Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

COPD_HUMAN

Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors . [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in COPD_HUMAN
GO:0000166 nucleotide binding 37.6812 4 no
GO:0043168 anion binding 37.6812 4 no
GO:0017076 purine nucleotide binding 36.2319 5 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 31.8841 4 no
GO:0043169 cation binding 24.6377 4 no
GO:0046872 metal ion binding 24.6377 5 no
GO:0030554 adenyl nucleotide binding 23.1884 6 no
GO:0032559 adenyl ribonucleotide binding 20.2899 5 no
GO:0003723 RNA binding 18.8406 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in COPD_HUMAN
GO:0048522 positive regulation of cellular process 53.6232 4 no
GO:0060255 regulation of macromolecule metabolic process 53.6232 4 no
GO:0031323 regulation of cellular metabolic process 50.7246 4 no
GO:0009889 regulation of biosynthetic process 46.3768 4 no
GO:0048523 negative regulation of cellular process 46.3768 4 no
GO:0010468 regulation of gene expression 44.9275 6 no
GO:0010556 regulation of macromolecule biosynthetic process 44.9275 5 no
GO:0010646 regulation of cell communication 44.9275 4 no
GO:0031326 regulation of cellular biosynthetic process 44.9275 5 no
GO:0080090 regulation of primary metabolic process 43.4783 4 no
GO:0009893 positive regulation of metabolic process 42.0290 4 no
GO:0051128 regulation of cellular component organization 42.0290 4 no
GO:0009966 regulation of signal transduction 40.5797 4 no
GO:0010604 positive regulation of macromolecule metabolic process 37.6812 5 no
GO:0008104 protein localization 36.2319 4 yes
GO:0031325 positive regulation of cellular metabolic process 36.2319 5 no
GO:1902531 regulation of intracellular signal transduction 34.7826 5 no
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 no
GO:0009891 positive regulation of biosynthetic process 31.8841 5 no
GO:0051246 regulation of protein metabolic process 31.8841 5 no
GO:0071702 organic substance transport 30.4348 4 yes
GO:0006996 organelle organization 30.4348 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 30.4348 6 no
GO:0031328 positive regulation of cellular biosynthetic process 30.4348 6 no
GO:0048584 positive regulation of response to stimulus 30.4348 4 no
GO:0071705 nitrogen compound transport 28.9855 4 yes
GO:0010647 positive regulation of cell communication 28.9855 5 no
GO:0023056 positive regulation of signaling 28.9855 4 no
GO:0009892 negative regulation of metabolic process 27.5362 4 no
GO:0009967 positive regulation of signal transduction 27.5362 5 no
GO:0051049 regulation of transport 27.5362 4 no
GO:0010648 negative regulation of cell communication 26.0870 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.0870 5 no
GO:0023057 negative regulation of signaling 26.0870 4 no
GO:0044087 regulation of cellular component biogenesis 26.0870 4 no
GO:0051252 regulation of RNA metabolic process 26.0870 5 no
GO:0036211 protein modification process 24.6377 4 no
GO:0043412 macromolecule modification 24.6377 4 no
GO:0010605 negative regulation of macromolecule metabolic process 24.6377 5 no
GO:0042981 regulation of apoptotic process 24.6377 5 no
GO:0043067 regulation of programmed cell death 24.6377 4 no
GO:0051247 positive regulation of protein metabolic process 24.6377 6 no
GO:0010628 positive regulation of gene expression 24.6377 7 no
GO:0031324 negative regulation of cellular metabolic process 24.6377 5 no
GO:0015031 protein transport 23.1884 4 yes
GO:0006355 regulation of DNA-templated transcription 23.1884 7 no
GO:0019220 regulation of phosphate metabolic process 23.1884 6 no
GO:0031399 regulation of protein modification process 23.1884 6 no
GO:0048585 negative regulation of response to stimulus 23.1884 4 no
GO:0051174 regulation of phosphorus metabolic process 23.1884 5 no
GO:2001141 regulation of RNA biosynthetic process 23.1884 6 no
GO:0071310 cellular response to organic substance 23.1884 4 no
GO:0009968 negative regulation of signal transduction 21.7391 5 no
GO:0033043 regulation of organelle organization 21.7391 5 no
GO:0051130 positive regulation of cellular component organization 21.7391 5 no
GO:0032880 regulation of protein localization 20.2899 5 no
GO:0060341 regulation of cellular localization 20.2899 4 no
GO:0001932 regulation of protein phosphorylation 20.2899 7 no
GO:0042127 regulation of cell population proliferation 20.2899 4 no
GO:0042325 regulation of phosphorylation 20.2899 7 no
GO:1902533 positive regulation of intracellular signal transduction 20.2899 6 no
GO:2000145 regulation of cell motility 20.2899 4 no
GO:0009894 regulation of catabolic process 20.2899 4 no
GO:0031344 regulation of cell projection organization 20.2899 5 no
GO:0050804 modulation of chemical synaptic transmission 20.2899 5 no
GO:0099177 regulation of trans-synaptic signaling 20.2899 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.2899 6 no
GO:0006886 intracellular protein transport 17.3913 4 yes
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 13.0435 4 yes
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 11.5942 4 yes
GO:0008344 adult locomotory behavior 7.2464 4 yes
GO:0021691 cerebellar Purkinje cell layer maturation 2.8986 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
COPE_HUMAN [view interactions] Low throughput no yes
