CA2D1_HUMAN
Evidence for PS localization
Functions
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CA2D1_HUMAN |
|---|---|---|---|---|
| GO:0005216 | monoatomic ion channel activity | 32.1429 | 4 | yes |
| GO:0005261 | monoatomic cation channel activity | 32.1429 | 5 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 32.1429 | 4 | yes |
| GO:0015267 | channel activity | 32.1429 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 32.1429 | 4 | yes |
| GO:0043169 | cation binding | 32.1429 | 4 | yes |
| GO:0046872 | metal ion binding | 32.1429 | 5 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 32.1429 | 5 | yes |
| GO:0005244 | voltage-gated monoatomic ion channel activity | 28.5714 | 5 | yes |
| GO:0005262 | calcium channel activity | 28.5714 | 6 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 28.5714 | 6 | yes |
| GO:0022832 | voltage-gated channel activity | 28.5714 | 6 | yes |
| GO:0022836 | gated channel activity | 28.5714 | 5 | yes |
| GO:0022843 | voltage-gated monoatomic cation channel activity | 25.0000 | 6 | yes |
| GO:0005245 | voltage-gated calcium channel activity | 21.4286 | 7 | yes |
| GO:0019900 | kinase binding | 21.4286 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CA2D1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 57.1429 | 4 | yes |
| GO:0051049 | regulation of transport | 50.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 46.4286 | 4 | no |
| GO:0008104 | protein localization | 42.8571 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 42.8571 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 39.2857 | 4 | no |
| GO:0009966 | regulation of signal transduction | 39.2857 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 39.2857 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 39.2857 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 39.2857 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 39.2857 | 4 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 35.7143 | 6 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.7143 | 5 | no |
| GO:0022607 | cellular component assembly | 35.7143 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.7143 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 35.7143 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 35.7143 | 4 | no |
| GO:0010959 | regulation of metal ion transport | 35.7143 | 6 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 35.7143 | 5 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 35.7143 | 5 | yes |
| GO:0006811 | monoatomic ion transport | 32.1429 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 32.1429 | 5 | yes |
| GO:0030001 | metal ion transport | 32.1429 | 6 | yes |
| GO:0044057 | regulation of system process | 32.1429 | 4 | yes |
| GO:0051924 | regulation of calcium ion transport | 32.1429 | 7 | yes |
| GO:0098655 | monoatomic cation transmembrane transport | 28.5714 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 28.5714 | 4 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 28.5714 | 7 | yes |
| GO:0006996 | organelle organization | 28.5714 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 28.5714 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 28.5714 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.5714 | 4 | no |
| GO:0030030 | cell projection organization | 28.5714 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 28.5714 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 28.5714 | 5 | no |
| GO:0072657 | protein localization to membrane | 28.5714 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 28.5714 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 28.5714 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 28.5714 | 4 | no |
| GO:0006816 | calcium ion transport | 28.5714 | 7 | yes |
| GO:0051050 | positive regulation of transport | 28.5714 | 4 | yes |
| GO:0070588 | calcium ion transmembrane transport | 25.0000 | 5 | yes |
| GO:0098657 | import into cell | 25.0000 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.0000 | 4 | no |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | no |
| GO:1990778 | protein localization to cell periphery | 25.0000 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0050890 | cognition | 25.0000 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 25.0000 | 4 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 25.0000 | 4 | yes |
| GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 25.0000 | 5 | yes |
| GO:0097553 | calcium ion transmembrane import into cytosol | 21.4286 | 6 | yes |
| GO:0007010 | cytoskeleton organization | 21.4286 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.4286 | 6 | no |
| GO:0072659 | protein localization to plasma membrane | 21.4286 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.4286 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 21.4286 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.4286 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 21.4286 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.4286 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 21.4286 | 4 | no |
| GO:0060341 | regulation of cellular localization | 21.4286 | 4 | no |
| GO:0034764 | positive regulation of transmembrane transport | 21.4286 | 5 | yes |
| GO:0043270 | positive regulation of monoatomic ion transport | 21.4286 | 5 | yes |
| GO:0051928 | positive regulation of calcium ion transport | 21.4286 | 6 | yes |
| GO:0071310 | cellular response to organic substance | 17.8571 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 17.8571 | 4 | yes |
| GO:1903522 | regulation of blood circulation | 17.8571 | 5 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 17.8571 | 7 | yes |
| GO:1904427 | positive regulation of calcium ion transmembrane transport | 17.8571 | 7 | yes |
| GO:2001257 | regulation of cation channel activity | 17.8571 | 6 | yes |
| GO:0001508 | action potential | 17.8571 | 4 | yes |
| GO:0034767 | positive regulation of monoatomic ion transmembrane transport | 17.8571 | 6 | yes |
| GO:0070509 | calcium ion import | 14.2857 | 8 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 14.2857 | 4 | yes |
| GO:0086001 | cardiac muscle cell action potential | 14.2857 | 5 | yes |
| GO:0086002 | cardiac muscle cell action potential involved in contraction | 14.2857 | 6 | yes |
| GO:0086010 | membrane depolarization during action potential | 14.2857 | 5 | yes |
| GO:0086012 | membrane depolarization during cardiac muscle cell action potential | 14.2857 | 6 | yes |
| GO:0086091 | regulation of heart rate by cardiac conduction | 14.2857 | 4 | yes |
| GO:0098659 | inorganic cation import across plasma membrane | 14.2857 | 5 | yes |
| GO:0098703 | calcium ion import across plasma membrane | 14.2857 | 6 | yes |
| GO:0099587 | inorganic ion import across plasma membrane | 14.2857 | 4 | yes |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 14.2857 | 6 | yes |
| GO:1901021 | positive regulation of calcium ion transmembrane transporter activity | 14.2857 | 6 | yes |
| GO:1901699 | cellular response to nitrogen compound | 14.2857 | 4 | yes |
| GO:1902656 | calcium ion import into cytosol | 14.2857 | 8 | yes |
| GO:2001259 | positive regulation of cation channel activity | 14.2857 | 6 | yes |
| GO:0008016 | regulation of heart contraction | 14.2857 | 6 | yes |
| GO:0032411 | positive regulation of transporter activity | 14.2857 | 4 | yes |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 14.2857 | 5 | yes |
| GO:0051899 | membrane depolarization | 14.2857 | 4 | yes |
| GO:0061337 | cardiac conduction | 14.2857 | 7 | yes |
| GO:0061577 | calcium ion transmembrane transport via high voltage-gated calcium channel | 10.7143 | 6 | yes |
| GO:0099623 | regulation of cardiac muscle cell membrane repolarization | 10.7143 | 4 | yes |
| GO:1904645 | response to amyloid-beta | 10.7143 | 4 | yes |
| GO:1904646 | cellular response to amyloid-beta | 10.7143 | 5 | yes |
| GO:0060402 | calcium ion transport into cytosol | 10.7143 | 4 | yes |
| GO:0098903 | regulation of membrane repolarization during action potential | 7.1429 | 4 | yes |
| GO:1901385 | regulation of voltage-gated calcium channel activity | 7.1429 | 7 | yes |
| GO:1901387 | positive regulation of voltage-gated calcium channel activity | 7.1429 | 7 | yes |
| GO:1901841 | regulation of high voltage-gated calcium channel activity | 7.1429 | 8 | yes |
| GO:1901843 | positive regulation of high voltage-gated calcium channel activity | 7.1429 | 8 | yes |
| GO:1902514 | regulation of calcium ion transmembrane transport via high voltage-gated calcium channel | 7.1429 | 8 | yes |
| GO:0060307 | regulation of ventricular cardiac muscle cell membrane repolarization | 7.1429 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TSP2_HUMAN | [view interactions] | Low throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAC1B_HUMAN | [view interactions] | Low throughput | no | yes |
| CACB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CAC1D_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CACB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAC1E_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAZ2B_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT2_HUMAN | [view interactions] | High throughput | no | yes |
| CALU_HUMAN | [view interactions] | High throughput | no | yes |
| CCD77_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| MYH7B_HUMAN | [view interactions] | High throughput | no | no |
| PLK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2B1H_HUMAN | [view interactions] | High throughput | no | yes |
| H33_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
| VMP1_HUMAN | [view interactions] | High throughput | no | yes |
| HASP_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| CEP76_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| TAZ_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| SUSD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GL8D2_HUMAN | [view interactions] | High throughput | no | yes |
| LMAN2_HUMAN | [view interactions] | High throughput | no | yes |
| T185A_HUMAN | [view interactions] | High throughput | no | no |
| BTNL8_HUMAN | [view interactions] | High throughput | no | no |
| PTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRK_HUMAN | [view interactions] | High throughput | no | no |
| ISLR_HUMAN | [view interactions] | High throughput | no | no |
| ERLN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PON2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| SG1D4_HUMAN | [view interactions] | High throughput | no | no |
| PRS33_HUMAN | [view interactions] | High throughput | no | no |
| DEF1_HUMAN | [view interactions] | High throughput | no | no |
| LMA2L_HUMAN | [view interactions] | High throughput | no | yes |
| SG1D1_HUMAN | [view interactions] | High throughput | no | no |
| CG069_HUMAN | [view interactions] | High throughput | no | no |
| LYZL1_HUMAN | [view interactions] | High throughput | no | no |
| FUT3_HUMAN | [view interactions] | High throughput | no | yes |
| NPT2B_HUMAN | [view interactions] | High throughput | no | no |
| CP19A_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| BY55_HUMAN | [view interactions] | High throughput | no | no |
| EP3B_HUMAN | [view interactions] | High throughput | no | no |
| DB123_HUMAN | [view interactions] | High throughput | no | no |
| PA2G5_HUMAN | [view interactions] | High throughput | no | yes |
| CCL19_HUMAN | [view interactions] | High throughput | no | no |
| DB135_HUMAN | [view interactions] | High throughput | no | no |
| NMS_HUMAN | [view interactions] | High throughput | no | no |
| LCFC1_HUMAN | [view interactions] | High throughput | no | no |
| CEAM8_HUMAN | [view interactions] | High throughput | no | no |
| APOC3_HUMAN | [view interactions] | High throughput | no | no |
| IGFL3_HUMAN | [view interactions] | High throughput | no | no |
| BRID5_HUMAN | [view interactions] | High throughput | no | no |
| FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PATE1_HUMAN | [view interactions] | High throughput | no | no |
| REL1_HUMAN | [view interactions] | High throughput | no | no |
| SLUR1_HUMAN | [view interactions] | High throughput | no | no |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDP_HUMAN | [view interactions] | High throughput | no | no |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| EP3A_HUMAN | [view interactions] | High throughput | no | no |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| DIK1A_HUMAN | [view interactions] | High throughput | no | yes |
| CLGN_HUMAN | [view interactions] | High throughput | no | no |
| ALKL2_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
| STT3B_HUMAN | [view interactions] | High throughput | no | yes |
| ABCB6_HUMAN | [view interactions] | High throughput | no | yes |
| RYR1_HUMAN | [view interactions] | High throughput | no | no |
| CA2D4_HUMAN | [view interactions] | High throughput | no | no |
| CACB2_HUMAN | [view interactions] | High throughput | no | yes |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |