Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DDAH1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DDAH1_HUMAN
GO:0046872 metal ion binding 36.3636 4 yes
GO:0019900 kinase binding 31.8182 4 no
GO:0019901 protein kinase binding 27.2727 5 no
GO:0016403 dimethylargininase activity 9.0909 5 yes
GO:0016597 amino acid binding 9.0909 4 yes
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 9.0909 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DDAH1_HUMAN
GO:0048522 positive regulation of cellular process 72.7273 4 yes
GO:0048523 negative regulation of cellular process 68.1818 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 63.6364 4 yes
GO:0031323 regulation of cellular metabolic process 63.6364 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 59.0909 5 yes
GO:0009893 positive regulation of metabolic process 59.0909 4 yes
GO:0031325 positive regulation of cellular metabolic process 59.0909 5 yes
GO:0060255 regulation of macromolecule metabolic process 54.5455 4 no
GO:0080090 regulation of primary metabolic process 54.5455 4 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0009966 regulation of signal transduction 45.4545 4 no
GO:0051246 regulation of protein metabolic process 45.4545 5 no
GO:0019220 regulation of phosphate metabolic process 40.9091 6 no
GO:0031399 regulation of protein modification process 40.9091 6 no
GO:0051049 regulation of transport 40.9091 4 no
GO:0051174 regulation of phosphorus metabolic process 40.9091 5 no
GO:0051247 positive regulation of protein metabolic process 40.9091 6 no
GO:0001932 regulation of protein phosphorylation 36.3636 7 no
GO:0010562 positive regulation of phosphorus metabolic process 36.3636 6 no
GO:0031401 positive regulation of protein modification process 36.3636 7 no
GO:0034762 regulation of transmembrane transport 36.3636 4 no
GO:0042325 regulation of phosphorylation 36.3636 7 no
GO:0045937 positive regulation of phosphate metabolic process 36.3636 7 no
GO:1902531 regulation of intracellular signal transduction 36.3636 5 no
GO:0051128 regulation of cellular component organization 36.3636 4 no
GO:0009889 regulation of biosynthetic process 36.3636 4 yes
GO:0031326 regulation of cellular biosynthetic process 36.3636 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 31.8182 6 yes
GO:0048585 negative regulation of response to stimulus 31.8182 4 yes
GO:0001934 positive regulation of protein phosphorylation 31.8182 8 no
GO:0009892 negative regulation of metabolic process 31.8182 4 no
GO:0010605 negative regulation of macromolecule metabolic process 31.8182 5 no
GO:0031324 negative regulation of cellular metabolic process 31.8182 5 no
GO:0034765 regulation of ion transmembrane transport 31.8182 5 no
GO:0042327 positive regulation of phosphorylation 31.8182 8 no
GO:0043085 positive regulation of catalytic activity 31.8182 4 no
GO:0043269 regulation of ion transport 31.8182 5 no
GO:0043549 regulation of kinase activity 31.8182 5 no
GO:0044057 regulation of system process 31.8182 4 no
GO:0045859 regulation of protein kinase activity 31.8182 6 no
GO:0051172 negative regulation of nitrogen compound metabolic process 31.8182 5 no
GO:0051338 regulation of transferase activity 31.8182 4 no
GO:0008104 protein localization 31.8182 4 no
GO:0010941 regulation of cell death 31.8182 4 no
GO:0042981 regulation of apoptotic process 31.8182 6 no
GO:0043067 regulation of programmed cell death 31.8182 5 no
GO:0006996 organelle organization 31.8182 4 no
GO:0009891 positive regulation of biosynthetic process 31.8182 5 yes
GO:0051240 positive regulation of multicellular organismal process 27.2727 4 yes
GO:0080134 regulation of response to stress 27.2727 4 yes
GO:0010038 response to metal ion 27.2727 4 no
GO:0022898 regulation of transmembrane transporter activity 27.2727 4 no
GO:0033674 positive regulation of kinase activity 27.2727 6 no
GO:0045860 positive regulation of protein kinase activity 27.2727 7 no
GO:0051050 positive regulation of transport 27.2727 4 no
GO:0051051 negative regulation of transport 27.2727 4 no
GO:0051347 positive regulation of transferase activity 27.2727 5 no
GO:0051726 regulation of cell cycle 27.2727 4 no
GO:1904062 regulation of cation transmembrane transport 27.2727 6 no
GO:0010468 regulation of gene expression 27.2727 5 no
GO:0010648 negative regulation of cell communication 27.2727 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.2727 5 no
GO:0023057 negative regulation of signaling 27.2727 4 no
GO:0006796 phosphate-containing compound metabolic process 27.2727 4 no
GO:0032880 regulation of protein localization 27.2727 5 no
GO:0060341 regulation of cellular localization 27.2727 4 no
GO:0051094 positive regulation of developmental process 22.7273 4 yes
GO:2000026 regulation of multicellular organismal development 22.7273 4 yes
GO:0001933 negative regulation of protein phosphorylation 22.7273 8 no
GO:0010563 negative regulation of phosphorus metabolic process 22.7273 6 no
GO:0010564 regulation of cell cycle process 22.7273 5 no
GO:0031400 negative regulation of protein modification process 22.7273 7 no
GO:0032412 regulation of ion transmembrane transporter activity 22.7273 5 no
GO:0042326 negative regulation of phosphorylation 22.7273 8 no
GO:0045936 negative regulation of phosphate metabolic process 22.7273 7 no
GO:0051248 negative regulation of protein metabolic process 22.7273 6 no
GO:0051336 regulation of hydrolase activity 22.7273 4 no
GO:0051592 response to calcium ion 22.7273 5 no
GO:0071900 regulation of protein serine/threonine kinase activity 22.7273 7 no
GO:0015031 protein transport 22.7273 4 no
GO:0071702 organic substance transport 22.7273 4 no
GO:0071705 nitrogen compound transport 22.7273 4 no
GO:0009894 regulation of catabolic process 22.7273 4 no
GO:0009968 negative regulation of signal transduction 22.7273 5 no
GO:0010556 regulation of macromolecule biosynthetic process 22.7273 5 no
GO:0022607 cellular component assembly 22.7273 4 no
GO:0031329 regulation of cellular catabolic process 22.7273 5 no
GO:0043933 protein-containing complex organization 22.7273 4 no
GO:0051252 regulation of RNA metabolic process 22.7273 5 no
GO:0009967 positive regulation of signal transduction 22.7273 5 no
GO:0010647 positive regulation of cell communication 22.7273 5 no
GO:0023056 positive regulation of signaling 22.7273 4 no
GO:0036211 protein modification process 22.7273 4 no
GO:0043412 macromolecule modification 22.7273 4 no
GO:0048584 positive regulation of response to stimulus 22.7273 4 no
GO:0019932 second-messenger-mediated signaling 22.7273 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 22.7273 4 yes
GO:0032768 regulation of monooxygenase activity 18.1818 5 yes
GO:0051341 regulation of oxidoreductase activity 18.1818 4 yes
GO:0080135 regulation of cellular response to stress 18.1818 4 yes
GO:1901565 organonitrogen compound catabolic process 18.1818 4 yes
GO:0042127 regulation of cell population proliferation 13.6364 4 yes
GO:0043436 oxoacid metabolic process 13.6364 4 yes
GO:0050999 regulation of nitric-oxide synthase activity 13.6364 6 yes
GO:0003018 vascular process in circulatory system 13.6364 4 yes
GO:0019752 carboxylic acid metabolic process 13.6364 5 yes
GO:0043116 negative regulation of vascular permeability 9.0909 4 yes
GO:0045428 regulation of nitric oxide biosynthetic process 9.0909 6 yes
GO:0045429 positive regulation of nitric oxide biosynthetic process 9.0909 7 yes
GO:0045765 regulation of angiogenesis 9.0909 5 yes
GO:0045766 positive regulation of angiogenesis 9.0909 6 yes
GO:0046395 carboxylic acid catabolic process 9.0909 5 yes
GO:0080164 regulation of nitric oxide metabolic process 9.0909 5 yes
GO:1900037 regulation of cellular response to hypoxia 9.0909 5 yes
GO:1900038 negative regulation of cellular response to hypoxia 9.0909 5 yes
GO:1901342 regulation of vasculature development 9.0909 5 yes
GO:1901605 alpha-amino acid metabolic process 9.0909 4 yes
GO:1901606 alpha-amino acid catabolic process 9.0909 5 yes
GO:1904018 positive regulation of vasculature development 9.0909 5 yes
GO:1904407 positive regulation of nitric oxide metabolic process 9.0909 6 yes
GO:0000052 citrulline metabolic process 9.0909 5 yes
GO:0003073 regulation of systemic arterial blood pressure 9.0909 4 yes
GO:0006525 arginine metabolic process 9.0909 6 yes
GO:0006527 arginine catabolic process 9.0909 5 yes
GO:0007263 nitric oxide mediated signal transduction 9.0909 5 yes
GO:0008285 negative regulation of cell population proliferation 9.0909 5 yes
GO:0009063 cellular amino acid catabolic process 9.0909 4 yes
GO:0009064 glutamine family amino acid metabolic process 9.0909 5 yes
GO:0009065 glutamine family amino acid catabolic process 9.0909 6 yes
GO:0016054 organic acid catabolic process 9.0909 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in DDAH1_HUMAN
DOID:0050700 cardiomyopathy 9.0909 4 no
DOID:0060036 intrinsic cardiomyopathy 9.0909 5 no
DOID:114 heart disease 9.0909 3 no
DOID:2843 long QT syndrome 9.0909 6 no
DOID:331 central nervous system disease 9.0909 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RETR1_HUMAN [view interactions] Low throughput no no
PSD10_HUMAN [view entry] [view interactions] Low throughput yes yes
DDAH1_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
IQCB1_HUMAN [view interactions] High throughput no no
FIBB_HUMAN [view entry] [view interactions] High throughput yes no
FSD1_HUMAN [view entry] [view interactions] High throughput yes no
DDAH2_HUMAN [view interactions] High throughput no yes
SDHF3_HUMAN [view interactions] High throughput no yes
MIC27_HUMAN [view entry] [view interactions] High throughput yes yes
ATPA_HUMAN [view interactions] High throughput no yes
BOLA3_HUMAN [view interactions] High throughput no yes
LYRM4_HUMAN [view interactions] High throughput no yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
APBB1_HUMAN [view interactions] High throughput no yes
PTN11_HUMAN [view entry] [view interactions] High throughput yes yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
AFG1L_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
NDKB_HUMAN [view entry] [view interactions] High throughput yes yes
E41L2_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes
AFTIN_HUMAN [view interactions] High throughput no yes
CD69_HUMAN [view interactions] High throughput no no
NFIP2_HUMAN [view interactions] High throughput no yes
RIT1_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
CLIC1_HUMAN [view interactions] High throughput no no
ADA_HUMAN [view interactions] High throughput no no
COPD_HUMAN [view entry] [view interactions] High throughput yes yes
CLIC4_HUMAN [view interactions] High throughput no no
KCY_HUMAN [view entry] [view interactions] High throughput yes yes
FEN1_HUMAN [view interactions] High throughput no yes
GLOD4_HUMAN [view entry] [view interactions] High throughput yes yes
HDHD3_HUMAN [view interactions] High throughput no yes
HINT2_HUMAN [view interactions] High throughput no yes
LACB2_HUMAN [view interactions] High throughput no yes
NENF_HUMAN [view interactions] High throughput no yes
PARK7_HUMAN [view entry] [view interactions] High throughput yes yes
PDP1_HUMAN [view interactions] High throughput no yes
6PGL_HUMAN [view interactions] High throughput no yes
UCHL1_HUMAN [view entry] [view interactions] High throughput yes yes
ACPM_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
RAB28_HUMAN [view interactions] Computational no yes