Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PRDX5_HUMAN

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PRDX5_HUMAN
GO:0003723 RNA binding 28.5714 4 no
GO:0046872 metal ion binding 22.2222 4 no
GO:0003677 DNA binding 15.8730 4 yes
GO:0003690 double-stranded DNA binding 11.1111 5 yes
GO:0043565 sequence-specific DNA binding 11.1111 5 yes
GO:0000976 transcription cis-regulatory region binding 9.5238 5 yes
GO:0001067 transcription regulatory region nucleic acid binding 9.5238 4 yes
GO:1990837 sequence-specific double-stranded DNA binding 9.5238 6 yes
GO:0004866 endopeptidase inhibitor activity 7.9365 5 yes
GO:0008379 thioredoxin peroxidase activity 7.9365 5 yes
GO:0030414 peptidase inhibitor activity 7.9365 4 yes
GO:0061135 endopeptidase regulator activity 7.9365 4 yes
GO:0140824 thioredoxin-dependent peroxiredoxin activity 7.9365 4 yes
GO:0001016 RNA polymerase III transcription regulatory region sequence-specific DNA binding 3.1746 6 yes
GO:0004869 cysteine-type endopeptidase inhibitor activity 3.1746 6 yes
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3.1746 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PRDX5_HUMAN
GO:0048522 positive regulation of cellular process 52.3810 4 no
GO:0048523 negative regulation of cellular process 49.2063 4 yes
GO:0010646 regulation of cell communication 44.4444 4 no
GO:0060255 regulation of macromolecule metabolic process 41.2698 4 yes
GO:0009966 regulation of signal transduction 39.6825 4 no
GO:0010468 regulation of gene expression 36.5079 5 yes
GO:0051171 regulation of nitrogen compound metabolic process 36.5079 4 yes
GO:0080090 regulation of primary metabolic process 36.5079 4 yes
GO:0009893 positive regulation of metabolic process 34.9206 4 yes
GO:0031323 regulation of cellular metabolic process 34.9206 4 yes
GO:0006996 organelle organization 33.3333 4 no
GO:0010941 regulation of cell death 31.7460 4 yes
GO:1902531 regulation of intracellular signal transduction 31.7460 5 no
GO:0042981 regulation of apoptotic process 30.1587 6 yes
GO:0043067 regulation of programmed cell death 30.1587 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 30.1587 5 no
GO:0023056 positive regulation of signaling 30.1587 4 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0006796 phosphate-containing compound metabolic process 26.9841 4 yes
GO:0009889 regulation of biosynthetic process 26.9841 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 26.9841 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.9841 5 yes
GO:0031326 regulation of cellular biosynthetic process 26.9841 5 yes
GO:0051128 regulation of cellular component organization 26.9841 4 no
GO:0051240 positive regulation of multicellular organismal process 26.9841 4 no
GO:0051252 regulation of RNA metabolic process 25.3968 5 yes
GO:0009967 positive regulation of signal transduction 25.3968 5 no
GO:0048584 positive regulation of response to stimulus 25.3968 4 no
GO:0008104 protein localization 25.3968 4 no
GO:0006355 regulation of DNA-templated transcription 23.8095 6 yes
GO:0060548 negative regulation of cell death 23.8095 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 23.8095 7 yes
GO:2001141 regulation of RNA biosynthetic process 23.8095 6 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 23.8095 5 no
GO:0051246 regulation of protein metabolic process 23.8095 5 no
GO:0010648 negative regulation of cell communication 23.8095 5 no
GO:0023057 negative regulation of signaling 23.8095 4 no
GO:0051049 regulation of transport 23.8095 4 no
GO:0009892 negative regulation of metabolic process 22.2222 4 yes
GO:0043066 negative regulation of apoptotic process 22.2222 7 yes
GO:0043069 negative regulation of programmed cell death 22.2222 6 yes
GO:0031325 positive regulation of cellular metabolic process 22.2222 5 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:0048585 negative regulation of response to stimulus 22.2222 4 no
GO:0010605 negative regulation of macromolecule metabolic process 20.6349 5 yes
GO:0019752 carboxylic acid metabolic process 20.6349 5 no
GO:0043436 oxoacid metabolic process 20.6349 4 no
GO:0045595 regulation of cell differentiation 20.6349 4 no
GO:0051094 positive regulation of developmental process 20.6349 4 no
GO:0071310 cellular response to organic substance 20.6349 4 no
GO:1902533 positive regulation of intracellular signal transduction 20.6349 6 no
GO:0071702 organic substance transport 20.6349 4 no
GO:0009968 negative regulation of signal transduction 20.6349 5 no
GO:0006753 nucleoside phosphate metabolic process 19.0476 4 yes
GO:0009117 nucleotide metabolic process 19.0476 5 yes
GO:0031324 negative regulation of cellular metabolic process 19.0476 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 19.0476 5 yes
GO:0009891 positive regulation of biosynthetic process 17.4603 5 yes
GO:1901701 cellular response to oxygen-containing compound 17.4603 4 yes
GO:0009890 negative regulation of biosynthetic process 14.2857 5 yes
GO:0000302 response to reactive oxygen species 11.1111 4 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 11.1111 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 11.1111 6 yes
GO:0034599 cellular response to oxidative stress 11.1111 4 yes
GO:0042743 hydrogen peroxide metabolic process 11.1111 4 yes
GO:0062197 cellular response to chemical stress 11.1111 4 yes
GO:0043086 negative regulation of catalytic activity 9.5238 4 yes
GO:0045892 negative regulation of DNA-templated transcription 9.5238 7 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 9.5238 6 yes
GO:0051253 negative regulation of RNA metabolic process 9.5238 6 yes
GO:1902679 negative regulation of RNA biosynthetic process 9.5238 7 yes
GO:1903507 negative regulation of nucleic acid-templated transcription 9.5238 8 yes
GO:0034614 cellular response to reactive oxygen species 7.9365 5 yes
GO:0042744 hydrogen peroxide catabolic process 7.9365 4 yes
GO:0006954 inflammatory response 4.7619 4 yes
GO:0051341 regulation of oxidoreductase activity 4.7619 4 yes
GO:0006359 regulation of transcription by RNA polymerase III 3.1746 7 yes
GO:0006739 NADP metabolic process 3.1746 7 yes
GO:0010712 regulation of collagen metabolic process 3.1746 4 yes
GO:0010714 positive regulation of collagen metabolic process 3.1746 5 yes
GO:0016480 negative regulation of transcription by RNA polymerase III 3.1746 8 yes
GO:0019362 pyridine nucleotide metabolic process 3.1746 5 yes
GO:0032965 regulation of collagen biosynthetic process 3.1746 5 yes
GO:0032967 positive regulation of collagen biosynthetic process 3.1746 6 yes
GO:0046496 nicotinamide nucleotide metabolic process 3.1746 6 yes
GO:0051354 negative regulation of oxidoreductase activity 3.1746 5 yes
GO:0060785 regulation of apoptosis involved in tissue homeostasis 3.1746 7 yes
GO:0070995 NADPH oxidation 3.1746 8 yes
GO:0072524 pyridine-containing compound metabolic process 3.1746 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in PRDX5_HUMAN
DOID:1289 neurodegenerative disease 3.1746 4 no
DOID:331 central nervous system disease 3.1746 3 no
DOID:10595 Charcot-Marie-Tooth disease 3.1746 6 no
DOID:440 neuromuscular disease 3.1746 5 no
DOID:574 peripheral nervous system disease 3.1746 3 no
DOID:870 neuropathy 3.1746 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PRDX5_HUMAN [view entry] [view interactions] Low throughput yes yes
SODC_HUMAN [view interactions] Low throughput no yes
HSC20_HUMAN [view interactions] High throughput no yes
CAV3_HUMAN [view interactions] High throughput no no
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
NUFP2_HUMAN [view interactions] High throughput no no
MCSP_HUMAN [view interactions] High throughput no no
CDN2D_HUMAN [view interactions] High throughput no no
CC90B_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
ERBB3_HUMAN [view interactions] High throughput no yes
ERBB4_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
TIF1A_HUMAN [view interactions] High throughput no yes
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no
SUFU_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
WWOX_HUMAN [view interactions] High throughput no yes
PPT1_HUMAN [view interactions] High throughput no yes
MAGA1_HUMAN [view interactions] High throughput no no
EM55_HUMAN [view entry] [view interactions] High throughput yes no
MYH7_HUMAN [view interactions] High throughput no no
