6PGD_HUMAN
Evidence for PS localization
Functions
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in 6PGD_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 43.7500 | 4 | yes |
| GO:0043168 | anion binding | 43.7500 | 4 | no |
| GO:0017076 | purine nucleotide binding | 42.1875 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 34.3750 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 34.3750 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 32.8125 | 6 | yes |
| GO:0043169 | cation binding | 26.5625 | 4 | no |
| GO:0046872 | metal ion binding | 26.5625 | 5 | no |
| GO:0005524 | ATP binding | 25.0000 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | no |
| GO:0003723 | RNA binding | 23.4375 | 4 | no |
| GO:0045296 | cadherin binding | 20.3125 | 4 | no |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 9.3750 | 4 | yes |
| GO:0050661 | NADP binding | 4.6875 | 7 | yes |
| GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity | 3.1250 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in 6PGD_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 54.6875 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 53.1250 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 43.7500 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 43.7500 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 42.1875 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.6250 | 4 | no |
| GO:0010468 | regulation of gene expression | 40.6250 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.6250 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 37.5000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 37.5000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.5000 | 5 | no |
| GO:0010646 | regulation of cell communication | 37.5000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.9375 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 34.3750 | 4 | no |
| GO:0051049 | regulation of transport | 34.3750 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 32.8125 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 32.8125 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.8125 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 32.8125 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 32.8125 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 32.8125 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 29.6875 | 5 | no |
| GO:0071310 | cellular response to organic substance | 29.6875 | 4 | no |
| GO:0008104 | protein localization | 29.6875 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 28.1250 | 7 | no |
| GO:0009892 | negative regulation of metabolic process | 28.1250 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 28.1250 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 26.5625 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 26.5625 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.5625 | 5 | no |
| GO:0060341 | regulation of cellular localization | 26.5625 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.5625 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.5625 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 25.0000 | 5 | no |
| GO:0032880 | regulation of protein localization | 25.0000 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 25.0000 | 7 | no |
| GO:0006163 | purine nucleotide metabolic process | 23.4375 | 5 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 23.4375 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 23.4375 | 5 | yes |
| GO:0072521 | purine-containing compound metabolic process | 23.4375 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 21.8750 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 21.8750 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.8750 | 4 | no |
| GO:0031399 | regulation of protein modification process | 21.8750 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.8750 | 6 | no |
| GO:0009968 | negative regulation of signal transduction | 20.3125 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 20.3125 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.3125 | 4 | no |
| GO:0036211 | protein modification process | 20.3125 | 4 | no |
| GO:0043412 | macromolecule modification | 20.3125 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.3125 | 4 | no |
| GO:0006996 | organelle organization | 20.3125 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 20.3125 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 20.3125 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 20.3125 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 20.3125 | 4 | no |
| GO:0051050 | positive regulation of transport | 20.3125 | 4 | no |
| GO:0014070 | response to organic cyclic compound | 20.3125 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 18.7500 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 18.7500 | 4 | yes |
| GO:0019362 | pyridine nucleotide metabolic process | 12.5000 | 5 | yes |
| GO:0046496 | nicotinamide nucleotide metabolic process | 12.5000 | 6 | yes |
| GO:0072524 | pyridine-containing compound metabolic process | 12.5000 | 4 | yes |
| GO:0016051 | carbohydrate biosynthetic process | 10.9375 | 4 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 9.3750 | 6 | yes |
| GO:0046364 | monosaccharide biosynthetic process | 9.3750 | 4 | yes |
| GO:0006739 | NADP metabolic process | 7.8125 | 6 | yes |
| GO:0016054 | organic acid catabolic process | 7.8125 | 4 | yes |
| GO:0046395 | carboxylic acid catabolic process | 7.8125 | 5 | yes |
| GO:0006098 | pentose-phosphate shunt | 6.2500 | 5 | yes |
| GO:0006740 | NADPH regeneration | 6.2500 | 4 | yes |
| GO:0016052 | carbohydrate catabolic process | 6.2500 | 4 | yes |
| GO:0051156 | glucose 6-phosphate metabolic process | 6.2500 | 4 | yes |
| GO:0009051 | pentose-phosphate shunt, oxidative branch | 4.6875 | 5 | yes |
| GO:0019321 | pentose metabolic process | 4.6875 | 4 | yes |
| GO:0019322 | pentose biosynthetic process | 4.6875 | 5 | yes |
| GO:0019520 | aldonic acid metabolic process | 3.1250 | 4 | yes |
| GO:0019521 | D-gluconate metabolic process | 3.1250 | 5 | yes |
| GO:0046176 | aldonic acid catabolic process | 3.1250 | 5 | yes |
| GO:0046177 | D-gluconate catabolic process | 3.1250 | 5 | yes |
| GO:0072329 | monocarboxylic acid catabolic process | 3.1250 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 6PGD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLGB_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| LMBL4_HUMAN | [view interactions] | High throughput | no | no |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| NKX21_HUMAN | [view interactions] | High throughput | no | no |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TISD_HUMAN | [view interactions] | High throughput | no | no |
| PPARG_HUMAN | [view interactions] | High throughput | no | yes |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS21_HUMAN | [view interactions] | High throughput | no | no |
| DUS28_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| FOXC1_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEO1_HUMAN | [view interactions] | High throughput | no | yes |
| RM19_HUMAN | [view interactions] | High throughput | no | yes |
| RM22_HUMAN | [view interactions] | High throughput | no | yes |
| RT11_HUMAN | [view interactions] | High throughput | no | yes |
| RT35_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC_HUMAN | [view interactions] | High throughput | no | yes |
| PGK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C560_HUMAN | [view interactions] | High throughput | no | no |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AL9A1_HUMAN | [view interactions] | High throughput | no | yes |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAL_HUMAN | [view interactions] | High throughput | no | yes |
| GNAI3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGB2_HUMAN | [view interactions] | High throughput | no | yes |
| AHSA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHRD1_HUMAN | [view interactions] | High throughput | no | yes |
| IF4H_HUMAN | [view interactions] | High throughput | no | yes |
| G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHSO_HUMAN | [view interactions] | High throughput | no | no |
| TCEA1_HUMAN | [view interactions] | High throughput | no | no |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| THOP1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXND5_HUMAN | [view interactions] | High throughput | no | yes |
| FABP5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| CDV3_HUMAN | [view interactions] | High throughput | no | no |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| INO1_HUMAN | [view interactions] | High throughput | no | no |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCBP1_HUMAN | [view interactions] | High throughput | no | yes |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAGL_HUMAN | [view interactions] | High throughput | no | no |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TALDO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GABT_HUMAN | [view interactions] | High throughput | no | yes |
| GSTO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| PREY_HUMAN | [view interactions] | High throughput | no | yes |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| HEBP1_HUMAN | [view interactions] | High throughput | no | yes |
| ACADM_HUMAN | [view interactions] | High throughput | no | yes |
| IVD_HUMAN | [view interactions] | High throughput | no | yes |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDR_HUMAN | [view interactions] | High throughput | no | no |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECI1_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSHR_HUMAN | [view interactions] | High throughput | no | yes |
| IDHC_HUMAN | [view interactions] | High throughput | no | no |
| AMPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MDHC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OAT_HUMAN | [view interactions] | High throughput | no | yes |
| AADAT_HUMAN | [view interactions] | High throughput | no | no |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| MIA40_HUMAN | [view interactions] | High throughput | no | yes |
| KAT3_HUMAN | [view interactions] | High throughput | no | yes |
| SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRXR2_HUMAN | [view interactions] | High throughput | no | yes |
| TRFE_HUMAN | [view interactions] | High throughput | no | no |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CBX3_HUMAN | [view interactions] | High throughput | no | yes |
| FBRL_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA4_HUMAN | [view interactions] | High throughput | no | yes |
| LSM8_HUMAN | [view interactions] | High throughput | no | yes |
| CDK4_HUMAN | [view interactions] | High throughput | no | no |
| USPL1_HUMAN | [view interactions] | High throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| MGN2_HUMAN | [view interactions] | High throughput | no | yes |
| MGN_HUMAN | [view interactions] | High throughput | no | yes |
| RBM8A_HUMAN | [view interactions] | High throughput | no | yes |
| CE290_HUMAN | [view interactions] | High throughput | no | no |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| RASA1_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KEAP1_HUMAN | [view interactions] | High throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| ACK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYLK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYLK4_HUMAN | [view interactions] | High throughput | no | no |
| NEK7_HUMAN | [view interactions] | High throughput | no | yes |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| PAK6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTK_HUMAN | [view interactions] | High throughput | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |