S10A4_HUMAN
Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed, PubMed, PubMed). Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis . Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (PubMed). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes . In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (PubMed, PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in S10A4_HUMAN |
---|---|---|---|---|
GO:0043169 | cation binding | 35.1351 | 4 | yes |
GO:0046872 | metal ion binding | 35.1351 | 5 | yes |
GO:0000166 | nucleotide binding | 35.1351 | 4 | no |
GO:0017076 | purine nucleotide binding | 32.4324 | 5 | no |
GO:0003723 | RNA binding | 29.7297 | 4 | yes |
GO:0043168 | anion binding | 29.7297 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 27.0270 | 6 | no |
GO:0032555 | purine ribonucleotide binding | 27.0270 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 27.0270 | 4 | no |
GO:0019900 | kinase binding | 24.3243 | 4 | no |
GO:0019901 | protein kinase binding | 24.3243 | 5 | no |
GO:0005524 | ATP binding | 21.6216 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 21.6216 | 5 | no |
GO:0003779 | actin binding | 13.5135 | 4 | yes |
GO:0005509 | calcium ion binding | 13.5135 | 6 | yes |
GO:0046914 | transition metal ion binding | 13.5135 | 6 | yes |
GO:0048018 | receptor ligand activity | 8.1081 | 4 | yes |
GO:0050786 | RAGE receptor binding | 8.1081 | 4 | yes |
GO:0042056 | chemoattractant activity | 5.4054 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in S10A4_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 64.8649 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 64.8649 | 4 | no |
GO:0010646 | regulation of cell communication | 56.7568 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 54.0541 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 54.0541 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 51.3514 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 51.3514 | 4 | no |
GO:0009966 | regulation of signal transduction | 48.6486 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 48.6486 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 48.6486 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 48.6486 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 48.6486 | 5 | no |
GO:0006996 | organelle organization | 48.6486 | 4 | no |
GO:0010468 | regulation of gene expression | 45.9459 | 6 | no |
GO:0051246 | regulation of protein metabolic process | 45.9459 | 5 | no |
GO:0008104 | protein localization | 45.9459 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 43.2432 | 5 | yes |
GO:0009892 | negative regulation of metabolic process | 43.2432 | 4 | no |
GO:0051128 | regulation of cellular component organization | 43.2432 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 40.5405 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 37.8378 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 37.8378 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 37.8378 | 5 | no |
GO:0006355 | regulation of DNA-templated transcription | 35.1351 | 7 | no |
GO:0009891 | positive regulation of biosynthetic process | 35.1351 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 35.1351 | 6 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 35.1351 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 35.1351 | 6 | no |
GO:0048585 | negative regulation of response to stimulus | 35.1351 | 4 | no |
GO:2001141 | regulation of RNA biosynthetic process | 35.1351 | 6 | no |
GO:0022607 | cellular component assembly | 35.1351 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 35.1351 | 6 | no |
GO:0023056 | positive regulation of signaling | 32.4324 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 32.4324 | 4 | yes |
GO:0009968 | negative regulation of signal transduction | 32.4324 | 5 | no |
GO:0010648 | negative regulation of cell communication | 32.4324 | 5 | no |
GO:0023057 | negative regulation of signaling | 32.4324 | 4 | no |
GO:0042981 | regulation of apoptotic process | 32.4324 | 5 | no |
GO:0043067 | regulation of programmed cell death | 32.4324 | 4 | no |
GO:0010647 | positive regulation of cell communication | 29.7297 | 5 | yes |
GO:0051094 | positive regulation of developmental process | 29.7297 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 29.7297 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 27.0270 | 5 | yes |
GO:1902533 | positive regulation of intracellular signal transduction | 27.0270 | 6 | yes |
GO:0036211 | protein modification process | 27.0270 | 4 | no |
GO:0043066 | negative regulation of apoptotic process | 27.0270 | 6 | no |
GO:0043069 | negative regulation of programmed cell death | 27.0270 | 5 | no |
GO:0043412 | macromolecule modification | 27.0270 | 4 | no |
GO:0009890 | negative regulation of biosynthetic process | 27.0270 | 5 | no |
GO:0006357 | regulation of transcription by RNA polymerase II | 24.3243 | 8 | no |
GO:0030162 | regulation of proteolysis | 24.3243 | 6 | no |
GO:0031399 | regulation of protein modification process | 24.3243 | 6 | no |
GO:0019220 | regulation of phosphate metabolic process | 24.3243 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 24.3243 | 5 | no |
GO:0060341 | regulation of cellular localization | 24.3243 | 4 | no |
GO:0045595 | regulation of cell differentiation | 21.6216 | 4 | no |
GO:0051248 | negative regulation of protein metabolic process | 21.6216 | 6 | no |
GO:0009894 | regulation of catabolic process | 21.6216 | 4 | no |
GO:0015031 | protein transport | 21.6216 | 4 | no |
GO:0071702 | organic substance transport | 21.6216 | 4 | no |
GO:0071705 | nitrogen compound transport | 21.6216 | 4 | no |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.6216 | 6 | no |
GO:0031327 | negative regulation of cellular biosynthetic process | 21.6216 | 6 | no |
GO:0042127 | regulation of cell population proliferation | 21.6216 | 4 | no |
GO:0042325 | regulation of phosphorylation | 21.6216 | 7 | no |
GO:0032880 | regulation of protein localization | 21.6216 | 5 | no |
GO:0051049 | regulation of transport | 21.6216 | 4 | no |
GO:0033043 | regulation of organelle organization | 21.6216 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 21.6216 | 4 | no |
GO:2000026 | regulation of multicellular organismal development | 21.6216 | 4 | no |
GO:0043122 | regulation of canonical NF-kappaB signal transduction | 18.9189 | 6 | yes |
GO:0043123 | positive regulation of canonical NF-kappaB signal transduction | 13.5135 | 7 | yes |
GO:0001837 | epithelial to mesenchymal transition | 5.4054 | 5 | yes |
GO:0048762 | mesenchymal cell differentiation | 5.4054 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
RHOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IFNB_HUMAN | [view interactions] | Low throughput | no | no |
ANXA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
S10A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
S10A1_HUMAN | [view interactions] | Low throughput | no | yes |
AREG_HUMAN | [view interactions] | Low throughput | no | no |
HBEGF_HUMAN | [view interactions] | Low throughput | no | no |
P53_HUMAN | [view interactions] | Low throughput | no | no |
BTC_HUMAN | [view interactions] | Low throughput | no | no |
EGF_HUMAN | [view interactions] | Low throughput | no | no |
EGFR_HUMAN | [view interactions] | Low throughput | no | no |
ERBB3_HUMAN | [view interactions] | Low throughput | no | yes |
ERBB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MDM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MYH9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CEP20_HUMAN | [view interactions] | Low throughput | no | yes |
EZRI_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
MAP2_HUMAN | [view interactions] | Low throughput | no | yes |
CCN3_HUMAN | [view interactions] | Low throughput | no | no |
FCG3A_HUMAN | [view interactions] | Low throughput | no | no |
LIPB1_HUMAN | [view interactions] | Low throughput | no | yes |
SMAD3_HUMAN | [view interactions] | Low throughput | no | yes |
SMAD2_HUMAN | [view interactions] | Low throughput | no | yes |
WDFY3_HUMAN | [view interactions] | High throughput | no | yes |
BRD1_HUMAN | [view interactions] | High throughput | no | yes |
BBX_HUMAN | [view interactions] | High throughput | no | no |
PTGR2_HUMAN | [view interactions] | High throughput | no | yes |
TNFA_HUMAN | [view interactions] | High throughput | no | no |
CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
BRD4_HUMAN | [view interactions] | High throughput | no | yes |
MT21E_HUMAN | [view interactions] | High throughput | no | no |
BEX2_HUMAN | [view interactions] | High throughput | no | yes |
ZBED1_HUMAN | [view interactions] | High throughput | no | yes |
CC28A_HUMAN | [view interactions] | High throughput | no | no |
RPRD2_HUMAN | [view interactions] | High throughput | no | yes |
CRBN_HUMAN | [view interactions] | High throughput | no | yes |
SPC24_HUMAN | [view interactions] | High throughput | no | no |
UMPS_HUMAN | [view interactions] | High throughput | no | no |
CCD14_HUMAN | [view interactions] | High throughput | no | yes |
NDK7_HUMAN | [view interactions] | High throughput | no | yes |
SPC25_HUMAN | [view interactions] | High throughput | no | no |
POTEI_HUMAN | [view interactions] | High throughput | no | no |
VCIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PATE2_HUMAN | [view interactions] | High throughput | no | no |
VWA8_HUMAN | [view interactions] | High throughput | no | yes |
MYH14_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DSCR6_HUMAN | [view interactions] | High throughput | no | no |
COE2_HUMAN | [view interactions] | High throughput | no | no |
SIA7F_HUMAN | [view interactions] | High throughput | no | yes |
TXNIP_HUMAN | [view interactions] | High throughput | no | no |
ML12A_HUMAN | [view interactions] | High throughput | no | no |
HAUS1_HUMAN | [view interactions] | High throughput | no | yes |
UBE3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SATB1_HUMAN | [view interactions] | High throughput | no | yes |
SATB2_HUMAN | [view interactions] | High throughput | no | yes |
AFG2A_HUMAN | [view interactions] | High throughput | no | yes |
SSNA1_HUMAN | [view interactions] | High throughput | no | no |
KI18B_HUMAN | [view interactions] | High throughput | no | no |
TT21B_HUMAN | [view interactions] | High throughput | no | yes |
HAUS4_HUMAN | [view interactions] | High throughput | no | yes |
S10A2_HUMAN | [view interactions] | High throughput | no | no |
PKN3_HUMAN | [view interactions] | High throughput | no | yes |
GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MS18B_HUMAN | [view interactions] | High throughput | no | no |
ODBA_HUMAN | [view interactions] | High throughput | no | yes |
DIAP3_HUMAN | [view interactions] | High throughput | no | no |
CE128_HUMAN | [view interactions] | High throughput | no | yes |
DPYL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ODBB_HUMAN | [view interactions] | High throughput | no | yes |
ALR_HUMAN | [view interactions] | High throughput | no | yes |
XRCC4_HUMAN | [view interactions] | High throughput | no | yes |
GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PXDN_HUMAN | [view interactions] | High throughput | no | no |
FA24B_HUMAN | [view interactions] | High throughput | no | no |
RCBT2_HUMAN | [view interactions] | High throughput | no | yes |
VPS39_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HSBP1_HUMAN | [view interactions] | High throughput | no | no |
VPS11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RCBT1_HUMAN | [view interactions] | High throughput | no | no |
GAN_HUMAN | [view interactions] | High throughput | no | yes |
ESS2_HUMAN | [view interactions] | High throughput | no | yes |
CE170_HUMAN | [view interactions] | High throughput | no | yes |
ZFHX4_HUMAN | [view interactions] | High throughput | no | yes |
STXB2_HUMAN | [view interactions] | High throughput | no | no |
CEP44_HUMAN | [view interactions] | High throughput | no | yes |
CC28B_HUMAN | [view interactions] | High throughput | no | no |
PO4F3_HUMAN | [view interactions] | High throughput | no | no |
BTF3_HUMAN | [view interactions] | High throughput | no | yes |
PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
SPPL3_HUMAN | [view interactions] | High throughput | no | no |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IGBP1_HUMAN | [view interactions] | High throughput | no | yes |
TM1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UNK_HUMAN | [view interactions] | High throughput | no | yes |
SGT1_HUMAN | [view interactions] | High throughput | no | no |
PSA1_HUMAN | [view interactions] | High throughput | no | yes |
SBP1_HUMAN | [view interactions] | High throughput | no | no |
RUXF_HUMAN | [view interactions] | High throughput | no | no |
PCH2_HUMAN | [view interactions] | High throughput | no | no |
ZZEF1_HUMAN | [view interactions] | High throughput | no | no |
CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ARL3_HUMAN | [view interactions] | High throughput | no | yes |
GPD1L_HUMAN | [view interactions] | High throughput | no | no |
TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
S100B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
H2AX_HUMAN | [view interactions] | High throughput | no | yes |
NPHP1_HUMAN | [view interactions] | High throughput | no | yes |
NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
SAM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PHF12_HUMAN | [view interactions] | High throughput | no | yes |
OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
SLAI1_HUMAN | [view interactions] | High throughput | no | no |
CDK2_HUMAN | [view interactions] | High throughput | no | yes |
STRN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SMC1A_HUMAN | [view interactions] | High throughput | no | yes |
CORO7_HUMAN | [view interactions] | High throughput | no | no |
S10A6_HUMAN | [view interactions] | High throughput | no | yes |
NPAT_HUMAN | [view interactions] | High throughput | no | no |
DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYNE2_HUMAN | [view interactions] | High throughput | no | no |
DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
QCR9_HUMAN | [view interactions] | High throughput | no | no |
RPP29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KAT7_HUMAN | [view interactions] | High throughput | no | yes |
DNJA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SUV91_HUMAN | [view interactions] | High throughput | no | no |
IGHG3_HUMAN | [view interactions] | High throughput | no | no |
ESCO2_HUMAN | [view interactions] | High throughput | no | no |
XIAP_HUMAN | [view interactions] | High throughput | no | yes |
RASA1_HUMAN | [view interactions] | High throughput | no | yes |
PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RIPK1_HUMAN | [view interactions] | High throughput | no | yes |
RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MATR3_HUMAN | [view interactions] | High throughput | no | yes |
HTRA4_HUMAN | [view interactions] | High throughput | no | no |
NRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAGE_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STING_HUMAN | [view interactions] | High throughput | no | yes |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
U119A_HUMAN | [view interactions] | High throughput | no | no |
NAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRPM4_HUMAN | [view interactions] | High throughput | no | no |
KS6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MKNK1_HUMAN | [view interactions] | High throughput | no | yes |
CEP43_HUMAN | [view interactions] | High throughput | no | no |
HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CEP76_HUMAN | [view interactions] | High throughput | no | yes |
MOV10_HUMAN | [view interactions] | High throughput | no | no |
NXF1_HUMAN | [view interactions] | High throughput | no | yes |
CNTRL_HUMAN | [view interactions] | High throughput | no | yes |