CA2D1_HUMAN
Evidence for PS localization
Functions
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CA2D1_HUMAN |
|---|---|---|---|---|
| GO:0005216 | ion channel activity | 51.8519 | 4 | yes |
| GO:0005261 | cation channel activity | 51.8519 | 5 | yes |
| GO:0005262 | calcium channel activity | 51.8519 | 6 | yes |
| GO:0008324 | cation transmembrane transporter activity | 51.8519 | 4 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 51.8519 | 6 | yes |
| GO:0015267 | channel activity | 51.8519 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 51.8519 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 51.8519 | 5 | yes |
| GO:0005244 | voltage-gated ion channel activity | 48.1481 | 4 | yes |
| GO:0022832 | voltage-gated channel activity | 48.1481 | 6 | yes |
| GO:0022836 | gated channel activity | 48.1481 | 5 | yes |
| GO:0022843 | voltage-gated cation channel activity | 48.1481 | 5 | yes |
| GO:0005245 | voltage-gated calcium channel activity | 44.4444 | 6 | yes |
| GO:0046872 | metal ion binding | 29.6296 | 4 | yes |
| GO:0035254 | glutamate receptor binding | 22.2222 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CA2D1_HUMAN |
|---|---|---|---|---|
| GO:0051049 | regulation of transport | 74.0741 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 70.3704 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 62.9630 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 62.9630 | 5 | yes |
| GO:0043269 | regulation of ion transport | 62.9630 | 5 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 55.5556 | 6 | yes |
| GO:0009966 | regulation of signal transduction | 48.1481 | 4 | no |
| GO:0010646 | regulation of cell communication | 48.1481 | 4 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 48.1481 | 4 | yes |
| GO:0032412 | regulation of ion transmembrane transporter activity | 48.1481 | 5 | yes |
| GO:2001257 | regulation of cation channel activity | 44.4444 | 6 | yes |
| GO:0008104 | protein localization | 44.4444 | 4 | no |
| GO:0051050 | positive regulation of transport | 40.7407 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 40.7407 | 5 | no |
| GO:0023056 | positive regulation of signaling | 40.7407 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.7407 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 37.0370 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.0370 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 37.0370 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 33.3333 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 33.3333 | 4 | no |
| GO:0006811 | ion transport | 33.3333 | 4 | yes |
| GO:0006812 | cation transport | 33.3333 | 5 | yes |
| GO:0006816 | calcium ion transport | 33.3333 | 7 | yes |
| GO:0010243 | response to organonitrogen compound | 33.3333 | 4 | yes |
| GO:0010959 | regulation of metal ion transport | 33.3333 | 6 | yes |
| GO:0030001 | metal ion transport | 33.3333 | 6 | yes |
| GO:0051924 | regulation of calcium ion transport | 29.6296 | 7 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 29.6296 | 7 | yes |
| GO:0009893 | positive regulation of metabolic process | 29.6296 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 29.6296 | 5 | no |
| GO:0060341 | regulation of cellular localization | 29.6296 | 4 | no |
| GO:0072657 | protein localization to membrane | 29.6296 | 4 | no |
| GO:1990778 | protein localization to cell periphery | 29.6296 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 29.6296 | 4 | no |
| GO:0033365 | protein localization to organelle | 29.6296 | 5 | no |
| GO:0034764 | positive regulation of transmembrane transport | 29.6296 | 5 | yes |
| GO:0034767 | positive regulation of ion transmembrane transport | 29.6296 | 6 | yes |
| GO:0043270 | positive regulation of ion transport | 29.6296 | 5 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 25.9259 | 7 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.9259 | 5 | no |
| GO:0022607 | cellular component assembly | 25.9259 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.9259 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.9259 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.9259 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 25.9259 | 4 | no |
| GO:0030030 | cell projection organization | 25.9259 | 4 | no |
| GO:0032880 | regulation of protein localization | 25.9259 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.9259 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 25.9259 | 5 | no |
| GO:0031399 | regulation of protein modification process | 25.9259 | 6 | no |
| GO:0006897 | endocytosis | 25.9259 | 5 | no |
| GO:0006898 | receptor-mediated endocytosis | 25.9259 | 6 | no |
| GO:0015031 | protein transport | 25.9259 | 4 | no |
| GO:0071702 | organic substance transport | 25.9259 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.9259 | 4 | no |
| GO:2001259 | positive regulation of cation channel activity | 22.2222 | 6 | yes |
| GO:0007268 | chemical synaptic transmission | 22.2222 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 22.2222 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 22.2222 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.2222 | 6 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 22.2222 | 5 | no |
| GO:0099537 | trans-synaptic signaling | 22.2222 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 22.2222 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.2222 | 4 | no |
| GO:0006886 | intracellular protein transport | 22.2222 | 4 | no |
| GO:0031623 | receptor internalization | 22.2222 | 7 | no |
| GO:0050806 | positive regulation of synaptic transmission | 22.2222 | 5 | no |
| GO:0072594 | establishment of protein localization to organelle | 22.2222 | 4 | no |
| GO:0098970 | postsynaptic neurotransmitter receptor diffusion trapping | 22.2222 | 4 | no |
| GO:0099601 | regulation of neurotransmitter receptor activity | 22.2222 | 4 | no |
| GO:0099628 | neurotransmitter receptor diffusion trapping | 22.2222 | 4 | no |
| GO:0032411 | positive regulation of transporter activity | 22.2222 | 4 | yes |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 22.2222 | 5 | yes |
| GO:0044057 | regulation of system process | 22.2222 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 18.5185 | 4 | yes |
| GO:0098655 | cation transmembrane transport | 18.5185 | 4 | yes |
| GO:0098660 | inorganic ion transmembrane transport | 18.5185 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 18.5185 | 5 | yes |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 18.5185 | 6 | yes |
| GO:0051899 | membrane depolarization | 14.8148 | 4 | yes |
| GO:0051928 | positive regulation of calcium ion transport | 14.8148 | 6 | yes |
| GO:0070588 | calcium ion transmembrane transport | 14.8148 | 6 | yes |
| GO:0097553 | calcium ion transmembrane import into cytosol | 14.8148 | 7 | yes |
| GO:1901385 | regulation of voltage-gated calcium channel activity | 14.8148 | 7 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 14.8148 | 4 | yes |
| GO:1904427 | positive regulation of calcium ion transmembrane transport | 14.8148 | 7 | yes |
| GO:0060402 | calcium ion transport into cytosol | 11.1111 | 4 | yes |
| GO:0061577 | calcium ion transmembrane transport via high voltage-gated calcium channel | 11.1111 | 7 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 11.1111 | 4 | yes |
| GO:0086010 | membrane depolarization during action potential | 11.1111 | 5 | yes |
| GO:1901021 | positive regulation of calcium ion transmembrane transporter activity | 11.1111 | 6 | yes |
| GO:1901652 | response to peptide | 11.1111 | 4 | yes |
| GO:1901653 | cellular response to peptide | 11.1111 | 5 | yes |
| GO:1901699 | cellular response to nitrogen compound | 11.1111 | 4 | yes |
| GO:1903522 | regulation of blood circulation | 11.1111 | 5 | yes |
| GO:1904645 | response to amyloid-beta | 11.1111 | 5 | yes |
| GO:1904646 | cellular response to amyloid-beta | 11.1111 | 6 | yes |
| GO:0001508 | action potential | 11.1111 | 4 | yes |
| GO:0008016 | regulation of heart contraction | 11.1111 | 6 | yes |
| GO:0086001 | cardiac muscle cell action potential | 7.4074 | 5 | yes |
| GO:0086002 | cardiac muscle cell action potential involved in contraction | 7.4074 | 6 | yes |
| GO:0086012 | membrane depolarization during cardiac muscle cell action potential | 7.4074 | 6 | yes |
| GO:0086091 | regulation of heart rate by cardiac conduction | 7.4074 | 4 | yes |
| GO:0098903 | regulation of membrane repolarization during action potential | 7.4074 | 4 | yes |
| GO:1901387 | positive regulation of voltage-gated calcium channel activity | 7.4074 | 7 | yes |
| GO:1901841 | regulation of high voltage-gated calcium channel activity | 7.4074 | 8 | yes |
| GO:1901843 | positive regulation of high voltage-gated calcium channel activity | 7.4074 | 8 | yes |
| GO:1902514 | regulation of calcium ion transmembrane transport via high voltage-gated calcium channel | 7.4074 | 8 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CAC1D_HUMAN | [view interactions] | Low throughput | no | yes |
| CACB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CACB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CAC1B_HUMAN | [view interactions] | Low throughput | no | yes |
| TSP2_HUMAN | [view interactions] | Low throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAZ2B_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT2_HUMAN | [view interactions] | High throughput | no | yes |
| CALU_HUMAN | [view interactions] | High throughput | no | yes |
| CCD77_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| MYH7B_HUMAN | [view interactions] | High throughput | no | no |
| PLK2_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2B1H_HUMAN | [view interactions] | High throughput | no | yes |
| H33_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
| VMP1_HUMAN | [view interactions] | High throughput | no | yes |
| HASP_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| CEP76_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| TAZ_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| SUSD4_HUMAN | [view interactions] | High throughput | no | yes |
| GL8D2_HUMAN | [view interactions] | High throughput | no | yes |
| LMAN2_HUMAN | [view interactions] | High throughput | no | yes |
| T185A_HUMAN | [view interactions] | High throughput | no | no |
| BTNL8_HUMAN | [view interactions] | High throughput | no | no |
| PTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRK_HUMAN | [view interactions] | High throughput | no | no |
| ISLR_HUMAN | [view interactions] | High throughput | no | no |
| ERLN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PON2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| SG1D4_HUMAN | [view interactions] | High throughput | no | no |
| PRS33_HUMAN | [view interactions] | High throughput | no | no |
| DEF1_HUMAN | [view interactions] | High throughput | no | no |
| LMA2L_HUMAN | [view interactions] | High throughput | no | yes |
| SG1D1_HUMAN | [view interactions] | High throughput | no | no |
| CG069_HUMAN | [view interactions] | High throughput | no | no |
| LYZL1_HUMAN | [view interactions] | High throughput | no | no |
| FUT3_HUMAN | [view interactions] | High throughput | no | yes |
| NPT2B_HUMAN | [view interactions] | High throughput | no | no |
| CP19A_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| BY55_HUMAN | [view interactions] | High throughput | no | no |
| EP3B_HUMAN | [view interactions] | High throughput | no | no |
| DB123_HUMAN | [view interactions] | High throughput | no | no |
| PA2G5_HUMAN | [view interactions] | High throughput | no | yes |
| CCL19_HUMAN | [view interactions] | High throughput | no | no |
| DB135_HUMAN | [view interactions] | High throughput | no | no |
| NMS_HUMAN | [view interactions] | High throughput | no | no |
| LCFC1_HUMAN | [view interactions] | High throughput | no | no |
| CEAM8_HUMAN | [view interactions] | High throughput | no | no |
| APOC3_HUMAN | [view interactions] | High throughput | no | no |
| IGFL3_HUMAN | [view interactions] | High throughput | no | no |
| BRID5_HUMAN | [view interactions] | High throughput | no | no |
| FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PATE1_HUMAN | [view interactions] | High throughput | no | no |
| REL1_HUMAN | [view interactions] | High throughput | no | no |
| SLUR1_HUMAN | [view interactions] | High throughput | no | no |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDP_HUMAN | [view interactions] | High throughput | no | no |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| EP3A_HUMAN | [view interactions] | High throughput | no | no |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| DIK1A_HUMAN | [view interactions] | High throughput | no | yes |
| CLGN_HUMAN | [view interactions] | High throughput | no | no |
| ALKL2_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
| STT3B_HUMAN | [view interactions] | High throughput | no | yes |
| ABCB6_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RYR1_HUMAN | [view interactions] | High throughput | no | no |
| CA2D4_HUMAN | [view interactions] | High throughput | no | no |
| CACB2_HUMAN | [view interactions] | High throughput | no | yes |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAC1F_HUMAN | [view interactions] | Computational | no | no |
| CCG3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CTSR1_HUMAN | [view interactions] | Computational | no | no |
| CCG1_HUMAN | [view interactions] | Computational | no | no |
| CAC1G_HUMAN | [view interactions] | Computational | no | no |
| CCG7_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCG2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CAC1A_HUMAN | [view interactions] | Computational | no | no |
| CCG8_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CAC1H_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CAC1E_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CACB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG6_HUMAN | [view interactions] | Computational | no | no |
| CAC1S_HUMAN | [view interactions] | Computational | no | no |