IDHP_HUMAN
Evidence for PS localization
Functions
Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in IDHP_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 29.6875 | 4 | yes |
| GO:0003723 | RNA binding | 21.8750 | 4 | no |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 14.0625 | 4 | yes |
| GO:0051287 | NAD binding | 14.0625 | 4 | yes |
| GO:0000287 | magnesium ion binding | 9.3750 | 5 | yes |
| GO:0004448 | isocitrate dehydrogenase [NAD(P)+] activity | 7.8125 | 5 | yes |
| GO:0004450 | isocitrate dehydrogenase (NADP+) activity | 3.1250 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in IDHP_HUMAN |
|---|---|---|---|---|
| GO:0019752 | carboxylic acid metabolic process | 40.6250 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 40.6250 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 40.6250 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.6250 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 37.5000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 37.5000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 37.5000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.9375 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 29.6875 | 4 | no |
| GO:0010468 | regulation of gene expression | 29.6875 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 28.1250 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 26.5625 | 4 | no |
| GO:0010646 | regulation of cell communication | 26.5625 | 4 | no |
| GO:0008104 | protein localization | 26.5625 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0006996 | organelle organization | 25.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 23.4375 | 4 | yes |
| GO:0010941 | regulation of cell death | 23.4375 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 23.4375 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 23.4375 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 23.4375 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.4375 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.4375 | 5 | no |
| GO:0022607 | cellular component assembly | 23.4375 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.4375 | 5 | no |
| GO:0071702 | organic substance transport | 23.4375 | 4 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 21.8750 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 21.8750 | 5 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 21.8750 | 6 | yes |
| GO:0043648 | dicarboxylic acid metabolic process | 21.8750 | 6 | yes |
| GO:0009966 | regulation of signal transduction | 21.8750 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 21.8750 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.3125 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.3125 | 5 | no |
| GO:0051049 | regulation of transport | 20.3125 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.3125 | 5 | no |
| GO:0071705 | nitrogen compound transport | 20.3125 | 4 | no |
| GO:0072350 | tricarboxylic acid metabolic process | 12.5000 | 6 | yes |
| GO:0006103 | 2-oxoglutarate metabolic process | 10.9375 | 7 | yes |
| GO:1902652 | secondary alcohol metabolic process | 10.9375 | 4 | yes |
| GO:0006102 | isocitrate metabolic process | 9.3750 | 5 | yes |
| GO:0006739 | NADP metabolic process | 6.2500 | 7 | yes |
| GO:0019362 | pyridine nucleotide metabolic process | 6.2500 | 5 | yes |
| GO:0046496 | nicotinamide nucleotide metabolic process | 6.2500 | 6 | yes |
| GO:0072524 | pyridine-containing compound metabolic process | 6.2500 | 4 | yes |
| GO:0046487 | glyoxylate metabolic process | 4.6875 | 4 | yes |
| GO:0006097 | glyoxylate cycle | 3.1250 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in IDHP_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 4.6875 | 3 | no |
| DOID:1289 | neurodegenerative disease | 3.1250 | 4 | no |
| DOID:0050155 | sensory system disease | 3.1250 | 3 | no |
| DOID:10584 | retinitis pigmentosa | 3.1250 | 7 | no |
| DOID:5614 | eye disease | 3.1250 | 4 | no |
| DOID:8466 | retinal degeneration | 3.1250 | 6 | no |
| DOID:9799 | eye degenerative disease | 3.1250 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HLAB_HUMAN | [view interactions] | Low throughput | no | yes |
| B2MG_HUMAN | [view interactions] | Low throughput | no | yes |
| IDHP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HCDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
| COPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIC1_HUMAN | [view interactions] | High throughput | no | no |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADX_HUMAN | [view interactions] | High throughput | no | no |
| GCSH_HUMAN | [view interactions] | High throughput | no | yes |
| GSTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COA7_HUMAN | [view interactions] | High throughput | no | yes |
| GRHPR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| NENF_HUMAN | [view interactions] | High throughput | no | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDP1_HUMAN | [view interactions] | High throughput | no | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACPM_HUMAN | [view interactions] | High throughput | no | yes |
| PGM1_HUMAN | [view interactions] | High throughput | no | no |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACADM_HUMAN | [view interactions] | High throughput | no | yes |
| ADHX_HUMAN | [view interactions] | High throughput | no | yes |
| TNC18_HUMAN | [view interactions] | High throughput | no | yes |
| TRM61_HUMAN | [view interactions] | High throughput | no | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYGL_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| SIR4_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L1_HUMAN | [view interactions] | High throughput | no | no |
| KBTB7_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| MAS_HUMAN | [view interactions] | High throughput | no | no |
| S15A1_HUMAN | [view interactions] | High throughput | no | no |
| S39A9_HUMAN | [view interactions] | High throughput | no | yes |
| KCMF1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| TAGL_HUMAN | [view interactions] | High throughput | no | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ2_HUMAN | [view interactions] | High throughput | no | yes |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| CEBPD_HUMAN | [view interactions] | High throughput | no | no |
| IRF2_HUMAN | [view interactions] | High throughput | no | yes |
| SNAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD3_HUMAN | [view interactions] | High throughput | no | yes |
