VPS39_HUMAN
Evidence for PS localization
Functions
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes (PubMed, PubMed, PubMed). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VPS39_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 25.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VPS39_HUMAN |
|---|---|---|---|---|
| GO:0071702 | organic substance transport | 80.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 80.0000 | 4 | yes |
| GO:0008104 | protein localization | 75.0000 | 4 | yes |
| GO:0015031 | protein transport | 75.0000 | 4 | yes |
| GO:0006886 | intracellular protein transport | 70.0000 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 65.0000 | 4 | yes |
| GO:0006996 | organelle organization | 55.0000 | 4 | yes |
| GO:0007034 | vacuolar transport | 50.0000 | 4 | yes |
| GO:0007041 | lysosomal transport | 50.0000 | 5 | yes |
| GO:0008333 | endosome to lysosome transport | 50.0000 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 45.0000 | 4 | no |
| GO:0016050 | vesicle organization | 45.0000 | 5 | yes |
| GO:0048284 | organelle fusion | 45.0000 | 5 | yes |
| GO:0061024 | membrane organization | 45.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | no |
| GO:0006906 | vesicle fusion | 35.0000 | 6 | yes |
| GO:0061025 | membrane fusion | 35.0000 | 5 | yes |
| GO:0090174 | organelle membrane fusion | 35.0000 | 6 | yes |
| GO:0051049 | regulation of transport | 35.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.0000 | 4 | no |
| GO:0016197 | endosomal transport | 30.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 30.0000 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 30.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0051050 | positive regulation of transport | 25.0000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 25.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 25.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:0034058 | endosomal vesicle fusion | 25.0000 | 7 | yes |
| GO:0033365 | protein localization to organelle | 25.0000 | 5 | no |
| GO:0017157 | regulation of exocytosis | 25.0000 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 25.0000 | 4 | no |
| GO:0051046 | regulation of secretion | 25.0000 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 25.0000 | 4 | no |
| GO:0032456 | endocytic recycling | 15.0000 | 5 | yes |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 15.0000 | 4 | yes |
| GO:1902774 | late endosome to lysosome transport | 15.0000 | 6 | yes |
| GO:0061909 | autophagosome-lysosome fusion | 10.0000 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VPS11_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PKHM1_HUMAN | [view interactions] | Low throughput | no | yes |
| STX17_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BORC6_HUMAN | [view interactions] | Low throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RILP_HUMAN | [view interactions] | Low throughput | no | no |
| VPS39_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SNW1_HUMAN | [view interactions] | Low throughput | no | yes |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| VPS18_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPS41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPE39_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| NOTC1_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDEL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFP11_HUMAN | [view interactions] | High throughput | no | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| UVRAG_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| EPN3_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KS6C1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZN263_HUMAN | [view interactions] | High throughput | no | yes |
| SPAT1_HUMAN | [view interactions] | High throughput | no | no |
| UBP54_HUMAN | [view interactions] | High throughput | no | yes |
| NPAT_HUMAN | [view interactions] | High throughput | no | no |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
| TXND3_HUMAN | [view interactions] | High throughput | no | no |
| MIA40_HUMAN | [view interactions] | High throughput | no | yes |
| FAXC_HUMAN | [view interactions] | High throughput | no | no |
| GDF3_HUMAN | [view interactions] | High throughput | no | no |
| S10A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IL1R1_HUMAN | [view interactions] | High throughput | no | no |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| ZN655_HUMAN | [view interactions] | High throughput | no | yes |
| NFRKB_HUMAN | [view interactions] | High throughput | no | yes |
| RBM25_HUMAN | [view interactions] | High throughput | no | yes |
| PR40A_HUMAN | [view interactions] | High throughput | no | yes |
| PTAR1_HUMAN | [view interactions] | High throughput | no | yes |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| ATG12_HUMAN | [view interactions] | High throughput | no | yes |
| SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| ATG3_HUMAN | [view interactions] | High throughput | no | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO6_HUMAN | [view interactions] | High throughput | no | yes |
| UAP1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7B_HUMAN | [view interactions] | Computational | no | no |
| CCZ1_HUMAN | [view interactions] | Computational | no | yes |
| CCZ1B_HUMAN | [view interactions] | Computational | no | yes |
| TGFA1_HUMAN | [view interactions] | Computational | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| YKT6_HUMAN | [view interactions] | Computational | no | yes |
| RAB6A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VTI1A_HUMAN | [view interactions] | Computational | no | yes |
| MON1A_HUMAN | [view interactions] | Computational | no | no |
| RRAGB_HUMAN | [view interactions] | Computational | no | yes |
| VP33B_HUMAN | [view interactions] | Computational | no | yes |
| VPS8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |