S10A9_HUMAN
Evidence for PS localization
Functions
S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism (PubMed, PubMed, PubMed). Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions (PubMed, PubMed, PubMed). The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase (PubMed, PubMed). Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX (PubMed, PubMed). The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities (PubMed, PubMed). Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration (PubMed, PubMed). Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER) (PubMed). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade (PubMed, PubMed). Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth (PubMed). Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3 (PubMed). Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK (PubMed). Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants (PubMed, PubMed). Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread (PubMed). Has transnitrosylase activity; in oxidatively-modified low-densitity lipoprotein (LDL(ox))-induced S-nitrosylation of GAPDH on Cys-247 proposed to transfer the NO moiety from NOS2/iNOS to GAPDH via its own S-nitrosylated Cys-3 (PubMed). The iNOS-S100A8/A9 transnitrosylase complex is proposed to also direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in S10A9_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 25.0000 | 4 | yes |
| GO:0003723 | RNA binding | 21.1538 | 4 | no |
| GO:0005509 | calcium ion binding | 17.3077 | 5 | yes |
| GO:0015631 | tubulin binding | 17.3077 | 4 | yes |
| GO:0008017 | microtubule binding | 13.4615 | 5 | yes |
| GO:0008270 | zinc ion binding | 13.4615 | 6 | yes |
| GO:0046914 | transition metal ion binding | 13.4615 | 5 | yes |
| GO:0031406 | carboxylic acid binding | 5.7692 | 4 | yes |
| GO:0035325 | Toll-like receptor binding | 5.7692 | 4 | yes |
| GO:0050786 | RAGE receptor binding | 5.7692 | 4 | yes |
| GO:0033293 | monocarboxylic acid binding | 3.8462 | 5 | yes |
| GO:0035662 | Toll-like receptor 4 binding | 3.8462 | 5 | yes |
| GO:0036041 | long-chain fatty acid binding | 3.8462 | 4 | yes |
| GO:0050542 | icosanoid binding | 3.8462 | 5 | yes |
| GO:0050543 | icosatetraenoic acid binding | 3.8462 | 5 | yes |
| GO:0050544 | arachidonic acid binding | 3.8462 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in S10A9_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 59.6154 | 4 | yes |
| GO:0010646 | regulation of cell communication | 53.8462 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 53.8462 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 53.8462 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 53.8462 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 51.9231 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 48.0769 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 48.0769 | 4 | yes |
| GO:0010468 | regulation of gene expression | 46.1538 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 42.3077 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 42.3077 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 40.3846 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 40.3846 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 40.3846 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.5385 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 36.5385 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 36.5385 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 36.5385 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 36.5385 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 36.5385 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 36.5385 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 36.5385 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 34.6154 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 34.6154 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 34.6154 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 32.6923 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 32.6923 | 4 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 32.6923 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 32.6923 | 6 | yes |
| GO:0006996 | organelle organization | 32.6923 | 4 | no |
| GO:0022607 | cellular component assembly | 32.6923 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 32.6923 | 6 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 30.7692 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 28.8462 | 5 | yes |
| GO:0010941 | regulation of cell death | 28.8462 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 26.9231 | 5 | yes |
| GO:0036211 | protein modification process | 26.9231 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 26.9231 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 26.9231 | 5 | yes |
| GO:0043412 | macromolecule modification | 26.9231 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 26.9231 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.0769 | 6 | yes |
| GO:0009894 | regulation of catabolic process | 23.0769 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.0769 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 23.0769 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.0769 | 5 | no |
| GO:0071310 | cellular response to organic substance | 23.0769 | 4 | no |
| GO:0010942 | positive regulation of cell death | 21.1538 | 5 | yes |
| GO:0030162 | regulation of proteolysis | 21.1538 | 6 | yes |
| GO:0043085 | positive regulation of catalytic activity | 21.1538 | 4 | yes |
| GO:0080134 | regulation of response to stress | 21.1538 | 4 | yes |
| GO:0031329 | regulation of cellular catabolic process | 21.1538 | 5 | no |
| GO:0031399 | regulation of protein modification process | 21.1538 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.1538 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.1538 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.1538 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 21.1538 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.1538 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.1538 | 4 | no |
| GO:0008104 | protein localization | 21.1538 | 4 | no |
| GO:0043065 | positive regulation of apoptotic process | 19.2308 | 7 | yes |
| GO:0043068 | positive regulation of programmed cell death | 19.2308 | 6 | yes |
| GO:0051336 | regulation of hydrolase activity | 19.2308 | 4 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 19.2308 | 6 | yes |
| GO:0032101 | regulation of response to external stimulus | 17.3077 | 4 | yes |
| GO:0033993 | response to lipid | 17.3077 | 4 | yes |
| GO:0031347 | regulation of defense response | 15.3846 | 5 | yes |
| GO:0052547 | regulation of peptidase activity | 15.3846 | 5 | yes |
| GO:0052548 | regulation of endopeptidase activity | 15.3846 | 6 | yes |
| GO:0006915 | apoptotic process | 15.3846 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 13.4615 | 5 | yes |
| GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 13.4615 | 8 | yes |
| GO:0045862 | positive regulation of proteolysis | 13.4615 | 7 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 13.4615 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 13.4615 | 6 | yes |
| GO:2000116 | regulation of cysteine-type endopeptidase activity | 13.4615 | 7 | yes |
| GO:2001233 | regulation of apoptotic signaling pathway | 13.4615 | 5 | yes |
| GO:0010950 | positive regulation of endopeptidase activity | 11.5385 | 7 | yes |
| GO:0010952 | positive regulation of peptidase activity | 11.5385 | 6 | yes |
| GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 11.5385 | 9 | yes |
| GO:0045927 | positive regulation of growth | 11.5385 | 4 | yes |
| GO:0050727 | regulation of inflammatory response | 11.5385 | 5 | yes |
| GO:2001056 | positive regulation of cysteine-type endopeptidase activity | 11.5385 | 8 | yes |
| GO:0001558 | regulation of cell growth | 11.5385 | 4 | yes |
| GO:0030307 | positive regulation of cell growth | 9.6154 | 5 | yes |
| GO:0031346 | positive regulation of cell projection organization | 9.6154 | 6 | yes |
| GO:0032103 | positive regulation of response to external stimulus | 9.6154 | 5 | yes |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity | 9.6154 | 4 | yes |
| GO:2001235 | positive regulation of apoptotic signaling pathway | 9.6154 | 6 | yes |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 9.6154 | 10 | yes |
| GO:0010975 | regulation of neuron projection development | 7.6923 | 7 | yes |
| GO:0031349 | positive regulation of defense response | 7.6923 | 5 | yes |
| GO:0032496 | response to lipopolysaccharide | 7.6923 | 4 | yes |
| GO:0042742 | defense response to bacterium | 7.6923 | 4 | yes |
| GO:0050729 | positive regulation of inflammatory response | 7.6923 | 6 | yes |
| GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 7.6923 | 5 | yes |
| GO:2001242 | regulation of intrinsic apoptotic signaling pathway | 7.6923 | 6 | yes |
| GO:0002237 | response to molecule of bacterial origin | 7.6923 | 4 | yes |
| GO:0017014 | protein nitrosylation | 5.7692 | 5 | yes |
| GO:0018119 | peptidyl-cysteine S-nitrosylation | 5.7692 | 6 | yes |
| GO:0018193 | peptidyl-amino acid modification | 5.7692 | 5 | yes |
| GO:0018198 | peptidyl-cysteine modification | 5.7692 | 6 | yes |
| GO:0019730 | antimicrobial humoral response | 5.7692 | 4 | yes |
| GO:0035606 | peptidyl-cysteine S-trans-nitrosylation | 5.7692 | 7 | yes |
| GO:0050832 | defense response to fungus | 5.7692 | 4 | yes |
| GO:0060326 | cell chemotaxis | 5.7692 | 4 | yes |
| GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 5.7692 | 5 | yes |
| GO:0010976 | positive regulation of neuron projection development | 3.8462 | 7 | yes |
| GO:0014002 | astrocyte development | 3.8462 | 5 | yes |
| GO:0021782 | glial cell development | 3.8462 | 4 | yes |
| GO:0030593 | neutrophil chemotaxis | 3.8462 | 5 | yes |
| GO:0045113 | regulation of integrin biosynthetic process | 3.8462 | 6 | yes |
| GO:0070486 | leukocyte aggregation | 3.8462 | 5 | yes |
| GO:0070488 | neutrophil aggregation | 3.8462 | 6 | yes |
| GO:0071621 | granulocyte chemotaxis | 3.8462 | 4 | yes |
| GO:0097530 | granulocyte migration | 3.8462 | 4 | yes |
| GO:1990266 | neutrophil migration | 3.8462 | 5 | yes |
| GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway | 3.8462 | 7 | yes |
| GO:0002544 | chronic inflammatory response | 3.8462 | 5 | yes |
| GO:0006954 | inflammatory response | 3.8462 | 4 | yes |
| GO:0007159 | leukocyte cell-cell adhesion | 3.8462 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in S10A9_HUMAN |
|---|---|---|---|---|
| DOID:0050686 | organ system cancer | 5.7692 | 3 | no |
| DOID:331 | central nervous system disease | 3.8462 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NCF2_HUMAN | [view interactions] | Low throughput | no | no |
| TBB5_HUMAN | [view interactions] | Low throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MK14_HUMAN | [view interactions] | Low throughput | no | yes |
| S10A8_HUMAN | [view interactions] | Low throughput | no | no |
| S10A9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NOS2_HUMAN | [view interactions] | Low throughput | no | yes |
| CD33_HUMAN | [view interactions] | Low throughput | no | no |
| SPR2E_HUMAN | [view interactions] | High throughput | no | no |
| RL36_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROL4_HUMAN | [view interactions] | High throughput | no | no |
| A1AT_HUMAN | [view interactions] | High throughput | no | no |
| ARNT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIP_HUMAN | [view interactions] | High throughput | no | no |
| MARH2_HUMAN | [view interactions] | High throughput | no | yes |
| MARH4_HUMAN | [view interactions] | High throughput | no | yes |
| RNF5_HUMAN | [view interactions] | High throughput | no | yes |
| RN170_HUMAN | [view interactions] | High throughput | no | yes |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
| OR2A4_HUMAN | [view interactions] | High throughput | no | no |
| TTC4_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TREX2_HUMAN | [view interactions] | High throughput | no | no |
| TT39A_HUMAN | [view interactions] | High throughput | no | yes |
| GNPAT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX17_HUMAN | [view interactions] | High throughput | no | yes |
| GPT2L_HUMAN | [view interactions] | High throughput | no | yes |
| SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
| DSCR6_HUMAN | [view interactions] | High throughput | no | no |
| ELOA2_HUMAN | [view interactions] | High throughput | no | yes |
| STK11_HUMAN | [view interactions] | High throughput | no | yes |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| PCYOX_HUMAN | [view interactions] | High throughput | no | yes |
| TEFM_HUMAN | [view interactions] | High throughput | no | no |
| GABPA_HUMAN | [view interactions] | High throughput | no | no |
| TSN6_HUMAN | [view interactions] | High throughput | no | yes |
| EGFL8_HUMAN | [view interactions] | High throughput | no | no |
| ERCC3_HUMAN | [view interactions] | High throughput | no | yes |
| KLK10_HUMAN | [view interactions] | High throughput | no | no |
| 5NT1A_HUMAN | [view interactions] | High throughput | no | yes |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| EPAB2_HUMAN | [view interactions] | High throughput | no | no |
| APTX_HUMAN | [view interactions] | High throughput | no | yes |
| PIGT_HUMAN | [view interactions] | High throughput | no | no |
| DKK2_HUMAN | [view interactions] | High throughput | no | no |
| PLCA_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BE_HUMAN | [view interactions] | High throughput | no | yes |
| MMTA2_HUMAN | [view interactions] | High throughput | no | yes |
| SARAF_HUMAN | [view interactions] | High throughput | no | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UPK1A_HUMAN | [view interactions] | High throughput | no | no |
| CCNC_HUMAN | [view interactions] | High throughput | no | yes |
| SSUH2_HUMAN | [view interactions] | High throughput | no | no |
| NUDT3_HUMAN | [view interactions] | High throughput | no | yes |
| SH23A_HUMAN | [view interactions] | High throughput | no | no |
| PHF11_HUMAN | [view interactions] | High throughput | no | no |
| GPN1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN550_HUMAN | [view interactions] | High throughput | no | yes |
| CR021_HUMAN | [view interactions] | High throughput | no | no |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| NALP7_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TF3C1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| U2AF1_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B6_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA5_HUMAN | [view interactions] | High throughput | no | yes |
| SNUT1_HUMAN | [view interactions] | High throughput | no | yes |
| TR150_HUMAN | [view interactions] | High throughput | no | yes |
| IF4A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOP1_HUMAN | [view interactions] | High throughput | no | yes |
| CD2B2_HUMAN | [view interactions] | High throughput | no | yes |
| TRA2A_HUMAN | [view interactions] | High throughput | no | yes |
| TRA2B_HUMAN | [view interactions] | High throughput | no | yes |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| VTNC_HUMAN | [view interactions] | High throughput | no | no |
| SAP18_HUMAN | [view interactions] | High throughput | no | yes |
| UT14A_HUMAN | [view interactions] | High throughput | no | yes |
| TPBG_HUMAN | [view interactions] | High throughput | no | yes |
| SRRT_HUMAN | [view interactions] | High throughput | no | yes |
| SP16H_HUMAN | [view interactions] | High throughput | no | yes |
| DHX15_HUMAN | [view interactions] | High throughput | no | yes |
| NICA_HUMAN | [view interactions] | High throughput | no | yes |
| SON_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF5_HUMAN | [view interactions] | High throughput | no | yes |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| SRSF7_HUMAN | [view interactions] | High throughput | no | yes |
| SSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF3_HUMAN | [view interactions] | High throughput | no | yes |
| ZN326_HUMAN | [view interactions] | High throughput | no | yes |
| ACINU_HUMAN | [view interactions] | High throughput | no | yes |
| PSRC1_HUMAN | [view interactions] | High throughput | no | no |
| CPLX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSB7_HUMAN | [view interactions] | High throughput | no | yes |
| DEK_HUMAN | [view interactions] | High throughput | no | yes |
| SRS11_HUMAN | [view interactions] | High throughput | no | yes |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| TOP2B_HUMAN | [view interactions] | High throughput | no | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| RL18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SURF4_HUMAN | [view interactions] | High throughput | no | yes |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LC7L3_HUMAN | [view interactions] | High throughput | no | yes |
| RANB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| AFAD_HUMAN | [view interactions] | High throughput | no | yes |
| TLE3_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP2_HUMAN | [view interactions] | High throughput | no | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| PCOC1_HUMAN | [view interactions] | High throughput | no | yes |
| DEST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL1D1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX21_HUMAN | [view interactions] | High throughput | no | yes |
| COMD1_HUMAN | [view interactions] | High throughput | no | yes |
| TPR_HUMAN | [view interactions] | High throughput | no | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| NUBP2_HUMAN | [view interactions] | High throughput | no | yes |
| TRUB1_HUMAN | [view interactions] | High throughput | no | no |
| SNX4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| PPME1_HUMAN | [view interactions] | High throughput | no | yes |
| RL39_HUMAN | [view interactions] | High throughput | no | no |
| STRN3_HUMAN | [view interactions] | High throughput | no | yes |
| OCAD2_HUMAN | [view interactions] | High throughput | no | yes |
| ATG5_HUMAN | [view interactions] | High throughput | no | no |
| ITBP1_HUMAN | [view interactions] | High throughput | no | no |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPCS2_HUMAN | [view interactions] | High throughput | no | yes |
| K1109_HUMAN | [view interactions] | High throughput | no | yes |
| SCAFB_HUMAN | [view interactions] | High throughput | no | yes |
| ZN737_HUMAN | [view interactions] | High throughput | no | no |
| GDIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARID2_HUMAN | [view interactions] | High throughput | no | no |
| DHX30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTN4R_HUMAN | [view interactions] | High throughput | no | no |
| RL12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOMO3_HUMAN | [view interactions] | High throughput | no | yes |
| RBP10_HUMAN | [view interactions] | High throughput | no | no |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIPB_HUMAN | [view interactions] | High throughput | no | yes |
| SRS10_HUMAN | [view interactions] | High throughput | no | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| ANF_HUMAN | [view interactions] | High throughput | no | no |
| PI4KA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TB22B_HUMAN | [view interactions] | High throughput | no | no |
| ZIC1_HUMAN | [view interactions] | High throughput | no | yes |
| SHCAF_HUMAN | [view interactions] | High throughput | no | yes |
| AIRE_HUMAN | [view interactions] | High throughput | no | no |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| CNR2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| HTRA4_HUMAN | [view interactions] | High throughput | no | no |
| RYK_HUMAN | [view interactions] | High throughput | no | no |
| USF2_HUMAN | [view interactions] | High throughput | no | no |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| PAK5_HUMAN | [view interactions] | High throughput | no | yes |
| TAGL_HUMAN | [view interactions] | High throughput | no | no |
| NUAK1_HUMAN | [view interactions] | High throughput | no | no |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD177_HUMAN | [view interactions] | High throughput | no | no |
| S100B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAGA1_HUMAN | [view interactions] | High throughput | no | no |
| MAGA3_HUMAN | [view interactions] | High throughput | no | no |
| MAGA6_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| EPAS1_HUMAN | [view interactions] | High throughput | no | no |
| FXL19_HUMAN | [view interactions] | High throughput | no | no |
| ING4_HUMAN | [view interactions] | High throughput | no | no |
| KDM4A_HUMAN | [view interactions] | High throughput | no | yes |
| PF21B_HUMAN | [view interactions] | High throughput | no | no |
| SMBT1_HUMAN | [view interactions] | High throughput | no | no |
| KMT5A_HUMAN | [view interactions] | High throughput | no | no |
| NSD2_HUMAN | [view interactions] | High throughput | no | yes |
| NAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRPM4_HUMAN | [view interactions] | High throughput | no | no |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| ASB3_HUMAN | [view interactions] | High throughput | no | yes |
| TOPRS_HUMAN | [view interactions] | High throughput | no | yes |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| MET23_HUMAN | [view interactions] | High throughput | no | no |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| ZN207_HUMAN | [view interactions] | High throughput | no | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| SUSD3_HUMAN | [view interactions] | High throughput | no | yes |
| DD19B_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| K1C17_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PPARG_HUMAN | [view interactions] | High throughput | no | yes |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| NFX1_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| SNIP1_HUMAN | [view interactions] | High throughput | no | no |
| DOCK8_HUMAN | [view interactions] | High throughput | no | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| RHG18_HUMAN | [view interactions] | High throughput | no | yes |
| RHG19_HUMAN | [view interactions] | High throughput | no | yes |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG29_HUMAN | [view interactions] | High throughput | no | yes |
| RHG36_HUMAN | [view interactions] | High throughput | no | yes |
| RHG04_HUMAN | [view interactions] | High throughput | no | no |
| ARHGQ_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PKH4B_HUMAN | [view interactions] | High throughput | no | yes |
| VAV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SENP7_HUMAN | [view interactions] | High throughput | no | yes |
| DUX4_HUMAN | [view interactions] | High throughput | no | no |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| S10A7_HUMAN | [view interactions] | High throughput | no | no |
| CYTA_HUMAN | [view interactions] | High throughput | no | no |
| SPB3_HUMAN | [view interactions] | High throughput | no | no |
| CASPE_HUMAN | [view interactions] | High throughput | no | no |
| TRFL_HUMAN | [view interactions] | High throughput | no | no |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RALY_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1_HUMAN | [view interactions] | High throughput | no | yes |
| RL26L_HUMAN | [view interactions] | High throughput | no | yes |
| CALL5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LEG7_HUMAN | [view interactions] | High throughput | no | no |
| SPB4_HUMAN | [view interactions] | High throughput | no | no |
| IRAK1_HUMAN | [view interactions] | Computational | no | yes |
| MYD88_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ANXA5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| TLR4_HUMAN | [view interactions] | Computational | no | yes |
| S10AC_HUMAN | [view interactions] | Computational | no | no |
| TIRAP_HUMAN | [view interactions] | Computational | no | no |
| LY96_HUMAN | [view interactions] | Computational | no | no |