Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

STX1A_HUMAN

Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed). Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed). Plays also an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in STX1A_HUMAN
GO:0019905 syntaxin binding 32.8571 4 no
GO:0043169 cation binding 32.8571 4 no
GO:0046872 metal ion binding 32.8571 5 no
GO:0019900 kinase binding 14.2857 4 yes
GO:0008200 ion channel inhibitor activity 5.7143 5 yes
GO:0016248 channel inhibitor activity 5.7143 4 yes
GO:0017081 chloride channel regulator activity 5.7143 5 yes
GO:0019869 chloride channel inhibitor activity 5.7143 6 yes
GO:0099106 ion channel regulator activity 5.7143 4 yes
GO:0005246 calcium channel regulator activity 2.8571 5 yes
GO:0019855 calcium channel inhibitor activity 2.8571 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in STX1A_HUMAN
GO:0048522 positive regulation of cellular process 55.7143 4 yes
GO:0051049 regulation of transport 54.2857 4 yes
GO:0071702 organic substance transport 54.2857 4 yes
GO:0010646 regulation of cell communication 51.4286 4 yes
GO:0051128 regulation of cellular component organization 50.0000 4 yes
GO:0071705 nitrogen compound transport 50.0000 4 yes
GO:0006996 organelle organization 48.5714 4 yes
GO:0008104 protein localization 47.1429 4 yes
GO:0050804 modulation of chemical synaptic transmission 41.4286 5 yes
GO:0099177 regulation of trans-synaptic signaling 41.4286 4 yes
GO:0015031 protein transport 40.0000 4 yes
GO:0061024 membrane organization 40.0000 4 yes
GO:0046903 secretion 38.5714 4 yes
GO:0051046 regulation of secretion 38.5714 5 yes
GO:0016050 vesicle organization 37.1429 5 yes
GO:0060627 regulation of vesicle-mediated transport 37.1429 4 yes
GO:1903530 regulation of secretion by cell 37.1429 4 yes
GO:0022607 cellular component assembly 37.1429 4 no
GO:0048523 negative regulation of cellular process 35.7143 4 no
GO:0051050 positive regulation of transport 34.2857 4 yes
GO:0060255 regulation of macromolecule metabolic process 34.2857 4 no
GO:0044087 regulation of cellular component biogenesis 32.8571 4 yes
GO:0017157 regulation of exocytosis 31.4286 5 yes
GO:0061025 membrane fusion 31.4286 5 yes
GO:0031323 regulation of cellular metabolic process 31.4286 4 no
GO:0043933 protein-containing complex organization 30.0000 4 no
GO:0006886 intracellular protein transport 28.5714 4 yes
GO:0023056 positive regulation of signaling 28.5714 4 yes
GO:0048284 organelle fusion 28.5714 5 yes
GO:0060341 regulation of cellular localization 28.5714 4 yes
GO:0006906 vesicle fusion 27.1429 6 yes
GO:0009966 regulation of signal transduction 27.1429 4 yes
GO:0023061 signal release 27.1429 4 yes
GO:0032880 regulation of protein localization 27.1429 5 yes
GO:0048278 vesicle docking 27.1429 4 yes
GO:0090174 organelle membrane fusion 27.1429 6 yes
GO:0009893 positive regulation of metabolic process 27.1429 4 no
GO:0010647 positive regulation of cell communication 25.7143 5 yes
GO:0098657 import into cell 25.7143 4 yes
GO:0099643 signal release from synapse 25.7143 5 yes
GO:0009889 regulation of biosynthetic process 25.7143 4 no
GO:0010556 regulation of macromolecule biosynthetic process 25.7143 5 no
GO:0031326 regulation of cellular biosynthetic process 25.7143 5 no
GO:0080090 regulation of primary metabolic process 25.7143 4 no
GO:0045055 regulated exocytosis 24.2857 4 yes
GO:0051047 positive regulation of secretion 24.2857 5 yes
GO:0065003 protein-containing complex assembly 24.2857 5 no
GO:1903532 positive regulation of secretion by cell 22.8571 5 yes
GO:0010468 regulation of gene expression 22.8571 6 no
GO:0010604 positive regulation of macromolecule metabolic process 22.8571 5 no
GO:0051246 regulation of protein metabolic process 22.8571 5 no
GO:0016079 synaptic vesicle exocytosis 21.4286 4 yes
GO:0048584 positive regulation of response to stimulus 21.4286 4 yes
GO:1903305 regulation of regulated secretory pathway 21.4286 6 yes
GO:0036211 protein modification process 20.0000 4 yes
GO:0043412 macromolecule modification 20.0000 4 yes
GO:0043254 regulation of protein-containing complex assembly 18.5714 5 yes
GO:0045921 positive regulation of exocytosis 18.5714 6 yes
GO:0050806 positive regulation of synaptic transmission 18.5714 5 yes
GO:0070201 regulation of establishment of protein localization 18.5714 6 yes
GO:0017156 calcium-ion regulated exocytosis 17.1429 5 yes
GO:0046928 regulation of neurotransmitter secretion 15.7143 5 yes
GO:0051223 regulation of protein transport 15.7143 5 yes
GO:0051588 regulation of neurotransmitter transport 15.7143 5 yes
GO:0009967 positive regulation of signal transduction 14.2857 5 yes
GO:0017158 regulation of calcium ion-dependent exocytosis 14.2857 7 yes
GO:0048499 synaptic vesicle membrane organization 12.8571 5 yes
GO:0051952 regulation of amine transport 12.8571 5 yes
GO:1903307 positive regulation of regulated secretory pathway 12.8571 7 yes
GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane 11.4286 4 yes
GO:0032446 protein modification by small protein conjugation 11.4286 7 yes
GO:0043687 post-translational protein modification 11.4286 5 yes
GO:0044057 regulation of system process 11.4286 4 yes
GO:0048488 synaptic vesicle endocytosis 11.4286 5 yes
GO:0070647 protein modification by small protein conjugation or removal 11.4286 6 yes
GO:0140238 presynaptic endocytosis 11.4286 4 yes
GO:0010807 regulation of synaptic vesicle priming 10.0000 6 yes
GO:0045956 positive regulation of calcium ion-dependent exocytosis 10.0000 8 yes
GO:0046883 regulation of hormone secretion 10.0000 4 yes
GO:0050433 regulation of catecholamine secretion 10.0000 5 yes
GO:0050708 regulation of protein secretion 10.0000 5 yes
GO:0001956 positive regulation of neurotransmitter secretion 8.5714 6 yes
GO:0002791 regulation of peptide secretion 8.5714 6 yes
GO:0050796 regulation of insulin secretion 8.5714 6 yes
GO:0051590 positive regulation of neurotransmitter transport 8.5714 5 yes
GO:0051954 positive regulation of amine transport 8.5714 5 yes
GO:0090087 regulation of peptide transport 8.5714 5 yes
GO:0090276 regulation of peptide hormone secretion 8.5714 5 yes
GO:0009914 hormone transport 7.1429 4 yes
GO:0018193 peptidyl-amino acid modification 7.1429 5 yes
GO:0031644 regulation of nervous system process 7.1429 5 yes
GO:0042886 amide transport 7.1429 5 yes
GO:0046879 hormone secretion 7.1429 5 yes
GO:0098815 modulation of excitatory postsynaptic potential 7.1429 4 yes
GO:0002790 peptide secretion 5.7143 5 yes
GO:0009306 protein secretion 5.7143 4 yes
GO:0015833 peptide transport 5.7143 5 yes
GO:0016925 protein sumoylation 5.7143 7 yes
GO:0018205 peptidyl-lysine modification 5.7143 6 yes
GO:0030072 peptide hormone secretion 5.7143 6 yes
GO:0030073 insulin secretion 5.7143 5 yes
GO:0033605 positive regulation of catecholamine secretion 5.7143 6 yes
GO:0035592 establishment of protein localization to extracellular region 5.7143 4 yes
GO:0071692 protein localization to extracellular region 5.7143 5 yes
GO:2000463 positive regulation of excitatory postsynaptic potential 5.7143 5 yes
GO:0010701 positive regulation of norepinephrine secretion 4.2857 7 yes
GO:0014061 regulation of norepinephrine secretion 4.2857 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
VAMP2_HUMAN [view entry] [view interactions] Low throughput yes no
VAMP1_HUMAN [view interactions] Low throughput no no
SNP23_HUMAN [view entry] [view interactions] Low throughput yes no
SNP29_HUMAN [view interactions] Low throughput no yes
SC22B_HUMAN [view entry] [view interactions] Low throughput yes no
SNP47_HUMAN [view entry] [view interactions] Low throughput yes yes
STXB1_HUMAN [view entry] [view interactions] Low throughput yes yes
SEPT5_HUMAN [view interactions] Low throughput no no
SNP25_HUMAN [view entry] [view interactions] Low throughput yes yes
APBA1_HUMAN [view interactions] Low throughput no no
VAMP8_HUMAN [view interactions] Low throughput no no
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
LRRK2_HUMAN [view interactions] Low throughput no yes
RUSC1_HUMAN [view entry] [view interactions] Low throughput yes yes
HD_HUMAN [view entry] [view interactions] Low throughput yes yes
CPLX1_HUMAN [view entry] [view interactions] Low throughput yes yes
VAMP7_HUMAN [view interactions] Low throughput no yes
SYT2_HUMAN [view entry] [view interactions] Low throughput yes no
RP3A_HUMAN [view entry] [view interactions] Low throughput yes yes
APBA2_HUMAN [view interactions] Low throughput no yes
SYT1_HUMAN [view entry] [view interactions] Low throughput yes no
KCMA1_HUMAN [view entry] [view interactions] Low throughput yes no
NSF_HUMAN [view entry] [view interactions] Low throughput yes yes
SYT7_HUMAN [view entry] [view interactions] Low throughput yes yes
TXLNA_HUMAN [view interactions] Low throughput no yes
STX1A_HUMAN [view entry] [view interactions] Low throughput yes yes
TXLNB_HUMAN [view interactions] Low throughput no no
VAMP3_HUMAN [view entry] [view interactions] Low throughput yes no
UN13A_HUMAN [view entry] [view interactions] Low throughput yes no
CMGA_HUMAN [view interactions] Low throughput no yes
CAPS1_HUMAN [view entry] [view interactions] Low throughput yes yes
STXB3_HUMAN [view entry] [view interactions] Low throughput yes yes
SNAA_HUMAN [view entry] [view interactions] Low throughput yes yes
UN13B_HUMAN [view interactions] Low throughput no no
STXB2_HUMAN [view interactions] Low throughput no no
SCNNA_HUMAN [view interactions] Low throughput no yes
SCNNG_HUMAN [view interactions] Low throughput no no
SCNNB_HUMAN [view interactions] Low throughput no yes
SYTL4_HUMAN [view interactions] Low throughput no yes
BRE1B_HUMAN [view interactions] Low throughput no yes
CPLX2_HUMAN [view entry] [view interactions] Low throughput yes yes
CFTR_HUMAN [view interactions] Low throughput no no
SYPH_HUMAN [view entry] [view interactions] Low throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] Low throughput yes no
SC6A1_HUMAN [view entry] [view interactions] Low throughput yes no
SC6A9_HUMAN [view entry] [view interactions] Low throughput yes yes
SC6A5_HUMAN [view interactions] Low throughput no no
SC6A2_HUMAN [view interactions] Low throughput no no
SC6A3_HUMAN [view entry] [view interactions] Low throughput yes yes
HGS_HUMAN [view entry] [view interactions] Low throughput yes yes
CAC1D_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
SNPH_HUMAN [view entry] [view interactions] Low throughput yes yes
VAPA_HUMAN [view entry] [view interactions] Low throughput yes yes
PRRT2_HUMAN [view entry] [view interactions] Low throughput yes no
STXB5_HUMAN [view entry] [view interactions] Low throughput yes yes
CDK5_HUMAN [view entry] [view interactions] Low throughput yes yes
AT2B2_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
DPP8_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
PSA3_HUMAN [view interactions] High throughput no no
SNAB_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO5_HUMAN [view interactions] High throughput no no
MAL_HUMAN [view interactions] High throughput no no
SMIM1_HUMAN [view interactions] High throughput no yes
UPK1B_HUMAN [view interactions] High throughput no no
SMIM3_HUMAN [view interactions] High throughput no no
R3GEF_HUMAN [view interactions] High throughput no yes
SC22A_HUMAN [view interactions] High throughput no no
CYB5B_HUMAN [view entry] [view interactions] High throughput yes yes
SERP2_HUMAN [view interactions] High throughput no no
PLPP6_HUMAN [view interactions] High throughput no yes
LIPR1_HUMAN [view interactions] High throughput no no
NKG7_HUMAN [view interactions] High throughput no no
TNFA_HUMAN [view interactions] High throughput no no
VAMP5_HUMAN [view interactions] High throughput no no
RTP2_HUMAN [view interactions] High throughput no no
VAMP4_HUMAN [view entry] [view interactions] High throughput yes yes
STX11_HUMAN [view interactions] High throughput no yes
ZFPL1_HUMAN [view interactions] High throughput no yes
FAM3C_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
NINJ2_HUMAN [view entry] [view interactions] High throughput yes no
DWORF_HUMAN [view interactions] High throughput no no
APOL2_HUMAN [view entry] [view interactions] High throughput yes yes
DDX49_HUMAN [view interactions] High throughput no no
ZN835_HUMAN [view interactions] High throughput no no
BET1_HUMAN [view interactions] High throughput no no
ZN479_HUMAN [view interactions] High throughput no no
CKLF7_HUMAN [view interactions] High throughput no no
GIMA5_HUMAN [view interactions] High throughput no no
STX4_HUMAN [view entry] [view interactions] High throughput yes no
TM222_HUMAN [view interactions] High throughput no no
ZN441_HUMAN [view interactions] High throughput no no
CD81_HUMAN [view interactions] High throughput no no
JAGN1_HUMAN [view interactions] High throughput no no
STX8_HUMAN [view interactions] High throughput no yes
TM14C_HUMAN [view interactions] High throughput no no
STX12_HUMAN [view entry] [view interactions] High throughput yes yes
NRM_HUMAN [view interactions] High throughput no no
VSTM4_HUMAN [view interactions] High throughput no yes
EKI2_HUMAN [view interactions] High throughput no yes
ERG28_HUMAN [view interactions] High throughput no yes
ABI3_HUMAN [view entry] [view interactions] High throughput yes no
ZN440_HUMAN [view interactions] High throughput no no
USE1_HUMAN [view interactions] High throughput no yes
UBFL1_HUMAN [view interactions] High throughput no no
STX6_HUMAN [view interactions] High throughput no yes
PLPP4_HUMAN [view interactions] High throughput no yes
TM41A_HUMAN [view interactions] High throughput no no
STX3_HUMAN [view entry] [view interactions] High throughput yes no
TM254_HUMAN [view interactions] High throughput no yes
CLC1A_HUMAN [view interactions] High throughput no no
SNORC_HUMAN [view interactions] High throughput no yes
ZN785_HUMAN [view interactions] High throughput no no
STX5_HUMAN [view interactions] High throughput no yes
AOC3_HUMAN [view interactions] High throughput no no
T3JAM_HUMAN [view interactions] High throughput no no
SEC20_HUMAN [view interactions] High throughput no yes
TM199_HUMAN [view interactions] High throughput no yes
TM100_HUMAN [view interactions] High throughput no yes
AQP3_HUMAN [view interactions] High throughput no no
BL1S6_HUMAN [view interactions] High throughput no yes
MALL_HUMAN [view interactions] High throughput no no
ZN707_HUMAN [view interactions] High throughput no yes
MIP_HUMAN [view interactions] High throughput no no
ZN490_HUMAN [view interactions] High throughput no no
BT2A2_HUMAN [view interactions] High throughput no no
CDC37_HUMAN [view interactions] High throughput no yes
AARD_HUMAN [view interactions] High throughput no no
SERP1_HUMAN [view interactions] High throughput no no
T10IP_HUMAN [view interactions] High throughput no no
RMD2_HUMAN [view interactions] High throughput no yes
ZN696_HUMAN [view interactions] High throughput no no
HMOX1_HUMAN [view interactions] High throughput no no
EMD_HUMAN [view interactions] High throughput no yes
VTI1B_HUMAN [view entry] [view interactions] High throughput yes yes
ZNF12_HUMAN [view interactions] High throughput no no
TMM60_HUMAN [view interactions] High throughput no no
PPLA_HUMAN [view interactions] High throughput no no
GIMA1_HUMAN [view interactions] High throughput no yes
TACAN_HUMAN [view interactions] High throughput no no
GOSR2_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
AR13B_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
ZN136_HUMAN [view interactions] High throughput no no
CLN6_HUMAN [view interactions] High throughput no no
TRDMT_HUMAN [view interactions] High throughput no yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
CCSE2_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
SOX4_HUMAN [view interactions] High throughput no yes
MDM2_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
GPM6B_HUMAN [view interactions] High throughput no yes
UBC9_HUMAN [view entry] [view interactions] High throughput yes yes
STX10_HUMAN [view interactions] High throughput no yes
C1GLT_HUMAN [view interactions] High throughput no yes
STX2_HUMAN [view interactions] High throughput no no
MYPR_HUMAN [view entry] [view interactions] High throughput yes yes
STX16_HUMAN [view interactions] High throughput no yes
APOL3_HUMAN [view interactions] High throughput no no
ZN557_HUMAN [view interactions] High throughput no no
TM128_HUMAN [view interactions] High throughput no yes
KIFC3_HUMAN [view interactions] High throughput no no
AIG1_HUMAN [view interactions] High throughput no no
PGAP2_HUMAN [view interactions] High throughput no yes
CXL16_HUMAN [view interactions] High throughput no no
CD003_HUMAN [view interactions] High throughput no yes
GOLM2_HUMAN [view interactions] High throughput no yes
TSNA1_HUMAN [view interactions] High throughput no yes
TEANC_HUMAN [view interactions] High throughput no no
ATRAP_HUMAN [view interactions] High throughput no yes
ANR46_HUMAN [view interactions] High throughput no yes
ZN250_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
VPS11_HUMAN [view entry] [view interactions] High throughput yes no
VPS18_HUMAN [view entry] [view interactions] High throughput yes no
VAPB_HUMAN [view entry] [view interactions] High throughput yes yes
MS18B_HUMAN [view interactions] High throughput no no
HAX1_HUMAN [view interactions] High throughput no no
NUFP1_HUMAN [view interactions] High throughput no yes
DGUOK_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
CDR2_HUMAN [view interactions] High throughput no yes
STXB6_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4C_HUMAN [view interactions] High throughput no yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
FAM9C_HUMAN [view interactions] High throughput no no
VATB1_HUMAN [view interactions] High throughput no no
VPS16_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
CPLX3_HUMAN [view interactions] High throughput no no
SNX4_HUMAN [view entry] [view interactions] High throughput yes yes
STX1B_HUMAN [view entry] [view interactions] High throughput yes yes
LRC4C_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK2_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes