metabolic process | 2.9412 | 5 | yes |
GO:0016480 | negative regulation of transcription by RNA polymerase III | 2.9412 | 9 | yes |
GO:0032965 | regulation of collagen biosynthetic process | 2.9412 | 5 | yes |
GO:0032967 | positive regulation of collagen biosynthetic process | 2.9412 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
SODC_HUMAN | [view interactions] | Low throughput | no | yes |
PRDX5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
UBE2A_HUMAN | [view interactions] | High throughput | no | no |
ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
ANCHR_HUMAN | [view interactions] | High throughput | no | yes |
PSRC1_HUMAN | [view interactions] | High throughput | no | no |
DUT_HUMAN | [view interactions] | High throughput | no | yes |
NDKA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DEST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FUBP1_HUMAN | [view interactions] | High throughput | no | yes |
G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HINT1_HUMAN | [view interactions] | High throughput | no | yes |
FUBP2_HUMAN | [view interactions] | High throughput | no | yes |
LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NEDD8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NIT2_HUMAN | [view interactions] | High throughput | no | yes |
NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MPPB_HUMAN | [view interactions] | High throughput | no | yes |
SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SPRE_HUMAN | [view interactions] | High throughput | no | yes |
TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
THIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KAD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
THIL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KPYM_HUMAN | [view interactions] | High throughput | no | yes |
THIM_HUMAN | [view interactions] | High throughput | no | yes |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COX17_HUMAN | [view interactions] | High throughput | no | yes |
F136A_HUMAN | [view interactions] | High throughput | no | yes |
NMES1_HUMAN | [view interactions] | High throughput | no | no |
AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ICAM1_HUMAN | [view interactions] | High throughput | no | no |
ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PREP_HUMAN | [view interactions] | High throughput | no | yes |
TM205_HUMAN | [view interactions] | High throughput | no | yes |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FAH2A_HUMAN | [view interactions] | High throughput | no | yes |
LEG3_HUMAN | [view interactions] | High throughput | no | yes |
KAD4_HUMAN | [view interactions] | High throughput | no | yes |
GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
GAL3B_HUMAN | [view interactions] | High throughput | no | no |
CATB_HUMAN | [view interactions] | High throughput | no | yes |
AATM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTDC_HUMAN | [view interactions] | High throughput | no | yes |
MX2_HUMAN | [view interactions] | High throughput | no | yes |
NUD19_HUMAN | [view interactions] | High throughput | no | no |
KAD2_HUMAN | [view interactions] | High throughput | no | no |
FRDA_HUMAN | [view interactions] | High throughput | no | yes |
GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GIMA8_HUMAN | [view interactions] | High throughput | no | yes |
GLRX5_HUMAN | [view interactions] | High throughput | no | yes |
KGUA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MSRB3_HUMAN | [view interactions] | High throughput | no | yes |
PTRD1_HUMAN | [view interactions] | High throughput | no | yes |
RFIP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
THIOM_HUMAN | [view interactions] | High throughput | no | yes |
SAP_HUMAN | [view interactions] | High throughput | no | yes |
THIO_HUMAN | [view interactions] | High throughput | no | yes |
TXD12_HUMAN | [view interactions] | High throughput | no | no |
ARF3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSBP1_HUMAN | [view interactions] | High throughput | no | no |
RL32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
B3A2_HUMAN | [view interactions] | High throughput | no | yes |
EHMT1_HUMAN | [view interactions] | High throughput | no | yes |
AGR2_HUMAN | [view interactions] | High throughput | no | no |
GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DHCR7_HUMAN | [view interactions] | High throughput | no | yes |
DET1_HUMAN | [view interactions] | High throughput | no | no |
GLUT4_HUMAN | [view interactions] | High throughput | no | no |
BABA1_HUMAN | [view interactions] | High throughput | no | yes |
ICT1_HUMAN | [view interactions] | High throughput | no | yes |
ATF2_HUMAN | [view interactions] | High throughput | no | yes |
OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
SIR4_HUMAN | [view interactions] | High throughput | no | yes |
SHLD3_HUMAN | [view interactions] | High throughput | no | yes |
SHOC2_HUMAN | [view interactions] | High throughput | no | yes |
ARHG6_HUMAN | [view interactions] | High throughput | no | no |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TAGL_HUMAN | [view interactions] | High throughput | no | no |
YJU2_HUMAN | [view interactions] | High throughput | no | yes |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
TRI55_HUMAN | [view interactions] | High throughput | no | no |
PINX1_HUMAN | [view interactions] | High throughput | no | yes |
IKKE_HUMAN | [view interactions] | High throughput | no | yes |
LIN54_HUMAN | [view interactions] | High throughput | no | yes |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
CAV3_HUMAN | [view interactions] | High throughput | no | no |
ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUFP2_HUMAN | [view interactions] | High throughput | no | no |
MCSP_HUMAN | [view interactions] | High throughput | no | no |
CDN2D_HUMAN | [view interactions] | High throughput | no | no |
CC90B_HUMAN | [view interactions] | High throughput | no | yes |
ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
ERBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
TIF1A_HUMAN | [view interactions] | High throughput | no | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SUFU_HUMAN | [view interactions] | High throughput | no | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WWOX_HUMAN | [view interactions] | High throughput | no | yes |
PPT1_HUMAN | [view interactions] | High throughput | no | yes |
MAGA1_HUMAN | [view interactions] | High throughput | no | no |
EM55_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYH7_HUMAN | [view interactions] | High throughput | no | no |
APC15_HUMAN | [view interactions] | High throughput | no | yes |
PCDBF_HUMAN | [view interactions] | High throughput | no | yes |
SLAI2_HUMAN | [view interactions] | High throughput | no | no |
URP2_HUMAN | [view interactions] | High throughput | no | no |
BD1L1_HUMAN | [view interactions] | High throughput | no | yes |
MYH3_HUMAN | [view interactions] | High throughput | no | no |
CETN2_HUMAN | [view interactions] | High throughput | no | yes |
NAA10_HUMAN | [view interactions] | High throughput | no | yes |
TMED2_HUMAN | [view interactions] | High throughput | no | yes |
CHMP3_HUMAN | [view interactions] | High throughput | no | yes |
NDC80_HUMAN | [view interactions] | High throughput | no | no |
SAM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SESD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TF3C4_HUMAN | [view interactions] | High throughput | no | no |
HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DS13A_HUMAN | [view interactions] | High throughput | no | no |
DUS19_HUMAN | [view interactions] | High throughput | no | yes |
DUS2_HUMAN | [view interactions] | High throughput | no | no |
DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PURA2_HUMAN | [view interactions] | High throughput | no | yes |
CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
U5S1_HUMAN | [view interactions] | High throughput | no | yes |
AAR2_HUMAN | [view interactions] | High throughput | no | no |
SHRPN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CCND1_HUMAN | [view interactions] | High throughput | no | yes |
RHG31_HUMAN | [view interactions] | High throughput | no | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
KIF23_HUMAN | [view interactions] | High throughput | no | yes |
BRD4_HUMAN | [view interactions] | High throughput | no | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
DCA10_HUMAN | [view interactions] | High throughput | no | no |
DTX3_HUMAN | [view interactions] | High throughput | no | yes |
BAG1_HUMAN | [view interactions] | High throughput | no | yes |
SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
MALT1_HUMAN | [view interactions] | High throughput | no | no |
BAP1_HUMAN | [view interactions] | High throughput | no | yes |
CCNF_HUMAN | [view interactions] | High throughput | no | no |
RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
UBP48_HUMAN | [view interactions] | High throughput | no | yes |
FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
RIPK2_HUMAN | [view interactions] | High throughput | no | yes |
CBL_HUMAN | [view interactions] | High throughput | no | yes |
PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLK1_HUMAN | [view interactions] | High throughput | no | yes |
PEX5_HUMAN | [view interactions] | High throughput | no | yes |
STAM1_HUMAN | [view interactions] | High throughput | no | yes |
VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SUMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SC24A_HUMAN | [view interactions] | High throughput | no | no |
IGBP1_HUMAN | [view interactions] | High throughput | no | yes |
PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SLD5_HUMAN | [view interactions] | High throughput | no | yes |
RS12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RD23B_HUMAN | [view interactions] | High throughput | no | yes |
PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOM40_HUMAN | [view interactions] | High throughput | no | yes |
UBE2B_HUMAN | [view interactions] | High throughput | no | no |
UBAP2_HUMAN | [view interactions] | High throughput | no | yes |
PTMS_HUMAN | [view interactions] | High throughput | no | yes |
MDHC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IFT27_HUMAN | [view interactions] | High throughput | no | yes |
PTGR1_HUMAN | [view interactions] | High throughput | no | yes |