BIN1_HUMAN
Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed). Is a negative regulator of endocytosis . Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates . May be involved in the regulation of MYC activity and the control cell proliferation (PubMed). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 35 | Lys | Asn | Myopathy,centronuclear,2(CNM2) | - |
| 151 | Asp | Asn | Myopathy,centronuclear,2(CNM2) | - |
| 145 | Arg | Cys | Myopathy,centronuclear,2(CNM2) | - |
| 154 | Arg | Gln | Myopathy,centronuclear,2(CNM2) | - |
| 234 | Arg | Cys | Myopathy,centronuclear,2(CNM2) | - |
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI000298 | LIG_AP2alpha_1 | LIG | 362 | 366 | - |
| ELMI000449 | LIG_Clathr_ClatBox_1 | LIG | 390 | 394 | - |
| ELMI000452 | LIG_Clathr_ClatBox_2 | LIG | 415 | 420 | - |
| ELMI002443 | LIG_SH3_3 | LIG | 308 | 314 | - |
| ELMI000298 | LIG_AP2alpha_1 | LIG | 362 | 366 | - |
| ELMI000449 | LIG_Clathr_ClatBox_1 | LIG | 390 | 394 | - |
| ELMI000452 | LIG_Clathr_ClatBox_2 | LIG | 415 | 420 | - |
| ELMI002443 | LIG_SH3_3 | LIG | 308 | 314 | - |
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in BIN1_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 35.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 32.5000 | 5 | no |
| GO:0043168 | anion binding | 30.0000 | 4 | no |
| GO:0043169 | cation binding | 28.7500 | 4 | no |
| GO:0046872 | metal ion binding | 28.7500 | 5 | no |
| GO:0000166 | nucleotide binding | 27.5000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.5000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 26.2500 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
| GO:0003723 | RNA binding | 22.5000 | 4 | no |
| GO:0003779 | actin binding | 13.7500 | 4 | yes |
| GO:0051020 | GTPase binding | 8.7500 | 4 | yes |
| GO:0002020 | protease binding | 7.5000 | 4 | yes |
| GO:0048156 | tau protein binding | 6.2500 | 4 | yes |
| GO:0004866 | endopeptidase inhibitor activity | 3.7500 | 5 | yes |
| GO:0030414 | peptidase inhibitor activity | 3.7500 | 4 | yes |
| GO:0061135 | endopeptidase regulator activity | 3.7500 | 4 | yes |
| GO:0019828 | aspartic-type endopeptidase inhibitor activity | 2.5000 | 6 | yes |
| GO:0070063 | RNA polymerase binding | 2.5000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in BIN1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 67.5000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 61.2500 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 56.2500 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 55.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 53.7500 | 4 | yes |
| GO:0010646 | regulation of cell communication | 52.5000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 47.5000 | 4 | yes |
| GO:0022607 | cellular component assembly | 45.0000 | 4 | yes |
| GO:0051049 | regulation of transport | 43.7500 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 41.2500 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 41.2500 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 41.2500 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 41.2500 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 38.7500 | 6 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 38.7500 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 37.5000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 35.0000 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 35.0000 | 5 | yes |
| GO:0008104 | protein localization | 35.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 33.7500 | 5 | yes |
| GO:0006996 | organelle organization | 32.5000 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 32.5000 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 32.5000 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 31.2500 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 31.2500 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 27.5000 | 5 | no |
| GO:0098657 | import into cell | 27.5000 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 26.2500 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.2500 | 4 | no |
| GO:0051050 | positive regulation of transport | 26.2500 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 26.2500 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 26.2500 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0071702 | organic substance transport | 25.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 25.0000 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 25.0000 | 6 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 25.0000 | 6 | yes |
| GO:0033043 | regulation of organelle organization | 25.0000 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0030030 | cell projection organization | 23.7500 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.7500 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.7500 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.7500 | 6 | no |
| GO:0061024 | membrane organization | 23.7500 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 23.7500 | 6 | no |
| GO:0036211 | protein modification process | 22.5000 | 4 | no |
| GO:0043412 | macromolecule modification | 22.5000 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.5000 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.5000 | 7 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 22.5000 | 4 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 22.5000 | 6 | yes |
| GO:0031344 | regulation of cell projection organization | 21.2500 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.2500 | 5 | no |
| GO:0141124 | intracellular signaling cassette | 21.2500 | 4 | no |
| GO:0015031 | protein transport | 21.2500 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 21.2500 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.2500 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 21.2500 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 20.0000 | 5 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 18.7500 | 8 | yes |
| GO:0044057 | regulation of system process | 18.7500 | 4 | yes |
| GO:0030100 | regulation of endocytosis | 17.5000 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 17.5000 | 4 | yes |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 17.5000 | 5 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 17.5000 | 6 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 17.5000 | 6 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 16.2500 | 5 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 16.2500 | 5 | yes |
| GO:0051051 | negative regulation of transport | 16.2500 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 16.2500 | 4 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 16.2500 | 6 | yes |
| GO:0051726 | regulation of cell cycle | 16.2500 | 4 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 15.0000 | 5 | yes |
| GO:0042981 | regulation of apoptotic process | 15.0000 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 15.0000 | 4 | yes |
| GO:0045597 | positive regulation of cell differentiation | 15.0000 | 5 | yes |
| GO:0045892 | negative regulation of DNA-templated transcription | 15.0000 | 8 | yes |
| GO:1902679 | negative regulation of RNA biosynthetic process | 15.0000 | 7 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 15.0000 | 5 | yes |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | 13.7500 | 9 | yes |
| GO:0007010 | cytoskeleton organization | 13.7500 | 5 | yes |
| GO:0010564 | regulation of cell cycle process | 13.7500 | 5 | yes |
| GO:0010959 | regulation of metal ion transport | 13.7500 | 6 | yes |
| GO:0030162 | regulation of proteolysis | 13.7500 | 6 | yes |
| GO:0048488 | synaptic vesicle endocytosis | 13.7500 | 5 | yes |
| GO:0051924 | regulation of calcium ion transport | 13.7500 | 7 | yes |
| GO:0140238 | presynaptic endocytosis | 13.7500 | 4 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 13.7500 | 6 | yes |
| GO:0010638 | positive regulation of organelle organization | 12.5000 | 6 | yes |
| GO:0031334 | positive regulation of protein-containing complex assembly | 12.5000 | 6 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 12.5000 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 12.5000 | 4 | yes |
| GO:0060284 | regulation of cell development | 12.5000 | 5 | yes |
| GO:0090257 | regulation of muscle system process | 12.5000 | 5 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 12.5000 | 7 | yes |
| GO:2000026 | regulation of multicellular organismal development | 12.5000 | 4 | yes |
| GO:0006937 | regulation of muscle contraction | 11.2500 | 6 | yes |
| GO:0032970 | regulation of actin filament-based process | 11.2500 | 4 | yes |
| GO:1902905 | positive regulation of supramolecular fiber organization | 11.2500 | 6 | yes |
| GO:0032271 | regulation of protein polymerization | 10.0000 | 6 | yes |
| GO:0032535 | regulation of cellular component size | 10.0000 | 4 | yes |
| GO:0045807 | positive regulation of endocytosis | 10.0000 | 5 | yes |
| GO:0050767 | regulation of neurogenesis | 10.0000 | 6 | yes |
| GO:0051960 | regulation of nervous system development | 10.0000 | 5 | yes |
| GO:0006942 | regulation of striated muscle contraction | 8.7500 | 7 | yes |
| GO:0008016 | regulation of heart contraction | 8.7500 | 6 | yes |
| GO:0010720 | positive regulation of cell development | 8.7500 | 6 | yes |
| GO:0032273 | positive regulation of protein polymerization | 8.7500 | 7 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 8.7500 | 5 | yes |
| GO:0043068 | positive regulation of programmed cell death | 8.7500 | 5 | yes |
| GO:0050769 | positive regulation of neurogenesis | 8.7500 | 6 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 8.7500 | 7 | yes |
| GO:0051962 | positive regulation of nervous system development | 8.7500 | 5 | yes |
| GO:0055117 | regulation of cardiac muscle contraction | 8.7500 | 7 | yes |
| GO:0110053 | regulation of actin filament organization | 8.7500 | 6 | yes |
| GO:1903522 | regulation of blood circulation | 8.7500 | 5 | yes |
| GO:0034763 | negative regulation of transmembrane transport | 7.5000 | 5 | yes |
| GO:0034766 | negative regulation of monoatomic ion transmembrane transport | 7.5000 | 6 | yes |
| GO:0043065 | positive regulation of apoptotic process | 7.5000 | 6 | yes |
| GO:0043271 | negative regulation of monoatomic ion transport | 7.5000 | 5 | yes |
| GO:0045664 | regulation of neuron differentiation | 7.5000 | 5 | yes |
| GO:0051926 | negative regulation of calcium ion transport | 7.5000 | 6 | yes |
| GO:1903170 | negative regulation of calcium ion transmembrane transport | 7.5000 | 7 | yes |
| GO:1904063 | negative regulation of cation transmembrane transport | 7.5000 | 7 | yes |
| GO:0007034 | vacuolar transport | 6.2500 | 4 | yes |
| GO:0007041 | lysosomal transport | 6.2500 | 5 | yes |
| GO:0043086 | negative regulation of catalytic activity | 6.2500 | 4 | yes |
| GO:0098901 | regulation of cardiac muscle cell action potential | 6.2500 | 4 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 5.0000 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 5.0000 | 5 | yes |
| GO:0030833 | regulation of actin filament polymerization | 5.0000 | 7 | yes |
| GO:0030838 | positive regulation of actin filament polymerization | 5.0000 | 7 | yes |
| GO:0034248 | regulation of amide metabolic process | 5.0000 | 4 | yes |
| GO:0052547 | regulation of peptidase activity | 5.0000 | 5 | yes |
| GO:0052548 | regulation of endopeptidase activity | 5.0000 | 6 | yes |
| GO:0086004 | regulation of cardiac muscle cell contraction | 5.0000 | 6 | yes |
| GO:1902514 | regulation of calcium ion transmembrane transport via high voltage-gated calcium channel | 5.0000 | 8 | yes |
| GO:1903115 | regulation of actin filament-based movement | 5.0000 | 5 | yes |
| GO:0006997 | nucleus organization | 3.7500 | 5 | yes |
| GO:0010466 | negative regulation of peptidase activity | 3.7500 | 6 | yes |
| GO:0010951 | negative regulation of endopeptidase activity | 3.7500 | 7 | yes |
| GO:0014013 | regulation of gliogenesis | 3.7500 | 7 | yes |
| GO:0014015 | positive regulation of gliogenesis | 3.7500 | 7 | yes |
| GO:0034249 | negative regulation of amide metabolic process | 3.7500 | 5 | yes |
| GO:0045685 | regulation of glial cell differentiation | 3.7500 | 5 | yes |
| GO:0045687 | positive regulation of glial cell differentiation | 3.7500 | 6 | yes |
| GO:0045822 | negative regulation of heart contraction | 3.7500 | 6 | yes |
| GO:0045861 | negative regulation of proteolysis | 3.7500 | 7 | yes |
| GO:0051346 | negative regulation of hydrolase activity | 3.7500 | 5 | yes |
| GO:0098911 | regulation of ventricular cardiac muscle cell action potential | 3.7500 | 5 | yes |
| GO:1902003 | regulation of amyloid-beta formation | 3.7500 | 5 | yes |
| GO:1902430 | negative regulation of amyloid-beta formation | 3.7500 | 6 | yes |
| GO:1902991 | regulation of amyloid precursor protein catabolic process | 3.7500 | 6 | yes |
| GO:1902992 | negative regulation of amyloid precursor protein catabolic process | 3.7500 | 7 | yes |
| GO:1903523 | negative regulation of blood circulation | 3.7500 | 5 | yes |
| GO:0033292 | T-tubule organization | 2.5000 | 5 | yes |
| GO:0043266 | regulation of potassium ion transport | 2.5000 | 7 | yes |
| GO:0043267 | negative regulation of potassium ion transport | 2.5000 | 6 | yes |
| GO:0045759 | negative regulation of action potential | 2.5000 | 4 | yes |
| GO:0045932 | negative regulation of muscle contraction | 2.5000 | 5 | yes |
| GO:0045988 | negative regulation of striated muscle contraction | 2.5000 | 6 | yes |
| GO:0048710 | regulation of astrocyte differentiation | 2.5000 | 6 | yes |
| GO:0048711 | positive regulation of astrocyte differentiation | 2.5000 | 7 | yes |
| GO:0055118 | negative regulation of cardiac muscle contraction | 2.5000 | 7 | yes |
| GO:0060988 | lipid tube assembly | 2.5000 | 7 | yes |
| GO:0061337 | cardiac conduction | 2.5000 | 7 | yes |
| GO:0065005 | protein-lipid complex assembly | 2.5000 | 6 | yes |
| GO:0071825 | protein-lipid complex organization | 2.5000 | 5 | yes |
| GO:0086091 | regulation of heart rate by cardiac conduction | 2.5000 | 4 | yes |
| GO:0106135 | negative regulation of cardiac muscle cell contraction | 2.5000 | 5 | yes |
| GO:1901379 | regulation of potassium ion transmembrane transport | 2.5000 | 7 | yes |
| GO:1901380 | negative regulation of potassium ion transmembrane transport | 2.5000 | 7 | yes |
| GO:1902959 | regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process | 2.5000 | 7 | yes |
| GO:1902960 | negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process | 2.5000 | 8 | yes |
| GO:1903946 | negative regulation of ventricular cardiac muscle cell action potential | 2.5000 | 5 | yes |
| GO:1904878 | negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel | 2.5000 | 8 | yes |
| GO:1905245 | regulation of aspartic-type peptidase activity | 2.5000 | 6 | yes |
| GO:1905246 | negative regulation of aspartic-type peptidase activity | 2.5000 | 7 | yes |
Disease
No data found.
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DLGP4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| XRCC4_HUMAN | [view interactions] | Low throughput | no | yes |
| F16P1_HUMAN | [view interactions] | Low throughput | no | no |
| REPS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RIN3_HUMAN | [view interactions] | Low throughput | no | yes |
| SNX4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CNRG_HUMAN | [view interactions] | Low throughput | no | no |
| MTM1_HUMAN | [view interactions] | Low throughput | no | yes |
| SOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AMPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NECP1_HUMAN | [view interactions] | Low throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIN2_HUMAN | [view interactions] | Low throughput | no | no |
| DYN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RYR1_HUMAN | [view interactions] | Low throughput | no | no |
| CACB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITA1_HUMAN | [view interactions] | Low throughput | no | yes |
| ITA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITA6_HUMAN | [view interactions] | Low throughput | no | yes |
| FHL2_HUMAN | [view interactions] | Low throughput | no | yes |
| MYC_HUMAN | [view interactions] | Low throughput | no | yes |
| CLIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYNE2_HUMAN | [view interactions] | Low throughput | no | no |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYNJ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WASL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| E2F1_HUMAN | [view interactions] | Low throughput | no | yes |
| ITCH_HUMAN | [view interactions] | Low throughput | no | yes |
| EH1L1_HUMAN | [view interactions] | Low throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLUS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BECN1_HUMAN | [view interactions] | Low throughput | no | yes |
| FCG3A_HUMAN | [view interactions] | Low throughput | no | no |
| FCG2A_HUMAN | [view interactions] | Low throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BACE1_HUMAN | [view interactions] | Low throughput | no | yes |
| PDK1_HUMAN | [view interactions] | Low throughput | no | yes |
| UBE2O_HUMAN | [view interactions] | Low throughput | no | yes |
| PLD1_HUMAN | [view interactions] | Low throughput | no | no |
| PLD2_HUMAN | [view interactions] | Low throughput | no | yes |
| SOS2_HUMAN | [view interactions] | Low throughput | no | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACTS_HUMAN | [view interactions] | Low throughput | no | no |
| ACTG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MBNL1_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RAB8B_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| XRCC6_HUMAN | [view interactions] | Low throughput | no | yes |
| XRCC5_HUMAN | [view interactions] | Low throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| IRS4_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NECP2_HUMAN | [view interactions] | High throughput | no | yes |
| MERTK_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| RFX3_HUMAN | [view interactions] | High throughput | no | yes |
| ZBTB3_HUMAN | [view interactions] | High throughput | no | yes |
| CUX1_HUMAN | [view interactions] | High throughput | no | yes |
| PE2R4_HUMAN | [view interactions] | High throughput | no | yes |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
| PIAS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PWP2A_HUMAN | [view interactions] | High throughput | no | no |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGRA3_HUMAN | [view interactions] | High throughput | no | yes |
| RNB3L_HUMAN | [view interactions] | High throughput | no | yes |
| FHL1_HUMAN | [view interactions] | High throughput | no | no |
| MTF2_HUMAN | [view interactions] | High throughput | no | no |
| ATF6A_HUMAN | [view interactions] | High throughput | no | yes |
| SMHD1_HUMAN | [view interactions] | High throughput | no | yes |
| WBP2_HUMAN | [view interactions] | High throughput | no | yes |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN451_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GAS6_HUMAN | [view interactions] | High throughput | no | no |
| GNL3_HUMAN | [view interactions] | High throughput | no | yes |
| KS6C1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAX6_HUMAN | [view interactions] | High throughput | no | no |
| RAB24_HUMAN | [view interactions] | High throughput | no | no |
| PEPL_HUMAN | [view interactions] | High throughput | no | yes |
| YETS2_HUMAN | [view interactions] | High throughput | no | no |
| LRIF1_HUMAN | [view interactions] | High throughput | no | yes |
| PSA7_HUMAN | [view interactions] | High throughput | no | yes |
| RBP2_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BCAT2_HUMAN | [view interactions] | High throughput | no | no |
| RL8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSNAX_HUMAN | [view interactions] | High throughput | no | yes |
| UBC9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCAF2_HUMAN | [view interactions] | High throughput | no | yes |
| RANB3_HUMAN | [view interactions] | High throughput | no | yes |
| PIAS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIAT9_HUMAN | [view interactions] | High throughput | no | no |
| SYNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIAS2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN251_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| Z518A_HUMAN | [view interactions] | High throughput | no | no |
| HUNK_HUMAN | [view interactions] | High throughput | no | yes |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| GRL1A_HUMAN | [view interactions] | High throughput | no | no |
| IPO8_HUMAN | [view interactions] | High throughput | no | no |
| KLF8_HUMAN | [view interactions] | High throughput | no | no |
| VPS18_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NONO_HUMAN | [view interactions] | High throughput | no | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B1_HUMAN | [view interactions] | High throughput | no | no |
| BGAL_HUMAN | [view interactions] | High throughput | no | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CBARP_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| PDE4D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM12_HUMAN | [view interactions] | High throughput | no | yes |
| STMN1_HUMAN | [view interactions] | High throughput | no | yes |
| ASAP2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX2_HUMAN | [view interactions] | High throughput | no | yes |
| AP180_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNEM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNLI1_HUMAN | [view interactions] | High throughput | no | yes |
| MGN2_HUMAN | [view interactions] | High throughput | no | yes |
| SYNRG_HUMAN | [view interactions] | High throughput | no | yes |
| NFS1_HUMAN | [view interactions] | High throughput | no | yes |
| RHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPAST_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |