Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CACB1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Regulatory subunit of L-type calcium channels (PubMed, PubMed, PubMed). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit . Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CACB1_HUMAN
GO:0005216 monoatomic ion channel activity 52.6316 4 yes
GO:0015267 channel activity 52.6316 4 yes
GO:0022836 gated channel activity 52.6316 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 52.6316 4 yes
GO:0005244 voltage-gated monoatomic ion channel activity 47.3684 5 yes
GO:0005261 monoatomic cation channel activity 47.3684 5 yes
GO:0008324 monoatomic cation transmembrane transporter activity 47.3684 4 yes
GO:0022832 voltage-gated channel activity 47.3684 6 yes
GO:0022843 voltage-gated monoatomic cation channel activity 47.3684 6 yes
GO:0046873 metal ion transmembrane transporter activity 47.3684 5 yes
GO:0005245 voltage-gated calcium channel activity 42.1053 7 yes
GO:0005262 calcium channel activity 42.1053 6 yes
GO:0015085 calcium ion transmembrane transporter activity 42.1053 6 yes
GO:0008331 high voltage-gated calcium channel activity 31.5789 8 yes
GO:0043169 cation binding 31.5789 4 no
GO:0046872 metal ion binding 31.5789 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in CACB1_HUMAN
GO:0051049 regulation of transport 68.4211 4 yes
GO:0034762 regulation of transmembrane transport 57.8947 4 yes
GO:0010959 regulation of metal ion transport 52.6316 6 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 52.6316 5 yes
GO:0043269 regulation of monoatomic ion transport 52.6316 5 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 52.6316 6 yes
GO:0048522 positive regulation of cellular process 52.6316 4 no
GO:0006811 monoatomic ion transport 52.6316 4 yes
GO:0030001 metal ion transport 47.3684 6 yes
GO:0044057 regulation of system process 47.3684 4 yes
GO:0051924 regulation of calcium ion transport 47.3684 7 yes
GO:0098655 monoatomic cation transmembrane transport 47.3684 4 yes
GO:0098662 inorganic cation transmembrane transport 47.3684 4 yes
GO:0006812 monoatomic cation transport 47.3684 5 yes
GO:0006816 calcium ion transport 42.1053 7 yes
GO:0070588 calcium ion transmembrane transport 42.1053 5 yes
GO:1903169 regulation of calcium ion transmembrane transport 42.1053 7 yes
GO:0051128 regulation of cellular component organization 42.1053 4 no
GO:0051050 positive regulation of transport 42.1053 4 no
GO:0010243 response to organonitrogen compound 36.8421 4 yes
GO:0098657 import into cell 36.8421 4 no
GO:0010646 regulation of cell communication 36.8421 4 no
GO:0022898 regulation of transmembrane transporter activity 36.8421 4 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 36.8421 5 no
GO:0048523 negative regulation of cellular process 36.8421 4 no
GO:0007268 chemical synaptic transmission 31.5789 7 yes
GO:0071310 cellular response to organic substance 31.5789 4 yes
GO:0071417 cellular response to organonitrogen compound 31.5789 4 yes
GO:0098916 anterograde trans-synaptic signaling 31.5789 6 yes
GO:0099536 synaptic signaling 31.5789 4 yes
GO:0099537 trans-synaptic signaling 31.5789 5 yes
GO:1901699 cellular response to nitrogen compound 31.5789 4 yes
GO:1901701 cellular response to oxygen-containing compound 31.5789 4 yes
GO:0097553 calcium ion transmembrane import into cytosol 31.5789 6 no
GO:0022607 cellular component assembly 31.5789 4 no
GO:0031323 regulation of cellular metabolic process 31.5789 4 no
GO:0051246 regulation of protein metabolic process 31.5789 5 no
GO:0060255 regulation of macromolecule metabolic process 31.5789 4 no
GO:0080090 regulation of primary metabolic process 31.5789 4 no
GO:0044087 regulation of cellular component biogenesis 31.5789 4 no
GO:0051130 positive regulation of cellular component organization 31.5789 5 no
GO:1904645 response to amyloid-beta 26.3158 4 yes
GO:1904646 cellular response to amyloid-beta 26.3158 5 yes
GO:0001508 action potential 26.3158 4 no
GO:0008016 regulation of heart contraction 26.3158 6 no
GO:0061337 cardiac conduction 26.3158 7 no
GO:0070509 calcium ion import 26.3158 8 no
GO:0086091 regulation of heart rate by cardiac conduction 26.3158 4 no
GO:0098659 inorganic cation import across plasma membrane 26.3158 5 no
GO:0098703 calcium ion import across plasma membrane 26.3158 6 no
GO:0099587 inorganic ion import across plasma membrane 26.3158 4 no
GO:1902656 calcium ion import into cytosol 26.3158 8 no
GO:1903522 regulation of blood circulation 26.3158 5 no
GO:0050804 modulation of chemical synaptic transmission 26.3158 5 no
GO:0099177 regulation of trans-synaptic signaling 26.3158 4 no
GO:0006996 organelle organization 26.3158 4 no
GO:0008104 protein localization 26.3158 4 no
GO:0019220 regulation of phosphate metabolic process 26.3158 6 no
GO:0051174 regulation of phosphorus metabolic process 26.3158 5 no
GO:0009892 negative regulation of metabolic process 26.3158 4 no
GO:0031324 negative regulation of cellular metabolic process 26.3158 5 no
GO:0051051 negative regulation of transport 26.3158 4 no
GO:0006937 regulation of muscle contraction 21.0526 6 yes
GO:0007528 neuromuscular junction development 21.0526 6 yes
GO:0034330 cell junction organization 21.0526 4 yes
GO:0050808 synapse organization 21.0526 5 yes
GO:0051240 positive regulation of multicellular organismal process 21.0526 4 yes
GO:0090257 regulation of muscle system process 21.0526 5 yes
GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel 21.0526 8 yes
GO:0086001 cardiac muscle cell action potential 21.0526 5 no
GO:0086002 cardiac muscle cell action potential involved in contraction 21.0526 6 no
GO:0009893 positive regulation of metabolic process 21.0526 4 no
GO:0010604 positive regulation of macromolecule metabolic process 21.0526 5 no
GO:0010647 positive regulation of cell communication 21.0526 5 no
GO:0023056 positive regulation of signaling 21.0526 4 no
GO:0030030 cell projection organization 21.0526 4 no
GO:0031344 regulation of cell projection organization 21.0526 5 no
GO:0031399 regulation of protein modification process 21.0526 6 no
GO:0042325 regulation of phosphorylation 21.0526 7 no
GO:0048584 positive regulation of response to stimulus 21.0526 4 no
GO:0051247 positive regulation of protein metabolic process 21.0526 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.0526 6 no
GO:0120036 plasma membrane bounded cell projection organization 21.0526 5 no
GO:0043266 regulation of potassium ion transport 21.0526 7 no
GO:1901379 regulation of potassium ion transmembrane transport 21.0526 7 no
GO:0009889 regulation of biosynthetic process 21.0526 4 no
GO:0009890 negative regulation of biosynthetic process 21.0526 5 no
GO:0044089 positive regulation of cellular component biogenesis 21.0526 5 no
GO:0010605 negative regulation of macromolecule metabolic process 21.0526 5 no
GO:0034763 negative regulation of transmembrane transport 21.0526 5 no
GO:0034766 negative regulation of monoatomic ion transmembrane transport 21.0526 6 no
GO:0043271 negative regulation of monoatomic ion transport 21.0526 5 no
GO:0060627 regulation of vesicle-mediated transport 21.0526 4 no
GO:1901019 regulation of calcium ion transmembrane transporter activity 21.0526 6 no
GO:1904063 negative regulation of cation transmembrane transport 21.0526 7 no
GO:0045933 positive regulation of muscle contraction 10.5263 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GEM_HUMAN [view interactions] Low throughput no yes
CAC1C_HUMAN [view entry] [view interactions] Low throughput yes no
CACB1_HUMAN [view entry] [view interactions] Low throughput yes yes
MTM1_HUMAN [view interactions] Low throughput no yes
BIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
CAC1A_HUMAN [view entry] [view interactions] Low throughput yes no
CAC1B_HUMAN [view interactions] Low throughput no yes
CAC1D_HUMAN [view entry] [view interactions] Low throughput yes yes
CAC1S_HUMAN [view interactions] Low throughput no no
CA2D1_HUMAN [view entry] [view interactions] Low throughput yes yes
CAC1E_HUMAN [view entry] [view interactions] Low throughput yes no
ATN1_HUMAN [view interactions] High throughput no yes
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
CACB3_HUMAN [view entry] [view interactions] High throughput yes no
WDR75_HUMAN [view interactions] High throughput no no
CBARP_HUMAN [view interactions] High throughput no no
KLH15_HUMAN [view interactions] High throughput no yes
NEK4_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CTBP2_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
NED4L_HUMAN [view entry] [view interactions] High throughput yes yes
CACB2_HUMAN [view interactions] High throughput no yes
EYA1_HUMAN [view interactions] High throughput no no
CCZ1_HUMAN [view interactions] High throughput no yes
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
SRPK1_HUMAN [view interactions] High throughput no yes
CNTP2_HUMAN [view entry] [view interactions] High throughput yes yes
GRIA2_HUMAN [view entry] [view interactions] High throughput yes yes