EM55_HUMAN
Evidence for PS localization
Functions
Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EM55_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 35.7143 | 4 | no |
| GO:0019900 | kinase binding | 28.5714 | 4 | no |
| GO:0000166 | nucleotide binding | 28.5714 | 4 | no |
| GO:0017076 | purine nucleotide binding | 28.5714 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 28.5714 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.5714 | 4 | no |
| GO:0016301 | kinase activity | 17.8571 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EM55_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 71.4286 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 67.8571 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 67.8571 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 67.8571 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 60.7143 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 57.1429 | 4 | no |
| GO:0010646 | regulation of cell communication | 53.5714 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 53.5714 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 50.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 50.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 50.0000 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 50.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 50.0000 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 46.4286 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 46.4286 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 46.4286 | 5 | no |
| GO:0031399 | regulation of protein modification process | 42.8571 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 42.8571 | 6 | no |
| GO:0006996 | organelle organization | 42.8571 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 39.2857 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 39.2857 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 39.2857 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 39.2857 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 35.7143 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 35.7143 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 35.7143 | 5 | no |
| GO:0023057 | negative regulation of signaling | 35.7143 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 35.7143 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 35.7143 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 32.1429 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 32.1429 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 32.1429 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 32.1429 | 7 | no |
| GO:0010647 | positive regulation of cell communication | 32.1429 | 5 | no |
| GO:0023056 | positive regulation of signaling | 32.1429 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 32.1429 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 32.1429 | 7 | no |
| GO:0048584 | positive regulation of response to stimulus | 32.1429 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 32.1429 | 5 | no |
| GO:0051338 | regulation of transferase activity | 32.1429 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.5714 | 5 | no |
| GO:0043086 | negative regulation of catalytic activity | 28.5714 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 28.5714 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.5714 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 28.5714 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 28.5714 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 28.5714 | 4 | no |
| GO:0051049 | regulation of transport | 28.5714 | 4 | no |
| GO:0080134 | regulation of response to stress | 28.5714 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 28.5714 | 7 | no |
| GO:0044087 | regulation of cellular component biogenesis | 28.5714 | 4 | no |
| GO:0030334 | regulation of cell migration | 25.0000 | 5 | yes |
| GO:2000145 | regulation of cell motility | 25.0000 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 7 | no |
| GO:0030162 | regulation of proteolysis | 25.0000 | 6 | no |
| GO:0036211 | protein modification process | 25.0000 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 25.0000 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 25.0000 | 5 | no |
| GO:0043412 | macromolecule modification | 25.0000 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | no |
| GO:0043549 | regulation of kinase activity | 25.0000 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 25.0000 | 6 | no |
| GO:0071310 | cellular response to organic substance | 25.0000 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | no |
| GO:0006915 | apoptotic process | 25.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0009894 | regulation of catabolic process | 25.0000 | 4 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0043933 | protein-containing complex organization | 25.0000 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.4286 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 21.4286 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 21.4286 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 21.4286 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 21.4286 | 8 | no |
| GO:0010243 | response to organonitrogen compound | 21.4286 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.4286 | 6 | no |
| GO:0031400 | negative regulation of protein modification process | 21.4286 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 21.4286 | 8 | no |
| GO:0045862 | positive regulation of proteolysis | 21.4286 | 7 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.4286 | 7 | no |
| GO:0051093 | negative regulation of developmental process | 21.4286 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 21.4286 | 4 | no |
| GO:0009896 | positive regulation of catabolic process | 21.4286 | 5 | no |
| GO:0032880 | regulation of protein localization | 21.4286 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 21.4286 | 5 | no |
| GO:0060341 | regulation of cellular localization | 21.4286 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 21.4286 | 4 | no |
| GO:0007010 | cytoskeleton organization | 21.4286 | 5 | no |
| GO:0032101 | regulation of response to external stimulus | 17.8571 | 4 | yes |
| GO:0002685 | regulation of leukocyte migration | 7.1429 | 4 | yes |
| GO:0002688 | regulation of leukocyte chemotaxis | 7.1429 | 5 | yes |
| GO:0050920 | regulation of chemotaxis | 7.1429 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| WHRN_HUMAN | [view interactions] | Low throughput | no | no |
| MRP4_HUMAN | [view interactions] | Low throughput | no | no |
| GLPC_HUMAN | [view interactions] | Low throughput | no | yes |
| UBP21_HUMAN | [view interactions] | Low throughput | no | no |
| GA45A_HUMAN | [view interactions] | High throughput | no | no |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR1H2_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6A6_HUMAN | [view interactions] | High throughput | no | yes |
| SMN_HUMAN | [view interactions] | High throughput | no | yes |
| STK3_HUMAN | [view interactions] | High throughput | no | yes |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| M3K20_HUMAN | [view interactions] | High throughput | no | yes |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| FA13A_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| NCBP1_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MGN2_HUMAN | [view interactions] | High throughput | no | yes |
| SARNP_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DKC1_HUMAN | [view interactions] | High throughput | no | yes |
| NAF1_HUMAN | [view interactions] | High throughput | no | yes |
| TAF9B_HUMAN | [view interactions] | High throughput | no | no |
| MTA70_HUMAN | [view interactions] | High throughput | no | no |
| RT15_HUMAN | [view interactions] | High throughput | no | yes |
| COAA1_HUMAN | [view interactions] | High throughput | no | no |
| MYH11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| KLH12_HUMAN | [view interactions] | High throughput | no | no |
| DNPEP_HUMAN | [view interactions] | High throughput | no | yes |
| ZN639_HUMAN | [view interactions] | High throughput | no | yes |
| GASP3_HUMAN | [view interactions] | High throughput | no | no |
| APH1A_HUMAN | [view interactions] | High throughput | no | yes |
| RPRM_HUMAN | [view interactions] | High throughput | no | no |
| DG2L6_HUMAN | [view interactions] | High throughput | no | no |
| DERL2_HUMAN | [view interactions] | High throughput | no | yes |
| PAQR8_HUMAN | [view interactions] | High throughput | no | no |
| INCA1_HUMAN | [view interactions] | High throughput | no | no |
| ACER1_HUMAN | [view interactions] | High throughput | no | no |
| PRIPO_HUMAN | [view interactions] | High throughput | no | no |
| PLCC_HUMAN | [view interactions] | High throughput | no | no |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S35E1_HUMAN | [view interactions] | High throughput | no | yes |
| SNG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UXT_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| SGSM2_HUMAN | [view interactions] | High throughput | no | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMOL2_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRS10_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| ARAID_HUMAN | [view interactions] | High throughput | no | no |
| ACER2_HUMAN | [view interactions] | High throughput | no | no |
| TM239_HUMAN | [view interactions] | High throughput | no | no |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| AGFG1_HUMAN | [view interactions] | High throughput | no | yes |
| ID1_HUMAN | [view interactions] | High throughput | no | yes |
| TAF1B_HUMAN | [view interactions] | High throughput | no | no |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLSPN_HUMAN | [view interactions] | High throughput | no | no |
| EEIG2_HUMAN | [view interactions] | High throughput | no | yes |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| XXLT1_HUMAN | [view interactions] | High throughput | no | no |
| TRPS1_HUMAN | [view interactions] | High throughput | no | no |
| ZN584_HUMAN | [view interactions] | High throughput | no | no |
| MYH4_HUMAN | [view interactions] | High throughput | no | no |
| ZN287_HUMAN | [view interactions] | High throughput | no | no |
| SKP1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHRS6_HUMAN | [view interactions] | High throughput | no | no |
| CAN12_HUMAN | [view interactions] | High throughput | no | no |
| PRPS2_HUMAN | [view interactions] | High throughput | no | no |
| CEA16_HUMAN | [view interactions] | High throughput | no | no |
| TR10A_HUMAN | [view interactions] | High throughput | no | no |
| SRP09_HUMAN | [view interactions] | High throughput | no | no |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| ITA2B_HUMAN | [view interactions] | High throughput | no | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFHD1_HUMAN | [view interactions] | High throughput | no | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |