KCY_HUMAN
Evidence for PS localization
Functions
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KCY_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 36.5854 | 4 | yes |
| GO:0000166 | nucleotide binding | 34.1463 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 31.7073 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 29.2683 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.2683 | 4 | yes |
| GO:0019900 | kinase binding | 26.8293 | 4 | no |
| GO:0043169 | cation binding | 24.3902 | 4 | no |
| GO:0046872 | metal ion binding | 24.3902 | 5 | no |
| GO:0019901 | protein kinase binding | 24.3902 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 19.5122 | 6 | yes |
| GO:0005524 | ATP binding | 17.0732 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 17.0732 | 5 | yes |
| GO:0016301 | kinase activity | 14.6341 | 4 | yes |
| GO:0004550 | nucleoside diphosphate kinase activity | 4.8780 | 5 | yes |
| GO:0016776 | phosphotransferase activity, phosphate group as acceptor | 4.8780 | 4 | yes |
| GO:0019205 | nucleobase-containing compound kinase activity | 4.8780 | 5 | yes |
| GO:0050145 | nucleoside monophosphate kinase activity | 4.8780 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KCY_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.5366 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 56.0976 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 46.3415 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 43.9024 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.9024 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 41.4634 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 39.0244 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.0244 | 5 | no |
| GO:0010646 | regulation of cell communication | 39.0244 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 36.5854 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 36.5854 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 36.5854 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.5854 | 5 | no |
| GO:0010468 | regulation of gene expression | 34.1463 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 34.1463 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 34.1463 | 5 | no |
| GO:0009966 | regulation of signal transduction | 34.1463 | 4 | no |
| GO:0022607 | cellular component assembly | 34.1463 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 31.7073 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.2683 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 29.2683 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 29.2683 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 29.2683 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 26.8293 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 26.8293 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 26.8293 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.8293 | 4 | no |
| GO:0051049 | regulation of transport | 26.8293 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 26.8293 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.8293 | 4 | no |
| GO:0006996 | organelle organization | 26.8293 | 4 | no |
| GO:0008104 | protein localization | 26.8293 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 26.8293 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.8293 | 4 | no |
| GO:0031399 | regulation of protein modification process | 26.8293 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.8293 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.3902 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.3902 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 24.3902 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 24.3902 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 24.3902 | 5 | no |
| GO:0033043 | regulation of organelle organization | 24.3902 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 24.3902 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.3902 | 5 | no |
| GO:0023057 | negative regulation of signaling | 24.3902 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 24.3902 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 24.3902 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 24.3902 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 24.3902 | 7 | no |
| GO:0141124 | intracellular signaling cassette | 21.9512 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 21.9512 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.9512 | 6 | no |
| GO:0043523 | regulation of neuron apoptotic process | 21.9512 | 6 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.9512 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.9512 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 21.9512 | 6 | no |
| GO:0043933 | protein-containing complex organization | 21.9512 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 21.9512 | 5 | no |
| GO:0080134 | regulation of response to stress | 21.9512 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 21.9512 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 21.9512 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 21.9512 | 7 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 17.0732 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 17.0732 | 5 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 17.0732 | 4 | yes |
| GO:0016310 | phosphorylation | 14.6341 | 5 | yes |
| GO:0009259 | ribonucleotide metabolic process | 12.1951 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 12.1951 | 4 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 12.1951 | 4 | yes |
| GO:0009132 | nucleoside diphosphate metabolic process | 9.7561 | 5 | yes |
| GO:0009165 | nucleotide biosynthetic process | 9.7561 | 6 | yes |
| GO:0009185 | ribonucleoside diphosphate metabolic process | 9.7561 | 6 | yes |
| GO:0090407 | organophosphate biosynthetic process | 9.7561 | 4 | yes |
| GO:1901137 | carbohydrate derivative biosynthetic process | 9.7561 | 4 | yes |
| GO:1901293 | nucleoside phosphate biosynthetic process | 9.7561 | 5 | yes |
| GO:0009260 | ribonucleotide biosynthetic process | 7.3171 | 6 | yes |
| GO:0046390 | ribose phosphate biosynthetic process | 7.3171 | 5 | yes |
| GO:0072527 | pyrimidine-containing compound metabolic process | 7.3171 | 4 | yes |
| GO:0006206 | pyrimidine nucleobase metabolic process | 4.8780 | 5 | yes |
| GO:0006220 | pyrimidine nucleotide metabolic process | 4.8780 | 5 | yes |
| GO:0006221 | pyrimidine nucleotide biosynthetic process | 4.8780 | 6 | yes |
| GO:0009112 | nucleobase metabolic process | 4.8780 | 4 | yes |
| GO:0009133 | nucleoside diphosphate biosynthetic process | 4.8780 | 6 | yes |
| GO:0009188 | ribonucleoside diphosphate biosynthetic process | 4.8780 | 7 | yes |
| GO:0009218 | pyrimidine ribonucleotide metabolic process | 4.8780 | 6 | yes |
| GO:0009220 | pyrimidine ribonucleotide biosynthetic process | 4.8780 | 7 | yes |
| GO:0072528 | pyrimidine-containing compound biosynthetic process | 4.8780 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BACE1_HUMAN | [view interactions] | Low throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| TTC19_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| KPCD1_HUMAN | [view interactions] | High throughput | no | yes |
| CDN2A_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CIDEB_HUMAN | [view interactions] | High throughput | no | yes |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| GPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CDK15_HUMAN | [view interactions] | High throughput | no | no |
| STX17_HUMAN | [view interactions] | High throughput | no | yes |
| MOK_HUMAN | [view interactions] | High throughput | no | no |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RWD2B_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| KAD5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACO13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT4_HUMAN | [view interactions] | High throughput | no | no |
| EFCE2_HUMAN | [view interactions] | High throughput | no | no |
| ECE2_HUMAN | [view interactions] | High throughput | no | no |
| NIT2_HUMAN | [view interactions] | High throughput | no | yes |
| TATD1_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB2_HUMAN | [view interactions] | High throughput | no | no |
| SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
| PDIP2_HUMAN | [view interactions] | High throughput | no | no |
| THEM4_HUMAN | [view interactions] | High throughput | no | no |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| GRHPR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAH2A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | no |
| GSTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THTM_HUMAN | [view interactions] | High throughput | no | yes |
| LACB2_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC4_HUMAN | [view interactions] | High throughput | no | no |
| GLRX5_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC1_HUMAN | [view interactions] | High throughput | no | no |
| FEN1_HUMAN | [view interactions] | High throughput | no | yes |
| GLOD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDHD3_HUMAN | [view interactions] | High throughput | no | yes |
| PDP1_HUMAN | [view interactions] | High throughput | no | yes |
| PGM1_HUMAN | [view interactions] | High throughput | no | no |
| DDAH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADX_HUMAN | [view interactions] | High throughput | no | no |
| GCSH_HUMAN | [view interactions] | High throughput | no | yes |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACPM_HUMAN | [view interactions] | High throughput | no | yes |
| SPD2B_HUMAN | [view interactions] | High throughput | no | no |
| PAI2_HUMAN | [view interactions] | High throughput | no | no |
| E2AK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| GDIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYDM_HUMAN | [view interactions] | High throughput | no | yes |
| C1TM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK7_HUMAN | [view interactions] | High throughput | no | yes |
| EPN3_HUMAN | [view interactions] | High throughput | no | no |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| LCMT1_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| NUP35_HUMAN | [view interactions] | High throughput | no | yes |
| ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
| TRI23_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |