Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

STK38_HUMAN

Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2. [View more on UniProt]

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No data found.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in STK38_HUMAN
GO:0019900 kinase binding 36.1702 4 yes
GO:0019901 protein kinase binding 36.1702 5 yes
GO:0017076 purine nucleotide binding 34.0426 4 yes
GO:0032555 purine ribonucleotide binding 34.0426 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 34.0426 4 yes
GO:0046872 metal ion binding 31.9149 4 yes
GO:0005524 ATP binding 29.7872 5 yes
GO:0030554 adenyl nucleotide binding 29.7872 5 yes
GO:0032559 adenyl ribonucleotide binding 29.7872 5 yes
GO:0016301 kinase activity 19.1489 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 17.0213 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 17.0213 4 yes
GO:0004674 protein serine/threonine kinase activity 14.8936 4 yes
GO:0106310 protein serine kinase activity 14.8936 4 yes
GO:0045296 cadherin binding 12.7660 4 yes
GO:0000287 magnesium ion binding 8.5106 5 yes
GO:0031435 mitogen-activated protein kinase kinase kinase binding 4.2553 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in STK38_HUMAN
GO:0048522 positive regulation of cellular process 65.9574 4 no
GO:0051171 regulation of nitrogen compound metabolic process 65.9574 4 yes
GO:0060255 regulation of macromolecule metabolic process 65.9574 4 yes
GO:0080090 regulation of primary metabolic process 65.9574 4 yes
GO:0010646 regulation of cell communication 63.8298 4 yes
GO:0048523 negative regulation of cellular process 63.8298 4 yes
GO:0031323 regulation of cellular metabolic process 61.7021 4 yes
GO:0009966 regulation of signal transduction 57.4468 4 yes
GO:0051246 regulation of protein metabolic process 55.3191 5 yes
GO:0009892 negative regulation of metabolic process 48.9362 4 yes
GO:0009893 positive regulation of metabolic process 46.8085 4 no
GO:0051128 regulation of cellular component organization 46.8085 4 no
GO:0010605 negative regulation of macromolecule metabolic process 46.8085 5 yes
GO:1902531 regulation of intracellular signal transduction 44.6809 5 yes
GO:0009889 regulation of biosynthetic process 44.6809 4 no
GO:0010468 regulation of gene expression 44.6809 5 no
GO:0010556 regulation of macromolecule biosynthetic process 44.6809 5 no
GO:0010604 positive regulation of macromolecule metabolic process 44.6809 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 44.6809 5 no
GO:0031326 regulation of cellular biosynthetic process 44.6809 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 42.5532 5 no
GO:0031324 negative regulation of cellular metabolic process 42.5532 5 yes
GO:0031399 regulation of protein modification process 42.5532 6 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 42.5532 5 yes
GO:0051252 regulation of RNA metabolic process 40.4255 5 no
GO:0036211 protein modification process 40.4255 4 yes
GO:0043412 macromolecule modification 40.4255 4 yes
GO:0006355 regulation of DNA-templated transcription 38.2979 6 no
GO:0031325 positive regulation of cellular metabolic process 38.2979 5 no
GO:1903506 regulation of nucleic acid-templated transcription 38.2979 7 no
GO:2001141 regulation of RNA biosynthetic process 38.2979 6 no
GO:0051247 positive regulation of protein metabolic process 38.2979 6 no
GO:0019220 regulation of phosphate metabolic process 38.2979 6 yes
GO:0051174 regulation of phosphorus metabolic process 38.2979 5 yes
GO:0006996 organelle organization 36.1702 4 no
GO:0001932 regulation of protein phosphorylation 36.1702 7 yes
GO:0042325 regulation of phosphorylation 36.1702 7 yes
GO:0051049 regulation of transport 34.0426 4 no
GO:0048584 positive regulation of response to stimulus 34.0426 4 no
GO:0051248 negative regulation of protein metabolic process 34.0426 6 yes
GO:0022607 cellular component assembly 31.9149 4 no
GO:0010941 regulation of cell death 31.9149 4 no
GO:0042981 regulation of apoptotic process 31.9149 6 no
GO:0043067 regulation of programmed cell death 31.9149 5 no
GO:0008104 protein localization 29.7872 4 no
GO:0010647 positive regulation of cell communication 29.7872 5 no
GO:0023056 positive regulation of signaling 29.7872 4 no
GO:0031400 negative regulation of protein modification process 29.7872 7 yes
GO:0043549 regulation of kinase activity 29.7872 5 yes
GO:0045859 regulation of protein kinase activity 29.7872 6 yes
GO:0051338 regulation of transferase activity 29.7872 4 yes
GO:0009891 positive regulation of biosynthetic process 27.6596 5 no
GO:0031328 positive regulation of cellular biosynthetic process 27.6596 6 no
GO:0031401 positive regulation of protein modification process 27.6596 7 no
GO:0043085 positive regulation of catalytic activity 27.6596 4 no
GO:0051050 positive regulation of transport 27.6596 4 no
GO:0009967 positive regulation of signal transduction 27.6596 5 no
GO:0044087 regulation of cellular component biogenesis 27.6596 4 no
GO:0080134 regulation of response to stress 27.6596 4 no
GO:0033043 regulation of organelle organization 27.6596 5 no
GO:0010648 negative regulation of cell communication 27.6596 5 yes
GO:0023057 negative regulation of signaling 27.6596 4 yes
GO:0048585 negative regulation of response to stimulus 27.6596 4 yes
GO:0071702 organic substance transport 25.5319 4 no
GO:0071705 nitrogen compound transport 25.5319 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.5319 6 no
GO:0045595 regulation of cell differentiation 25.5319 4 no
GO:0010243 response to organonitrogen compound 25.5319 4 no
GO:0050804 modulation of chemical synaptic transmission 25.5319 5 no
GO:0071310 cellular response to organic substance 25.5319 4 no
GO:0099177 regulation of trans-synaptic signaling 25.5319 4 no
GO:0001934 positive regulation of protein phosphorylation 25.5319 8 no
GO:0010562 positive regulation of phosphorus metabolic process 25.5319 6 no
GO:0042327 positive regulation of phosphorylation 25.5319 8 no
GO:0045937 positive regulation of phosphate metabolic process 25.5319 7 no
GO:0051336 regulation of hydrolase activity 25.5319 4 no
GO:0051130 positive regulation of cellular component organization 25.5319 5 no
GO:0006796 phosphate-containing compound metabolic process 25.5319 4 yes
GO:0009968 negative regulation of signal transduction 25.5319 5 yes
GO:0010563 negative regulation of phosphorus metabolic process 25.5319 6 yes
GO:0043408 regulation of MAPK cascade 25.5319 6 yes
GO:0045936 negative regulation of phosphate metabolic process 25.5319 7 yes
GO:0045597 positive regulation of cell differentiation 23.4043 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.4043 6 no
GO:0051094 positive regulation of developmental process 23.4043 4 no
GO:0032101 regulation of response to external stimulus 23.4043 4 no
GO:0009894 regulation of catabolic process 23.4043 4 no
GO:0050776 regulation of immune response 23.4043 4 no
GO:0051240 positive regulation of multicellular organismal process 23.4043 4 no
GO:1902533 positive regulation of intracellular signal transduction 23.4043 6 no
GO:0001933 negative regulation of protein phosphorylation 23.4043 8 yes
GO:0006468 protein phosphorylation 23.4043 5 yes
GO:0016310 phosphorylation 23.4043 5 yes
GO:0042326 negative regulation of phosphorylation 23.4043 8 yes
GO:0015031 protein transport 21.2766 4 no
GO:0006357 regulation of transcription by RNA polymerase II 21.2766 7 no
GO:0042127 regulation of cell population proliferation 21.2766 4 no
GO:1901701 cellular response to oxygen-containing compound 21.2766 4 no
GO:0033674 positive regulation of kinase activity 21.2766 6 no
GO:0045860 positive regulation of protein kinase activity 21.2766 7 no
GO:0051345 positive regulation of hydrolase activity 21.2766 5 no
GO:0051347 positive regulation of transferase activity 21.2766 5 no
GO:0051726 regulation of cell cycle 21.2766 4 no
GO:0010628 positive regulation of gene expression 21.2766 6 no
GO:0030030 cell projection organization 21.2766 4 no
GO:0071900 regulation of protein serine/threonine kinase activity 19.1489 7 yes
GO:0018193 peptidyl-amino acid modification 17.0213 5 yes
GO:0043086 negative regulation of catalytic activity 17.0213 4 yes
GO:1902532 negative regulation of intracellular signal transduction 12.7660 6 yes
GO:0018105 peptidyl-serine phosphorylation 12.7660 6 yes
GO:0018209 peptidyl-serine modification 12.7660 6 yes
GO:0006469 negative regulation of protein kinase activity 10.6383 7 yes
GO:0033673 negative regulation of kinase activity 10.6383 6 yes
GO:0051348 negative regulation of transferase activity 10.6383 5 yes
GO:0043409 negative regulation of MAPK cascade 8.5106 7 yes
GO:0043405 regulation of MAP kinase activity 6.3830 8 yes
GO:0043407 negative regulation of MAP kinase activity 4.2553 8 yes
GO:0071901 negative regulation of protein serine/threonine kinase activity 4.2553 8 yes

Disease

Term Name % Distance from top the of the tree Annotated in STK38_HUMAN
DOID:0050700 cardiomyopathy 6.3830 4 no
DOID:0060036 intrinsic cardiomyopathy 6.3830 5 no
DOID:114 heart disease 6.3830 3 no
DOID:2843 long QT syndrome 6.3830 6 no
DOID:0050686 organ system cancer 4.2553 3 no
DOID:10273 heart conduction disease 4.2553 4 no
DOID:0111962 combined immunodeficiency 4.2553 4 no
DOID:612 primary immunodeficiency disease 4.2553 3 no
DOID:627 severe combined immunodeficiency 4.2553 5 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CAV1_HUMAN [view interactions] Low throughput no no
PEBP1_HUMAN [view entry] [view interactions] Low throughput yes yes
STK38_HUMAN [view entry] [view interactions] Low throughput yes yes
ISG15_HUMAN [view interactions] Low throughput no no
M3K1_HUMAN [view interactions] Low throughput no yes
M3K2_HUMAN [view interactions] Low throughput no yes
S100B_HUMAN [view entry] [view interactions] Low throughput yes yes
H31_HUMAN [view interactions] Low throughput no yes
SOCS2_HUMAN [view interactions] Low throughput no yes
TRI25_HUMAN [view interactions] Low throughput no yes
HEY1_HUMAN [view interactions] Low throughput no yes
TRAF3_HUMAN [view entry] [view interactions] Low throughput yes yes
SENP2_HUMAN [view interactions] Low throughput no yes
BECN1_HUMAN [view interactions] Low throughput no yes
HERC5_HUMAN [view interactions] Low throughput no yes
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
H2A2C_HUMAN [view interactions] Low throughput no yes
H2B2E_HUMAN [view interactions] Low throughput no yes
CTDP1_HUMAN [view interactions] Low throughput no yes
MOB1A_HUMAN [view interactions] Low throughput no yes
MICA1_HUMAN [view interactions] Low throughput no yes
STK4_HUMAN [view interactions] Low throughput no yes
MOB2_HUMAN [view interactions] Low throughput no no
MOB1B_HUMAN [view interactions] Low throughput no yes
NCK1_HUMAN [view interactions] Low throughput no yes
SH3G3_HUMAN [view entry] [view interactions] High throughput yes no
CRK_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K1_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
CAV2_HUMAN [view interactions] High throughput no no
LCK_HUMAN [view entry] [view interactions] High throughput yes no
GAB2_HUMAN [view interactions] High throughput no yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
EXOS1_HUMAN [view interactions] High throughput no yes
RBM28_HUMAN [view interactions] High throughput no yes
MOV10_HUMAN [view interactions] High throughput no no
HDAC2_HUMAN [view interactions] High throughput no yes
CHERP_HUMAN [view interactions] High throughput no no
UBR4_HUMAN [view entry] [view interactions] High throughput yes yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
EXOS2_HUMAN [view interactions] High throughput no yes
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
DCAF7_HUMAN [view interactions] High throughput no yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
RBM34_HUMAN [view interactions] High throughput no yes
RPAB1_HUMAN [view interactions] High throughput no yes
GYS1_HUMAN [view interactions] High throughput no yes
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
SC16A_HUMAN [view interactions] High throughput no yes
MTOR_HUMAN [view entry] [view interactions] High throughput yes yes
RICTR_HUMAN [view interactions] High throughput no yes
SIN1_HUMAN [view interactions] High throughput no yes
CHK2_HUMAN [view interactions] High throughput no yes
NOTC1_HUMAN [view interactions] High throughput no yes
PLK4_HUMAN [view interactions] High throughput no yes
PRDM4_HUMAN [view interactions] High throughput no no
ST38L_HUMAN [view entry] [view interactions] High throughput yes yes
VDR_HUMAN [view interactions] High throughput no no
T2FB_HUMAN [view interactions] High throughput no yes
TRI14_HUMAN [view interactions] High throughput no yes
BANP_HUMAN [view interactions] High throughput no yes
MYSM1_HUMAN [view interactions] High throughput no yes
MYD88_HUMAN [view entry] [view interactions] High throughput yes yes
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
TFE2_HUMAN [view interactions] High throughput no no
GRK5_HUMAN [view interactions] High throughput no yes
FBX6_HUMAN [view interactions] High throughput no yes
IF4A3_HUMAN [view entry] [view interactions] High throughput yes yes
MGN_HUMAN [view interactions] High throughput no yes
SMUF1_HUMAN [view interactions] High throughput no yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
ZBTB1_HUMAN [view interactions] High throughput no no
KAT5_HUMAN [view interactions] High throughput no yes
EWS_HUMAN [view interactions] High throughput no yes
ID2_HUMAN [view interactions] High throughput no no
GAN_HUMAN [view interactions] High throughput no yes
CDK8_HUMAN [view interactions] High throughput no no
CDK19_HUMAN [view interactions] High throughput no yes
SKI_HUMAN [view interactions] High throughput no yes
MDM2_HUMAN [view interactions] High throughput no yes
RC3H1_HUMAN [view interactions] High throughput no yes
CCNB1_HUMAN [view interactions] High throughput no no
CRBN_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
ZN598_HUMAN [view interactions] High throughput no no
RNF31_HUMAN [view interactions] High throughput no yes
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
MEPCE_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
SNAI1_HUMAN [view interactions] High throughput no yes
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
TISD_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
FAF1_HUMAN [view interactions] High throughput no yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT7B_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
TRIM6_HUMAN [view interactions] High throughput no no
EMC4_HUMAN [view interactions] High throughput no yes
PDS5B_HUMAN [view interactions] High throughput no yes
CDCA5_HUMAN [view interactions] High throughput no yes
NIPBL_HUMAN [view interactions] High throughput no yes
SCC4_HUMAN [view interactions] High throughput no no
BCAR1_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
CIC_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
IF16_HUMAN [view interactions] High throughput no no
TXNIP_HUMAN [view interactions] High throughput no no
UFL1_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
SKA3_HUMAN [view interactions] High throughput no no
PAGE4_HUMAN [view interactions] High throughput no no
DUS16_HUMAN [view interactions] High throughput no yes
HNRC2_HUMAN [view interactions] High throughput no no
LTOR5_HUMAN [view interactions] High throughput no yes
CCD96_HUMAN [view interactions] High throughput no no
LN28A_HUMAN [view interactions] High throughput no no
D2HDH_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
RHBT1_HUMAN [view interactions] High throughput no yes
RHBT2_HUMAN [view interactions] High throughput no no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
EM55_HUMAN [view entry] [view interactions] High throughput yes no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
GBF1_HUMAN [view interactions] High throughput no yes
PERI_HUMAN [view entry] [view interactions] High throughput yes no
RNF43_HUMAN [view interactions] High throughput no yes
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
AGO3_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
EZH1_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
JARD2_HUMAN [view interactions] High throughput no yes
MTF2_HUMAN [view interactions] High throughput no no
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
GATA3_HUMAN [view interactions] High throughput no no
EHMT2_HUMAN [view entry] [view interactions] High throughput yes yes
MALD2_HUMAN [view interactions] High throughput no yes
PAK4_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
SAP_HUMAN [view interactions] High throughput no yes
FRYL_HUMAN [view entry] [view interactions] Computational yes yes
DI3L2_HUMAN [view interactions] Computational no yes
FRY_HUMAN [view interactions] Computational no yes