COPZ1_HUMAN [view interactions] Low throughput no no
SAC1_HUMAN [view entry] [view interactions] Low throughput yes yes
COPA_HUMAN [view entry] [view interactions] Low throughput yes yes
COPG1_HUMAN [view interactions] Low throughput no yes
DRD3_HUMAN [view entry] [view interactions] Low throughput yes no
COPB_HUMAN [view interactions] Low throughput no yes
COPD_HUMAN [view entry] [view interactions] Low throughput yes yes
COPB2_HUMAN [view entry] [view interactions] Low throughput yes yes
ATX3_HUMAN [view interactions] High throughput no yes
S15A3_HUMAN [view interactions] High throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
LMBRL_HUMAN [view interactions] High throughput no no
NFX1_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
RBM39_HUMAN [view interactions] High throughput no yes
MT21E_HUMAN [view interactions] High throughput no no
INSI2_HUMAN [view interactions] High throughput no yes
FA20C_HUMAN [view interactions] High throughput no no
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
FZR1_HUMAN [view interactions] High throughput no no
WDR5_HUMAN [view interactions] High throughput no no
COPZ2_HUMAN [view interactions] High throughput no no
SC61B_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
EP300_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
BAP1_HUMAN [view interactions] High throughput no yes
FBX43_HUMAN [view interactions] High throughput no no
NOLC1_HUMAN [view interactions] High throughput no yes
PPM1G_HUMAN [view interactions] High throughput no no
SCYL1_HUMAN [view interactions] High throughput no yes
SPTC1_HUMAN [view interactions] High throughput no yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
FOXA1_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
GOLP3_HUMAN [view interactions] High throughput no no
GLP3L_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
DX39B_HUMAN [view interactions] High throughput no no
ACE2_HUMAN [view interactions] High throughput no no
PARPT_HUMAN [view interactions] High throughput no no
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
EZH2_HUMAN [view interactions] High throughput no no
CL16A_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
MORC2_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
WBP2_HUMAN [view interactions] High throughput no yes
PDE4B_HUMAN [view entry] [view interactions] High throughput yes yes
DDB2_HUMAN [view interactions] High throughput no yes
DIAP1_HUMAN [view interactions] High throughput no yes
TLE3_HUMAN [view interactions] High throughput no yes
KLC1_HUMAN [view entry] [view interactions] High throughput yes no
P4R3A_HUMAN [view interactions] High throughput no yes
NOB1_HUMAN [view interactions] High throughput no yes
SF3B1_HUMAN [view interactions] High throughput no yes
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
CLIC4_HUMAN [view interactions] High throughput no no
GLOD4_HUMAN [view entry] [view interactions] High throughput yes yes
GRHPR_HUMAN [view entry] [view interactions] High throughput yes no
HDHD3_HUMAN [view interactions] High throughput no yes
HINT2_HUMAN [view interactions] High throughput no yes
IDHP_HUMAN [view entry] [view interactions] High throughput yes yes
PARK7_HUMAN [view entry] [view interactions] High throughput yes yes
PDP1_HUMAN [view interactions] High throughput no yes
IPYR2_HUMAN [view interactions] High throughput no yes
TPIS_HUMAN [view entry] [view interactions] High throughput yes yes
CLIC1_HUMAN [view interactions] High throughput no no
DDAH1_HUMAN [view entry] [view interactions] High throughput yes no
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
ADX_HUMAN [view interactions] High throughput no no
FEN1_HUMAN [view interactions] High throughput no yes
GCSH_HUMAN [view interactions] High throughput no yes
G6PI_HUMAN [view entry] [view interactions] High throughput yes yes
GSTP1_HUMAN [view entry] [view interactions] High throughput yes no
ACPM_HUMAN [view interactions] High throughput no yes
PGM1_HUMAN [view interactions] High throughput no no
PRDX6_HUMAN [view entry] [view interactions] High throughput yes yes
SODC_HUMAN [view interactions] High throughput no yes
SC22B_HUMAN [view entry] [view interactions] High throughput yes no
ERP44_HUMAN [view interactions] High throughput no yes
PSMD3_HUMAN [view interactions] High throughput no yes
ELP1_HUMAN [view interactions] High throughput no yes
THIO_HUMAN [view interactions] High throughput no yes
SAHH_HUMAN [view entry] [view interactions] High throughput yes yes
PSA4_HUMAN [view entry] [view interactions] High throughput yes yes
MOES_HUMAN [view entry] [view interactions] High throughput yes no
MATR3_HUMAN [view interactions] High throughput no yes
ACLY_HUMAN [view entry] [view interactions] High throughput yes yes
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
AKA12_HUMAN [view entry] [view interactions] High throughput yes no
MCM6_HUMAN [view interactions] High throughput no yes
GANAB_HUMAN [view interactions] High throughput no yes
CNDP2_HUMAN [view entry] [view interactions] High throughput yes yes
SRPK1_HUMAN [view interactions] High throughput no yes
CND3_HUMAN [view interactions] High throughput no yes
TMOD3_HUMAN [view interactions] High throughput no yes
PUF60_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
NIN_HUMAN [view interactions] High throughput no no
RHBL4_HUMAN [view interactions] High throughput no no
RN183_HUMAN [view interactions] High throughput no no
B3GA1_HUMAN [view interactions] High throughput no yes
CAV1_HUMAN [view interactions] High throughput no no
RCAS1_HUMAN [view interactions] High throughput no yes
ELOV5_HUMAN [view interactions] High throughput no yes
EMD_HUMAN [view interactions] High throughput no yes
ERGI1_HUMAN [view interactions] High throughput no yes
ERGI2_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
3BHS7_HUMAN [view interactions] High throughput no no
TMT1A_HUMAN [view interactions] High throughput no no
PXMP2_HUMAN [view interactions] High throughput no no
RAB9A_HUMAN [view interactions] High throughput no yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
ZFPL1_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
STING_HUMAN [view interactions] High throughput no yes
ARF1_HUMAN [view entry] [view interactions] High throughput yes yes
ARF3_HUMAN [view entry] [view interactions] High throughput yes no
ARF4_HUMAN [view entry] [view interactions] High throughput yes no
ARF5_HUMAN [view entry] [view interactions] High throughput yes no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
ARL1_HUMAN [view interactions] High throughput no yes
TRI23_HUMAN [view interactions] High throughput no yes
SC6A1_HUMAN [view entry] [view interactions] High throughput yes no
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
WWTR1_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
HMGB2_HUMAN [view interactions] High throughput no yes
PAN2_HUMAN [view interactions] High throughput no no
KEAP1_HUMAN [view interactions] High throughput no yes
NUDC1_HUMAN [view interactions] High throughput no no
OTUB1_HUMAN [view interactions] High throughput no yes
TBG1_HUMAN [view entry] [view interactions] High throughput yes yes
NICA_HUMAN [view interactions] High throughput no yes
ARMC6_HUMAN [view interactions] High throughput no yes
ATLA3_HUMAN [view interactions] High throughput no no
CNTRB_HUMAN [view interactions] High throughput no yes
KSR1_HUMAN [view interactions] High throughput no yes
KI67_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
KPCB_HUMAN [view entry] [view interactions] High throughput yes yes
ARGAL_HUMAN [view interactions] High throughput no yes
RMC1_HUMAN [view interactions] High throughput no no
VCAM1_HUMAN [view interactions] High throughput no no
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
HG2A_HUMAN [view interactions] High throughput no yes
NCF1_HUMAN [view interactions] High throughput no no
P2RY6_HUMAN [view interactions] High throughput no no
UN93B_HUMAN [view interactions] High throughput no yes
SHF_HUMAN [view interactions] High throughput no no
FRK_HUMAN [view interactions] High throughput no no
PACE1_HUMAN [view interactions] High throughput no yes
SNRK_HUMAN [view interactions] High throughput no yes
SG196_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
TMEDA_HUMAN [view interactions] High throughput no yes
TMED9_HUMAN [view interactions] High throughput no yes
VGFR3_HUMAN [view interactions] High throughput no yes
ROS1_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
PHLA3_HUMAN [view interactions] High throughput no yes
T22D1_HUMAN [view interactions] High throughput no no
SNW1_HUMAN [view interactions] High throughput no yes
CDC5L_HUMAN [view interactions] High throughput no yes
PTBP3_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
INSR_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ESR2_HUMAN [view interactions] High throughput no no
DSCAM_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
TM216_HUMAN [view interactions] High throughput no no
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA5_HUMAN [view interactions] High throughput no no
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
EPHA8_HUMAN [view interactions] High throughput no no
EPHB6_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
MUSK_HUMAN [view entry] [view interactions] High throughput yes no
NTRK1_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
STYK1_HUMAN [view interactions] High throughput no yes
LBHD1_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO3_HUMAN [view entry] [view interactions] High throughput yes yes
COPG2_HUMAN [view interactions] High throughput no yes
FOXP3_HUMAN [view interactions] High throughput no no
ITA4_HUMAN [view interactions] High throughput no no
CCDC8_HUMAN [view interactions] High throughput no yes
RING2_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
HYPK_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
TES_HUMAN [view interactions] High throughput no yes
LNP_HUMAN [view interactions] High throughput no yes
ZN598_HUMAN [view interactions] High throughput no no
PLAK_HUMAN [view entry] [view interactions] High throughput yes yes
EGLN3_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
RIOK1_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
RN181_HUMAN [view interactions] High throughput no no
GLP1R_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
TM41B_HUMAN [view interactions] High throughput no yes
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
NR2C2_HUMAN [view interactions] High throughput no yes
NHLC2_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes