1433G_HUMAN
Evidence for PS localization
Functions
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 28%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in 1433G_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 30.5263 | 4 | no |
| GO:0017076 | purine nucleotide binding | 30.2632 | 5 | no |
| GO:0043168 | anion binding | 30.2632 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 28.1579 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.6316 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 26.0526 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 23.9474 | 5 | no |
| GO:0005524 | ATP binding | 23.4211 | 5 | no |
| GO:0043169 | cation binding | 21.0526 | 4 | no |
| GO:0046872 | metal ion binding | 20.5263 | 5 | no |
| GO:0019900 | kinase binding | 18.1579 | 4 | yes |
| GO:0003723 | RNA binding | 17.8947 | 4 | yes |
| GO:0019901 | protein kinase binding | 16.5789 | 5 | yes |
| GO:0019887 | protein kinase regulator activity | 7.1053 | 4 | yes |
| GO:1990782 | protein tyrosine kinase binding | 3.6842 | 6 | yes |
| GO:0045309 | protein phosphorylated amino acid binding | 3.4211 | 4 | yes |
| GO:0030971 | receptor tyrosine kinase binding | 2.3684 | 4 | yes |
| GO:0004860 | protein kinase inhibitor activity | 1.8421 | 5 | yes |
| GO:0005080 | protein kinase C binding | 1.8421 | 6 | yes |
| GO:0005159 | insulin-like growth factor receptor binding | 1.8421 | 4 | yes |
| GO:0019210 | kinase inhibitor activity | 1.8421 | 4 | yes |
| GO:0050815 | phosphoserine residue binding | 1.5789 | 5 | yes |
| GO:0030291 | protein serine/threonine kinase inhibitor activity | 1.3158 | 6 | yes |
| GO:0008426 | protein kinase C inhibitor activity | 0.7895 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in 1433G_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 55.2632 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.6316 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 46.3158 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 46.0526 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 45.2632 | 4 | yes |
| GO:0010646 | regulation of cell communication | 43.1579 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 42.8947 | 4 | no |
| GO:0009966 | regulation of signal transduction | 39.2105 | 4 | yes |
| GO:0006996 | organelle organization | 38.9474 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 35.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 34.4737 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 33.6842 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.4211 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.1579 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 32.8947 | 5 | yes |
| GO:0010468 | regulation of gene expression | 32.1053 | 6 | no |
| GO:0008104 | protein localization | 31.3158 | 4 | yes |
| GO:0022607 | cellular component assembly | 31.0526 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.7368 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.4737 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 29.4737 | 5 | no |
| GO:0023056 | positive regulation of signaling | 27.3684 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 26.8421 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 26.5789 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.7895 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 3BP5L_HUMAN | [view interactions] | High throughput | no | yes |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| AASS_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACADM_HUMAN | [view interactions] | High throughput | no | yes |
| ACAP1_HUMAN | [view interactions] | High throughput | no | yes |
| ACINU_HUMAN | [view interactions] | High throughput | no | yes |
| ACK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACO13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |