COPD_HUMAN
Evidence for PS localization
Functions
Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in COPD_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 27.0833 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.0000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
| GO:0019900 | kinase binding | 22.9167 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.9167 | 4 | no |
| GO:0003723 | RNA binding | 20.8333 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in COPD_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.2500 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 56.2500 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 54.1667 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 52.0833 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 52.0833 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.0833 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 47.9167 | 4 | no |
| GO:0010646 | regulation of cell communication | 47.9167 | 4 | no |
| GO:0010468 | regulation of gene expression | 43.7500 | 5 | no |
| GO:0009966 | regulation of signal transduction | 43.7500 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.5833 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 39.5833 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 39.5833 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 39.5833 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 35.4167 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 35.4167 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 35.4167 | 5 | no |
| GO:0008104 | protein localization | 33.3333 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010941 | regulation of cell death | 33.3333 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 31.2500 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 31.2500 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 31.2500 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 31.2500 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 31.2500 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 31.2500 | 5 | no |
| GO:0023056 | positive regulation of signaling | 31.2500 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 31.2500 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 31.2500 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 31.2500 | 5 | no |
| GO:0023057 | negative regulation of signaling | 31.2500 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 31.2500 | 4 | no |
| GO:0071702 | organic substance transport | 29.1667 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.1667 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 29.1667 | 5 | no |
| GO:0071705 | nitrogen compound transport | 27.0833 | 4 | yes |
| GO:0010628 | positive regulation of gene expression | 27.0833 | 6 | no |
| GO:0036211 | protein modification process | 27.0833 | 4 | no |
| GO:0043412 | macromolecule modification | 27.0833 | 4 | no |
| GO:0031399 | regulation of protein modification process | 27.0833 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 27.0833 | 7 | no |
| GO:0006996 | organelle organization | 27.0833 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.0833 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 27.0833 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 27.0833 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.0833 | 6 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0060548 | negative regulation of cell death | 25.0000 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.0000 | 7 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0051338 | regulation of transferase activity | 25.0000 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 25.0000 | 4 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0015031 | protein transport | 22.9167 | 4 | yes |
| GO:0043549 | regulation of kinase activity | 22.9167 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 22.9167 | 4 | no |
| GO:0071310 | cellular response to organic substance | 22.9167 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 22.9167 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.9167 | 6 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 22.9167 | 4 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 22.9167 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.9167 | 6 | no |
| GO:0009894 | regulation of catabolic process | 22.9167 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.9167 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 20.8333 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 20.8333 | 5 | no |
| GO:0030162 | regulation of proteolysis | 20.8333 | 6 | no |
| GO:0043066 | negative regulation of apoptotic process | 20.8333 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 20.8333 | 6 | no |
| GO:0043436 | oxoacid metabolic process | 20.8333 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 20.8333 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 20.8333 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.8333 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 20.8333 | 6 | no |
| GO:0031329 | regulation of cellular catabolic process | 20.8333 | 5 | no |
| GO:0033043 | regulation of organelle organization | 20.8333 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 20.8333 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.8333 | 6 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.8333 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.8333 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.8333 | 7 | no |
| GO:0080134 | regulation of response to stress | 20.8333 | 4 | no |
| GO:0080135 | regulation of cellular response to stress | 20.8333 | 4 | no |
| GO:0006886 | intracellular protein transport | 16.6667 | 4 | yes |
| GO:0048193 | Golgi vesicle transport | 14.5833 | 5 | yes |
| GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport | 12.5000 | 4 | yes |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 12.5000 | 6 | yes |
| GO:0008344 | adult locomotory behavior | 8.3333 | 4 | yes |
| GO:0021691 | cerebellar Purkinje cell layer maturation | 4.1667 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COPA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COPG1_HUMAN | [view interactions] | Low throughput | no | yes |
| DRD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| COPB_HUMAN | [view interactions] | Low throughput | no | yes |
| COPD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COPB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COPE_HUMAN | [view interactions] | Low throughput | no | yes |
| COPZ1_HUMAN | [view interactions] | Low throughput | no | no |
| HMGB2_HUMAN | [view interactions] | High throughput | no | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| KEAP1_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC1_HUMAN | [view interactions] | High throughput | no | no |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NICA_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC6_HUMAN | [view interactions] | High throughput | no | yes |
| ATLA3_HUMAN | [view interactions] | High throughput | no | no |
| CNTRB_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARGAL_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| HG2A_HUMAN | [view interactions] | High throughput | no | yes |
| NCF1_HUMAN | [view interactions] | High throughput | no | no |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| SHF_HUMAN | [view interactions] | High throughput | no | no |
| FRK_HUMAN | [view interactions] | High throughput | no | no |
| PACE1_HUMAN | [view interactions] | High throughput | no | yes |
| SNRK_HUMAN | [view interactions] | High throughput | no | yes |
| SG196_HUMAN | [view interactions] | High throughput | no | yes |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| TMED9_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| ROS1_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PHLA3_HUMAN | [view interactions] | High throughput | no | yes |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| TM216_HUMAN | [view interactions] | High throughput | no | no |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA5_HUMAN | [view interactions] | High throughput | no | no |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPHA8_HUMAN | [view interactions] | High throughput | no | no |
| EPHB6_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| MUSK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STYK1_HUMAN | [view interactions] | High throughput | no | yes |
| LBHD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO3_HUMAN | [view interactions] | High throughput | no | yes |
| COPG2_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| HYPK_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIOK1_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| RN181_HUMAN | [view interactions] | High throughput | no | no |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TM41B_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| S15A3_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| NFX1_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| RMC1_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| MT21E_HUMAN | [view interactions] | High throughput | no | no |
| INSI2_HUMAN | [view interactions] | High throughput | no | yes |
| FA20C_HUMAN | [view interactions] | High throughput | no | no |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| COPZ2_HUMAN | [view interactions] | High throughput | no | no |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| FBX43_HUMAN | [view interactions] | High throughput | no | no |
| NOLC1_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1G_HUMAN | [view interactions] | High throughput | no | no |
| SCYL1_HUMAN | [view interactions] | High throughput | no | yes |
| SPTC1_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WBP2_HUMAN | [view interactions] | High throughput | no | yes |
| PDE4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDB2_HUMAN | [view interactions] | High throughput | no | yes |
| DIAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TLE3_HUMAN | [view interactions] | High throughput | no | yes |
| KLC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P4R3A_HUMAN | [view interactions] | High throughput | no | yes |
| NOB1_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B1_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIC4_HUMAN | [view interactions] | High throughput | no | no |
| GLOD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRHPR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDHD3_HUMAN | [view interactions] | High throughput | no | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDP1_HUMAN | [view interactions] | High throughput | no | yes |
| IPYR2_HUMAN | [view interactions] | High throughput | no | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIC1_HUMAN | [view interactions] | High throughput | no | no |
| DDAH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADX_HUMAN | [view interactions] | High throughput | no | no |
| FEN1_HUMAN | [view interactions] | High throughput | no | yes |
| GCSH_HUMAN | [view interactions] | High throughput | no | yes |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACPM_HUMAN | [view interactions] | High throughput | no | yes |
| PGM1_HUMAN | [view interactions] | High throughput | no | no |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERP44_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STT3B_HUMAN | [view interactions] | Computational | no | yes |
| TMED2_HUMAN | [view interactions] | Computational | no | yes |
| ARFG1_HUMAN | [view interactions] | Computational | no | no |
| RINT1_HUMAN | [view interactions] | Computational | no | yes |
| ARF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SC23B_HUMAN | [view interactions] | Computational | no | yes |
| NBAS_HUMAN | [view interactions] | Computational | no | yes |
| SC23A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |