S10A9_HUMAN
Evidence for PS localization
Functions
S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism (PubMed, PubMed, PubMed). Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions (PubMed, PubMed, PubMed). The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase (PubMed, PubMed). Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX (PubMed, PubMed). The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities (PubMed, PubMed). Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration (PubMed, PubMed). Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER) (PubMed). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade (PubMed, PubMed). Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth (PubMed). Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3 (PubMed). Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK (PubMed). Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants (PubMed, PubMed). Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread (PubMed). Has transnitrosylase activity; in oxidatively-modified low-densitity lipoprotein (LDL(ox))-induced S-nitrosylation of GAPDH on Cys-247 proposed to transfer the NO moiety from NOS2/iNOS to GAPDH via its own S-nitrosylated Cys-3 (PubMed). The iNOS-S100A8/A9 transnitrosylase complex is proposed to also direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in S10A9_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 25.8065 | 4 | yes |
| GO:0046872 | metal ion binding | 25.8065 | 5 | yes |
| GO:0043168 | anion binding | 24.1935 | 4 | yes |
| GO:0003723 | RNA binding | 20.9677 | 4 | no |
| GO:0015631 | tubulin binding | 14.5161 | 4 | yes |
| GO:0005509 | calcium ion binding | 12.9032 | 6 | yes |
| GO:0008270 | zinc ion binding | 12.9032 | 7 | yes |
| GO:0046914 | transition metal ion binding | 12.9032 | 6 | yes |
| GO:0008017 | microtubule binding | 11.2903 | 5 | yes |
| GO:0031406 | carboxylic acid binding | 6.4516 | 4 | yes |
| GO:0050786 | RAGE receptor binding | 4.8387 | 4 | yes |
| GO:0033293 | monocarboxylic acid binding | 3.2258 | 5 | yes |
| GO:0035325 | Toll-like receptor binding | 3.2258 | 4 | yes |
| GO:0035662 | Toll-like receptor 4 binding | 3.2258 | 5 | yes |
| GO:0036041 | long-chain fatty acid binding | 3.2258 | 4 | yes |
| GO:0050542 | icosanoid binding | 3.2258 | 5 | yes |
| GO:0050543 | icosatetraenoic acid binding | 3.2258 | 5 | yes |
| GO:0050544 | arachidonic acid binding | 3.2258 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in S10A9_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 59.6774 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 54.8387 | 4 | yes |
| GO:0010646 | regulation of cell communication | 54.8387 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 51.6129 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 51.6129 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 48.3871 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 46.7742 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 46.7742 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 46.7742 | 4 | yes |
| GO:0010468 | regulation of gene expression | 46.7742 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 46.7742 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 45.1613 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 41.9355 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 41.9355 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 40.3226 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 38.7097 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 38.7097 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 38.7097 | 5 | no |
| GO:0022607 | cellular component assembly | 38.7097 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 37.0968 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 35.4839 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 35.4839 | 5 | yes |
| GO:0006996 | organelle organization | 35.4839 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.4839 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 35.4839 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 33.8710 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 33.8710 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 32.2581 | 6 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 32.2581 | 7 | yes |
| GO:0009967 | positive regulation of signal transduction | 32.2581 | 5 | yes |
| GO:0036211 | protein modification process | 29.0323 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 29.0323 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 29.0323 | 4 | yes |
| GO:0043412 | macromolecule modification | 29.0323 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 29.0323 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 29.0323 | 6 | no |
| GO:0043933 | protein-containing complex organization | 29.0323 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 29.0323 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 27.4194 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 27.4194 | 6 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 27.4194 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 27.4194 | 6 | no |
| GO:0008104 | protein localization | 27.4194 | 4 | no |
| GO:0033043 | regulation of organelle organization | 25.8065 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 24.1935 | 6 | yes |
| GO:0080134 | regulation of response to stress | 24.1935 | 4 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 24.1935 | 6 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 24.1935 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 24.1935 | 5 | no |
| GO:0023057 | negative regulation of signaling | 24.1935 | 4 | no |
| GO:0032101 | regulation of response to external stimulus | 22.5806 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 22.5806 | 5 | yes |
| GO:0009894 | regulation of catabolic process | 22.5806 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.5806 | 4 | no |
| GO:0051049 | regulation of transport | 22.5806 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 22.5806 | 5 | no |
| GO:0033993 | response to lipid | 20.9677 | 4 | yes |
| GO:0043068 | positive regulation of programmed cell death | 20.9677 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 20.9677 | 4 | no |
| GO:0031399 | regulation of protein modification process | 20.9677 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.9677 | 5 | no |
| GO:0043065 | positive regulation of apoptotic process | 19.3548 | 6 | yes |
| GO:0030162 | regulation of proteolysis | 17.7419 | 6 | yes |
| GO:0031347 | regulation of defense response | 17.7419 | 5 | yes |
| GO:0043085 | positive regulation of catalytic activity | 17.7419 | 4 | yes |
| GO:0006915 | apoptotic process | 17.7419 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 16.1290 | 5 | yes |
| GO:0051336 | regulation of hydrolase activity | 16.1290 | 4 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 16.1290 | 6 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 16.1290 | 6 | yes |
| GO:2001233 | regulation of apoptotic signaling pathway | 14.5161 | 5 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 12.9032 | 5 | yes |
| GO:0140546 | defense response to symbiont | 12.9032 | 4 | yes |
| GO:2001242 | regulation of intrinsic apoptotic signaling pathway | 12.9032 | 6 | yes |
| GO:0001558 | regulation of cell growth | 12.9032 | 4 | yes |
| GO:0045862 | positive regulation of proteolysis | 11.2903 | 7 | yes |
| GO:0052547 | regulation of peptidase activity | 11.2903 | 5 | yes |
| GO:0052548 | regulation of endopeptidase activity | 11.2903 | 6 | yes |
| GO:0031349 | positive regulation of defense response | 9.6774 | 5 | yes |
| GO:0032103 | positive regulation of response to external stimulus | 9.6774 | 5 | yes |
| GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 9.6774 | 9 | yes |
| GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 9.6774 | 8 | yes |
| GO:0045927 | positive regulation of growth | 9.6774 | 4 | yes |
| GO:0050727 | regulation of inflammatory response | 9.6774 | 5 | yes |
| GO:2000116 | regulation of cysteine-type endopeptidase activity | 9.6774 | 7 | yes |
| GO:2001056 | positive regulation of cysteine-type endopeptidase activity | 9.6774 | 8 | yes |
| GO:0010950 | positive regulation of endopeptidase activity | 9.6774 | 7 | yes |
| GO:0010952 | positive regulation of peptidase activity | 9.6774 | 6 | yes |
| GO:0010975 | regulation of neuron projection development | 9.6774 | 7 | yes |
| GO:0030307 | positive regulation of cell growth | 8.0645 | 5 | yes |
| GO:0031346 | positive regulation of cell projection organization | 8.0645 | 6 | yes |
| GO:2001235 | positive regulation of apoptotic signaling pathway | 8.0645 | 6 | yes |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 8.0645 | 10 | yes |
| GO:0032496 | response to lipopolysaccharide | 6.4516 | 4 | yes |
| GO:0050729 | positive regulation of inflammatory response | 6.4516 | 6 | yes |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity | 6.4516 | 4 | yes |
| GO:0060326 | cell chemotaxis | 6.4516 | 4 | yes |
| GO:0002237 | response to molecule of bacterial origin | 6.4516 | 4 | yes |
| GO:0006954 | inflammatory response | 6.4516 | 4 | yes |
| GO:0018193 | peptidyl-amino acid modification | 6.4516 | 5 | yes |
| GO:0019730 | antimicrobial humoral response | 4.8387 | 4 | yes |
| GO:0021782 | glial cell development | 4.8387 | 4 | yes |
| GO:0035606 | peptidyl-cysteine S-trans-nitrosylation | 4.8387 | 7 | yes |
| GO:0042742 | defense response to bacterium | 4.8387 | 4 | yes |
| GO:0050832 | defense response to fungus | 4.8387 | 4 | yes |
| GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 4.8387 | 5 | yes |
| GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 4.8387 | 5 | yes |
| GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway | 4.8387 | 7 | yes |
| GO:0001667 | ameboidal-type cell migration | 4.8387 | 4 | yes |
| GO:0017014 | protein nitrosylation | 4.8387 | 5 | yes |
| GO:0018119 | peptidyl-cysteine S-nitrosylation | 4.8387 | 6 | yes |
| GO:0018198 | peptidyl-cysteine modification | 4.8387 | 6 | yes |
| GO:0030593 | neutrophil chemotaxis | 3.2258 | 5 | yes |
| GO:0035425 | autocrine signaling | 3.2258 | 4 | yes |
| GO:0043542 | endothelial cell migration | 3.2258 | 6 | yes |
| GO:0045113 | regulation of integrin biosynthetic process | 3.2258 | 6 | yes |
| GO:0070486 | leukocyte aggregation | 3.2258 | 5 | yes |
| GO:0070488 | neutrophil aggregation | 3.2258 | 6 | yes |
| GO:0071621 | granulocyte chemotaxis | 3.2258 | 4 | yes |
| GO:0097530 | granulocyte migration | 3.2258 | 4 | yes |
| GO:1990266 | neutrophil migration | 3.2258 | 5 | yes |
| GO:0002544 | chronic inflammatory response | 3.2258 | 5 | yes |
| GO:0007159 | leukocyte cell-cell adhesion | 3.2258 | 4 | yes |
| GO:0010631 | epithelial cell migration | 3.2258 | 5 | yes |
| GO:0010976 | positive regulation of neuron projection development | 3.2258 | 7 | yes |
| GO:0014002 | astrocyte development | 3.2258 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NCF2_HUMAN | [view interactions] | Low throughput | no | no |
| TBB5_HUMAN | [view interactions] | Low throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MK14_HUMAN | [view interactions] | Low throughput | no | yes |
| S10A8_HUMAN | [view interactions] | Low throughput | no | no |
| S10A9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NOS2_HUMAN | [view interactions] | Low throughput | no | yes |
| METL9_HUMAN | [view interactions] | Low throughput | no | yes |
| CD33_HUMAN | [view interactions] | Low throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| S10A7_HUMAN | [view interactions] | High throughput | no | no |
| CYTA_HUMAN | [view interactions] | High throughput | no | no |
| SPB3_HUMAN | [view interactions] | High throughput | no | no |
| CASPE_HUMAN | [view interactions] | High throughput | no | no |
| TRFL_HUMAN | [view interactions] | High throughput | no | no |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RALY_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1_HUMAN | [view interactions] | High throughput | no | yes |
| RL26L_HUMAN | [view interactions] | High throughput | no | yes |
| CALL5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LEG7_HUMAN | [view interactions] | High throughput | no | no |
| SPB4_HUMAN | [view interactions] | High throughput | no | no |
| SPR2E_HUMAN | [view interactions] | High throughput | no | no |
| RL36_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROL4_HUMAN | [view interactions] | High throughput | no | no |
| A1AT_HUMAN | [view interactions] | High throughput | no | no |
| ARNT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIP_HUMAN | [view interactions] | High throughput | no | no |
| MARH2_HUMAN | [view interactions] | High throughput | no | yes |
| MARH4_HUMAN | [view interactions] | High throughput | no | yes |
| RNF5_HUMAN | [view interactions] | High throughput | no | yes |
| RN170_HUMAN | [view interactions] | High throughput | no | yes |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
| OR2A4_HUMAN | [view interactions] | High throughput | no | no |
| TTC4_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TREX2_HUMAN | [view interactions] | High throughput | no | no |
| TT39A_HUMAN | [view interactions] | High throughput | no | yes |
| GNPAT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX17_HUMAN | [view interactions] | High throughput | no | yes |
| GPT2L_HUMAN | [view interactions] | High throughput | no | yes |
| SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
| DSCR6_HUMAN | [view interactions] | High throughput | no | no |
| ELOA2_HUMAN | [view interactions] | High throughput | no | yes |
| STK11_HUMAN | [view interactions] | High throughput | no | yes |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| PCYOX_HUMAN | [view interactions] | High throughput | no | yes |
| TEFM_HUMAN | [view interactions] | High throughput | no | no |
| GABPA_HUMAN | [view interactions] | High throughput | no | no |
| TSN6_HUMAN | [view interactions] | High throughput | no | yes |
| EGFL8_HUMAN | [view interactions] | High throughput | no | no |
| ERCC3_HUMAN | [view interactions] | High throughput | no | yes |
| KLK10_HUMAN | [view interactions] | High throughput | no | no |
| 5NT1A_HUMAN | [view interactions] | High throughput | no | yes |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| EPAB2_HUMAN | [view interactions] | High throughput | no | no |
| APTX_HUMAN | [view interactions] | High throughput | no | yes |
| PIGT_HUMAN | [view interactions] | High throughput | no | no |
| DKK2_HUMAN | [view interactions] | High throughput | no | no |
| PLCA_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BE_HUMAN | [view interactions] | High throughput | no | yes |
| MMTA2_HUMAN | [view interactions] | High throughput | no | yes |
| SARAF_HUMAN | [view interactions] | High throughput | no | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UPK1A_HUMAN | [view interactions] | High throughput | no | no |
| CCNC_HUMAN | [view interactions] | High throughput | no | yes |
| SSUH2_HUMAN | [view interactions] | High throughput | no | no |
| NUDT3_HUMAN | [view interactions] | High throughput | no | yes |
| SH23A_HUMAN | [view interactions] | High throughput | no | no |
| PHF11_HUMAN | [view interactions] | High throughput | no | no |
| GPN1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN550_HUMAN | [view interactions] | High throughput | no | no |
| CR021_HUMAN | [view interactions] | High throughput | no | no |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| NALP7_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERCC8_HUMAN | [view interactions] | High throughput | no | no |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| LATS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF8_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| LOXL2_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TRI33_HUMAN | [view interactions] | High throughput | no | yes |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| HSF1_HUMAN | [view interactions] | High throughput | no | yes |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| UBP20_HUMAN | [view interactions] | High throughput | no | yes |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TF3C1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| U2AF1_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B6_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA5_HUMAN | [view interactions] | High throughput | no | yes |
| SNUT1_HUMAN | [view interactions] | High throughput | no | yes |
| TR150_HUMAN | [view interactions] | High throughput | no | yes |
| IF4A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOP1_HUMAN | [view interactions] | High throughput | no | yes |
| CD2B2_HUMAN | [view interactions] | High throughput | no | yes |
| TRA2A_HUMAN | [view interactions] | High throughput | no | yes |
| TRA2B_HUMAN | [view interactions] | High throughput | no | yes |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| VTNC_HUMAN | [view interactions] | High throughput | no | no |
| SAP18_HUMAN | [view interactions] | High throughput | no | yes |
| UT14A_HUMAN | [view interactions] | High throughput | no | yes |
| TPBG_HUMAN | [view interactions] | High throughput | no | yes |
| SRRT_HUMAN | [view interactions] | High throughput | no | yes |
| RL18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SP16H_HUMAN | [view interactions] | High throughput | no | yes |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX15_HUMAN | [view interactions] | High throughput | no | yes |
| RANB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NICA_HUMAN | [view interactions] | High throughput | no | yes |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SON_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP2_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF5_HUMAN | [view interactions] | High throughput | no | yes |
| PCOC1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| RL1D1_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF7_HUMAN | [view interactions] | High throughput | no | yes |
| DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| COMD1_HUMAN | [view interactions] | High throughput | no | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| TRUB1_HUMAN | [view interactions] | High throughput | no | no |
| SRSF3_HUMAN | [view interactions] | High throughput | no | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| ZN326_HUMAN | [view interactions] | High throughput | no | yes |
| RL39_HUMAN | [view interactions] | High throughput | no | no |
| ACINU_HUMAN | [view interactions] | High throughput | no | yes |
| OCAD2_HUMAN | [view interactions] | High throughput | no | yes |
| PSRC1_HUMAN | [view interactions] | High throughput | no | no |
| ITBP1_HUMAN | [view interactions] | High throughput | no | no |
| CPLX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSB7_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DEK_HUMAN | [view interactions] | High throughput | no | yes |
| SPCS2_HUMAN | [view interactions] | High throughput | no | yes |
| SRS11_HUMAN | [view interactions] | High throughput | no | yes |
| BLTP1_HUMAN | [view interactions] | High throughput | no | yes |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| SCAFB_HUMAN | [view interactions] | High throughput | no | yes |
| TOP2B_HUMAN | [view interactions] | High throughput | no | yes |
| ZN737_HUMAN | [view interactions] | High throughput | no | no |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| GDIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| ARID2_HUMAN | [view interactions] | High throughput | no | no |
| SURF4_HUMAN | [view interactions] | High throughput | no | yes |
| DHX30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LC7L3_HUMAN | [view interactions] | High throughput | no | yes |
| RTN4R_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| RL12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLE3_HUMAN | [view interactions] | High throughput | no | yes |
| NOMO3_HUMAN | [view interactions] | High throughput | no | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| RBP10_HUMAN | [view interactions] | High throughput | no | no |
| DEST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| TRIPB_HUMAN | [view interactions] | High throughput | no | yes |
| DDX21_HUMAN | [view interactions] | High throughput | no | yes |
| SRS10_HUMAN | [view interactions] | High throughput | no | yes |
| TPR_HUMAN | [view interactions] | High throughput | no | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUBP2_HUMAN | [view interactions] | High throughput | no | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PPME1_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| ANF_HUMAN | [view interactions] | High throughput | no | no |
| FOXO1_HUMAN | [view interactions] | High throughput | no | yes |
| PI4KA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| TB22B_HUMAN | [view interactions] | High throughput | no | no |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| ZIC1_HUMAN | [view interactions] | High throughput | no | yes |
| DCA10_HUMAN | [view interactions] | High throughput | no | no |
| SHCAF_HUMAN | [view interactions] | High throughput | no | yes |
| DCA12_HUMAN | [view interactions] | High throughput | no | yes |
| AIRE_HUMAN | [view interactions] | High throughput | no | no |
| RBBP5_HUMAN | [view interactions] | High throughput | no | yes |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| TP4AP_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| CNR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNF34_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| HTRA4_HUMAN | [view interactions] | High throughput | no | no |
| RYK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| USF2_HUMAN | [view interactions] | High throughput | no | no |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| PAK5_HUMAN | [view interactions] | High throughput | no | yes |
| TAGL_HUMAN | [view interactions] | High throughput | no | no |
| NUAK1_HUMAN | [view interactions] | High throughput | no | no |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD177_HUMAN | [view interactions] | High throughput | no | no |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODFP2_HUMAN | [view interactions] | High throughput | no | no |
| S100B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAGA1_HUMAN | [view interactions] | High throughput | no | no |
| MAGA3_HUMAN | [view interactions] | High throughput | no | no |
| MAGA6_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| EPAS1_HUMAN | [view interactions] | High throughput | no | no |
| FXL19_HUMAN | [view interactions] | High throughput | no | no |
| ING4_HUMAN | [view interactions] | High throughput | no | no |
| KDM4A_HUMAN | [view interactions] | High throughput | no | yes |
| PF21B_HUMAN | [view interactions] | High throughput | no | no |
| SMBT1_HUMAN | [view interactions] | High throughput | no | no |
| KMT5A_HUMAN | [view interactions] | High throughput | no | no |
| NSD2_HUMAN | [view interactions] | High throughput | no | yes |
| NAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRPM4_HUMAN | [view interactions] | High throughput | no | no |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| ASB3_HUMAN | [view interactions] | High throughput | no | yes |
| TOPRS_HUMAN | [view interactions] | High throughput | no | yes |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| MET23_HUMAN | [view interactions] | High throughput | no | no |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| ZN207_HUMAN | [view interactions] | High throughput | no | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| SUSD3_HUMAN | [view interactions] | High throughput | no | yes |
| DD19B_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| K1C17_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PPARG_HUMAN | [view interactions] | High throughput | no | yes |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| NFX1_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| SNIP1_HUMAN | [view interactions] | High throughput | no | no |
| DOCK8_HUMAN | [view interactions] | High throughput | no | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| RHG18_HUMAN | [view interactions] | High throughput | no | yes |
| RHG19_HUMAN | [view interactions] | High throughput | no | yes |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG29_HUMAN | [view interactions] | High throughput | no | yes |
| RHG36_HUMAN | [view interactions] | High throughput | no | yes |
| RHG04_HUMAN | [view interactions] | High throughput | no | no |
| ARHGQ_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PKH4B_HUMAN | [view interactions] | High throughput | no | yes |
| VAV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SENP7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUX4_HUMAN | [view interactions] | High throughput | no | no |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |