CACB1_HUMAN
Evidence for PS localization
Functions
Regulatory subunit of L-type calcium channels (PubMed, PubMed, PubMed). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit . Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CACB1_HUMAN |
|---|---|---|---|---|
| GO:0005216 | ion channel activity | 70.0000 | 4 | yes |
| GO:0005244 | voltage-gated ion channel activity | 70.0000 | 4 | yes |
| GO:0005245 | voltage-gated calcium channel activity | 70.0000 | 6 | yes |
| GO:0005261 | cation channel activity | 70.0000 | 5 | yes |
| GO:0005262 | calcium channel activity | 70.0000 | 6 | yes |
| GO:0008324 | cation transmembrane transporter activity | 70.0000 | 4 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 70.0000 | 6 | yes |
| GO:0015267 | channel activity | 70.0000 | 4 | yes |
| GO:0022832 | voltage-gated channel activity | 70.0000 | 6 | yes |
| GO:0022836 | gated channel activity | 70.0000 | 5 | yes |
| GO:0022843 | voltage-gated cation channel activity | 70.0000 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 70.0000 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 70.0000 | 5 | yes |
| GO:0046872 | metal ion binding | 35.0000 | 4 | no |
| GO:0005246 | calcium channel regulator activity | 25.0000 | 4 | no |
| GO:0008331 | high voltage-gated calcium channel activity | 20.0000 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CACB1_HUMAN |
|---|---|---|---|---|
| GO:0034762 | regulation of transmembrane transport | 90.0000 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 90.0000 | 5 | yes |
| GO:0043269 | regulation of ion transport | 90.0000 | 5 | yes |
| GO:0051049 | regulation of transport | 90.0000 | 4 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 70.0000 | 6 | yes |
| GO:0048522 | positive regulation of cellular process | 65.0000 | 4 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 60.0000 | 4 | yes |
| GO:0032412 | regulation of ion transmembrane transporter activity | 60.0000 | 5 | yes |
| GO:2001257 | regulation of cation channel activity | 55.0000 | 6 | yes |
| GO:0051050 | positive regulation of transport | 50.0000 | 4 | no |
| GO:0010959 | regulation of metal ion transport | 40.0000 | 6 | yes |
| GO:0051924 | regulation of calcium ion transport | 40.0000 | 7 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 40.0000 | 7 | yes |
| GO:0006811 | ion transport | 40.0000 | 4 | no |
| GO:0006812 | cation transport | 40.0000 | 5 | no |
| GO:0006816 | calcium ion transport | 40.0000 | 7 | no |
| GO:0008104 | protein localization | 40.0000 | 4 | no |
| GO:0030001 | metal ion transport | 40.0000 | 6 | no |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 40.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 40.0000 | 4 | no |
| GO:0044057 | regulation of system process | 40.0000 | 4 | no |
| GO:0006897 | endocytosis | 35.0000 | 5 | no |
| GO:0009966 | regulation of signal transduction | 35.0000 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 35.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 35.0000 | 5 | no |
| GO:0050806 | positive regulation of synaptic transmission | 35.0000 | 5 | no |
| GO:0071702 | organic substance transport | 35.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 35.0000 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 35.0000 | 4 | no |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 30.0000 | 6 | yes |
| GO:0006886 | intracellular protein transport | 30.0000 | 4 | no |
| GO:0007034 | vacuolar transport | 30.0000 | 4 | no |
| GO:0007041 | lysosomal transport | 30.0000 | 5 | no |
| GO:0008333 | endosome to lysosome transport | 30.0000 | 5 | no |
| GO:0015031 | protein transport | 30.0000 | 4 | no |
| GO:0033365 | protein localization to organelle | 30.0000 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 30.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 30.0000 | 4 | no |
| GO:0099601 | regulation of neurotransmitter receptor activity | 30.0000 | 4 | no |
| GO:1903522 | regulation of blood circulation | 30.0000 | 5 | no |
| GO:0007528 | neuromuscular junction development | 25.0000 | 6 | yes |
| GO:0010243 | response to organonitrogen compound | 25.0000 | 4 | yes |
| GO:0034330 | cell junction organization | 25.0000 | 4 | yes |
| GO:0050808 | synapse organization | 25.0000 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 25.0000 | 4 | yes |
| GO:1901385 | regulation of voltage-gated calcium channel activity | 25.0000 | 7 | yes |
| GO:1901699 | cellular response to nitrogen compound | 25.0000 | 4 | yes |
| GO:0032411 | positive regulation of transporter activity | 25.0000 | 4 | no |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 25.0000 | 5 | no |
| GO:0034764 | positive regulation of transmembrane transport | 25.0000 | 5 | no |
| GO:0034767 | positive regulation of ion transmembrane transport | 25.0000 | 6 | no |
| GO:0043270 | positive regulation of ion transport | 25.0000 | 5 | no |
| GO:0072657 | protein localization to membrane | 25.0000 | 4 | no |
| GO:1904064 | positive regulation of cation transmembrane transport | 25.0000 | 7 | no |
| GO:1990778 | protein localization to cell periphery | 25.0000 | 5 | no |
| GO:2001259 | positive regulation of cation channel activity | 25.0000 | 6 | no |
| GO:0006898 | receptor-mediated endocytosis | 25.0000 | 6 | no |
| GO:0031623 | receptor internalization | 25.0000 | 7 | no |
| GO:0051128 | regulation of cellular component organization | 25.0000 | 4 | no |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | 25.0000 | 6 | no |
| GO:0051968 | positive regulation of synaptic transmission, glutamatergic | 25.0000 | 6 | no |
| GO:0061462 | protein localization to lysosome | 25.0000 | 7 | no |
| GO:0072594 | establishment of protein localization to organelle | 25.0000 | 4 | no |
| GO:0072665 | protein localization to vacuole | 25.0000 | 6 | no |
| GO:0072666 | establishment of protein localization to vacuole | 25.0000 | 5 | no |
| GO:0098943 | neurotransmitter receptor transport, postsynaptic endosome to lysosome | 25.0000 | 4 | no |
| GO:0098970 | postsynaptic neurotransmitter receptor diffusion trapping | 25.0000 | 4 | no |
| GO:0099628 | neurotransmitter receptor diffusion trapping | 25.0000 | 4 | no |
| GO:2000311 | regulation of AMPA receptor activity | 25.0000 | 5 | no |
| GO:0008016 | regulation of heart contraction | 25.0000 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 25.0000 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
| GO:0007268 | chemical synaptic transmission | 20.0000 | 6 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 20.0000 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 20.0000 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 20.0000 | 4 | yes |
| GO:1901652 | response to peptide | 20.0000 | 4 | yes |
| GO:1901653 | cellular response to peptide | 20.0000 | 5 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 20.0000 | 4 | yes |
| GO:1902514 | regulation of calcium ion transmembrane transport via high voltage-gated calcium channel | 20.0000 | 8 | yes |
| GO:1904645 | response to amyloid-beta | 20.0000 | 5 | yes |
| GO:1904646 | cellular response to amyloid-beta | 20.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GEM_HUMAN | [view interactions] | Low throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CACB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MTM1_HUMAN | [view interactions] | Low throughput | no | yes |
| BIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAC1A_HUMAN | [view interactions] | Low throughput | no | no |
| CAC1B_HUMAN | [view interactions] | Low throughput | no | yes |
| CAC1D_HUMAN | [view interactions] | Low throughput | no | yes |
| CAC1S_HUMAN | [view interactions] | Low throughput | no | no |
| CA2D1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATN1_HUMAN | [view interactions] | High throughput | no | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CBARP_HUMAN | [view interactions] | High throughput | no | no |
| WDR75_HUMAN | [view interactions] | High throughput | no | no |
| CACB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KLH15_HUMAN | [view interactions] | High throughput | no | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTBP2_HUMAN | [view interactions] | High throughput | no | no |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NED4L_HUMAN | [view interactions] | High throughput | no | yes |
| CACB2_HUMAN | [view interactions] | High throughput | no | yes |
| EYA1_HUMAN | [view interactions] | High throughput | no | no |
| CCZ1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1F_HUMAN | [view interactions] | Computational | no | no |
| CCG1_HUMAN | [view interactions] | Computational | no | no |
| CA2D4_HUMAN | [view interactions] | Computational | no | no |
| CAC1G_HUMAN | [view interactions] | Computational | no | no |
| CA2D2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCG7_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCG2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCG8_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CAC1H_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CA2D3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CAC1E_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCG4_HUMAN | [view entry] [view interactions] | Computational | yes | no |