S10A4_HUMAN
Evidence for PS localization
Functions
Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed, PubMed, PubMed). Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis . Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (PubMed). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes . In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in S10A4_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 30.0000 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 30.0000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 30.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.0000 | 4 | no |
| GO:0046872 | metal ion binding | 26.6667 | 4 | yes |
| GO:0019900 | kinase binding | 26.6667 | 4 | no |
| GO:0019901 | protein kinase binding | 26.6667 | 5 | no |
| GO:0005524 | ATP binding | 23.3333 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 23.3333 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 23.3333 | 5 | no |
| GO:0003779 | actin binding | 16.6667 | 4 | yes |
| GO:0005509 | calcium ion binding | 16.6667 | 5 | yes |
| GO:0046914 | transition metal ion binding | 10.0000 | 5 | yes |
| GO:0050786 | RAGE receptor binding | 10.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in S10A4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.6667 | 4 | yes |
| GO:0006996 | organelle organization | 56.6667 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 56.6667 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 46.6667 | 4 | yes |
| GO:0008104 | protein localization | 46.6667 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.6667 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 46.6667 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 43.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 43.3333 | 5 | no |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 40.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 40.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 36.6667 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 36.6667 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 36.6667 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 36.6667 | 5 | no |
| GO:0071702 | organic substance transport | 33.3333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.0000 | 4 | yes |
| GO:0015031 | protein transport | 30.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 30.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 30.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.0000 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.6667 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 26.6667 | 4 | no |
| GO:0061024 | membrane organization | 26.6667 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 26.6667 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.6667 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.6667 | 6 | no |
| GO:0031399 | regulation of protein modification process | 26.6667 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 26.6667 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.6667 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 26.6667 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 26.6667 | 5 | no |
| GO:0010941 | regulation of cell death | 26.6667 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 26.6667 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 26.6667 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 26.6667 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 23.3333 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 23.3333 | 5 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.3333 | 6 | yes |
| GO:0030030 | cell projection organization | 23.3333 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.3333 | 7 | no |
| GO:0006355 | regulation of DNA-templated transcription | 23.3333 | 6 | no |
| GO:0030162 | regulation of proteolysis | 23.3333 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 23.3333 | 4 | no |
| GO:0043549 | regulation of kinase activity | 23.3333 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 23.3333 | 4 | no |
| GO:0051338 | regulation of transferase activity | 23.3333 | 4 | no |
| GO:0071310 | cellular response to organic substance | 23.3333 | 4 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 23.3333 | 7 | no |
| GO:2000026 | regulation of multicellular organismal development | 23.3333 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 23.3333 | 6 | no |
| GO:0009968 | negative regulation of signal transduction | 23.3333 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 23.3333 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.3333 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 23.3333 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 23.3333 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 23.3333 | 4 | no |
| GO:0051049 | regulation of transport | 23.3333 | 4 | no |
| GO:0060548 | negative regulation of cell death | 23.3333 | 5 | no |
| GO:0009894 | regulation of catabolic process | 23.3333 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 23.3333 | 6 | no |
| GO:0043122 | regulation of I-kappaB kinase/NF-kappaB signaling | 20.0000 | 6 | yes |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 13.3333 | 7 | yes |
| GO:0001837 | epithelial to mesenchymal transition | 6.6667 | 5 | yes |
| GO:0048762 | mesenchymal cell differentiation | 6.6667 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in S10A4_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 10.0000 | 3 | no |
| DOID:0050155 | sensory system disease | 6.6667 | 3 | no |
| DOID:0050563 | nonsyndromic deafness | 6.6667 | 5 | no |
| DOID:0050564 | autosomal dominant nonsyndromic deafness | 6.6667 | 6 | no |
| DOID:2742 | auditory system disease | 6.6667 | 4 | no |
| DOID:1289 | neurodegenerative disease | 6.6667 | 4 | no |
| DOID:231 | motor neuron disease | 6.6667 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| S10A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| S10A1_HUMAN | [view interactions] | Low throughput | no | yes |
| AREG_HUMAN | [view interactions] | Low throughput | no | no |
| HBEGF_HUMAN | [view interactions] | Low throughput | no | no |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| EGF_HUMAN | [view interactions] | Low throughput | no | no |
| BTC_HUMAN | [view interactions] | Low throughput | no | no |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| ERBB3_HUMAN | [view interactions] | Low throughput | no | yes |
| ERBB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MDM2_HUMAN | [view interactions] | Low throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CEP20_HUMAN | [view interactions] | Low throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MAP2_HUMAN | [view interactions] | Low throughput | no | yes |
| CCN3_HUMAN | [view interactions] | Low throughput | no | no |
| FCG3A_HUMAN | [view interactions] | Low throughput | no | no |
| LIPB1_HUMAN | [view interactions] | Low throughput | no | yes |
| SMAD3_HUMAN | [view interactions] | Low throughput | no | yes |
| SMAD2_HUMAN | [view interactions] | Low throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANXA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| S100B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2AX_HUMAN | [view interactions] | High throughput | no | yes |
| NPHP1_HUMAN | [view interactions] | High throughput | no | yes |
| NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| SAM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHF12_HUMAN | [view interactions] | High throughput | no | yes |
| OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
| SLAI1_HUMAN | [view interactions] | High throughput | no | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| STRN3_HUMAN | [view interactions] | High throughput | no | yes |
| SMC1A_HUMAN | [view interactions] | High throughput | no | yes |
| ESCO2_HUMAN | [view interactions] | High throughput | no | no |
| XIAP_HUMAN | [view interactions] | High throughput | no | yes |
| IGHG3_HUMAN | [view interactions] | High throughput | no | no |
| SUV91_HUMAN | [view interactions] | High throughput | no | no |
| DNJA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAT7_HUMAN | [view interactions] | High throughput | no | yes |
| RPP29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR9_HUMAN | [view interactions] | High throughput | no | no |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNE2_HUMAN | [view interactions] | High throughput | no | no |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPAT_HUMAN | [view interactions] | High throughput | no | no |
| S10A6_HUMAN | [view interactions] | High throughput | no | yes |
| CORO7_HUMAN | [view interactions] | High throughput | no | no |
| RASA1_HUMAN | [view interactions] | High throughput | no | yes |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIPK1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA4_HUMAN | [view interactions] | High throughput | no | no |
| NRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAGE_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| U119A_HUMAN | [view interactions] | High throughput | no | no |
| NAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRPM4_HUMAN | [view interactions] | High throughput | no | no |
| KS6A1_HUMAN | [view interactions] | High throughput | no | yes |
| MKNK1_HUMAN | [view interactions] | High throughput | no | yes |
| CEP43_HUMAN | [view interactions] | High throughput | no | no |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CEP76_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
| WDFY3_HUMAN | [view interactions] | High throughput | no | yes |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| BBX_HUMAN | [view interactions] | High throughput | no | no |
| PTGR2_HUMAN | [view interactions] | High throughput | no | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| MT21E_HUMAN | [view interactions] | High throughput | no | no |
| BEX2_HUMAN | [view interactions] | High throughput | no | yes |
| ZBED1_HUMAN | [view interactions] | High throughput | no | yes |
| CC28A_HUMAN | [view interactions] | High throughput | no | no |
| RPRD2_HUMAN | [view interactions] | High throughput | no | yes |
| CRBN_HUMAN | [view interactions] | High throughput | no | yes |
| SPC24_HUMAN | [view interactions] | High throughput | no | no |
| UMPS_HUMAN | [view interactions] | High throughput | no | no |
| CCD14_HUMAN | [view interactions] | High throughput | no | yes |
| NDK7_HUMAN | [view interactions] | High throughput | no | yes |
| SPC25_HUMAN | [view interactions] | High throughput | no | no |
| POTEI_HUMAN | [view interactions] | High throughput | no | no |
| VCIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PATE2_HUMAN | [view interactions] | High throughput | no | no |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| MYH14_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DSCR6_HUMAN | [view interactions] | High throughput | no | no |
| COE2_HUMAN | [view interactions] | High throughput | no | no |
| SIA7F_HUMAN | [view interactions] | High throughput | no | yes |
| TXNIP_HUMAN | [view interactions] | High throughput | no | no |
| ML12A_HUMAN | [view interactions] | High throughput | no | no |
| HAUS1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3A_HUMAN | [view interactions] | High throughput | no | yes |
| SATB1_HUMAN | [view interactions] | High throughput | no | yes |
| SATB2_HUMAN | [view interactions] | High throughput | no | yes |
| AFG2H_HUMAN | [view interactions] | High throughput | no | yes |
| SSNA1_HUMAN | [view interactions] | High throughput | no | no |
| KI18B_HUMAN | [view interactions] | High throughput | no | no |
| TT21B_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS4_HUMAN | [view interactions] | High throughput | no | yes |
| S10A2_HUMAN | [view interactions] | High throughput | no | no |
| PKN3_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MS18B_HUMAN | [view interactions] | High throughput | no | no |
| ODBA_HUMAN | [view interactions] | High throughput | no | yes |
| DIAP3_HUMAN | [view interactions] | High throughput | no | no |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODBB_HUMAN | [view interactions] | High throughput | no | yes |
| ALR_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC4_HUMAN | [view interactions] | High throughput | no | yes |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PXDN_HUMAN | [view interactions] | High throughput | no | no |
| FA24B_HUMAN | [view interactions] | High throughput | no | no |
| RCBT2_HUMAN | [view interactions] | High throughput | no | yes |
| VPS39_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSBP1_HUMAN | [view interactions] | High throughput | no | no |
| VPS11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCBT1_HUMAN | [view interactions] | High throughput | no | no |
| GAN_HUMAN | [view interactions] | High throughput | no | yes |
| ESS2_HUMAN | [view interactions] | High throughput | no | yes |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| ZFHX4_HUMAN | [view interactions] | High throughput | no | yes |
| STXB2_HUMAN | [view interactions] | High throughput | no | no |
| CEP44_HUMAN | [view interactions] | High throughput | no | yes |
| CC28B_HUMAN | [view interactions] | High throughput | no | no |
| PO4F3_HUMAN | [view interactions] | High throughput | no | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IGBP1_HUMAN | [view interactions] | High throughput | no | yes |
| TM1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| SGT1_HUMAN | [view interactions] | High throughput | no | no |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| SBP1_HUMAN | [view interactions] | High throughput | no | no |
| RUXF_HUMAN | [view interactions] | High throughput | no | no |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| ZZEF1_HUMAN | [view interactions] | High throughput | no | no |
| PGRP1_HUMAN | [view interactions] | Computational | no | no |
| TCHP_HUMAN | [view interactions] | Computational | no | yes |
| RTKN_HUMAN | [view interactions] | Computational | no | yes |
| PLMN_HUMAN | [view interactions] | Computational | no | no |