SCOT1_HUMAN
Evidence for PS localization
Functions
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SCOT1_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 26.2295 | 4 | no |
| GO:0008410 | CoA-transferase activity | 4.9180 | 4 | yes |
| GO:0008260 | 3-oxoacid CoA-transferase activity | 3.2787 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SCOT1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 45.9016 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 39.3443 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.7049 | 4 | no |
| GO:0010646 | regulation of cell communication | 34.4262 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 32.7869 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 31.1475 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 31.1475 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 31.1475 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 31.1475 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 29.5082 | 4 | no |
| GO:0010468 | regulation of gene expression | 29.5082 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.8689 | 5 | no |
| GO:0022607 | cellular component assembly | 27.8689 | 4 | no |
| GO:0006996 | organelle organization | 26.2295 | 4 | no |
| GO:0009966 | regulation of signal transduction | 26.2295 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 26.2295 | 5 | no |
| GO:0051049 | regulation of transport | 24.5902 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 24.5902 | 4 | no |
| GO:0010941 | regulation of cell death | 24.5902 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 24.5902 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 22.9508 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.3115 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 21.3115 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 21.3115 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.3115 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 21.3115 | 5 | no |
| GO:0008104 | protein localization | 21.3115 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 18.0328 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 18.0328 | 4 | yes |
| GO:0051050 | positive regulation of transport | 14.7541 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 14.7541 | 4 | yes |
| GO:0032880 | regulation of protein localization | 14.7541 | 5 | yes |
| GO:1903829 | positive regulation of protein localization | 13.1148 | 5 | yes |
| GO:0016042 | lipid catabolic process | 13.1148 | 4 | yes |
| GO:0051046 | regulation of secretion | 11.4754 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 11.4754 | 4 | yes |
| GO:0051047 | positive regulation of secretion | 9.8361 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 9.8361 | 6 | yes |
| GO:1903532 | positive regulation of secretion by cell | 9.8361 | 5 | yes |
| GO:0007507 | heart development | 9.8361 | 4 | yes |
| GO:0031667 | response to nutrient levels | 9.8361 | 4 | yes |
| GO:0051223 | regulation of protein transport | 8.1967 | 5 | yes |
| GO:0050708 | regulation of protein secretion | 6.5574 | 5 | yes |
| GO:0051222 | positive regulation of protein transport | 6.5574 | 5 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 6.5574 | 6 | yes |
| GO:0007420 | brain development | 6.5574 | 4 | yes |
| GO:0046883 | regulation of hormone secretion | 6.5574 | 4 | yes |
| GO:0050714 | positive regulation of protein secretion | 4.9180 | 6 | yes |
| GO:0050796 | regulation of insulin secretion | 4.9180 | 6 | yes |
| GO:0060612 | adipose tissue development | 4.9180 | 5 | yes |
| GO:0061448 | connective tissue development | 4.9180 | 4 | yes |
| GO:0090087 | regulation of peptide transport | 4.9180 | 5 | yes |
| GO:0090276 | regulation of peptide hormone secretion | 4.9180 | 5 | yes |
| GO:0097305 | response to alcohol | 4.9180 | 4 | yes |
| GO:1901568 | fatty acid derivative metabolic process | 4.9180 | 4 | yes |
| GO:1901569 | fatty acid derivative catabolic process | 4.9180 | 5 | yes |
| GO:1902224 | ketone body metabolic process | 4.9180 | 4 | yes |
| GO:0002791 | regulation of peptide secretion | 4.9180 | 6 | yes |
| GO:0046887 | positive regulation of hormone secretion | 4.9180 | 5 | yes |
| GO:0046952 | ketone body catabolic process | 4.9180 | 4 | yes |
| GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus | 3.2787 | 7 | yes |
| GO:0090277 | positive regulation of peptide hormone secretion | 3.2787 | 6 | yes |
| GO:0002793 | positive regulation of peptide secretion | 3.2787 | 6 | yes |
| GO:0032024 | positive regulation of insulin secretion | 3.2787 | 7 | yes |
| GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus | 3.2787 | 8 | yes |
| GO:0042182 | ketone catabolic process | 3.2787 | 4 | yes |
| GO:0045471 | response to ethanol | 3.2787 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SCOT1_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 4.9180 | 3 | no |
| DOID:0060286 | combined oxidative phosphorylation deficiency | 3.2787 | 4 | no |
| DOID:700 | mitochondrial metabolism disease | 3.2787 | 3 | no |
| DOID:12377 | spinal muscular atrophy | 3.2787 | 6 | no |
| DOID:1289 | neurodegenerative disease | 3.2787 | 4 | no |
| DOID:231 | motor neuron disease | 3.2787 | 5 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 3.2787 | 6 | no |
| DOID:440 | neuromuscular disease | 3.2787 | 5 | no |
| DOID:574 | peripheral nervous system disease | 3.2787 | 3 | no |
| DOID:870 | neuropathy | 3.2787 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SCOT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MTPN_HUMAN | [view interactions] | High throughput | no | yes |
| NDKA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBX3_HUMAN | [view interactions] | High throughput | no | yes |
| MK14_HUMAN | [view interactions] | High throughput | no | yes |
| PTMS_HUMAN | [view interactions] | High throughput | no | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBBP7_HUMAN | [view interactions] | High throughput | no | yes |
| SMAP_HUMAN | [view interactions] | High throughput | no | yes |
| THOP1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AHNK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HINT1_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYPA1_HUMAN | [view interactions] | High throughput | no | yes |
| MDHC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAE1L_HUMAN | [view interactions] | High throughput | no | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| TALDO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
| SH3L3_HUMAN | [view interactions] | High throughput | no | no |
| SUCB2_HUMAN | [view interactions] | High throughput | no | no |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| ADRO_HUMAN | [view interactions] | High throughput | no | no |
| SYYM_HUMAN | [view interactions] | High throughput | no | no |
| ASPG_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSHR_HUMAN | [view interactions] | High throughput | no | yes |
| OAT_HUMAN | [view interactions] | High throughput | no | yes |
| AADAT_HUMAN | [view interactions] | High throughput | no | no |
| MIA40_HUMAN | [view interactions] | High throughput | no | yes |
| IF4G2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAT3_HUMAN | [view interactions] | High throughput | no | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRXR2_HUMAN | [view interactions] | High throughput | no | yes |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRFE_HUMAN | [view interactions] | High throughput | no | no |
| TYK2_HUMAN | [view interactions] | High throughput | no | no |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| KAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCOT2_HUMAN | [view interactions] | High throughput | no | no |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODBA_HUMAN | [view interactions] | High throughput | no | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAK5_HUMAN | [view interactions] | High throughput | no | yes |
| ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMC1_HUMAN | [view interactions] | High throughput | no | no |
| AL1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| COQ8A_HUMAN | [view interactions] | High throughput | no | no |
| PRS35_HUMAN | [view interactions] | High throughput | no | no |
| PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| JAZF1_HUMAN | [view interactions] | High throughput | no | yes |
| BMP2K_HUMAN | [view interactions] | High throughput | no | yes |
| AGRB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B2L14_HUMAN | [view interactions] | High throughput | no | yes |
| KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COMP_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMEM9_HUMAN | [view interactions] | High throughput | no | no |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN7_HUMAN | [view interactions] | High throughput | no | yes |
| VMA21_HUMAN | [view interactions] | High throughput | no | no |
| TCOF_HUMAN | [view interactions] | High throughput | no | yes |
| TOIP1_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UPAR_HUMAN | [view interactions] | High throughput | no | yes |
| SDHF2_HUMAN | [view interactions] | High throughput | no | yes |
| SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCAF4_HUMAN | [view interactions] | High throughput | no | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| SEP11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSME1_HUMAN | [view interactions] | High throughput | no | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDES1_HUMAN | [view interactions] | High throughput | no | no |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM9_HUMAN | [view interactions] | High throughput | no | yes |
| TM177_HUMAN | [view interactions] | High throughput | no | no |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPHM_HUMAN | [view interactions] | High throughput | no | yes |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| S10AG_HUMAN | [view interactions] | High throughput | no | no |
| PGK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PURA2_HUMAN | [view interactions] | High throughput | no | yes |
| IDHC_HUMAN | [view interactions] | High throughput | no | no |
| THIL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ETFB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| BDH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| THIC_HUMAN | [view interactions] | Computational | no | yes |
| ECHB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HMCS1_HUMAN | [view interactions] | Computational | no | yes |
| HMGC2_HUMAN | [view interactions] | Computational | no | no |
| DEOC_HUMAN | [view interactions] | Computational | no | no |
| ETFA_HUMAN | [view interactions] | Computational | no | yes |
| THIM_HUMAN | [view interactions] | Computational | no | yes |
| ECHP_HUMAN | [view interactions] | Computational | no | no |
| HMGCL_HUMAN | [view interactions] | Computational | no | yes |
| THIK_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| BDH2_HUMAN | [view interactions] | Computational | no | no |
| HMCS2_HUMAN | [view interactions] | Computational | no | no |
| AACS_HUMAN | [view interactions] | Computational | no | yes |