CAC1D_HUMAN
Evidence for PS localization
Functions
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the high-voltage activated (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003647 | LIG_CaM_NSCaTE_8 | LIG | 53 | 60 | - |
| ELMI004106 | LIG_WRC_WIRS_1 | LIG | 2033 | 2038 | - |
| ELMI003647 | LIG_CaM_NSCaTE_8 | LIG | 53 | 60 | - |
| ELMI004106 | LIG_WRC_WIRS_1 | LIG | 2033 | 2038 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CAC1D_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 57.1429 | 4 | yes |
| GO:0046872 | metal ion binding | 57.1429 | 5 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 47.6190 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 47.6190 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 47.6190 | 5 | yes |
| GO:0005216 | monoatomic ion channel activity | 42.8571 | 4 | yes |
| GO:0005261 | monoatomic cation channel activity | 42.8571 | 5 | yes |
| GO:0015267 | channel activity | 42.8571 | 4 | yes |
| GO:0022836 | gated channel activity | 42.8571 | 5 | yes |
| GO:0005244 | voltage-gated monoatomic ion channel activity | 38.0952 | 5 | yes |
| GO:0005262 | calcium channel activity | 38.0952 | 6 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 38.0952 | 6 | yes |
| GO:0022832 | voltage-gated channel activity | 38.0952 | 6 | yes |
| GO:0022843 | voltage-gated monoatomic cation channel activity | 38.0952 | 6 | yes |
| GO:0005245 | voltage-gated calcium channel activity | 33.3333 | 7 | yes |
| GO:0019900 | kinase binding | 23.8095 | 4 | no |
| GO:0042805 | actinin binding | 9.5238 | 4 | yes |
| GO:0051393 | alpha-actinin binding | 9.5238 | 5 | yes |
| GO:0086007 | voltage-gated calcium channel activity involved in cardiac muscle cell action potential | 9.5238 | 8 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CAC1D_HUMAN |
|---|---|---|---|---|
| GO:0051049 | regulation of transport | 71.4286 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 61.9048 | 4 | no |
| GO:0010646 | regulation of cell communication | 57.1429 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 52.3810 | 4 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 52.3810 | 5 | yes |
| GO:0008104 | protein localization | 47.6190 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.6190 | 4 | no |
| GO:0071310 | cellular response to organic substance | 47.6190 | 4 | no |
| GO:0010959 | regulation of metal ion transport | 47.6190 | 6 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 47.6190 | 5 | yes |
| GO:0044057 | regulation of system process | 47.6190 | 4 | yes |
| GO:0051050 | positive regulation of transport | 47.6190 | 4 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 42.8571 | 6 | yes |
| GO:0006811 | monoatomic ion transport | 42.8571 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 42.8571 | 5 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 42.8571 | 4 | yes |
| GO:0030001 | metal ion transport | 42.8571 | 6 | yes |
| GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 42.8571 | 5 | yes |
| GO:0098655 | monoatomic cation transmembrane transport | 42.8571 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 42.8571 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 38.0952 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 38.0952 | 4 | no |
| GO:0051924 | regulation of calcium ion transport | 38.0952 | 7 | yes |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
| GO:1903169 | regulation of calcium ion transmembrane transport | 33.3333 | 7 | no |
| GO:0010243 | response to organonitrogen compound | 33.3333 | 4 | no |
| GO:0001508 | action potential | 33.3333 | 4 | yes |
| GO:0006816 | calcium ion transport | 33.3333 | 7 | yes |
| GO:0043270 | positive regulation of monoatomic ion transport | 33.3333 | 5 | yes |
| GO:0070588 | calcium ion transmembrane transport | 33.3333 | 5 | yes |
| GO:0098657 | import into cell | 33.3333 | 4 | yes |
| GO:0032970 | regulation of actin filament-based process | 28.5714 | 4 | no |
| GO:0034330 | cell junction organization | 28.5714 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 28.5714 | 4 | no |
| GO:0032411 | positive regulation of transporter activity | 28.5714 | 4 | no |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 28.5714 | 5 | no |
| GO:0034764 | positive regulation of transmembrane transport | 28.5714 | 5 | no |
| GO:0034767 | positive regulation of monoatomic ion transmembrane transport | 28.5714 | 6 | no |
| GO:0007268 | chemical synaptic transmission | 28.5714 | 7 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 28.5714 | 6 | no |
| GO:0099536 | synaptic signaling | 28.5714 | 4 | no |
| GO:0099537 | trans-synaptic signaling | 28.5714 | 5 | no |
| GO:0008016 | regulation of heart contraction | 28.5714 | 6 | yes |
| GO:0097553 | calcium ion transmembrane import into cytosol | 28.5714 | 6 | yes |
| GO:1903522 | regulation of blood circulation | 28.5714 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 23.8095 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.8095 | 5 | no |
| GO:0022607 | cellular component assembly | 23.8095 | 4 | no |
| GO:0023056 | positive regulation of signaling | 23.8095 | 4 | no |
| GO:0050808 | synapse organization | 23.8095 | 5 | no |
| GO:0006937 | regulation of muscle contraction | 23.8095 | 6 | no |
| GO:0010038 | response to metal ion | 23.8095 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 23.8095 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 23.8095 | 4 | no |
| GO:0090257 | regulation of muscle system process | 23.8095 | 5 | no |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 23.8095 | 6 | no |
| GO:1904064 | positive regulation of cation transmembrane transport | 23.8095 | 7 | no |
| GO:2001257 | regulation of cation channel activity | 23.8095 | 6 | no |
| GO:0006996 | organelle organization | 23.8095 | 4 | no |
| GO:0032880 | regulation of protein localization | 23.8095 | 5 | no |
| GO:0060341 | regulation of cellular localization | 23.8095 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 23.8095 | 4 | no |
| GO:0072657 | protein localization to membrane | 23.8095 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 23.8095 | 4 | no |
| GO:0071417 | cellular response to organonitrogen compound | 23.8095 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 23.8095 | 4 | no |
| GO:0051928 | positive regulation of calcium ion transport | 23.8095 | 6 | yes |
| GO:0086001 | cardiac muscle cell action potential | 23.8095 | 5 | yes |
| GO:0086002 | cardiac muscle cell action potential involved in contraction | 23.8095 | 6 | yes |
| GO:0098659 | inorganic cation import across plasma membrane | 23.8095 | 5 | yes |
| GO:0099587 | inorganic ion import across plasma membrane | 23.8095 | 4 | yes |
| GO:0070509 | calcium ion import | 19.0476 | 8 | yes |
| GO:0098703 | calcium ion import across plasma membrane | 19.0476 | 6 | yes |
| GO:1902656 | calcium ion import into cytosol | 19.0476 | 8 | yes |
| GO:0031279 | regulation of cyclase activity | 14.2857 | 4 | yes |
| GO:0043085 | positive regulation of catalytic activity | 14.2857 | 4 | yes |
| GO:0045761 | regulation of adenylate cyclase activity | 14.2857 | 5 | yes |
| GO:0051339 | regulation of lyase activity | 14.2857 | 4 | yes |
| GO:0051899 | membrane depolarization | 14.2857 | 4 | yes |
| GO:0061337 | cardiac conduction | 14.2857 | 7 | yes |
| GO:0086010 | membrane depolarization during action potential | 14.2857 | 5 | yes |
| GO:0086012 | membrane depolarization during cardiac muscle cell action potential | 14.2857 | 6 | yes |
| GO:0086091 | regulation of heart rate by cardiac conduction | 14.2857 | 4 | yes |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 9.5238 | 4 | yes |
| GO:0031281 | positive regulation of cyclase activity | 9.5238 | 5 | yes |
| GO:0043266 | regulation of potassium ion transport | 9.5238 | 7 | yes |
| GO:0045762 | positive regulation of adenylate cyclase activity | 9.5238 | 6 | yes |
| GO:0051349 | positive regulation of lyase activity | 9.5238 | 5 | yes |
| GO:0099623 | regulation of cardiac muscle cell membrane repolarization | 9.5238 | 4 | yes |
| GO:1901016 | regulation of potassium ion transmembrane transporter activity | 9.5238 | 6 | yes |
| GO:1901379 | regulation of potassium ion transmembrane transport | 9.5238 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ERBIN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRRC7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WHRN_HUMAN | [view interactions] | Low throughput | no | no |
| HLAB_HUMAN | [view interactions] | Low throughput | no | yes |
| B2MG_HUMAN | [view interactions] | Low throughput | no | yes |
| CACB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CA2D1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GABR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CABP4_HUMAN | [view interactions] | Low throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SHAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CACB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCNN4_HUMAN | [view interactions] | Low throughput | no | no |
| RYR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| JPH3_HUMAN | [view interactions] | Low throughput | no | no |
| JPH4_HUMAN | [view interactions] | Low throughput | no | no |
| KCNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCNB2_HUMAN | [view interactions] | Low throughput | no | no |
| AT1A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CAC1B_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CACB2_HUMAN | [view interactions] | High throughput | no | yes |
| NALCN_HUMAN | [view interactions] | High throughput | no | no |
| SCNAA_HUMAN | [view interactions] | High throughput | no | no |
| SCN9A_HUMAN | [view interactions] | High throughput | no | yes |
| SCNBA_HUMAN | [view interactions] | High throughput | no | no |
| SCN5A_HUMAN | [view interactions] | High throughput | no | no |
| BRK1_HUMAN | [view interactions] | High throughput | no | no |
| CACB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |