SCOT1_HUMAN
Evidence for PS localization
Functions
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SCOT1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 29.0323 | 4 | no |
| GO:0000166 | nucleotide binding | 27.4194 | 4 | no |
| GO:0003723 | RNA binding | 25.8065 | 4 | no |
| GO:0017076 | purine nucleotide binding | 24.1935 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 20.9677 | 4 | no |
| GO:0008260 | succinyl-CoA:3-oxo-acid CoA-transferase activity | 3.2258 | 5 | yes |
| GO:0008410 | CoA-transferase activity | 3.2258 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SCOT1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 45.1613 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 43.5484 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.3226 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 37.0968 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 37.0968 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 35.4839 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 33.8710 | 4 | no |
| GO:0010646 | regulation of cell communication | 33.8710 | 4 | no |
| GO:0006996 | organelle organization | 32.2581 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 32.2581 | 4 | no |
| GO:0010468 | regulation of gene expression | 32.2581 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 32.2581 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.2581 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 32.2581 | 5 | no |
| GO:0009966 | regulation of signal transduction | 30.6452 | 4 | no |
| GO:0022607 | cellular component assembly | 29.0323 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 27.4194 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 27.4194 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.4194 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 27.4194 | 5 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 25.8065 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 25.8065 | 5 | no |
| GO:0072521 | purine-containing compound metabolic process | 25.8065 | 4 | no |
| GO:0008104 | protein localization | 25.8065 | 4 | no |
| GO:0006163 | purine nucleotide metabolic process | 24.1935 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 24.1935 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 24.1935 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 24.1935 | 5 | no |
| GO:0023057 | negative regulation of signaling | 24.1935 | 4 | no |
| GO:0051049 | regulation of transport | 24.1935 | 4 | no |
| GO:0071702 | organic substance transport | 24.1935 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.1935 | 4 | no |
| GO:1901565 | organonitrogen compound catabolic process | 22.5806 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.5806 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.5806 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.5806 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 20.9677 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.9677 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.9677 | 6 | no |
| GO:0019693 | ribose phosphate metabolic process | 20.9677 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 20.9677 | 4 | no |
| GO:0071705 | nitrogen compound transport | 20.9677 | 4 | no |
| GO:0043933 | protein-containing complex organization | 20.9677 | 4 | no |
| GO:0016042 | lipid catabolic process | 8.0645 | 4 | yes |
| GO:0042182 | ketone catabolic process | 3.2258 | 4 | yes |
| GO:0046952 | ketone body catabolic process | 3.2258 | 4 | yes |
| GO:1901568 | fatty acid derivative metabolic process | 3.2258 | 4 | yes |
| GO:1901569 | fatty acid derivative catabolic process | 3.2258 | 5 | yes |
| GO:1902224 | ketone body metabolic process | 3.2258 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SCOT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ADRO_HUMAN | [view interactions] | High throughput | no | no |
| SYYM_HUMAN | [view interactions] | High throughput | no | no |
| ASPG_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSHR_HUMAN | [view interactions] | High throughput | no | yes |
| OAT_HUMAN | [view interactions] | High throughput | no | yes |
| AADAT_HUMAN | [view interactions] | High throughput | no | no |
| MIA40_HUMAN | [view interactions] | High throughput | no | yes |
| IF4G2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAT3_HUMAN | [view interactions] | High throughput | no | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRXR2_HUMAN | [view interactions] | High throughput | no | yes |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRFE_HUMAN | [view interactions] | High throughput | no | no |
| TYK2_HUMAN | [view interactions] | High throughput | no | no |
| ARPC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | no |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRSK2_HUMAN | [view interactions] | High throughput | no | no |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAOK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCOT2_HUMAN | [view interactions] | High throughput | no | no |
| PAK5_HUMAN | [view interactions] | High throughput | no | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODBA_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMC1_HUMAN | [view interactions] | High throughput | no | no |
| COQ8A_HUMAN | [view interactions] | High throughput | no | no |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| AL1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS35_HUMAN | [view interactions] | High throughput | no | no |
| PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| JAZF1_HUMAN | [view interactions] | High throughput | no | yes |
| BMP2K_HUMAN | [view interactions] | High throughput | no | yes |
| AGRB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B2L14_HUMAN | [view interactions] | High throughput | no | yes |
| KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COMP_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMEM9_HUMAN | [view interactions] | High throughput | no | no |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN7_HUMAN | [view interactions] | High throughput | no | yes |
| VMA21_HUMAN | [view interactions] | High throughput | no | no |
| TCOF_HUMAN | [view interactions] | High throughput | no | yes |
| TOIP1_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UPAR_HUMAN | [view interactions] | High throughput | no | yes |
| SDHF2_HUMAN | [view interactions] | High throughput | no | yes |
| SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCAF4_HUMAN | [view interactions] | High throughput | no | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| SEP11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSME1_HUMAN | [view interactions] | High throughput | no | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDES1_HUMAN | [view interactions] | High throughput | no | no |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM9_HUMAN | [view interactions] | High throughput | no | yes |
| TM177_HUMAN | [view interactions] | High throughput | no | no |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPHM_HUMAN | [view interactions] | High throughput | no | yes |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| S10AG_HUMAN | [view interactions] | High throughput | no | no |
| PGK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PURA2_HUMAN | [view interactions] | High throughput | no | yes |
| IDHC_HUMAN | [view interactions] | High throughput | no | no |
| MTPN_HUMAN | [view interactions] | High throughput | no | yes |
| NDKA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBX3_HUMAN | [view interactions] | High throughput | no | yes |
| MK14_HUMAN | [view interactions] | High throughput | no | yes |
| PTMS_HUMAN | [view interactions] | High throughput | no | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBBP7_HUMAN | [view interactions] | High throughput | no | yes |
| SMAP_HUMAN | [view interactions] | High throughput | no | yes |
| THOP1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AHNK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HINT1_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYPA1_HUMAN | [view interactions] | High throughput | no | yes |
| MDHC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAE1L_HUMAN | [view interactions] | High throughput | no | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| TALDO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
| SH3L3_HUMAN | [view interactions] | High throughput | no | no |
| SUCB2_HUMAN | [view interactions] | High throughput | no | no |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |