VPS39_HUMAN
Evidence for PS localization
Functions
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes (PubMed, PubMed, PubMed). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VPS39_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 27.7778 | 4 | no |
| GO:0046872 | metal ion binding | 27.7778 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VPS39_HUMAN |
|---|---|---|---|---|
| GO:0071702 | organic substance transport | 77.7778 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 77.7778 | 4 | yes |
| GO:0006886 | intracellular protein transport | 72.2222 | 4 | yes |
| GO:0006996 | organelle organization | 72.2222 | 4 | yes |
| GO:0008104 | protein localization | 72.2222 | 4 | yes |
| GO:0015031 | protein transport | 72.2222 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 61.1111 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 61.1111 | 4 | yes |
| GO:0007034 | vacuolar transport | 55.5556 | 4 | yes |
| GO:0007041 | lysosomal transport | 55.5556 | 5 | yes |
| GO:0016050 | vesicle organization | 55.5556 | 5 | yes |
| GO:0061024 | membrane organization | 55.5556 | 4 | yes |
| GO:0006906 | vesicle fusion | 50.0000 | 6 | yes |
| GO:0048284 | organelle fusion | 50.0000 | 5 | yes |
| GO:0061025 | membrane fusion | 50.0000 | 5 | yes |
| GO:0090174 | organelle membrane fusion | 50.0000 | 6 | yes |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 44.4444 | 4 | no |
| GO:0034058 | endosomal vesicle fusion | 38.8889 | 7 | yes |
| GO:0035542 | regulation of SNARE complex assembly | 38.8889 | 6 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 38.8889 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 38.8889 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 38.8889 | 5 | no |
| GO:0051049 | regulation of transport | 38.8889 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 38.8889 | 4 | no |
| GO:0009966 | regulation of signal transduction | 38.8889 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 33.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0033365 | protein localization to organelle | 27.7778 | 5 | no |
| GO:0072594 | establishment of protein localization to organelle | 27.7778 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 27.7778 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 27.7778 | 5 | no |
| GO:0010468 | regulation of gene expression | 27.7778 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 27.7778 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 27.7778 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 27.7778 | 5 | no |
| GO:0017157 | regulation of exocytosis | 27.7778 | 5 | no |
| GO:0022607 | cellular component assembly | 27.7778 | 4 | no |
| GO:0023056 | positive regulation of signaling | 27.7778 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 27.7778 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.7778 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 27.7778 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 27.7778 | 6 | no |
| GO:0051046 | regulation of secretion | 27.7778 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 27.7778 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 27.7778 | 4 | no |
| GO:0006913 | nucleocytoplasmic transport | 22.2222 | 5 | no |
| GO:0009894 | regulation of catabolic process | 22.2222 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 22.2222 | 7 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.2222 | 5 | no |
| GO:0051050 | positive regulation of transport | 22.2222 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 22.2222 | 4 | no |
| GO:0051169 | nuclear transport | 22.2222 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 22.2222 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.2222 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.2222 | 5 | no |
| GO:0070925 | organelle assembly | 22.2222 | 5 | no |
| GO:1903305 | regulation of regulated secretory pathway | 22.2222 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.2222 | 4 | no |
| GO:0007033 | vacuole organization | 22.2222 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 22.2222 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 22.2222 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.2222 | 4 | no |
| GO:0032456 | endocytic recycling | 16.6667 | 4 | yes |
| GO:1902774 | late endosome to lysosome transport | 16.6667 | 6 | yes |
| GO:0061909 | autophagosome-lysosome fusion | 11.1111 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VPS11_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PKHM1_HUMAN | [view interactions] | Low throughput | no | yes |
| STX17_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BORC6_HUMAN | [view interactions] | Low throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RILP_HUMAN | [view interactions] | Low throughput | no | no |
| VPS39_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SNW1_HUMAN | [view interactions] | Low throughput | no | yes |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| VPS18_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPS41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPE39_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| NOTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUNX1_HUMAN | [view interactions] | High throughput | no | yes |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFP11_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| UVRAG_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| EPN3_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KS6C1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZN263_HUMAN | [view interactions] | High throughput | no | yes |
| SPAT1_HUMAN | [view interactions] | High throughput | no | no |
| UBP54_HUMAN | [view interactions] | High throughput | no | yes |
| NPAT_HUMAN | [view interactions] | High throughput | no | no |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
| TXND3_HUMAN | [view interactions] | High throughput | no | no |
| MIA40_HUMAN | [view interactions] | High throughput | no | yes |
| FAXC_HUMAN | [view interactions] | High throughput | no | no |
| GDF3_HUMAN | [view interactions] | High throughput | no | no |
| S10A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IL1R1_HUMAN | [view interactions] | High throughput | no | no |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| ZN655_HUMAN | [view interactions] | High throughput | no | yes |
| NFRKB_HUMAN | [view interactions] | High throughput | no | yes |
| RBM25_HUMAN | [view interactions] | High throughput | no | yes |
| PR40A_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| PTAR1_HUMAN | [view interactions] | High throughput | no | yes |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| ATG12_HUMAN | [view interactions] | High throughput | no | yes |
| SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| ATG3_HUMAN | [view interactions] | High throughput | no | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO6_HUMAN | [view interactions] | High throughput | no | yes |
| UAP1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |