Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

S10A4_HUMAN

GO
G2C
SynGO

Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed, PubMed, PubMed). Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis . Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (PubMed). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes . In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (PubMed, PubMed). [View more on UniProt]

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Download full PS network for entry.

No data found.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in S10A4_HUMAN
GO:0043169 cation binding 35.1351 4 yes
GO:0046872 metal ion binding 35.1351 5 yes
GO:0000166 nucleotide binding 35.1351 4 no
GO:0017076 purine nucleotide binding 32.4324 5 no
GO:0003723 RNA binding 29.7297 4 yes
GO:0043168 anion binding 29.7297 4 no
GO:0030554 adenyl nucleotide binding 27.0270 6 no
GO:0032555 purine ribonucleotide binding 27.0270 4 no
GO:0035639 purine ribonucleoside triphosphate binding 27.0270 4 no
GO:0019900 kinase binding 24.3243 4 no
GO:0019901 protein kinase binding 24.3243 5 no
GO:0005524 ATP binding 21.6216 5 no
GO:0032559 adenyl ribonucleotide binding 21.6216 5 no
GO:0003779 actin binding 13.5135 4 yes
GO:0005509 calcium ion binding 13.5135 6 yes
GO:0046914 transition metal ion binding 13.5135 6 yes
GO:0048018 receptor ligand activity 8.1081 4 yes
GO:0050786 RAGE receptor binding 8.1081 4 yes
GO:0042056 chemoattractant activity 5.4054 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in S10A4_HUMAN
GO:0048522 positive regulation of cellular process 64.8649 4 yes
GO:0048523 negative regulation of cellular process 64.8649 4 no
GO:0010646 regulation of cell communication 56.7568 4 yes
GO:0060255 regulation of macromolecule metabolic process 54.0541 4 no
GO:0080090 regulation of primary metabolic process 54.0541 4 no
GO:0009889 regulation of biosynthetic process 51.3514 4 no
GO:0031323 regulation of cellular metabolic process 51.3514 4 no
GO:0009966 regulation of signal transduction 48.6486 4 yes
GO:0009893 positive regulation of metabolic process 48.6486 4 no
GO:0010556 regulation of macromolecule biosynthetic process 48.6486 5 no
GO:0010604 positive regulation of macromolecule metabolic process 48.6486 5 no
GO:0031326 regulation of cellular biosynthetic process 48.6486 5 no
GO:0006996 organelle organization 48.6486 4 no
GO:0010468 regulation of gene expression 45.9459 6 no
GO:0051246 regulation of protein metabolic process 45.9459 5 no
GO:0008104 protein localization 45.9459 4 no
GO:1902531 regulation of intracellular signal transduction 43.2432 5 yes
GO:0009892 negative regulation of metabolic process 43.2432 4 no
GO:0051128 regulation of cellular component organization 43.2432 4 no
GO:0031325 positive regulation of cellular metabolic process 40.5405 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.8378 5 no
GO:0051252 regulation of RNA metabolic process 37.8378 5 no
GO:0031324 negative regulation of cellular metabolic process 37.8378 5 no
GO:0006355 regulation of DNA-templated transcription 35.1351 7 no
GO:0009891 positive regulation of biosynthetic process 35.1351 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 35.1351 6 no
GO:0010605 negative regulation of macromolecule metabolic process 35.1351 5 no
GO:0031328 positive regulation of cellular biosynthetic process 35.1351 6 no
GO:0048585 negative regulation of response to stimulus 35.1351 4 no
GO:2001141 regulation of RNA biosynthetic process 35.1351 6 no
GO:0022607 cellular component assembly 35.1351 4 no
GO:0051247 positive regulation of protein metabolic process 35.1351 6 no
GO:0023056 positive regulation of signaling 32.4324 4 yes
GO:0048584 positive regulation of response to stimulus 32.4324 4 yes
GO:0009968 negative regulation of signal transduction 32.4324 5 no
GO:0010648 negative regulation of cell communication 32.4324 5 no
GO:0023057 negative regulation of signaling 32.4324 4 no
GO:0042981 regulation of apoptotic process 32.4324 5 no
GO:0043067 regulation of programmed cell death 32.4324 4 no
GO:0010647 positive regulation of cell communication 29.7297 5 yes
GO:0051094 positive regulation of developmental process 29.7297 4 no
GO:0051240 positive regulation of multicellular organismal process 29.7297 4 no
GO:0009967 positive regulation of signal transduction 27.0270 5 yes
GO:1902533 positive regulation of intracellular signal transduction 27.0270 6 yes
GO:0036211 protein modification process 27.0270 4 no
GO:0043066 negative regulation of apoptotic process 27.0270 6 no
GO:0043069 negative regulation of programmed cell death 27.0270 5 no
GO:0043412 macromolecule modification 27.0270 4 no
GO:0009890 negative regulation of biosynthetic process 27.0270 5 no
GO:0006357 regulation of transcription by RNA polymerase II 24.3243 8 no
GO:0030162 regulation of proteolysis 24.3243 6 no
GO:0031399 regulation of protein modification process 24.3243 6 no
GO:0019220 regulation of phosphate metabolic process 24.3243 6 no
GO:0051174 regulation of phosphorus metabolic process 24.3243 5 no
GO:0060341 regulation of cellular localization 24.3243 4 no
GO:0045595 regulation of cell differentiation 21.6216 4 no
GO:0051248 negative regulation of protein metabolic process 21.6216 6 no
GO:0009894 regulation of catabolic process 21.6216 4 no
GO:0015031 protein transport 21.6216 4 no
GO:0071702 organic substance transport 21.6216 4 no
GO:0071705 nitrogen compound transport 21.6216 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.6216 6 no
GO:0031327 negative regulation of cellular biosynthetic process 21.6216 6 no
GO:0042127 regulation of cell population proliferation 21.6216 4 no
GO:0042325 regulation of phosphorylation 21.6216 7 no
GO:0032880 regulation of protein localization 21.6216 5 no
GO:0051049 regulation of transport 21.6216 4 no
GO:0033043 regulation of organelle organization 21.6216 5 no
GO:0044087 regulation of cellular component biogenesis 21.6216 4 no
GO:2000026 regulation of multicellular organismal development 21.6216 4 no
GO:0043122 regulation of canonical NF-kappaB signal transduction 18.9189 6 yes
GO:0043123 positive regulation of canonical NF-kappaB signal transduction 13.5135 7 yes
GO:0001837 epithelial to mesenchymal transition 5.4054 5 yes
GO:0048762 mesenchymal cell differentiation 5.4054 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
IFNB_HUMAN [view interactions] Low throughput no no
ANXA2_HUMAN [view entry] [view interactions] Low throughput yes no
S10A4_HUMAN [view entry] [view interactions] Low throughput yes no
S10A1_HUMAN [view interactions] Low throughput no yes
AREG_HUMAN [view interactions] Low throughput no no
HBEGF_HUMAN [view interactions] Low throughput no no
P53_HUMAN [view interactions] Low throughput no no
BTC_HUMAN [view interactions] Low throughput no no
EGF_HUMAN [view interactions] Low throughput no no
EGFR_HUMAN [view interactions] Low throughput no no
ERBB3_HUMAN [view interactions] Low throughput no yes
ERBB4_HUMAN [view entry] [view interactions] Low throughput yes yes
MDM2_HUMAN [view entry] [view interactions] Low throughput yes yes
MYH9_HUMAN [view entry] [view interactions] Low throughput yes no
CEP20_HUMAN [view interactions] Low throughput no yes
EZRI_HUMAN [view entry] [view interactions] Low throughput yes no
MAP2_HUMAN [view interactions] Low throughput no yes
CCN3_HUMAN [view interactions] Low throughput no no
FCG3A_HUMAN [view interactions] Low throughput no no
LIPB1_HUMAN [view interactions] Low throughput no yes
SMAD3_HUMAN [view interactions] Low throughput no yes
SMAD2_HUMAN [view interactions] Low throughput no yes
WDFY3_HUMAN [view interactions] High throughput no yes
BRD1_HUMAN [view interactions] High throughput no yes
BBX_HUMAN [view interactions] High throughput no no
PTGR2_HUMAN [view interactions] High throughput no yes
TNFA_HUMAN [view interactions] High throughput no no
CHM4C_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
MT21E_HUMAN [view interactions] High throughput no no
BEX2_HUMAN [view interactions] High throughput no yes
ZBED1_HUMAN [view interactions] High throughput no yes
CC28A_HUMAN [view interactions] High throughput no no
RPRD2_HUMAN [view interactions] High throughput no yes
CRBN_HUMAN [view interactions] High throughput no yes
SPC24_HUMAN [view interactions] High throughput no no
UMPS_HUMAN [view interactions] High throughput no no
CCD14_HUMAN [view interactions] High throughput no yes
NDK7_HUMAN [view interactions] High throughput no yes
SPC25_HUMAN [view interactions] High throughput no no
POTEI_HUMAN [view interactions] High throughput no no
VCIP1_HUMAN [view entry] [view interactions] High throughput yes no
PATE2_HUMAN [view interactions] High throughput no no
VWA8_HUMAN [view interactions] High throughput no yes
MYH14_HUMAN [view entry] [view interactions] High throughput yes no
DSCR6_HUMAN [view interactions] High throughput no no
COE2_HUMAN [view interactions] High throughput no no
SIA7F_HUMAN [view interactions] High throughput no yes
TXNIP_HUMAN [view interactions] High throughput no no
ML12A_HUMAN [view interactions] High throughput no no
HAUS1_HUMAN [view interactions] High throughput no yes
UBE3A_HUMAN [view entry] [view interactions] High throughput yes yes
SATB1_HUMAN [view interactions] High throughput no yes
SATB2_HUMAN [view interactions] High throughput no yes
AFG2A_HUMAN [view interactions] High throughput no yes
SSNA1_HUMAN [view interactions] High throughput no no
KI18B_HUMAN [view interactions] High throughput no no
TT21B_HUMAN [view interactions] High throughput no yes
HAUS4_HUMAN [view interactions] High throughput no yes
S10A2_HUMAN [view interactions] High throughput no no
PKN3_HUMAN [view interactions] High throughput no yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
MS18B_HUMAN [view interactions] High throughput no no
ODBA_HUMAN [view interactions] High throughput no yes
DIAP3_HUMAN [view interactions] High throughput no no
CE128_HUMAN [view interactions] High throughput no yes
DPYL4_HUMAN [view entry] [view interactions] High throughput yes yes
ODBB_HUMAN [view interactions] High throughput no yes
ALR_HUMAN [view interactions] High throughput no yes
XRCC4_HUMAN [view interactions] High throughput no yes
GAK_HUMAN [view entry] [view interactions] High throughput yes yes
PXDN_HUMAN [view interactions] High throughput no no
FA24B_HUMAN [view interactions] High throughput no no
RCBT2_HUMAN [view interactions] High throughput no yes
VPS39_HUMAN [view entry] [view interactions] High throughput yes no
HSBP1_HUMAN [view interactions] High throughput no no
VPS11_HUMAN [view entry] [view interactions] High throughput yes no
RCBT1_HUMAN [view interactions] High throughput no no
GAN_HUMAN [view interactions] High throughput no yes
ESS2_HUMAN [view interactions] High throughput no yes
CE170_HUMAN [view interactions] High throughput no yes
ZFHX4_HUMAN [view interactions] High throughput no yes
STXB2_HUMAN [view interactions] High throughput no no
CEP44_HUMAN [view interactions] High throughput no yes
CC28B_HUMAN [view interactions] High throughput no no
PO4F3_HUMAN [view interactions] High throughput no no
BTF3_HUMAN [view interactions] High throughput no yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
SPPL3_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
IGBP1_HUMAN [view interactions] High throughput no yes
TM1L2_HUMAN [view entry] [view interactions] High throughput yes yes
UNK_HUMAN [view interactions] High throughput no yes
SGT1_HUMAN [view interactions] High throughput no no
PSA1_HUMAN [view interactions] High throughput no yes
SBP1_HUMAN [view interactions] High throughput no no
RUXF_HUMAN [view interactions] High throughput no no
PCH2_HUMAN [view interactions] High throughput no no
ZZEF1_HUMAN [view interactions] High throughput no no
CATA_HUMAN [view entry] [view interactions] High throughput yes no
ARL3_HUMAN [view interactions] High throughput no yes
GPD1L_HUMAN [view interactions] High throughput no no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
S100B_HUMAN [view entry] [view interactions] High throughput yes yes
H2AX_HUMAN [view interactions] High throughput no yes
NPHP1_HUMAN [view interactions] High throughput no yes
NEDD1_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
SAM50_HUMAN [view entry] [view interactions] High throughput yes yes
PHF12_HUMAN [view interactions] High throughput no yes
OSGEP_HUMAN [view interactions] High throughput no yes
SLAI1_HUMAN [view interactions] High throughput no no
CDK2_HUMAN [view interactions] High throughput no yes
STRN3_HUMAN [view entry] [view interactions] High throughput yes yes
SMC1A_HUMAN [view interactions] High throughput no yes
CORO7_HUMAN [view interactions] High throughput no no
S10A6_HUMAN [view interactions] High throughput no yes
NPAT_HUMAN [view interactions] High throughput no no
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
SYNE2_HUMAN [view interactions] High throughput no no
DNJB6_HUMAN [view entry] [view interactions] High throughput yes yes
QCR9_HUMAN [view interactions] High throughput no no
RPP29_HUMAN [view entry] [view interactions] High throughput yes yes
KAT7_HUMAN [view interactions] High throughput no yes
DNJA3_HUMAN [view entry] [view interactions] High throughput yes yes
SUV91_HUMAN [view interactions] High throughput no no
IGHG3_HUMAN [view interactions] High throughput no no
ESCO2_HUMAN [view interactions] High throughput no no
XIAP_HUMAN [view interactions] High throughput no yes
RASA1_HUMAN [view interactions] High throughput no yes
PEBP1_HUMAN [view entry] [view interactions] High throughput yes yes
RIPK1_HUMAN [view interactions] High throughput no yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
MATR3_HUMAN [view interactions] High throughput no yes
HTRA4_HUMAN [view interactions] High throughput no no
NRG1_HUMAN [view entry] [view interactions] High throughput yes no
RAGE_HUMAN [view entry] [view interactions] High throughput yes no
STING_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
BAG6_HUMAN [view entry] [view interactions] High throughput yes yes
U119A_HUMAN [view interactions] High throughput no no
NAC1_HUMAN [view entry] [view interactions] High throughput yes yes
CYBP_HUMAN [view entry] [view interactions] High throughput yes yes
TRPM4_HUMAN [view interactions] High throughput no no
KS6A1_HUMAN [view entry] [view interactions] High throughput yes yes
MKNK1_HUMAN [view interactions] High throughput no yes
CEP43_HUMAN [view interactions] High throughput no no
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
CEP76_HUMAN [view interactions] High throughput no yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
CNTRL_HUMAN [view interactions] High throughput no yes