6PGD_HUMAN
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in 6PGD_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 28.0000 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 28.0000 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 28.0000 | 4 | no |
GO:0045296 | cadherin binding | 22.0000 | 4 | no |
GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 12.0000 | 4 | yes |
GO:0050661 | NADP binding | 6.0000 | 4 | yes |
GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity | 4.0000 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in 6PGD_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 52.0000 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 44.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 44.0000 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 42.0000 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 42.0000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
GO:0010646 | regulation of cell communication | 38.0000 | 4 | no |
GO:0009966 | regulation of signal transduction | 36.0000 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 34.0000 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 32.0000 | 4 | yes |
GO:0010468 | regulation of gene expression | 32.0000 | 5 | no |
GO:0051049 | regulation of transport | 30.0000 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 30.0000 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.0000 | 5 | no |
GO:0008104 | protein localization | 26.0000 | 4 | no |
GO:0060341 | regulation of cellular localization | 26.0000 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.0000 | 5 | no |
GO:0019752 | carboxylic acid metabolic process | 24.0000 | 5 | yes |
GO:0043436 | oxoacid metabolic process | 24.0000 | 4 | yes |
GO:0051050 | positive regulation of transport | 24.0000 | 4 | no |
GO:0036211 | protein modification process | 24.0000 | 4 | no |
GO:0043412 | macromolecule modification | 24.0000 | 4 | no |
GO:0071310 | cellular response to organic substance | 24.0000 | 4 | no |
GO:0032880 | regulation of protein localization | 24.0000 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 24.0000 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 24.0000 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 24.0000 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 24.0000 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 22.0000 | 4 | no |
GO:0010941 | regulation of cell death | 22.0000 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 22.0000 | 5 | no |
GO:0043067 | regulation of programmed cell death | 22.0000 | 5 | no |
GO:0051128 | regulation of cellular component organization | 22.0000 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 22.0000 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 22.0000 | 4 | no |
GO:0006753 | nucleoside phosphate metabolic process | 18.0000 | 4 | yes |
GO:0009117 | nucleotide metabolic process | 18.0000 | 5 | yes |
GO:0032787 | monocarboxylic acid metabolic process | 12.0000 | 6 | yes |
GO:0016051 | carbohydrate biosynthetic process | 10.0000 | 4 | yes |
GO:0016054 | organic acid catabolic process | 10.0000 | 4 | yes |
GO:0046395 | carboxylic acid catabolic process | 10.0000 | 5 | yes |
GO:0006098 | pentose-phosphate shunt | 8.0000 | 5 | yes |
GO:0006739 | NADP metabolic process | 8.0000 | 7 | yes |
GO:0006740 | NADPH regeneration | 8.0000 | 4 | yes |
GO:0016052 | carbohydrate catabolic process | 8.0000 | 4 | yes |
GO:0019362 | pyridine nucleotide metabolic process | 8.0000 | 5 | yes |
GO:0046364 | monosaccharide biosynthetic process | 8.0000 | 4 | yes |
GO:0046496 | nicotinamide nucleotide metabolic process | 8.0000 | 6 | yes |
GO:0051156 | glucose 6-phosphate metabolic process | 8.0000 | 4 | yes |
GO:0072524 | pyridine-containing compound metabolic process | 8.0000 | 4 | yes |
GO:0009051 | pentose-phosphate shunt, oxidative branch | 6.0000 | 5 | yes |
GO:0019321 | pentose metabolic process | 6.0000 | 4 | yes |
GO:0019322 | pentose biosynthetic process | 6.0000 | 5 | yes |
GO:0019520 | aldonic acid metabolic process | 4.0000 | 4 | yes |
GO:0019521 | D-gluconate metabolic process | 4.0000 | 5 | yes |
GO:0044275 | cellular carbohydrate catabolic process | 4.0000 | 4 | yes |
GO:0046176 | aldonic acid catabolic process | 4.0000 | 5 | yes |
GO:0046177 | D-gluconate catabolic process | 4.0000 | 6 | yes |
GO:0072329 | monocarboxylic acid catabolic process | 4.0000 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
6PGD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LEO1_HUMAN | [view interactions] | High throughput | no | yes |
RM19_HUMAN | [view interactions] | High throughput | no | yes |
RM22_HUMAN | [view interactions] | High throughput | no | yes |
RT11_HUMAN | [view interactions] | High throughput | no | yes |
RT35_HUMAN | [view interactions] | High throughput | no | yes |
NUDC_HUMAN | [view interactions] | High throughput | no | yes |
PGK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
C560_HUMAN | [view interactions] | High throughput | no | no |
ATG7_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RIT1_HUMAN | [view interactions] | High throughput | no | yes |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AL9A1_HUMAN | [view interactions] | High throughput | no | yes |
EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AGAL_HUMAN | [view interactions] | High throughput | no | yes |
GNAI3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HMGB2_HUMAN | [view interactions] | High throughput | no | yes |
AHSA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHRD1_HUMAN | [view interactions] | High throughput | no | yes |
IF4H_HUMAN | [view interactions] | High throughput | no | yes |
G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DHSO_HUMAN | [view interactions] | High throughput | no | no |
TCEA1_HUMAN | [view interactions] | High throughput | no | no |
TGM2_HUMAN | [view interactions] | High throughput | no | no |
THOP1_HUMAN | [view interactions] | High throughput | no | yes |
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KS6A1_HUMAN | [view interactions] | High throughput | no | yes |
TXND5_HUMAN | [view interactions] | High throughput | no | yes |
FABP5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
THIM_HUMAN | [view interactions] | High throughput | no | yes |
CDV3_HUMAN | [view interactions] | High throughput | no | no |
CATL1_HUMAN | [view interactions] | High throughput | no | yes |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
INO1_HUMAN | [view interactions] | High throughput | no | no |
MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NCBP1_HUMAN | [view interactions] | High throughput | no | yes |
RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
TAGL_HUMAN | [view interactions] | High throughput | no | no |
UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
SUMO3_HUMAN | [view interactions] | High throughput | no | yes |
TALDO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GABT_HUMAN | [view interactions] | High throughput | no | yes |
GSTO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HINT2_HUMAN | [view interactions] | High throughput | no | yes |
PREY_HUMAN | [view interactions] | High throughput | no | yes |
ETFA_HUMAN | [view interactions] | High throughput | no | yes |
ECHM_HUMAN | [view interactions] | High throughput | no | yes |
HEBP1_HUMAN | [view interactions] | High throughput | no | yes |
ACADM_HUMAN | [view interactions] | High throughput | no | yes |
IVD_HUMAN | [view interactions] | High throughput | no | yes |
HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ALDR_HUMAN | [view interactions] | High throughput | no | no |
PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECI1_HUMAN | [view interactions] | High throughput | no | yes |
AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GSHR_HUMAN | [view interactions] | High throughput | no | yes |
IDHC_HUMAN | [view interactions] | High throughput | no | no |
AMPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MDHC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OAT_HUMAN | [view interactions] | High throughput | no | yes |
AADAT_HUMAN | [view interactions] | High throughput | no | no |
ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
MIA40_HUMAN | [view interactions] | High throughput | no | yes |
KAT3_HUMAN | [view interactions] | High throughput | no | yes |
SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRXR2_HUMAN | [view interactions] | High throughput | no | yes |
TRFE_HUMAN | [view interactions] | High throughput | no | no |
TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI14_HUMAN | [view interactions] | High throughput | no | yes |
AGR2_HUMAN | [view interactions] | High throughput | no | no |
DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
CBX3_HUMAN | [view interactions] | High throughput | no | yes |
FBRL_HUMAN | [view interactions] | High throughput | no | yes |
TBB5_HUMAN | [view interactions] | High throughput | no | yes |
ACE2_HUMAN | [view interactions] | High throughput | no | no |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
LSM8_HUMAN | [view interactions] | High throughput | no | yes |
CDK4_HUMAN | [view interactions] | High throughput | no | no |
USPL1_HUMAN | [view interactions] | High throughput | no | yes |
IQCB1_HUMAN | [view interactions] | High throughput | no | no |
MGN2_HUMAN | [view interactions] | High throughput | no | yes |
MGN_HUMAN | [view interactions] | High throughput | no | yes |
RBM8A_HUMAN | [view interactions] | High throughput | no | yes |
CE290_HUMAN | [view interactions] | High throughput | no | no |
OFD1_HUMAN | [view interactions] | High throughput | no | yes |
KSR1_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
RASA1_HUMAN | [view interactions] | High throughput | no | yes |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
ACK1_HUMAN | [view interactions] | High throughput | no | yes |
M3K7_HUMAN | [view interactions] | High throughput | no | yes |
MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RIPK4_HUMAN | [view interactions] | High throughput | no | no |
KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYLK_HUMAN | [view interactions] | High throughput | no | no |
MYLK4_HUMAN | [view interactions] | High throughput | no | no |
NEK7_HUMAN | [view interactions] | High throughput | no | yes |
KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
PAK6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LTK_HUMAN | [view interactions] | High throughput | no | no |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HLAB_HUMAN | [view interactions] | High throughput | no | yes |
AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
IKKE_HUMAN | [view interactions] | High throughput | no | yes |
TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
GLGB_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
LMBL4_HUMAN | [view interactions] | High throughput | no | no |
TERF1_HUMAN | [view interactions] | High throughput | no | no |
SNF5_HUMAN | [view interactions] | High throughput | no | yes |
LMTK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ISG15_HUMAN | [view interactions] | High throughput | no | no |
CDK2_HUMAN | [view interactions] | High throughput | no | yes |
WWOX_HUMAN | [view interactions] | High throughput | no | yes |
MOV10_HUMAN | [view interactions] | High throughput | no | no |
NXF1_HUMAN | [view interactions] | High throughput | no | yes |
CDC73_HUMAN | [view interactions] | High throughput | no | yes |
NKX21_HUMAN | [view interactions] | High throughput | no | no |
BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TISD_HUMAN | [view interactions] | High throughput | no | no |
PPARG_HUMAN | [view interactions] | High throughput | no | yes |
AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DUS21_HUMAN | [view interactions] | High throughput | no | no |
DUS28_HUMAN | [view interactions] | High throughput | no | yes |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
NEK4_HUMAN | [view interactions] | High throughput | no | yes |
CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BRD4_HUMAN | [view interactions] | High throughput | no | yes |
RBM39_HUMAN | [view interactions] | High throughput | no | yes |
DDX58_HUMAN | [view interactions] | High throughput | no | yes |
PD1L1_HUMAN | [view interactions] | High throughput | no | no |
TKTL2_HUMAN | [view interactions] | Computational | no | no |
RPE_HUMAN | [view interactions] | Computational | no | yes |
6PGL_HUMAN | [view interactions] | Computational | no | yes |
GNTK_HUMAN | [view interactions] | Computational | no | yes |
G6PE_HUMAN | [view interactions] | Computational | no | yes |
ESTD_HUMAN | [view interactions] | Computational | no | yes |
RPIA_HUMAN | [view interactions] | Computational | no | yes |
PGM1_HUMAN | [view interactions] | Computational | no | no |
PGK2_HUMAN | [view interactions] | Computational | no | no |
TKTL1_HUMAN | [view interactions] | Computational | no | no |
RPEL1_HUMAN | [view interactions] | Computational | no | yes |