SNX4_HUMAN
Evidence for PS localization
Functions
Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed). Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SNX4_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 27.2727 | 4 | no |
| GO:0035091 | phosphatidylinositol binding | 18.1818 | 4 | yes |
| GO:0005154 | epidermal growth factor receptor binding | 12.1212 | 5 | yes |
| GO:0005158 | insulin receptor binding | 12.1212 | 4 | yes |
| GO:0070851 | growth factor receptor binding | 12.1212 | 4 | yes |
| GO:1990459 | transferrin receptor binding | 12.1212 | 4 | yes |
| GO:1990460 | leptin receptor binding | 12.1212 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 9.0909 | 5 | yes |
| GO:0032266 | phosphatidylinositol-3-phosphate binding | 6.0606 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SNX4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.6364 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 57.5758 | 4 | yes |
| GO:0010646 | regulation of cell communication | 51.5152 | 4 | yes |
| GO:0006996 | organelle organization | 51.5152 | 4 | no |
| GO:0008104 | protein localization | 48.4848 | 4 | yes |
| GO:0051049 | regulation of transport | 45.4545 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 42.4242 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 39.3939 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.3939 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 36.3636 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 36.3636 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 36.3636 | 4 | yes |
| GO:0071702 | organic substance transport | 36.3636 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 36.3636 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 36.3636 | 4 | no |
| GO:0060341 | regulation of cellular localization | 36.3636 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.3636 | 4 | no |
| GO:0022607 | cellular component assembly | 36.3636 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 33.3333 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:0015031 | protein transport | 30.3030 | 4 | yes |
| GO:0051050 | positive regulation of transport | 30.3030 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 30.3030 | 5 | yes |
| GO:0010468 | regulation of gene expression | 30.3030 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.3030 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.3030 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.3030 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 30.3030 | 5 | no |
| GO:0032880 | regulation of protein localization | 30.3030 | 5 | no |
| GO:0009894 | regulation of catabolic process | 27.2727 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 27.2727 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 27.2727 | 7 | no |
| GO:0009892 | negative regulation of metabolic process | 27.2727 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 27.2727 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.2727 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.2727 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 27.2727 | 6 | no |
| GO:0007010 | cytoskeleton organization | 27.2727 | 5 | no |
| GO:0030030 | cell projection organization | 27.2727 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 24.2424 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 24.2424 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.2424 | 5 | no |
| GO:0006886 | intracellular protein transport | 24.2424 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 24.2424 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 24.2424 | 5 | no |
| GO:0010638 | positive regulation of organelle organization | 21.2121 | 6 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 21.2121 | 5 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 21.2121 | 5 | yes |
| GO:0051046 | regulation of secretion | 21.2121 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 21.2121 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 21.2121 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.2121 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 21.2121 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.2121 | 4 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 21.2121 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.2121 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 21.2121 | 6 | no |
| GO:0061024 | membrane organization | 21.2121 | 4 | no |
| GO:0098657 | import into cell | 21.2121 | 4 | no |
| GO:0030162 | regulation of proteolysis | 21.2121 | 6 | no |
| GO:0033365 | protein localization to organelle | 21.2121 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.2121 | 6 | no |
| GO:0070925 | organelle assembly | 21.2121 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 21.2121 | 4 | no |
| GO:0071310 | cellular response to organic substance | 21.2121 | 4 | no |
| GO:0051726 | regulation of cell cycle | 21.2121 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 21.2121 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.2121 | 6 | no |
| GO:0046883 | regulation of hormone secretion | 18.1818 | 4 | yes |
| GO:0051047 | positive regulation of secretion | 18.1818 | 5 | yes |
| GO:0080134 | regulation of response to stress | 18.1818 | 4 | yes |
| GO:1903532 | positive regulation of secretion by cell | 18.1818 | 5 | yes |
| GO:0009896 | positive regulation of catabolic process | 15.1515 | 5 | yes |
| GO:0010506 | regulation of autophagy | 15.1515 | 6 | yes |
| GO:0017157 | regulation of exocytosis | 15.1515 | 5 | yes |
| GO:0031329 | regulation of cellular catabolic process | 15.1515 | 5 | yes |
| GO:0032456 | endocytic recycling | 15.1515 | 4 | yes |
| GO:1902115 | regulation of organelle assembly | 15.1515 | 5 | yes |
| GO:0016241 | regulation of macroautophagy | 12.1212 | 7 | yes |
| GO:0031347 | regulation of defense response | 12.1212 | 5 | yes |
| GO:0032101 | regulation of response to external stimulus | 12.1212 | 4 | yes |
| GO:0045921 | positive regulation of exocytosis | 12.1212 | 6 | yes |
| GO:0046887 | positive regulation of hormone secretion | 12.1212 | 5 | yes |
| GO:1902117 | positive regulation of organelle assembly | 12.1212 | 6 | yes |
| GO:0010508 | positive regulation of autophagy | 9.0909 | 7 | yes |
| GO:0031331 | positive regulation of cellular catabolic process | 9.0909 | 6 | yes |
| GO:0031349 | positive regulation of defense response | 9.0909 | 5 | yes |
| GO:0032103 | positive regulation of response to external stimulus | 9.0909 | 5 | yes |
| GO:0050727 | regulation of inflammatory response | 9.0909 | 5 | yes |
| GO:0050729 | positive regulation of inflammatory response | 9.0909 | 6 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 9.0909 | 6 | yes |
| GO:1903307 | positive regulation of regulated secretory pathway | 9.0909 | 7 | yes |
| GO:0002684 | positive regulation of immune system process | 6.0606 | 4 | yes |
| GO:0002697 | regulation of immune effector process | 6.0606 | 4 | yes |
| GO:0002699 | positive regulation of immune effector process | 6.0606 | 5 | yes |
| GO:0002703 | regulation of leukocyte mediated immunity | 6.0606 | 5 | yes |
| GO:0002886 | regulation of myeloid leukocyte mediated immunity | 6.0606 | 6 | yes |
| GO:0016239 | positive regulation of macroautophagy | 6.0606 | 8 | yes |
| GO:0043300 | regulation of leukocyte degranulation | 6.0606 | 5 | yes |
| GO:0043302 | positive regulation of leukocyte degranulation | 6.0606 | 6 | yes |
| GO:0043304 | regulation of mast cell degranulation | 6.0606 | 6 | yes |
| GO:0043306 | positive regulation of mast cell degranulation | 6.0606 | 7 | yes |
| GO:0044088 | regulation of vacuole organization | 6.0606 | 6 | yes |
| GO:0044090 | positive regulation of vacuole organization | 6.0606 | 7 | yes |
| GO:1903593 | regulation of histamine secretion by mast cell | 6.0606 | 4 | yes |
| GO:1903595 | positive regulation of histamine secretion by mast cell | 6.0606 | 5 | yes |
| GO:2000785 | regulation of autophagosome assembly | 6.0606 | 6 | yes |
| GO:2000786 | positive regulation of autophagosome assembly | 6.0606 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIBRA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ZEP1_HUMAN | [view interactions] | High throughput | no | yes |
| BECN1_HUMAN | [view interactions] | High throughput | no | yes |
| SNX30_HUMAN | [view interactions] | High throughput | no | no |
| ANKY2_HUMAN | [view interactions] | High throughput | no | no |
| CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCBA_HUMAN | [view interactions] | High throughput | no | yes |
| SNX4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX7_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| VPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPT5H_HUMAN | [view interactions] | High throughput | no | yes |
| PTN5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAGA6_HUMAN | [view interactions] | High throughput | no | no |
| AR6P1_HUMAN | [view interactions] | High throughput | no | yes |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| DG2L6_HUMAN | [view interactions] | High throughput | no | no |
| CSN6_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS18_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| SNX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| LEPR_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| AGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| MECR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPQM_HUMAN | [view interactions] | High throughput | no | no |
| DRD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| PAAT_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHBT1_HUMAN | [view interactions] | High throughput | no | yes |
| PI51C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INT2_HUMAN | [view interactions] | High throughput | no | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC3_HUMAN | [view interactions] | High throughput | no | yes |
| S10A9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPR_HUMAN | [view interactions] | High throughput | no | yes |
| DYLT3_HUMAN | [view interactions] | High throughput | no | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO5_HUMAN | [view interactions] | High throughput | no | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |