KCY_HUMAN
Evidence for PS localization
Functions
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KCY_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 30.5556 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 30.5556 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.5556 | 4 | yes |
| GO:0019900 | kinase binding | 30.5556 | 4 | no |
| GO:0019901 | protein kinase binding | 27.7778 | 5 | no |
| GO:0046872 | metal ion binding | 27.7778 | 4 | no |
| GO:0005524 | ATP binding | 16.6667 | 5 | yes |
| GO:0016301 | kinase activity | 16.6667 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 16.6667 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 16.6667 | 5 | yes |
| GO:0004550 | nucleoside diphosphate kinase activity | 8.3333 | 5 | yes |
| GO:0016776 | phosphotransferase activity, phosphate group as acceptor | 8.3333 | 4 | yes |
| GO:0019205 | nucleobase-containing compound kinase activity | 8.3333 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KCY_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.8889 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 55.5556 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 38.8889 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 38.8889 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 38.8889 | 4 | no |
| GO:0010646 | regulation of cell communication | 38.8889 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 36.1111 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 36.1111 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 36.1111 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0010941 | regulation of cell death | 33.3333 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 33.3333 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 33.3333 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0006996 | organelle organization | 30.5556 | 4 | no |
| GO:0009966 | regulation of signal transduction | 30.5556 | 4 | no |
| GO:0022607 | cellular component assembly | 30.5556 | 4 | no |
| GO:0051049 | regulation of transport | 30.5556 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.5556 | 5 | no |
| GO:0010468 | regulation of gene expression | 27.7778 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 27.7778 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.7778 | 5 | no |
| GO:0008104 | protein localization | 27.7778 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 25.0000 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 25.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 22.2222 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 22.2222 | 5 | yes |
| GO:0043066 | negative regulation of apoptotic process | 22.2222 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 22.2222 | 6 | no |
| GO:0060548 | negative regulation of cell death | 22.2222 | 5 | no |
| GO:0007010 | cytoskeleton organization | 22.2222 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 22.2222 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.2222 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.2222 | 4 | no |
| GO:0031399 | regulation of protein modification process | 22.2222 | 6 | no |
| GO:0033043 | regulation of organelle organization | 22.2222 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 22.2222 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 22.2222 | 7 | no |
| GO:0045595 | regulation of cell differentiation | 22.2222 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 22.2222 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.2222 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.2222 | 5 | no |
| GO:0016310 | phosphorylation | 19.4444 | 5 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 19.4444 | 4 | yes |
| GO:0009259 | ribonucleotide metabolic process | 16.6667 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 16.6667 | 4 | yes |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 16.6667 | 4 | yes |
| GO:0009141 | nucleoside triphosphate metabolic process | 13.8889 | 5 | yes |
| GO:0009165 | nucleotide biosynthetic process | 13.8889 | 6 | yes |
| GO:0018130 | heterocycle biosynthetic process | 13.8889 | 4 | yes |
| GO:0019438 | aromatic compound biosynthetic process | 13.8889 | 4 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 13.8889 | 4 | yes |
| GO:0090407 | organophosphate biosynthetic process | 13.8889 | 4 | yes |
| GO:1901137 | carbohydrate derivative biosynthetic process | 13.8889 | 4 | yes |
| GO:1901293 | nucleoside phosphate biosynthetic process | 13.8889 | 5 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 13.8889 | 4 | yes |
| GO:0009260 | ribonucleotide biosynthetic process | 11.1111 | 6 | yes |
| GO:0046390 | ribose phosphate biosynthetic process | 11.1111 | 5 | yes |
| GO:0006220 | pyrimidine nucleotide metabolic process | 8.3333 | 5 | yes |
| GO:0006221 | pyrimidine nucleotide biosynthetic process | 8.3333 | 6 | yes |
| GO:0009132 | nucleoside diphosphate metabolic process | 8.3333 | 5 | yes |
| GO:0009142 | nucleoside triphosphate biosynthetic process | 8.3333 | 6 | yes |
| GO:0009185 | ribonucleoside diphosphate metabolic process | 8.3333 | 6 | yes |
| GO:0009218 | pyrimidine ribonucleotide metabolic process | 8.3333 | 6 | yes |
| GO:0009220 | pyrimidine ribonucleotide biosynthetic process | 8.3333 | 7 | yes |
| GO:0072527 | pyrimidine-containing compound metabolic process | 8.3333 | 4 | yes |
| GO:0072528 | pyrimidine-containing compound biosynthetic process | 8.3333 | 5 | yes |
| GO:0006165 | nucleoside diphosphate phosphorylation | 5.5556 | 6 | yes |
| GO:0046939 | nucleotide phosphorylation | 5.5556 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BACE1_HUMAN | [view interactions] | Low throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| TTC19_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| KPCD1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| ATG5_HUMAN | [view interactions] | High throughput | no | no |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CIDEB_HUMAN | [view interactions] | High throughput | no | yes |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| GPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CDK15_HUMAN | [view interactions] | High throughput | no | no |
| STX17_HUMAN | [view interactions] | High throughput | no | yes |
| MOK_HUMAN | [view interactions] | High throughput | no | no |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RWD2B_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| ACO13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT4_HUMAN | [view interactions] | High throughput | no | no |
| EFCE2_HUMAN | [view interactions] | High throughput | no | no |
| ECE2_HUMAN | [view interactions] | High throughput | no | no |
| NIT2_HUMAN | [view interactions] | High throughput | no | yes |
| TATD1_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB2_HUMAN | [view interactions] | High throughput | no | no |
| SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
| PDIP2_HUMAN | [view interactions] | High throughput | no | no |
| THEM4_HUMAN | [view interactions] | High throughput | no | no |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| GRHPR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAH2A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| GSTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THTM_HUMAN | [view interactions] | High throughput | no | yes |
| LACB2_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC4_HUMAN | [view interactions] | High throughput | no | no |
| GLRX5_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC1_HUMAN | [view interactions] | High throughput | no | no |
| FEN1_HUMAN | [view interactions] | High throughput | no | yes |
| GLOD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDHD3_HUMAN | [view interactions] | High throughput | no | yes |
| PDP1_HUMAN | [view interactions] | High throughput | no | yes |
| PGM1_HUMAN | [view interactions] | High throughput | no | no |
| DDAH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADX_HUMAN | [view interactions] | High throughput | no | no |
| GCSH_HUMAN | [view interactions] | High throughput | no | yes |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACPM_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| RIR2B_HUMAN | [view interactions] | Computational | no | yes |
| NDKA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DCK_HUMAN | [view interactions] | Computational | no | no |
| NDK5_HUMAN | [view interactions] | Computational | no | yes |
| AGM1_HUMAN | [view interactions] | Computational | no | no |
| RIR2_HUMAN | [view interactions] | Computational | no | no |
| KTHY_HUMAN | [view interactions] | Computational | no | yes |
| CMPK2_HUMAN | [view interactions] | Computational | no | yes |
| UMPS_HUMAN | [view interactions] | Computational | no | no |
| RIR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NDK3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NDK7_HUMAN | [view interactions] | Computational | no | yes |
| NDKM_HUMAN | [view interactions] | Computational | no | yes |