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NAC1_HUMAN

Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed, PubMed, PubMed). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions. [View more on UniProt]

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ELM instance Name Type Start End Partner
ELMI003034 LIG_14-3-3_CanoR_1 LIG 388 394 -

Molecular function

Term Name % Distance from the top of the tree Annotated in NAC1_HUMAN
GO:0046872 metal ion binding 54.2857 4 yes
GO:0017076 purine nucleotide binding 42.8571 4 no
GO:0030554 adenyl nucleotide binding 42.8571 5 no
GO:0005524 ATP binding 40.0000 5 no
GO:0032555 purine ribonucleotide binding 40.0000 4 no
GO:0032559 adenyl ribonucleotide binding 40.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 40.0000 4 no
GO:0005509 calcium ion binding 25.7143 5 yes
GO:0008324 cation transmembrane transporter activity 25.7143 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 25.7143 4 yes
GO:0046873 metal ion transmembrane transporter activity 25.7143 5 yes
GO:0022853 active ion transmembrane transporter activity 22.8571 4 yes
GO:0003723 RNA binding 22.8571 4 no
GO:0015081 sodium ion transmembrane transporter activity 20.0000 6 yes
GO:0015085 calcium ion transmembrane transporter activity 17.1429 6 yes
GO:0015291 secondary active transmembrane transporter activity 14.2857 4 yes
GO:0015297 antiporter activity 14.2857 5 yes
GO:0005432 calcium:sodium antiporter activity 11.4286 7 yes
GO:0015298 solute:cation antiporter activity 11.4286 5 yes
GO:0015368 calcium:cation antiporter activity 11.4286 7 yes
GO:0140828 metal cation:monoatomic cation antiporter activity 11.4286 6 yes
GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential 8.5714 6 yes
GO:1905060 calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration 8.5714 8 yes
GO:0030506 ankyrin binding 5.7143 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NAC1_HUMAN
GO:0048523 negative regulation of cellular process 65.7143 4 yes
GO:0048522 positive regulation of cellular process 62.8571 4 yes
GO:0010646 regulation of cell communication 60.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 57.1429 4 yes
GO:0080090 regulation of primary metabolic process 57.1429 4 yes
GO:0031323 regulation of cellular metabolic process 54.2857 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 54.2857 4 yes
GO:0051246 regulation of protein metabolic process 48.5714 5 yes
GO:0009966 regulation of signal transduction 45.7143 4 no
GO:0010468 regulation of gene expression 45.7143 5 yes
GO:0051049 regulation of transport 42.8571 4 yes
GO:0009892 negative regulation of metabolic process 42.8571 4 yes
GO:0048878 chemical homeostasis 40.0000 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 40.0000 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 37.1429 5 yes
GO:0071310 cellular response to organic substance 37.1429 4 yes
GO:0031324 negative regulation of cellular metabolic process 34.2857 5 yes
GO:0044057 regulation of system process 34.2857 4 yes
GO:0050801 ion homeostasis 34.2857 5 yes
GO:0010647 positive regulation of cell communication 34.2857 5 no
GO:0023056 positive regulation of signaling 34.2857 4 no
GO:1902531 regulation of intracellular signal transduction 34.2857 5 no
GO:0030003 cellular cation homeostasis 31.4286 5 yes
GO:0051248 negative regulation of protein metabolic process 31.4286 6 yes
GO:0055065 metal ion homeostasis 31.4286 7 yes
GO:0055080 cation homeostasis 31.4286 6 yes
GO:0098771 inorganic ion homeostasis 31.4286 6 yes
GO:0051128 regulation of cellular component organization 31.4286 4 no
GO:0009893 positive regulation of metabolic process 31.4286 4 no
GO:0006873 cellular ion homeostasis 31.4286 4 yes
GO:0006875 cellular metal ion homeostasis 31.4286 6 yes
GO:0031399 regulation of protein modification process 28.5714 6 yes
GO:1903522 regulation of blood circulation 28.5714 5 yes
GO:0006996 organelle organization 28.5714 4 no
GO:0008104 protein localization 28.5714 4 no
GO:0009889 regulation of biosynthetic process 28.5714 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0031326 regulation of cellular biosynthetic process 28.5714 5 no
GO:0006811 ion transport 28.5714 4 yes
GO:0008016 regulation of heart contraction 28.5714 6 yes
GO:0014070 response to organic cyclic compound 28.5714 4 yes
GO:0030001 metal ion transport 25.7143 6 yes
GO:0031400 negative regulation of protein modification process 25.7143 7 yes
GO:0043269 regulation of ion transport 25.7143 5 yes
GO:0051240 positive regulation of multicellular organismal process 25.7143 4 yes
GO:0098655 cation transmembrane transport 25.7143 4 yes
GO:0098660 inorganic ion transmembrane transport 25.7143 4 yes
GO:0098662 inorganic cation transmembrane transport 25.7143 5 yes
GO:0022607 cellular component assembly 25.7143 4 no
GO:0010648 negative regulation of cell communication 25.7143 5 no
GO:0023057 negative regulation of signaling 25.7143 4 no
GO:0048585 negative regulation of response to stimulus 25.7143 4 no
GO:0010556 regulation of macromolecule biosynthetic process 25.7143 5 no
GO:0009967 positive regulation of signal transduction 25.7143 5 no
GO:0048584 positive regulation of response to stimulus 25.7143 4 no
GO:1902533 positive regulation of intracellular signal transduction 25.7143 6 no
GO:0006812 cation transport 25.7143 5 yes
GO:0051174 regulation of phosphorus metabolic process 22.8571 5 yes
GO:0055074 calcium ion homeostasis 22.8571 8 yes
GO:0071407 cellular response to organic cyclic compound 22.8571 5 yes
GO:0072503 cellular divalent inorganic cation homeostasis 22.8571 6 yes
GO:0072507 divalent inorganic cation homeostasis 22.8571 7 yes
GO:0090257 regulation of muscle system process 22.8571 5 yes
GO:0036211 protein modification process 22.8571 4 no
GO:0043412 macromolecule modification 22.8571 4 no
GO:0006796 phosphate-containing compound metabolic process 22.8571 4 no
GO:0009968 negative regulation of signal transduction 22.8571 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.8571 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 22.8571 5 no
GO:0051252 regulation of RNA metabolic process 22.8571 5 no
GO:0009894 regulation of catabolic process 22.8571 4 no
GO:0033993 response to lipid 22.8571 4 no
GO:0006874 cellular calcium ion homeostasis 22.8571 7 yes
GO:0006937 regulation of muscle contraction 22.8571 6 yes
GO:0006942 regulation of striated muscle contraction 22.8571 7 yes
GO:0010959 regulation of metal ion transport 22.8571 6 yes
GO:0019220 regulation of phosphate metabolic process 22.8571 6 yes
GO:0019932 second-messenger-mediated signaling 20.0000 4 yes
GO:0034762 regulation of transmembrane transport 20.0000 4 yes
GO:0034765 regulation of ion transmembrane transport 20.0000 5 yes
GO:0035725 sodium ion transmembrane transport 20.0000 6 yes
GO:0045936 negative regulation of phosphate metabolic process 20.0000 7 yes
GO:0062197 cellular response to chemical stress 20.0000 4 yes
GO:0086064 cell communication by electrical coupling involved in cardiac conduction 20.0000 4 yes
GO:0098657 import into cell 20.0000 4 yes
GO:0098659 inorganic cation import across plasma membrane 20.0000 5 yes
GO:0099587 inorganic ion import across plasma membrane 20.0000 4 yes
GO:1901701 cellular response to oxygen-containing compound 20.0000 4 yes
GO:1904062 regulation of cation transmembrane transport 20.0000 6 yes
GO:0006814 sodium ion transport 20.0000 7 yes
GO:0010563 negative regulation of phosphorus metabolic process 20.0000 6 yes
GO:0019722 calcium-mediated signaling 20.0000 5 yes
GO:0034599 cellular response to oxidative stress 17.1429 4 yes
GO:0042325 regulation of phosphorylation 17.1429 7 yes
GO:0051094 positive regulation of developmental process 17.1429 4 yes
GO:0051282 regulation of sequestering of calcium ion 17.1429 4 yes
GO:0051924 regulation of calcium ion transport 17.1429 7 yes
GO:0055117 regulation of cardiac muscle contraction 17.1429 7 yes
GO:0070588 calcium ion transmembrane transport 17.1429 6 yes
GO:1903169 regulation of calcium ion transmembrane transport 17.1429 7 yes
GO:1903779 regulation of cardiac conduction 17.1429 4 yes
GO:0001932 regulation of protein phosphorylation 17.1429 7 yes
GO:0002028 regulation of sodium ion transport 17.1429 7 yes
GO:0006816 calcium ion transport 17.1429 7 yes
GO:0010243 response to organonitrogen compound 17.1429 4 yes
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 17.1429 6 yes
GO:0030004 cellular monovalent inorganic cation homeostasis 14.2857 6 yes
GO:0036376 sodium ion export across plasma membrane 14.2857 4 yes
GO:0042326 negative regulation of phosphorylation 14.2857 8 yes
GO:0043086 negative regulation of catalytic activity 14.2857 4 yes
GO:0043549 regulation of kinase activity 14.2857 5 yes
GO:0045859 regulation of protein kinase activity 14.2857 6 yes
GO:0051279 regulation of release of sequestered calcium ion into cytosol 14.2857 5 yes
GO:0051338 regulation of transferase activity 14.2857 4 yes
GO:0055067 monovalent inorganic cation homeostasis 14.2857 7 yes
GO:0055078 sodium ion homeostasis 14.2857 8 yes
GO:0055119 relaxation of cardiac muscle 14.2857 5 yes
GO:0071417 cellular response to organonitrogen compound 14.2857 4 yes
GO:0090075 relaxation of muscle 14.2857 4 yes
GO:0097553 calcium ion transmembrane import into cytosol 14.2857 7 yes
GO:1901699 cellular response to nitrogen compound 14.2857 4 yes
GO:2000026 regulation of multicellular organismal development 14.2857 4 yes
GO:0001933 negative regulation of protein phosphorylation 14.2857 8 yes
GO:0003018 vascular process in circulatory system 14.2857 4 yes
GO:0006883 cellular sodium ion homeostasis 14.2857 7 yes
GO:0006936 muscle contraction 14.2857 4 yes
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 14.2857 6 yes
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 14.2857 7 yes
GO:0030334 regulation of cell migration 11.4286 5 yes
GO:0033673 negative regulation of kinase activity 11.4286 6 yes
GO:0034284 response to monosaccharide 11.4286 5 yes
GO:0035150 regulation of tube size 11.4286 4 yes
GO:0035296 regulation of tube diameter 11.4286 5 yes
GO:0036293 response to decreased oxygen levels 11.4286 4 yes
GO:0051348 negative regulation of transferase activity 11.4286 5 yes
GO:0055001 muscle cell development 11.4286 4 yes
GO:0060048 cardiac muscle contraction 11.4286 6 yes
GO:0071900 regulation of protein serine/threonine kinase activity 11.4286 7 yes
GO:0097746 blood vessel diameter maintenance 11.4286 5 yes
GO:0098703 calcium ion import across plasma membrane 11.4286 6 yes
GO:2000145 regulation of cell motility 11.4286 4 yes
GO:0006469 negative regulation of protein kinase activity 11.4286 7 yes
GO:0006941 striated muscle contraction 11.4286 5 yes
GO:0009743 response to carbohydrate 11.4286 4 yes
GO:0009746 response to hexose 11.4286 6 yes
GO:0009749 response to glucose 11.4286 7 yes
GO:0030278 regulation of ossification 8.5714 4 yes
GO:0030335 positive regulation of cell migration 8.5714 6 yes
GO:0030500 regulation of bone mineralization 8.5714 5 yes
GO:0031667 response to nutrient levels 8.5714 4 yes
GO:0035994 response to muscle stretch 8.5714 4 yes
GO:0036294 cellular response to decreased oxygen levels 8.5714 5 yes
GO:0040017 positive regulation of locomotion 8.5714 4 yes
GO:0042542 response to hydrogen peroxide 8.5714 4 yes
GO:0051899 membrane depolarization 8.5714 4 yes
GO:0070167 regulation of biomineral tissue development 8.5714 4 yes
GO:0071453 cellular response to oxygen levels 8.5714 4 yes
GO:0071456 cellular response to hypoxia 8.5714 4 yes
GO:0071901 negative regulation of protein serine/threonine kinase activity 8.5714 8 yes
GO:0086010 membrane depolarization during action potential 8.5714 5 yes
GO:0086012 membrane depolarization during cardiac muscle cell action potential 8.5714 6 yes
GO:2000147 positive regulation of cell motility 8.5714 5 yes
GO:0000302 response to reactive oxygen species 8.5714 4 yes
GO:0030501 positive regulation of bone mineralization 5.7143 6 yes
GO:0031000 response to caffeine 5.7143 6 yes
GO:0033198 response to ATP 5.7143 4 yes
GO:0034614 cellular response to reactive oxygen species 5.7143 5 yes
GO:0042310 vasoconstriction 5.7143 6 yes
GO:0043279 response to alkaloid 5.7143 5 yes
GO:0044557 relaxation of smooth muscle 5.7143 5 yes
GO:0045778 positive regulation of ossification 5.7143 5 yes
GO:0046683 response to organophosphorus 5.7143 4 yes
GO:0051591 response to cAMP 5.7143 4 yes
GO:0055006 cardiac cell development 5.7143 4 yes
GO:0055013 cardiac muscle cell development 5.7143 5 yes
GO:0060402 calcium ion transport into cytosol 5.7143 4 yes
GO:0070169 positive regulation of biomineral tissue development 5.7143 5 yes
GO:0070509 calcium ion import 5.7143 8 yes
GO:0071312 cellular response to alkaloid 5.7143 5 yes
GO:0071313 cellular response to caffeine 5.7143 6 yes
GO:0071320 cellular response to cAMP 5.7143 5 yes
GO:0071415 cellular response to purine-containing compound 5.7143 5 yes
GO:0098719 sodium ion import across plasma membrane 5.7143 6 yes
GO:0098735 positive regulation of the force of heart contraction 5.7143 4 yes
GO:0110151 positive regulation of biomineralization 5.7143 4 yes
GO:1901660 calcium ion export 5.7143 8 yes
GO:0006939 smooth muscle contraction 5.7143 5 yes
GO:0010649 regulation of cell communication by electrical coupling 5.7143 5 yes
GO:0010762 regulation of fibroblast migration 5.7143 6 yes
GO:0010763 positive regulation of fibroblast migration 5.7143 7 yes
GO:0014074 response to purine-containing compound 5.7143 5 yes
GO:0014829 vascular associated smooth muscle contraction 5.7143 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in NAC1_HUMAN
DOID:114 heart disease 5.7143 3 no
DOID:12930 dilated cardiomyopathy 5.7143 6 no
DOID:423 myopathy 5.7143 5 no
DOID:66 muscle tissue disease 5.7143 4 no
DOID:0050700 cardiomyopathy 5.7143 4 no
DOID:0060036 intrinsic cardiomyopathy 5.7143 5 no
DOID:0080000 muscular disease 5.7143 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NR0B1_HUMAN [view interactions] Low throughput no no
NANOG_HUMAN [view interactions] Low throughput no no
NANP8_HUMAN [view interactions] Low throughput no no
PP2BB_HUMAN [view entry] [view interactions] Low throughput yes yes
ZFP42_HUMAN [view interactions] Low throughput no no
ZN281_HUMAN [view interactions] Low throughput no no
P5F1B_HUMAN [view interactions] Low throughput no no
PO5F1_HUMAN [view interactions] Low throughput no yes
S10A1_HUMAN [view interactions] Low throughput no yes
CAV3_HUMAN [view interactions] Low throughput no no
AT1A1_HUMAN [view entry] [view interactions] Low throughput yes no
AT1A2_HUMAN [view entry] [view interactions] Low throughput yes yes
PLM_HUMAN [view interactions] Low throughput no no
NAC1_HUMAN [view entry] [view interactions] High throughput yes yes
RTCB_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
YBOX1_HUMAN [view interactions] High throughput no yes
RENT1_HUMAN [view entry] [view interactions] High throughput yes yes
SYN2_HUMAN [view entry] [view interactions] High throughput yes no
LA_HUMAN [view interactions] High throughput no yes
SNTB1_HUMAN [view entry] [view interactions] High throughput yes yes
RUVB1_HUMAN [view interactions] High throughput no yes
RBPS2_HUMAN [view interactions] High throughput no no
2ABA_HUMAN [view interactions] High throughput no yes
PANK4_HUMAN [view interactions] High throughput no no
PABP1_HUMAN [view entry] [view interactions] High throughput yes yes
NTPCR_HUMAN [view interactions] High throughput no yes
MATR3_HUMAN [view interactions] High throughput no yes
MYCBP_HUMAN [view interactions] High throughput no yes
GPX1_HUMAN [view entry] [view interactions] High throughput yes yes
FBLN5_HUMAN [view interactions] High throughput no no
FA98A_HUMAN [view interactions] High throughput no no
F120A_HUMAN [view interactions] High throughput no yes
DNJB5_HUMAN [view interactions] High throughput no yes
DNJB4_HUMAN [view entry] [view interactions] High throughput yes yes
DNJA3_HUMAN [view entry] [view interactions] High throughput yes yes
DMD_HUMAN [view entry] [view interactions] High throughput yes no
DDX1_HUMAN [view entry] [view interactions] High throughput yes yes
ATX2L_HUMAN [view interactions] High throughput no no
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
PGTA_HUMAN [view interactions] High throughput no yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
PDE3A_HUMAN [view interactions] High throughput no no
POPD2_HUMAN [view interactions] High throughput no no
STK39_HUMAN [view entry] [view interactions] High throughput yes yes
S10A2_HUMAN [view interactions] High throughput no no
S10A3_HUMAN [view interactions] High throughput no no
S10A4_HUMAN [view entry] [view interactions] High throughput yes no
S10A5_HUMAN [view interactions] High throughput no no
S10A6_HUMAN [view interactions] High throughput no yes
S10A7_HUMAN [view interactions] High throughput no no
S10A8_HUMAN [view interactions] High throughput no no
S10A9_HUMAN [view entry] [view interactions] High throughput yes no
S10AA_HUMAN [view interactions] High throughput no no
S10AB_HUMAN [view interactions] High throughput no no
S10AC_HUMAN [view interactions] High throughput no no
S10AD_HUMAN [view interactions] High throughput no yes
S10AE_HUMAN [view interactions] High throughput no no
S1A7A_HUMAN [view interactions] High throughput no no
S100B_HUMAN [view entry] [view interactions] High throughput yes yes
S100G_HUMAN [view interactions] High throughput no no
S100P_HUMAN [view interactions] High throughput no no
S100Z_HUMAN [view interactions] High throughput no no
SCHI1_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
AT1A3_HUMAN [view entry] [view interactions] High throughput yes no
AT2A2_HUMAN [view entry] [view interactions] High throughput yes yes
ITPR1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CSK_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
MK11_HUMAN [view interactions] High throughput no yes
KGP2_HUMAN [view entry] [view interactions] Computational yes yes
KAPCB_HUMAN [view entry] [view interactions] Computational yes yes
NAC2_HUMAN [view entry] [view interactions] Computational yes no
NAC3_HUMAN [view entry] [view interactions] Computational yes no
KAPCG_HUMAN [view interactions] Computational no no
KGP1_HUMAN [view interactions] Computational no yes
TRPC3_HUMAN [view interactions] Computational no no
KAPCA_HUMAN [view entry] [view interactions] Computational yes yes