APC15_HUMAN [view interactions] High throughput no yes
PCDBF_HUMAN [view interactions] High throughput no yes
SLAI2_HUMAN [view interactions] High throughput no no
URP2_HUMAN [view interactions] High throughput no no
BD1L1_HUMAN [view interactions] High throughput no yes
MYH3_HUMAN [view interactions] High throughput no no
CETN2_HUMAN [view interactions] High throughput no yes
NAA10_HUMAN [view interactions] High throughput no yes
TMED2_HUMAN [view interactions] High throughput no yes
CHMP3_HUMAN [view interactions] High throughput no yes
NDC80_HUMAN [view interactions] High throughput no no
SAM50_HUMAN [view entry] [view interactions] High throughput yes yes
TRI32_HUMAN [view entry] [view interactions] High throughput yes yes
SESD1_HUMAN [view entry] [view interactions] High throughput yes no
TF3C4_HUMAN [view interactions] High throughput no no
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
DUS19_HUMAN [view interactions] High throughput no yes
DUS2_HUMAN [view interactions] High throughput no no
DUS4_HUMAN [view entry] [view interactions] High throughput yes no
FACD2_HUMAN [view interactions] High throughput no no
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
PURA2_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
U5S1_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
SHRPN_HUMAN [view entry] [view interactions] High throughput yes yes
GPC1_HUMAN [view entry] [view interactions] High throughput yes no
CCND1_HUMAN [view interactions] High throughput no yes
RHG31_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KIF23_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
DCA10_HUMAN [view interactions] High throughput no no
DTX3_HUMAN [view interactions] High throughput no yes
BAG1_HUMAN [view interactions] High throughput no yes
SAR1B_HUMAN [view interactions] High throughput no yes
SRBP2_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
CLK1_HUMAN [view interactions] High throughput no yes
PEX5_HUMAN [view interactions] High throughput no yes
STAM1_HUMAN [view interactions] High throughput no yes
VAMP2_HUMAN [view entry] [view interactions] High throughput yes no
PRDX2_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX6_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX1_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO1_HUMAN [view interactions] High throughput no yes
SC24A_HUMAN [view interactions] High throughput no no
IGBP1_HUMAN [view interactions] High throughput no yes
PTN23_HUMAN [view entry] [view interactions] High throughput yes yes
SLD5_HUMAN [view interactions] High throughput no yes
RS12_HUMAN [view entry] [view interactions] High throughput yes yes
RD23B_HUMAN [view interactions] High throughput no yes
PARK7_HUMAN [view entry] [view interactions] High throughput yes yes
TOM40_HUMAN [view interactions] High throughput no yes
UBE2B_HUMAN [view interactions] High throughput no no
UBAP2_HUMAN [view interactions] High throughput no yes
PTMS_HUMAN [view interactions] High throughput no yes
MDHC_HUMAN [view entry] [view interactions] High throughput yes yes
IFT27_HUMAN [view interactions] High throughput no yes
PTGR1_HUMAN [view interactions] High throughput no yes
UBE2A_HUMAN [view interactions] High throughput no no
ZNRD2_HUMAN [view interactions] High throughput no yes
ANCHR_HUMAN [view interactions] High throughput no yes
PSRC1_HUMAN [view interactions] High throughput no no
DUT_HUMAN [view interactions] High throughput no yes
NDKA_HUMAN [view entry] [view interactions] High throughput yes yes
AL7A1_HUMAN [view entry] [view interactions] High throughput yes no
ALDOC_HUMAN [view entry] [view interactions] High throughput yes yes
CATA_HUMAN [view entry] [view interactions] High throughput yes no
COF1_HUMAN [view entry] [view interactions] High throughput yes no
DEST_HUMAN [view entry] [view interactions] High throughput yes yes
FUBP1_HUMAN [view interactions] High throughput no yes
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
HINT1_HUMAN [view interactions] High throughput no yes
FUBP2_HUMAN [view interactions] High throughput no yes
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD8_HUMAN [view interactions] High throughput no yes
NIT2_HUMAN [view interactions] High throughput no yes
NDKB_HUMAN [view entry] [view interactions] High throughput yes yes
PEBP1_HUMAN [view entry] [view interactions] High throughput yes yes
MPPB_HUMAN [view interactions] High throughput no yes
SODM_HUMAN [view entry] [view interactions] High throughput yes no
SPRE_HUMAN [view interactions] High throughput no yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
THIK_HUMAN [view entry] [view interactions] High throughput yes yes
KAD3_HUMAN [view entry] [view interactions] High throughput yes yes
COF2_HUMAN [view entry] [view interactions] High throughput yes yes
THIL_HUMAN [view entry] [view interactions] High throughput yes yes
KPYM_HUMAN [view interactions] High throughput no yes
THIM_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
MDHM_HUMAN [view entry] [view interactions] High throughput yes yes
COX17_HUMAN [view interactions] High throughput no yes
F136A_HUMAN [view interactions] High throughput no yes
NMES1_HUMAN [view interactions] High throughput no no
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
PPIA_HUMAN [view entry] [view interactions] High throughput yes yes
ICAM1_HUMAN [view interactions] High throughput no no
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
PREP_HUMAN [view interactions] High throughput no yes
TM205_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
FAH2A_HUMAN [view interactions] High throughput no yes
LEG3_HUMAN [view interactions] High throughput no yes
KAD4_HUMAN [view interactions] High throughput no yes
GAL3A_HUMAN [view interactions] High throughput no yes
GAL3B_HUMAN [view interactions] High throughput no yes
CATB_HUMAN [view interactions] High throughput no yes
AATM_HUMAN [view entry] [view interactions] High throughput yes yes
MTDC_HUMAN [view interactions] High throughput no yes
MX2_HUMAN [view interactions] High throughput no yes
NUD19_HUMAN [view interactions] High throughput no no
KAD2_HUMAN [view interactions] High throughput no no
FRDA_HUMAN [view interactions] High throughput no yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
GIMA8_HUMAN [view interactions] High throughput no yes
GLRX5_HUMAN [view interactions] High throughput no yes
KGUA_HUMAN [view entry] [view interactions] High throughput yes yes
MSRB3_HUMAN [view interactions] High throughput no yes
PTRD1_HUMAN [view interactions] High throughput no yes
RFIP5_HUMAN [view entry] [view interactions] High throughput yes yes
THIOM_HUMAN [view interactions] High throughput no yes
SAP_HUMAN [view interactions] High throughput no yes
THIO_HUMAN [view interactions] High throughput no yes
TXD12_HUMAN [view interactions] High throughput no no
ARF3_HUMAN [view entry] [view interactions] High throughput yes no
RL27A_HUMAN [view entry] [view interactions] High throughput yes yes
RL4_HUMAN [view entry] [view interactions] High throughput yes yes
HSBP1_HUMAN [view interactions] High throughput no no
RL32_HUMAN [view entry] [view interactions] High throughput yes yes
B3A2_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
GLUT4_HUMAN [view interactions] High throughput no no
BABA1_HUMAN [view interactions] High throughput no yes
ICT1_HUMAN [view interactions] High throughput no yes
ATF2_HUMAN [view interactions] High throughput no yes
OTUB1_HUMAN [view interactions] High throughput no yes
SIR4_HUMAN [view interactions] High throughput no yes
SHLD3_HUMAN [view interactions] High throughput no yes
SHOC2_HUMAN [view interactions] High throughput no yes
ARHG6_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
TAGL_HUMAN [view interactions] High throughput no no
YJU2_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
SCRB2_HUMAN [view interactions] High throughput no yes
TRI55_HUMAN [view interactions] High throughput no no
PINX1_HUMAN [view interactions] High throughput no yes
IKKE_HUMAN [view interactions] High throughput no yes
LIN54_HUMAN [view interactions] High throughput no yes
GSHR_HUMAN [view interactions] Computational no yes
TRXR1_HUMAN [view interactions] Computational no yes
PRDX3_HUMAN [view interactions] Computational no yes
PRDX4_HUMAN [view interactions] Computational no yes