| KDM4C_HUMAN | [view interactions] | High throughput | no | no |
| KDM4D_HUMAN | [view interactions] | High throughput | no | yes |
| IF2P_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PA2G4_HUMAN | [view interactions] | High throughput | no | yes |
| RM12_HUMAN | [view interactions] | High throughput | no | yes |
| RU2B_HUMAN | [view interactions] | High throughput | no | yes |
| ZN207_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SND1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRNN_HUMAN | [view interactions] | High throughput | no | no |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO3_HUMAN | [view interactions] | High throughput | no | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| GLMP_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
| TGFR2_HUMAN | [view interactions] | High throughput | no | no |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| NFIX_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| ERP44_HUMAN | [view interactions] | High throughput | no | yes |
| SMHD1_HUMAN | [view interactions] | High throughput | no | yes |
| SF3A3_HUMAN | [view interactions] | High throughput | no | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIF1_HUMAN | [view interactions] | High throughput | no | yes |
| SF3A1_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RO52_HUMAN | [view interactions] | High throughput | no | yes |
| P5CS_HUMAN | [view interactions] | High throughput | no | yes |
| CNBP_HUMAN | [view interactions] | High throughput | no | no |
| RNF5_HUMAN | [view interactions] | High throughput | no | yes |
| RN103_HUMAN | [view interactions] | High throughput | no | no |
| RN170_HUMAN | [view interactions] | High throughput | no | yes |
| RN185_HUMAN | [view interactions] | High throughput | no | no |
| RNFT1_HUMAN | [view interactions] | High throughput | no | no |
| TRI13_HUMAN | [view interactions] | High throughput | no | no |
| ZNRF4_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| INSRR_HUMAN | [view interactions] | High throughput | no | no |
| CD80_HUMAN | [view interactions] | High throughput | no | no |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| HXC5_HUMAN | [view interactions] | High throughput | no | no |
| OR2A4_HUMAN | [view interactions] | High throughput | no | no |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
| OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
| NGN3_HUMAN | [view interactions] | High throughput | no | no |
| PLCA_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM42_HUMAN | [view interactions] | High throughput | no | yes |
| TECTB_HUMAN | [view interactions] | High throughput | no | no |
| SSUH2_HUMAN | [view interactions] | High throughput | no | no |
| TIDC1_HUMAN | [view interactions] | High throughput | no | yes |
| PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| SARAF_HUMAN | [view interactions] | High throughput | no | no |
| CR021_HUMAN | [view interactions] | High throughput | no | no |
| SYT6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| WIF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| KIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| WIPI1_HUMAN | [view interactions] | High throughput | no | yes |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| CLU_HUMAN | [view interactions] | High throughput | no | yes |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MUS81_HUMAN | [view interactions] | High throughput | no | no |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| IDHC_HUMAN | [view interactions] | High throughput | no | no |
| G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IDH3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDH3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDH3G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| TPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THTR_HUMAN | [view interactions] | High throughput | no | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| FABPH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYPL1_HUMAN | [view interactions] | High throughput | no | yes |
| DEST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLRX5_HUMAN | [view interactions] | High throughput | no | yes |
| CATB_HUMAN | [view interactions] | High throughput | no | yes |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| AL4A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| ICAM1_HUMAN | [view interactions] | High throughput | no | no |
| PTRD1_HUMAN | [view interactions] | High throughput | no | yes |
| AMPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ISOC2_HUMAN | [view interactions] | High throughput | no | yes |
| INHBA_HUMAN | [view interactions] | High throughput | no | no |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THIL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIC4_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCP2_HUMAN | [view interactions] | High throughput | no | no |
| FRDA_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SIR3_HUMAN | [view interactions] | Computational | no | yes |
| ASXL1_HUMAN | [view interactions] | Computational | no | no |
| PUR8_HUMAN | [view interactions] | Computational | no | yes |
| ODO1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DHE4_HUMAN | [view interactions] | Computational | no | yes |
| DHE3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NIT2_HUMAN | [view interactions] | Computational | no | yes |
| ARLY_HUMAN | [view interactions] | Computational | no | no |
| OGDHL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ALAT2_HUMAN | [view interactions] | Computational | no | yes |
| NNTM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DNM3A_HUMAN | [view interactions] | Computational | no | yes |
| ACOHC_HUMAN | [view interactions] | Computational | no | yes |
| TET2_HUMAN | [view interactions] | Computational | no | yes |
| NPM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AATM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| D2HDH_HUMAN | [view interactions] | Computational | no | no |
| RIMKB_HUMAN | [view interactions] | Computational | no | no |
| SSDH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FUMH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AATC2_HUMAN | [view interactions] | Computational | no | no |
| ALAT1_HUMAN | [view interactions] | Computational | no | no |
| OXLA_HUMAN | [view interactions] | Computational | no | no |
| MDHM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |