Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NAC1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed, PubMed, PubMed). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI003034 LIG_14-3-3_CanoR_1 LIG 388 394 -
ELMI003034 LIG_14-3-3_CanoR_1 LIG 388 394 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NAC1_HUMAN
GO:0043169 cation binding 51.7241 4 yes
GO:0046872 metal ion binding 51.7241 5 yes
GO:0043168 anion binding 41.3793 4 no
GO:0000166 nucleotide binding 34.4828 4 no
GO:0005524 ATP binding 34.4828 5 no
GO:0017076 purine nucleotide binding 34.4828 5 no
GO:0030554 adenyl nucleotide binding 34.4828 6 no
GO:0032555 purine ribonucleotide binding 34.4828 4 no
GO:0032559 adenyl ribonucleotide binding 34.4828 5 no
GO:0035639 purine ribonucleoside triphosphate binding 34.4828 4 no
GO:0005509 calcium ion binding 31.0345 6 yes
GO:0003723 RNA binding 27.5862 4 no
GO:0008324 monoatomic cation transmembrane transporter activity 24.1379 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 24.1379 4 yes
GO:0046873 metal ion transmembrane transporter activity 24.1379 5 yes
GO:0016462 pyrophosphatase activity 24.1379 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 24.1379 4 no
GO:0016887 ATP hydrolysis activity 24.1379 7 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 24.1379 6 no
GO:0022853 active monoatomic ion transmembrane transporter activity 20.6897 4 yes
GO:0015081 sodium ion transmembrane transporter activity 17.2414 6 yes
GO:0015085 calcium ion transmembrane transporter activity 13.7931 6 yes
GO:0005432 calcium:sodium antiporter activity 6.8966 7 yes
GO:0015291 secondary active transmembrane transporter activity 6.8966 4 yes
GO:0015297 antiporter activity 6.8966 5 yes
GO:0015368 calcium:monoatomic cation antiporter activity 6.8966 6 yes
GO:0030506 ankyrin binding 6.8966 4 yes
GO:0140828 metal cation:monoatomic cation antiporter activity 6.8966 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NAC1_HUMAN
GO:0048523 negative regulation of cellular process 68.9655 4 yes
GO:0031323 regulation of cellular metabolic process 62.0690 4 yes
GO:0048522 positive regulation of cellular process 62.0690 4 no
GO:0010646 regulation of cell communication 55.1724 4 yes
GO:0060255 regulation of macromolecule metabolic process 51.7241 4 yes
GO:0080090 regulation of primary metabolic process 51.7241 4 yes
GO:0051049 regulation of transport 48.2759 4 yes
GO:0031326 regulation of cellular biosynthetic process 44.8276 5 yes
GO:0009889 regulation of biosynthetic process 44.8276 4 yes
GO:0009892 negative regulation of metabolic process 44.8276 4 yes
GO:0031324 negative regulation of cellular metabolic process 41.3793 5 yes
GO:0051246 regulation of protein metabolic process 41.3793 5 yes
GO:0009966 regulation of signal transduction 41.3793 4 no
GO:0010468 regulation of gene expression 41.3793 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 41.3793 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 41.3793 5 yes
GO:0071310 cellular response to organic substance 37.9310 4 yes
GO:1902531 regulation of intracellular signal transduction 37.9310 5 no
GO:0006996 organelle organization 34.4828 4 no
GO:0010647 positive regulation of cell communication 34.4828 5 no
GO:0023056 positive regulation of signaling 34.4828 4 no
GO:0048584 positive regulation of response to stimulus 34.4828 4 no
GO:0014070 response to organic cyclic compound 31.0345 4 yes
GO:0044057 regulation of system process 31.0345 4 yes
GO:0051240 positive regulation of multicellular organismal process 31.0345 4 yes
GO:0009893 positive regulation of metabolic process 31.0345 4 no
GO:0051128 regulation of cellular component organization 31.0345 4 no
GO:0009967 positive regulation of signal transduction 31.0345 5 no
GO:0006811 monoatomic ion transport 31.0345 4 yes
GO:0006873 intracellular monoatomic ion homeostasis 31.0345 4 yes
GO:0010959 regulation of metal ion transport 27.5862 6 yes
GO:0030001 metal ion transport 27.5862 6 yes
GO:0030003 intracellular monoatomic cation homeostasis 27.5862 5 yes
GO:0043269 regulation of monoatomic ion transport 27.5862 5 yes
GO:0051248 negative regulation of protein metabolic process 27.5862 6 yes
GO:0055080 monoatomic cation homeostasis 27.5862 4 yes
GO:0098655 monoatomic cation transmembrane transport 27.5862 4 yes
GO:0098662 inorganic cation transmembrane transport 27.5862 4 yes
GO:0141124 intracellular signaling cassette 27.5862 4 yes
GO:0008104 protein localization 27.5862 4 no
GO:0010604 positive regulation of macromolecule metabolic process 27.5862 5 no
GO:0033993 response to lipid 27.5862 4 no
GO:1902533 positive regulation of intracellular signal transduction 27.5862 6 no
GO:0006812 monoatomic cation transport 27.5862 5 yes
GO:0031399 regulation of protein modification process 24.1379 6 yes
GO:0031400 negative regulation of protein modification process 24.1379 7 yes
GO:0034762 regulation of transmembrane transport 24.1379 4 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 24.1379 5 yes
GO:1903522 regulation of blood circulation 24.1379 5 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 24.1379 6 yes
GO:0009890 negative regulation of biosynthetic process 24.1379 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 24.1379 5 no
GO:0023057 negative regulation of signaling 24.1379 4 no
GO:0031327 negative regulation of cellular biosynthetic process 24.1379 6 no
GO:0051252 regulation of RNA metabolic process 24.1379 5 no
GO:0022607 cellular component assembly 24.1379 4 no
GO:0051050 positive regulation of transport 24.1379 4 no
GO:0031325 positive regulation of cellular metabolic process 24.1379 5 no
GO:0008016 regulation of heart contraction 24.1379 6 yes
GO:0019220 regulation of phosphate metabolic process 20.6897 6 yes
GO:0019722 calcium-mediated signaling 20.6897 5 yes
GO:0035725 sodium ion transmembrane transport 20.6897 5 yes
GO:0045936 negative regulation of phosphate metabolic process 20.6897 7 yes
GO:0051094 positive regulation of developmental process 20.6897 4 yes
GO:0051174 regulation of phosphorus metabolic process 20.6897 5 yes
GO:0051924 regulation of calcium ion transport 20.6897 7 yes
GO:0062197 cellular response to chemical stress 20.6897 4 yes
GO:0071407 cellular response to organic cyclic compound 20.6897 5 yes
GO:0086064 cell communication by electrical coupling involved in cardiac conduction 20.6897 4 yes
GO:0090257 regulation of muscle system process 20.6897 5 yes
GO:0098657 import into cell 20.6897 4 yes
GO:1901701 cellular response to oxygen-containing compound 20.6897 4 yes
GO:1903169 regulation of calcium ion transmembrane transport 20.6897 7 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 20.6897 6 no
GO:0010648 negative regulation of cell communication 20.6897 5 no
GO:0031347 regulation of defense response 20.6897 5 no
GO:0032101 regulation of response to external stimulus 20.6897 4 no
GO:0042981 regulation of apoptotic process 20.6897 5 no
GO:0043067 regulation of programmed cell death 20.6897 4 no
GO:0048585 negative regulation of response to stimulus 20.6897 4 no
GO:0080134 regulation of response to stress 20.6897 4 no
GO:0051130 positive regulation of cellular component organization 20.6897 5 no
GO:0009894 regulation of catabolic process 20.6897 4 no
GO:0033043 regulation of organelle organization 20.6897 5 no
GO:0009891 positive regulation of biosynthetic process 20.6897 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 20.6897 6 no
GO:0031328 positive regulation of cellular biosynthetic process 20.6897 6 no
GO:0006814 sodium ion transport 20.6897 7 yes
GO:0006937 regulation of muscle contraction 20.6897 6 yes
GO:0006942 regulation of striated muscle contraction 20.6897 7 yes
GO:0010563 negative regulation of phosphorus metabolic process 20.6897 6 yes
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 17.2414 6 yes
GO:0034599 cellular response to oxidative stress 17.2414 4 yes
GO:0036376 sodium ion export across plasma membrane 17.2414 4 yes
GO:0051282 regulation of sequestering of calcium ion 17.2414 4 yes
GO:0055001 muscle cell development 17.2414 4 yes
GO:0055074 calcium ion homeostasis 17.2414 4 yes
GO:0055078 sodium ion homeostasis 17.2414 4 yes
GO:0055117 regulation of cardiac muscle contraction 17.2414 7 yes
GO:0055119 relaxation of cardiac muscle 17.2414 5 yes
GO:0090075 relaxation of muscle 17.2414 4 yes
GO:0098659 inorganic cation import across plasma membrane 17.2414 5 yes
GO:0099587 inorganic ion import across plasma membrane 17.2414 4 yes
GO:0006874 intracellular calcium ion homeostasis 17.2414 5 yes
GO:0006883 intracellular sodium ion homeostasis 17.2414 5 yes
GO:0006936 muscle contraction 17.2414 4 yes
GO:0010243 response to organonitrogen compound 17.2414 4 yes
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 13.7931 6 yes
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 13.7931 7 yes
GO:0035150 regulation of tube size 13.7931 4 yes
GO:0035296 regulation of tube diameter 13.7931 5 yes
GO:0042325 regulation of phosphorylation 13.7931 7 yes
GO:0042326 negative regulation of phosphorylation 13.7931 8 yes
GO:0043086 negative regulation of catalytic activity 13.7931 4 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 13.7931 5 yes
GO:0060048 cardiac muscle contraction 13.7931 6 yes
GO:0070588 calcium ion transmembrane transport 13.7931 5 yes
GO:0071417 cellular response to organonitrogen compound 13.7931 4 yes
GO:0097746 blood vessel diameter maintenance 13.7931 5 yes
GO:1901699 cellular response to nitrogen compound 13.7931 4 yes
GO:2000026 regulation of multicellular organismal development 13.7931 4 yes
GO:0001932 regulation of protein phosphorylation 13.7931 7 yes
GO:0001933 negative regulation of protein phosphorylation 13.7931 8 yes
GO:0003018 vascular process in circulatory system 13.7931 4 yes
GO:0006816 calcium ion transport 13.7931 7 yes
GO:0006941 striated muscle contraction 13.7931 5 yes
GO:0030278 regulation of ossification 10.3448 4 yes
GO:0030500 regulation of bone mineralization 10.3448 5 yes
GO:0033673 negative regulation of kinase activity 10.3448 6 yes
GO:0035994 response to muscle stretch 10.3448 4 yes
GO:0043549 regulation of kinase activity 10.3448 5 yes
GO:0045859 regulation of protein kinase activity 10.3448 6 yes
GO:0051338 regulation of transferase activity 10.3448 4 yes
GO:0051348 negative regulation of transferase activity 10.3448 5 yes
GO:0051899 membrane depolarization 10.3448 4 yes
GO:0070167 regulation of biomineral tissue development 10.3448 5 yes
GO:0086010 membrane depolarization during action potential 10.3448 5 yes
GO:0086012 membrane depolarization during cardiac muscle cell action potential 10.3448 6 yes
GO:0097553 calcium ion transmembrane import into cytosol 10.3448 6 yes
GO:1903779 regulation of cardiac conduction 10.3448 7 yes
GO:0000302 response to reactive oxygen species 10.3448 4 yes
GO:0006469 negative regulation of protein kinase activity 10.3448 7 yes
GO:0010649 regulation of cell communication by electrical coupling 6.8966 5 yes
GO:0014074 response to purine-containing compound 6.8966 5 yes
GO:0014829 vascular associated smooth muscle contraction 6.8966 6 yes
GO:0030501 positive regulation of bone mineralization 6.8966 6 yes
GO:0031000 response to caffeine 6.8966 6 yes
GO:0034614 cellular response to reactive oxygen species 6.8966 5 yes
GO:0042310 vasoconstriction 6.8966 6 yes
GO:0043279 response to alkaloid 6.8966 5 yes
GO:0044557 relaxation of smooth muscle 6.8966 5 yes
GO:0045778 positive regulation of ossification 6.8966 5 yes
GO:0055006 cardiac cell development 6.8966 4 yes
GO:0055013 cardiac muscle cell development 6.8966 5 yes
GO:0060402 calcium ion transport into cytosol 6.8966 4 yes
GO:0070169 positive regulation of biomineral tissue development 6.8966 5 yes
GO:0070509 calcium ion import 6.8966 8 yes
GO:0071312 cellular response to alkaloid 6.8966 5 yes
GO:0071313 cellular response to caffeine 6.8966 6 yes
GO:0071415 cellular response to purine-containing compound 6.8966 5 yes
GO:0071900 regulation of protein serine/threonine kinase activity 6.8966 7 yes
GO:0071901 negative regulation of protein serine/threonine kinase activity 6.8966 8 yes
GO:0098703 calcium ion import across plasma membrane 6.8966 6 yes
GO:0098719 sodium ion import across plasma membrane 6.8966 6 yes
GO:0098735 positive regulation of the force of heart contraction 6.8966 4 yes
GO:1901660 calcium ion export 6.8966 8 yes
GO:1902656 calcium ion import into cytosol 6.8966 8 yes
GO:0006939 smooth muscle contraction 6.8966 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ZFP42_HUMAN [view interactions] Low throughput no no
ZN281_HUMAN [view interactions] Low throughput no no
P5F1B_HUMAN [view interactions] Low throughput no no
PO5F1_HUMAN [view interactions] Low throughput no yes
S10A1_HUMAN [view interactions] Low throughput no yes
CAV3_HUMAN [view interactions] Low throughput no no
AT1A1_HUMAN [view entry] [view interactions] Low throughput yes no
AT1A2_HUMAN [view entry] [view interactions] Low throughput yes yes
PLM_HUMAN [view interactions] Low throughput no no
NR0B1_HUMAN [view interactions] Low throughput no no
NANP8_HUMAN [view interactions] Low throughput no no
NANOG_HUMAN [view interactions] Low throughput no no
PP2BB_HUMAN [view entry] [view interactions] Low throughput yes yes
POPD2_HUMAN [view interactions] High throughput no no
STK39_HUMAN [view entry] [view interactions] High throughput yes yes
S10A2_HUMAN [view interactions] High throughput no no
S10A3_HUMAN [view interactions] High throughput no no
S10A4_HUMAN [view entry] [view interactions] High throughput yes no
S10A5_HUMAN [view interactions] High throughput no no
S10A6_HUMAN [view interactions] High throughput no yes
S10A7_HUMAN [view interactions] High throughput no no
S10A8_HUMAN [view interactions] High throughput no no
S10A9_HUMAN [view entry] [view interactions] High throughput yes no
S10AA_HUMAN [view interactions] High throughput no no
S10AB_HUMAN [view interactions] High throughput no no
S10AC_HUMAN [view interactions] High throughput no no
S10AD_HUMAN [view interactions] High throughput no yes
S10AE_HUMAN [view interactions] High throughput no no
S1A7A_HUMAN [view interactions] High throughput no no
S100B_HUMAN [view entry] [view interactions] High throughput yes yes
S100G_HUMAN [view interactions] High throughput no no
S100P_HUMAN [view interactions] High throughput no no
S100Z_HUMAN [view interactions] High throughput no no
SCHI1_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
AT1A3_HUMAN [view entry] [view interactions] High throughput yes no
AT2A2_HUMAN [view entry] [view interactions] High throughput yes yes
ITPR1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
CSK_HUMAN [view interactions] High throughput no yes
SPPL3_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
MK11_HUMAN [view interactions] High throughput no yes
STING_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
ATX2L_HUMAN [view interactions] High throughput no no
DDX1_HUMAN [view entry] [view interactions] High throughput yes yes
DMD_HUMAN [view entry] [view interactions] High throughput yes no
DNJA3_HUMAN [view entry] [view interactions] High throughput yes yes
DNJB4_HUMAN [view entry] [view interactions] High throughput yes yes
DNJB5_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
F120A_HUMAN [view interactions] High throughput no yes
FA98A_HUMAN [view interactions] High throughput no no
FBLN5_HUMAN [view interactions] High throughput no no
GPX1_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
MATR3_HUMAN [view interactions] High throughput no yes
PABP1_HUMAN [view entry] [view interactions] High throughput yes yes
PANK4_HUMAN [view interactions] High throughput no no
2ABA_HUMAN [view interactions] High throughput no yes
PGTA_HUMAN [view interactions] High throughput no yes
RBPS2_HUMAN [view interactions] High throughput no no
RTCB_HUMAN [view interactions] High throughput no yes
RUVB1_HUMAN [view interactions] High throughput no yes
NAC1_HUMAN [view entry] [view interactions] High throughput yes yes
SNTB1_HUMAN [view entry] [view interactions] High throughput yes yes
LA_HUMAN [view interactions] High throughput no yes
SYN2_HUMAN [view entry] [view interactions] High throughput yes no
RENT1_HUMAN [view entry] [view interactions] High throughput yes yes
YBOX1_HUMAN [view interactions] High throughput no yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
PDE3A_HUMAN [view interactions] High throughput no no