Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SENP7_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation . Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SENP7_HUMAN
GO:0044389 ubiquitin-like protein ligase binding 33.3333 4 no
GO:0005509 calcium ion binding 33.3333 6 no
GO:0043169 cation binding 33.3333 4 no
GO:0046872 metal ion binding 33.3333 5 no
GO:0003723 RNA binding 33.3333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SENP7_HUMAN
GO:0031323 regulation of cellular metabolic process 66.6667 4 no
GO:0031326 regulation of cellular biosynthetic process 66.6667 5 no
GO:0048522 positive regulation of cellular process 66.6667 4 no
GO:0051252 regulation of RNA metabolic process 66.6667 5 no
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 no
GO:0080090 regulation of primary metabolic process 66.6667 4 no
GO:0018193 peptidyl-amino acid modification 66.6667 5 yes
GO:0036211 protein modification process 66.6667 4 yes
GO:0043412 macromolecule modification 66.6667 4 yes
GO:0009889 regulation of biosynthetic process 66.6667 4 no
GO:0009893 positive regulation of metabolic process 66.6667 4 no
GO:0010468 regulation of gene expression 66.6667 6 no
GO:0010556 regulation of macromolecule biosynthetic process 66.6667 5 no
GO:0010604 positive regulation of macromolecule metabolic process 66.6667 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 66.6667 5 no
GO:0032496 response to lipopolysaccharide 50.0000 4 no
GO:0033993 response to lipid 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0051247 positive regulation of protein metabolic process 50.0000 6 no
GO:2001141 regulation of RNA biosynthetic process 50.0000 6 no
GO:0009891 positive regulation of biosynthetic process 50.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 50.0000 6 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 50.0000 6 no
GO:0018205 peptidyl-lysine modification 50.0000 6 yes
GO:0043687 post-translational protein modification 50.0000 5 yes
GO:0070647 protein modification by small protein conjugation or removal 50.0000 6 yes
GO:0002237 response to molecule of bacterial origin 50.0000 4 no
GO:0006355 regulation of DNA-templated transcription 50.0000 7 no
GO:0030162 regulation of proteolysis 33.3333 6 no
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0032101 regulation of response to external stimulus 33.3333 4 no
GO:0042981 regulation of apoptotic process 33.3333 5 no
GO:0043065 positive regulation of apoptotic process 33.3333 6 no
GO:0043067 regulation of programmed cell death 33.3333 4 no
GO:0043068 positive regulation of programmed cell death 33.3333 5 no
GO:0045862 positive regulation of proteolysis 33.3333 7 no
GO:0045927 positive regulation of growth 33.3333 4 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:1902533 positive regulation of intracellular signal transduction 33.3333 6 no
GO:0002064 epithelial cell development 33.3333 4 no
GO:0006996 organelle organization 33.3333 4 no
GO:0009894 regulation of catabolic process 33.3333 4 no
GO:0010001 glial cell differentiation 33.3333 4 no
GO:0010243 response to organonitrogen compound 33.3333 4 no
GO:0010628 positive regulation of gene expression 33.3333 7 no
GO:0010712 regulation of collagen metabolic process 33.3333 4 no
GO:0030030 cell projection organization 33.3333 4 no
GO:0031175 neuron projection development 33.3333 6 no
GO:0032495 response to muramyl dipeptide 33.3333 4 no
GO:0032965 regulation of collagen biosynthetic process 33.3333 5 no
GO:0048523 negative regulation of cellular process 33.3333 4 no
GO:0048708 astrocyte differentiation 33.3333 5 no
GO:0051129 negative regulation of cellular component organization 33.3333 5 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0120036 plasma membrane bounded cell projection organization 33.3333 5 no
GO:0006357 regulation of transcription by RNA polymerase II 33.3333 8 no
GO:0045893 positive regulation of DNA-templated transcription 33.3333 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0045944 positive regulation of transcription by RNA polymerase II 33.3333 9 no
GO:0051254 positive regulation of RNA metabolic process 33.3333 6 no
GO:1902680 positive regulation of RNA biosynthetic process 33.3333 7 no
GO:0140546 defense response to symbiont 33.3333 4 yes
GO:0016925 protein sumoylation 33.3333 7 no
GO:0032446 protein modification by small protein conjugation 33.3333 7 no
GO:0006915 apoptotic process 33.3333 4 no
GO:0006954 inflammatory response 33.3333 4 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010646 regulation of cell communication 33.3333 4 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0010975 regulation of neuron projection development 33.3333 7 no
GO:0014002 astrocyte development 33.3333 5 no
GO:0021782 glial cell development 33.3333 4 no
GO:0023056 positive regulation of signaling 33.3333 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CBX5_HUMAN [view interactions] Low throughput no yes
TIF1B_HUMAN [view interactions] Low throughput no yes
CBX1_HUMAN [view interactions] Low throughput no yes
CBX3_HUMAN [view interactions] Low throughput no yes
SPOP_HUMAN [view interactions] Low throughput no no
SUMO2_HUMAN [view entry] [view interactions] Low throughput yes yes
SUMO3_HUMAN [view entry] [view interactions] Low throughput yes yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
BCL6_HUMAN [view interactions] High throughput no no
RBBP4_HUMAN [view interactions] High throughput no yes
CYTA_HUMAN [view interactions] High throughput no no
ML12B_HUMAN [view interactions] High throughput no no
AHDC1_HUMAN [view interactions] High throughput no yes
CHAP1_HUMAN [view interactions] High throughput no yes
SETB2_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
ZCH18_HUMAN [view interactions] High throughput no yes
SIAH2_HUMAN [view interactions] High throughput no no
NOTC1_HUMAN [view entry] [view interactions] High throughput yes yes
PLK1_HUMAN [view interactions] High throughput no yes
BIRC2_HUMAN [view interactions] High throughput no yes
CARD9_HUMAN [view interactions] High throughput no no
S10A9_HUMAN [view entry] [view interactions] High throughput yes no
SP110_HUMAN [view interactions] High throughput no no
TULP3_HUMAN [view interactions] High throughput no yes
DX39A_HUMAN [view interactions] High throughput no yes
DAXX_HUMAN [view interactions] High throughput no yes
ZCH10_HUMAN [view interactions] High throughput no yes
H2B2E_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
H33_HUMAN [view interactions] High throughput no yes
H31_HUMAN [view interactions] High throughput no yes