Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SUMO3_HUMAN

Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed, PubMed, PubMed). Plays a role in the regulation of sumoylation status of SETX (PubMed). [View more on UniProt]

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No data found.

ELM instance Name Type Start End Partner
ELMI000881 MOD_SUMO_for_1 MOD 10 13 -
ELMI000881 MOD_SUMO_for_1 MOD 10 13 -

Molecular function

Term Name % Distance from the top of the tree Annotated in SUMO3_HUMAN
GO:0003723 RNA binding 42.0561 4 no
GO:0043168 anion binding 29.9065 4 no
GO:0000166 nucleotide binding 27.1028 4 no
GO:0017076 purine nucleotide binding 26.1682 5 no
GO:0043169 cation binding 25.2336 4 no
GO:0032555 purine ribonucleotide binding 24.2991 4 no
GO:0035639 purine ribonucleoside triphosphate binding 24.2991 4 no
GO:0046872 metal ion binding 23.3645 5 no
GO:0044389 ubiquitin-like protein ligase binding 11.2150 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SUMO3_HUMAN
GO:0048522 positive regulation of cellular process 48.5981 4 no
GO:0031323 regulation of cellular metabolic process 46.7290 4 no
GO:0060255 regulation of macromolecule metabolic process 44.8598 4 no
GO:0080090 regulation of primary metabolic process 44.8598 4 no
GO:0009889 regulation of biosynthetic process 40.1869 4 no
GO:0010556 regulation of macromolecule biosynthetic process 40.1869 5 no
GO:0031326 regulation of cellular biosynthetic process 40.1869 5 no
GO:0048523 negative regulation of cellular process 40.1869 4 no
GO:0010468 regulation of gene expression 36.4486 6 no
GO:0051128 regulation of cellular component organization 35.5140 4 no
GO:0009893 positive regulation of metabolic process 33.6449 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 32.7103 5 no
GO:0006996 organelle organization 29.9065 4 no
GO:0031325 positive regulation of cellular metabolic process 29.9065 5 no
GO:0051246 regulation of protein metabolic process 29.9065 5 no
GO:0010604 positive regulation of macromolecule metabolic process 28.9720 5 no
GO:0051252 regulation of RNA metabolic process 28.0374 5 no
GO:0060341 regulation of cellular localization 26.1682 4 yes
GO:0008104 protein localization 26.1682 4 no
GO:0032880 regulation of protein localization 25.2336 5 yes
GO:0009892 negative regulation of metabolic process 25.2336 4 no
GO:0010646 regulation of cell communication 25.2336 4 no
GO:0022607 cellular component assembly 25.2336 4 no
GO:0071702 organic substance transport 25.2336 4 no
GO:0071705 nitrogen compound transport 25.2336 4 no
GO:0006355 regulation of DNA-templated transcription 24.2991 7 no
GO:0010605 negative regulation of macromolecule metabolic process 24.2991 5 no
GO:2001141 regulation of RNA biosynthetic process 24.2991 6 no
GO:0009891 positive regulation of biosynthetic process 23.3645 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.3645 6 no
GO:0031328 positive regulation of cellular biosynthetic process 23.3645 6 no
GO:0031324 negative regulation of cellular metabolic process 22.4299 5 no
GO:0036211 protein modification process 21.4953 4 yes
GO:0043412 macromolecule modification 21.4953 4 yes
GO:0051247 positive regulation of protein metabolic process 21.4953 6 no
GO:0051049 regulation of transport 21.4953 4 no
GO:0051130 positive regulation of cellular component organization 20.5607 5 no
GO:0043687 post-translational protein modification 18.6916 5 yes
GO:0070647 protein modification by small protein conjugation or removal 17.7570 6 yes
GO:0032446 protein modification by small protein conjugation 16.8224 7 yes
GO:0018193 peptidyl-amino acid modification 13.0841 5 yes
GO:0018205 peptidyl-lysine modification 13.0841 6 yes
GO:0016925 protein sumoylation 12.1495 7 yes
GO:1900180 regulation of protein localization to nucleus 7.4766 6 yes
GO:0043392 negative regulation of DNA binding 2.8037 5 yes
GO:0051100 negative regulation of binding 2.8037 4 yes
GO:0051101 regulation of DNA binding 2.8037 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
STXB5_HUMAN [view entry] [view interactions] Low throughput yes yes
SLX4_HUMAN [view interactions] Low throughput no yes
RN168_HUMAN [view interactions] Low throughput no no
RNF8_HUMAN [view interactions] Low throughput no yes
DAXX_HUMAN [view interactions] Low throughput no yes
RN111_HUMAN [view interactions] Low throughput no yes
NF2IP_HUMAN [view interactions] Low throughput no no
HIPK2_HUMAN [view interactions] Low throughput no yes
YAP1_HUMAN [view interactions] Low throughput no yes
WWTR1_HUMAN [view interactions] Low throughput no yes
SENP5_HUMAN [view entry] [view interactions] Low throughput yes no
EGLN3_HUMAN [view interactions] Low throughput no no
KCNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
IRF7_HUMAN [view interactions] Low throughput no yes
ATX7_HUMAN [view interactions] Low throughput no no
OTUB2_HUMAN [view interactions] Low throughput no no
SENP7_HUMAN [view entry] [view interactions] Low throughput yes yes
SENP2_HUMAN [view interactions] Low throughput no yes
UBC9_HUMAN [view entry] [view interactions] Low throughput yes yes
CBX5_HUMAN [view interactions] Low throughput no yes
ERR1_HUMAN [view interactions] Low throughput no yes
ERR3_HUMAN [view interactions] Low throughput no yes
CBX4_HUMAN [view interactions] Low throughput no yes
EP300_HUMAN [view interactions] Low throughput no yes
HIF1A_HUMAN [view interactions] Low throughput no no
USPL1_HUMAN [view interactions] Low throughput no yes
KCNA5_HUMAN [view interactions] Low throughput no no
NPM_HUMAN [view entry] [view interactions] Low throughput yes yes
RNF4_HUMAN [view interactions] Low throughput no yes
SP100_HUMAN [view interactions] Low throughput no no
DESI1_HUMAN [view interactions] Low throughput no yes
SENP6_HUMAN [view entry] [view interactions] Low throughput yes yes
SENP1_HUMAN [view entry] [view interactions] Low throughput yes no
PIAS2_HUMAN [view interactions] Low throughput no yes
TYDP2_HUMAN [view interactions] Low throughput no no
UBP25_HUMAN [view interactions] Low throughput no yes
TDG_HUMAN [view interactions] Low throughput no yes
CAF1A_HUMAN [view interactions] Low throughput no yes
GLI2_HUMAN [view interactions] Low throughput no yes
SAE2_HUMAN [view interactions] Low throughput no yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
SUMO3_HUMAN [view entry] [view interactions] Low throughput yes yes
HNRPM_HUMAN [view entry] [view interactions] High throughput yes yes
RL6_HUMAN [view entry] [view interactions] High throughput yes yes
FSCN1_HUMAN [view entry] [view interactions] High throughput yes yes
TIF1B_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
FLNC_HUMAN [view entry] [view interactions] High throughput yes no
PLCB1_HUMAN [view entry] [view interactions] High throughput yes yes
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
EWS_HUMAN [view interactions] High throughput no yes
GABP1_HUMAN [view interactions] High throughput no yes
RENT1_HUMAN [view entry] [view interactions] High throughput yes yes
GT2D1_HUMAN [view interactions] High throughput no yes
INT7_HUMAN [view interactions] High throughput no no
TBC14_HUMAN [view interactions] High throughput no yes
ARC_HUMAN [view entry] [view interactions] High throughput yes no
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
ESR2_HUMAN [view interactions] High throughput no no
RN123_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
NR2C2_HUMAN [view interactions] High throughput no yes
TIP_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
SUMO2_HUMAN [view entry] [view interactions] High throughput yes yes
CARM1_HUMAN [view interactions] High throughput no yes
SHIP2_HUMAN [view interactions] High throughput no yes
ACTN2_HUMAN [view entry] [view interactions] High throughput yes yes
RAN_HUMAN [view entry] [view interactions] High throughput yes no
RANG_HUMAN [view interactions] High throughput no no
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
MIDN_HUMAN [view interactions] High throughput no no
CSK_HUMAN [view interactions] High throughput no yes
PIAS3_HUMAN [view entry] [view interactions] High throughput yes yes
NC2A_HUMAN [view interactions] High throughput no yes
ALDOB_HUMAN [view interactions] High throughput no no
ECHM_HUMAN [view interactions] High throughput no yes
INO1_HUMAN [view interactions] High throughput no no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
PLPHP_HUMAN [view interactions] High throughput no yes
SC23B_HUMAN [view interactions] High throughput no yes
DYLT1_HUMAN [view interactions] High throughput no no
ENOG_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP2_HUMAN [view interactions] High throughput no yes
MTAP_HUMAN [view interactions] High throughput no no
PFKAM_HUMAN [view entry] [view interactions] High throughput yes yes
6PGD_HUMAN [view entry] [view interactions] High throughput yes no
RD23A_HUMAN [view interactions] High throughput no yes
RD23B_HUMAN [view interactions] High throughput no yes
SC23A_HUMAN [view entry] [view interactions] High throughput yes yes
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
UFD1_HUMAN [view interactions] High throughput no no
PIAS4_HUMAN [view interactions] High throughput no yes
TAGL2_HUMAN [view entry] [view interactions] High throughput yes no
ANXA7_HUMAN [view entry] [view interactions] High throughput yes yes
TAGL3_HUMAN [view entry] [view interactions] High throughput yes yes
CDN1A_HUMAN [view interactions] High throughput no no
UCHL3_HUMAN [view interactions] High throughput no yes
MAPK3_HUMAN [view interactions] High throughput no no
CCD93_HUMAN [view entry] [view interactions] High throughput yes yes
PFD1_HUMAN [view interactions] High throughput no yes
KDM2B_HUMAN [view interactions] High throughput no no
SMN_HUMAN [view interactions] High throughput no yes
SFXN3_HUMAN [view entry] [view interactions] High throughput yes yes
KITH_HUMAN [view interactions] High throughput no yes
H31_HUMAN [view interactions] High throughput no yes
TTHY_HUMAN [view interactions] High throughput no no
UBE3A_HUMAN [view entry] [view interactions] High throughput yes yes
SAE1_HUMAN [view entry] [view interactions] High throughput yes yes
ITPR2_HUMAN [view interactions] High throughput no yes
RCC2_HUMAN [view interactions] High throughput no no
XIAP_HUMAN [view interactions] High throughput no yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
UTP15_HUMAN [view interactions] High throughput no no
RM18_HUMAN [view interactions] High throughput no yes
SMC1A_HUMAN [view interactions] High throughput no yes
RT35_HUMAN [view interactions] High throughput no yes
EXOC3_HUMAN [view entry] [view interactions] High throughput yes no
RPAB2_HUMAN [view interactions] High throughput no yes
CAV1_HUMAN [view interactions] High throughput no no
SYDE2_HUMAN [view interactions] High throughput no no
ARI1B_HUMAN [view interactions] High throughput no yes
SNUT1_HUMAN [view interactions] High throughput no yes
CHD8_HUMAN [view interactions] High throughput no no
STOM_HUMAN [view entry] [view interactions] High throughput yes yes
PPB1_HUMAN [view interactions] High throughput no no
H2B2E_HUMAN [view interactions] High throughput no yes
ZN106_HUMAN [view interactions] High throughput no no
RAGP1_HUMAN [view entry] [view interactions] High throughput yes yes
DHX30_HUMAN [view entry] [view interactions] High throughput yes yes
BEND3_HUMAN [view interactions] High throughput no yes
ASCC3_HUMAN [view interactions] High throughput no yes
ATX2L_HUMAN [view interactions] High throughput no no
RBM33_HUMAN [view interactions] High throughput no yes
NCOR2_HUMAN [view interactions] High throughput no yes
FABD_HUMAN [view interactions] High throughput no yes
FA98A_HUMAN [view interactions] High throughput no no
PML_HUMAN [view interactions] High throughput no yes
NUFP2_HUMAN [view interactions] High throughput no no
DDB2_HUMAN [view interactions] High throughput no yes
RLF_HUMAN [view interactions] High throughput no no
HELZ_HUMAN [view interactions] High throughput no yes
ODO1_HUMAN [view entry] [view interactions] High throughput yes yes
PBIP1_HUMAN [view entry] [view interactions] High throughput yes no
AMRP_HUMAN [view interactions] High throughput no yes
MEIS1_HUMAN [view interactions] High throughput no no
TSR1_HUMAN [view interactions] High throughput no no
ATX2_HUMAN [view interactions] High throughput no yes
ZBT39_HUMAN [view interactions] High throughput no yes
ZN496_HUMAN [view interactions] High throughput no no
KAISO_HUMAN [view interactions] High throughput no yes
ZCH12_HUMAN [view interactions] High throughput no yes
F221A_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ATX1_HUMAN [view interactions] High throughput no yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
NEDD8_HUMAN [view entry] [view interactions] High throughput yes yes
RBP2_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
PCGF2_HUMAN [view interactions] High throughput no no
PAX6_HUMAN [view interactions] High throughput no no
PIAS1_HUMAN [view entry] [view interactions] High throughput yes yes
ZN451_HUMAN [view entry] [view interactions] High throughput yes no
ZMYM2_HUMAN [view interactions] High throughput no yes
RU17_HUMAN [view interactions] High throughput no yes
MORC3_HUMAN [view interactions] High throughput no yes
ARIP4_HUMAN [view interactions] High throughput no yes
HIPK1_HUMAN [view interactions] High throughput no no
RENT2_HUMAN [view interactions] High throughput no no
CIP1_HUMAN [view interactions] High throughput no no
HOMEZ_HUMAN [view interactions] High throughput no no
ALDR_HUMAN [view interactions] High throughput no no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
RUNX1_HUMAN [view interactions] High throughput no yes
SERPH_HUMAN [view interactions] High throughput no no
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
PP2AA_HUMAN [view entry] [view interactions] High throughput yes yes
ACTS_HUMAN [view interactions] High throughput no no
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
IF2A_HUMAN [view entry] [view interactions] High throughput yes yes
SOX10_HUMAN [view interactions] High throughput no yes
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
NOP58_HUMAN [view interactions] High throughput no yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
SAFB1_HUMAN [view interactions] High throughput no yes
RS14_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
ANM1_HUMAN [view interactions] High throughput no yes
MOES_HUMAN [view entry] [view interactions] High throughput yes no
GNAI2_HUMAN [view entry] [view interactions] High throughput yes yes
MSH2_HUMAN [view interactions] High throughput no yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC2_HUMAN [view entry] [view interactions] High throughput yes yes
NFL_HUMAN [view entry] [view interactions] High throughput yes yes
IMPA1_HUMAN [view entry] [view interactions] High throughput yes yes
PGAM1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB14_HUMAN [view entry] [view interactions] High throughput yes yes
RACK1_HUMAN [view interactions] High throughput no yes
XPP1_HUMAN [view interactions] High throughput no yes
ZHX1_HUMAN [view interactions] High throughput no no
GBP2_HUMAN [view interactions] High throughput no yes
NACC1_HUMAN [view interactions] High throughput no yes
HSP74_HUMAN [view entry] [view interactions] High throughput yes yes
GSTP1_HUMAN [view entry] [view interactions] High throughput yes no
HNRPF_HUMAN [view interactions] High throughput no yes
TBB5_HUMAN [view interactions] High throughput no yes
EF1A1_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
RL3_HUMAN [view entry] [view interactions] High throughput yes yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
PGK1_HUMAN [view entry] [view interactions] High throughput yes yes
GDIB_HUMAN [view entry] [view interactions] High throughput yes yes
ATPA_HUMAN [view interactions] High throughput no yes
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
MDHM_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
K2C5_HUMAN [view entry] [view interactions] High throughput yes no
DX39B_HUMAN [view interactions] High throughput no no
TCPE_HUMAN [view entry] [view interactions] High throughput yes yes
EF1G_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3D_HUMAN [view interactions] High throughput no yes
RAP1A_HUMAN [view entry] [view interactions] High throughput yes no
RAP1B_HUMAN [view entry] [view interactions] High throughput yes no
ATPB_HUMAN [view interactions] High throughput no yes
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
SYTC_HUMAN [view interactions] High throughput no yes
GDIR1_HUMAN [view entry] [view interactions] High throughput yes yes
COPD_HUMAN [view entry] [view interactions] High throughput yes yes
K1C10_HUMAN [view interactions] High throughput no no
RS3_HUMAN [view entry] [view interactions] High throughput yes yes
KIF22_HUMAN [view interactions] High throughput no no
SUMO1_HUMAN [view entry] [view interactions] High throughput yes yes
NUP93_HUMAN [view interactions] High throughput no yes
CAP1_HUMAN [view entry] [view interactions] High throughput yes yes
NONO_HUMAN [view interactions] High throughput no yes
ZBT38_HUMAN [view interactions] High throughput no no
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
MATR3_HUMAN [view interactions] High throughput no yes
HNRH2_HUMAN [view entry] [view interactions] High throughput yes yes
UBA1_HUMAN [view entry] [view interactions] High throughput yes yes
WDR1_HUMAN [view entry] [view interactions] High throughput yes yes
IDHP_HUMAN [view entry] [view interactions] High throughput yes yes
SYWC_HUMAN [view interactions] High throughput no yes
RL11_HUMAN [view entry] [view interactions] High throughput yes yes
ACTN4_HUMAN [view entry] [view interactions] High throughput yes yes
GTF2I_HUMAN [view interactions] High throughput no yes
IF6_HUMAN [view interactions] High throughput no yes
TBB2B_HUMAN [view entry] [view interactions] High throughput yes yes
K2C1_HUMAN [view interactions] High throughput no no
THOP1_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
GBB1_HUMAN [view entry] [view interactions] High throughput yes yes
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
NFAT5_HUMAN [view interactions] High throughput no yes