VPS16_HUMAN
Evidence for PS localization
Functions
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed, PubMed, PubMed, PubMed, PubMed). Required for recruitment of VPS33A to the HOPS complex (PubMed). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS33A but not VPS33B (PubMed). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 52 | Asn | Lys | Dystonia30(DYT30) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VPS16_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 23.6842 | 4 | no |
| GO:0017076 | purine nucleotide binding | 21.0526 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 21.0526 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.0526 | 4 | no |
| GO:0043168 | anion binding | 21.0526 | 4 | no |
| GO:0003779 | actin binding | 15.7895 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VPS16_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 55.2632 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 55.2632 | 4 | yes |
| GO:0008104 | protein localization | 52.6316 | 4 | yes |
| GO:0071702 | organic substance transport | 50.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 50.0000 | 4 | yes |
| GO:0015031 | protein transport | 47.3684 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 44.7368 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 42.1053 | 4 | no |
| GO:0006886 | intracellular protein transport | 42.1053 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 42.1053 | 4 | yes |
| GO:0010646 | regulation of cell communication | 39.4737 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.8421 | 4 | no |
| GO:0007034 | vacuolar transport | 34.2105 | 4 | yes |
| GO:0016050 | vesicle organization | 34.2105 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 31.5789 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 31.5789 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 31.5789 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 31.5789 | 4 | no |
| GO:0007041 | lysosomal transport | 31.5789 | 5 | yes |
| GO:0061024 | membrane organization | 31.5789 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 31.5789 | 4 | no |
| GO:0009894 | regulation of catabolic process | 31.5789 | 4 | no |
| GO:0036211 | protein modification process | 28.9474 | 4 | no |
| GO:0043412 | macromolecule modification | 28.9474 | 4 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 28.9474 | 5 | yes |
| GO:0048284 | organelle fusion | 28.9474 | 5 | yes |
| GO:0061025 | membrane fusion | 28.9474 | 5 | yes |
| GO:0090174 | organelle membrane fusion | 28.9474 | 6 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.3158 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 26.3158 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.3158 | 4 | no |
| GO:0033043 | regulation of organelle organization | 26.3158 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.3158 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.3158 | 6 | no |
| GO:0022607 | cellular component assembly | 26.3158 | 4 | no |
| GO:0006906 | vesicle fusion | 26.3158 | 6 | yes |
| GO:0009896 | positive regulation of catabolic process | 26.3158 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 23.6842 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.6842 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.6842 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.6842 | 5 | no |
| GO:0032880 | regulation of protein localization | 23.6842 | 5 | no |
| GO:0060341 | regulation of cellular localization | 23.6842 | 4 | no |
| GO:0035542 | regulation of SNARE complex assembly | 23.6842 | 6 | yes |
| GO:0010648 | negative regulation of cell communication | 21.0526 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.0526 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 21.0526 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 21.0526 | 4 | no |
| GO:0031399 | regulation of protein modification process | 21.0526 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 21.0526 | 4 | no |
| GO:0051049 | regulation of transport | 21.0526 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 21.0526 | 4 | no |
| GO:0033365 | protein localization to organelle | 21.0526 | 5 | no |
| GO:0034058 | endosomal vesicle fusion | 21.0526 | 7 | yes |
| GO:0043933 | protein-containing complex organization | 21.0526 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 21.0526 | 4 | no |
| GO:0007033 | vacuole organization | 18.4211 | 5 | yes |
| GO:0022411 | cellular component disassembly | 13.1579 | 4 | yes |
| GO:0032984 | protein-containing complex disassembly | 7.8947 | 5 | yes |
| GO:0097352 | autophagosome maturation | 7.8947 | 6 | yes |
| GO:0042144 | vacuole fusion, non-autophagic | 5.2632 | 7 | yes |
| GO:0097576 | vacuole fusion | 5.2632 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VP33A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VPS18_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VPS16_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS11_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SPE39_HUMAN | [view interactions] | Low throughput | no | yes |
| TGFA1_HUMAN | [view interactions] | Low throughput | no | no |
| STX17_HUMAN | [view interactions] | Low throughput | no | yes |
| MON1B_HUMAN | [view interactions] | Low throughput | no | yes |
| RILP_HUMAN | [view interactions] | Low throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UVRAG_HUMAN | [view interactions] | Low throughput | no | yes |
| TSR1_HUMAN | [view interactions] | High throughput | no | no |
| TNPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WAPL_HUMAN | [view interactions] | High throughput | no | yes |
| PSB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RM54_HUMAN | [view interactions] | High throughput | no | yes |
| FAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN800_HUMAN | [view interactions] | High throughput | no | yes |
| VPS41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C1QT6_HUMAN | [view interactions] | High throughput | no | no |
| PIAS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFAH_HUMAN | [view interactions] | High throughput | no | no |
| RIOK2_HUMAN | [view interactions] | High throughput | no | yes |
| MTOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP9A_HUMAN | [view interactions] | High throughput | no | yes |
| RT15_HUMAN | [view interactions] | High throughput | no | yes |
| CT55_HUMAN | [view interactions] | High throughput | no | no |
| F167A_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPR2_HUMAN | [view interactions] | High throughput | no | yes |
| MOCS3_HUMAN | [view interactions] | High throughput | no | yes |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS39_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHM1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| BCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STA5A_HUMAN | [view interactions] | High throughput | no | no |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| CI072_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| EXOC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBG13_HUMAN | [view interactions] | High throughput | no | no |
| ZN417_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKTIP_HUMAN | [view interactions] | High throughput | no | yes |
| PKNX1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| ACV1B_HUMAN | [view interactions] | High throughput | no | no |
| VPS8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT17_HUMAN | [view interactions] | High throughput | no | yes |
| PR40A_HUMAN | [view interactions] | High throughput | no | no |
| P33MX_HUMAN | [view interactions] | High throughput | no | yes |
| TTC31_HUMAN | [view interactions] | High throughput | no | yes |
| ESRP2_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR7_HUMAN | [view interactions] | High throughput | no | no |
| LYPD4_HUMAN | [view interactions] | High throughput | no | no |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CDCA5_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXCR4_HUMAN | [view interactions] | High throughput | no | no |
| VCIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRSF2_HUMAN | [view interactions] | High throughput | no | yes |
| SEM4C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STXB4_HUMAN | [view interactions] | High throughput | no | yes |
| TBCD4_HUMAN | [view interactions] | High throughput | no | yes |
| CC127_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSPB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PMM1_HUMAN | [view interactions] | High throughput | no | yes |
| ST1C4_HUMAN | [view interactions] | High throughput | no | no |
| SOLH1_HUMAN | [view interactions] | High throughput | no | no |
| CI163_HUMAN | [view interactions] | High throughput | no | no |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| D2HDH_HUMAN | [view interactions] | High throughput | no | no |
| B4GT2_HUMAN | [view interactions] | High throughput | no | no |
| AMZ1_HUMAN | [view interactions] | High throughput | no | no |
| FBXW5_HUMAN | [view interactions] | High throughput | no | no |
| CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
| CIB3_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARMC5_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| ATG10_HUMAN | [view interactions] | High throughput | no | yes |
| ATG3_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |