Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SNX4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed). Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SNX4_HUMAN
GO:0035091 phosphatidylinositol binding 19.4444 4 yes
GO:0005154 epidermal growth factor receptor binding 11.1111 5 yes
GO:0070851 growth factor receptor binding 11.1111 4 yes
GO:1901981 phosphatidylinositol phosphate binding 11.1111 5 yes
GO:1990459 transferrin receptor binding 11.1111 4 yes
GO:1990460 leptin receptor binding 11.1111 4 yes
GO:0032266 phosphatidylinositol-3-phosphate binding 5.5556 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SNX4_HUMAN
GO:0008104 protein localization 61.1111 4 yes
GO:0016192 vesicle-mediated transport 58.3333 4 yes
GO:0048522 positive regulation of cellular process 58.3333 4 yes
GO:0006996 organelle organization 55.5556 4 no
GO:0010646 regulation of cell communication 50.0000 4 yes
GO:0071702 organic substance transport 50.0000 4 yes
GO:0015031 protein transport 47.2222 4 yes
GO:0031323 regulation of cellular metabolic process 47.2222 4 yes
GO:0071705 nitrogen compound transport 47.2222 4 yes
GO:0051049 regulation of transport 41.6667 4 yes
GO:0051128 regulation of cellular component organization 41.6667 4 yes
GO:0022607 cellular component assembly 41.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 41.6667 4 no
GO:0023056 positive regulation of signaling 38.8889 4 yes
GO:0009893 positive regulation of metabolic process 36.1111 4 yes
GO:0010647 positive regulation of cell communication 36.1111 5 yes
GO:0016197 endosomal transport 36.1111 4 yes
GO:0061024 membrane organization 36.1111 4 no
GO:0009966 regulation of signal transduction 36.1111 4 no
GO:0080090 regulation of primary metabolic process 36.1111 4 no
GO:0009894 regulation of catabolic process 33.3333 4 yes
GO:0051050 positive regulation of transport 33.3333 4 yes
GO:0048523 negative regulation of cellular process 33.3333 4 no
GO:0006886 intracellular protein transport 33.3333 4 no
GO:0051171 regulation of nitrogen compound metabolic process 33.3333 4 no
GO:0048584 positive regulation of response to stimulus 30.5556 4 yes
GO:0051046 regulation of secretion 30.5556 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 30.5556 5 no
GO:0051246 regulation of protein metabolic process 30.5556 5 no
GO:0031329 regulation of cellular catabolic process 27.7778 5 yes
GO:1903530 regulation of secretion by cell 27.7778 4 yes
GO:0006897 endocytosis 27.7778 5 no
GO:0016050 vesicle organization 27.7778 5 no
GO:0010468 regulation of gene expression 27.7778 5 no
GO:0016482 cytosolic transport 27.7778 4 no
GO:0042147 retrograde transport, endosome to Golgi 27.7778 5 no
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 yes
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 yes
GO:0006906 vesicle fusion 25.0000 6 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0048284 organelle fusion 25.0000 5 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0061025 membrane fusion 25.0000 5 no
GO:0090174 organelle membrane fusion 25.0000 6 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0033043 regulation of organelle organization 22.2222 5 yes
GO:0044087 regulation of cellular component biogenesis 22.2222 4 yes
GO:0051047 positive regulation of secretion 22.2222 5 yes
GO:0051130 positive regulation of cellular component organization 22.2222 5 yes
GO:0060627 regulation of vesicle-mediated transport 22.2222 4 yes
GO:0046903 secretion 22.2222 4 no
GO:0071310 cellular response to organic substance 22.2222 4 no
GO:0009967 positive regulation of signal transduction 22.2222 5 no
GO:0010556 regulation of macromolecule biosynthetic process 22.2222 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0051252 regulation of RNA metabolic process 22.2222 5 no
GO:0010941 regulation of cell death 22.2222 4 no
GO:0051247 positive regulation of protein metabolic process 22.2222 6 no
GO:0010506 regulation of autophagy 19.4444 6 yes
GO:0016241 regulation of macroautophagy 19.4444 7 yes
GO:0017157 regulation of exocytosis 19.4444 5 yes
GO:0043269 regulation of ion transport 19.4444 5 yes
GO:0098876 vesicle-mediated transport to the plasma membrane 19.4444 4 yes
GO:1903532 positive regulation of secretion by cell 19.4444 5 yes
GO:0009896 positive regulation of catabolic process 16.6667 5 yes
GO:0032101 regulation of response to external stimulus 16.6667 4 yes
GO:0046883 regulation of hormone secretion 16.6667 4 yes
GO:0080134 regulation of response to stress 16.6667 4 yes
GO:0010638 positive regulation of organelle organization 13.8889 6 yes
GO:0031347 regulation of defense response 13.8889 5 yes
GO:0032456 endocytic recycling 13.8889 5 yes
GO:0043270 positive regulation of ion transport 13.8889 5 yes
GO:0044089 positive regulation of cellular component biogenesis 13.8889 5 yes
GO:0045921 positive regulation of exocytosis 13.8889 6 yes
GO:1903305 regulation of regulated secretory pathway 13.8889 6 yes
GO:0032103 positive regulation of response to external stimulus 11.1111 5 yes
GO:0046887 positive regulation of hormone secretion 11.1111 5 yes
GO:0050727 regulation of inflammatory response 11.1111 5 yes
GO:0050776 regulation of immune response 11.1111 4 yes
GO:1903307 positive regulation of regulated secretory pathway 11.1111 7 yes
GO:0002684 positive regulation of immune system process 8.3333 4 yes
GO:0002694 regulation of leukocyte activation 8.3333 4 yes
GO:0002696 positive regulation of leukocyte activation 8.3333 5 yes
GO:0002697 regulation of immune effector process 8.3333 4 yes
GO:0002699 positive regulation of immune effector process 8.3333 5 yes
GO:0002703 regulation of leukocyte mediated immunity 8.3333 5 yes
GO:0002886 regulation of myeloid leukocyte mediated immunity 8.3333 6 yes
GO:0031331 positive regulation of cellular catabolic process 8.3333 6 yes
GO:0031349 positive regulation of defense response 8.3333 5 yes
GO:0043300 regulation of leukocyte degranulation 8.3333 5 yes
GO:0043302 positive regulation of leukocyte degranulation 8.3333 6 yes
GO:0050729 positive regulation of inflammatory response 8.3333 6 yes
GO:0050778 positive regulation of immune response 8.3333 5 yes
GO:0050865 regulation of cell activation 8.3333 4 yes
GO:0050867 positive regulation of cell activation 8.3333 5 yes
GO:0010508 positive regulation of autophagy 5.5556 7 yes
GO:0016239 positive regulation of macroautophagy 5.5556 8 yes
GO:0033003 regulation of mast cell activation 5.5556 5 yes
GO:0033005 positive regulation of mast cell activation 5.5556 6 yes
GO:0033006 regulation of mast cell activation involved in immune response 5.5556 5 yes
GO:0033008 positive regulation of mast cell activation involved in immune response 5.5556 6 yes
GO:0043304 regulation of mast cell degranulation 5.5556 6 yes
GO:0043306 positive regulation of mast cell degranulation 5.5556 7 yes
GO:0044088 regulation of vacuole organization 5.5556 6 yes
GO:0044090 positive regulation of vacuole organization 5.5556 7 yes
GO:1902115 regulation of organelle assembly 5.5556 5 yes
GO:1902117 positive regulation of organelle assembly 5.5556 6 yes
GO:1903593 regulation of histamine secretion by mast cell 5.5556 4 yes
GO:1903595 positive regulation of histamine secretion by mast cell 5.5556 5 yes
GO:2000785 regulation of autophagosome assembly 5.5556 6 yes
GO:2000786 positive regulation of autophagosome assembly 5.5556 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in SNX4_HUMAN
DOID:1289 neurodegenerative disease 5.5556 4 no
DOID:331 central nervous system disease 5.5556 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
KIBRA_HUMAN [view interactions] Low throughput no yes
DCTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
PGFRB_HUMAN [view interactions] High throughput no yes
INSR_HUMAN [view interactions] High throughput no yes
LEPR_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
AGK_HUMAN [view entry] [view interactions] High throughput yes yes
LMBRL_HUMAN [view interactions] High throughput no no
MECR_HUMAN [view entry] [view interactions] High throughput yes yes
TCPQM_HUMAN [view interactions] High throughput no no
DRD2_HUMAN [view entry] [view interactions] High throughput yes no
NPAS1_HUMAN [view interactions] High throughput no no
PAAT_HUMAN [view interactions] High throughput no yes
DNJB6_HUMAN [view entry] [view interactions] High throughput yes yes
EFMT3_HUMAN [view interactions] High throughput no no
RHOC_HUMAN [view interactions] High throughput no no
RHBT1_HUMAN [view interactions] High throughput no yes
PI51C_HUMAN [view entry] [view interactions] High throughput yes yes
PSA_HUMAN [view entry] [view interactions] High throughput yes yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
INT2_HUMAN [view interactions] High throughput no yes
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
NUDC3_HUMAN [view interactions] High throughput no yes
S10A9_HUMAN [view entry] [view interactions] High throughput yes no
STX12_HUMAN [view entry] [view interactions] High throughput yes yes
SNX1_HUMAN [view entry] [view interactions] High throughput yes yes
RYR2_HUMAN [view entry] [view interactions] High throughput yes yes
STX1A_HUMAN [view entry] [view interactions] High throughput yes yes
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
ACE2_HUMAN [view interactions] High throughput no no
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
ZEP1_HUMAN [view interactions] High throughput no yes
BECN1_HUMAN [view interactions] High throughput no yes
ABCBA_HUMAN [view interactions] High throughput no yes
SNX30_HUMAN [view interactions] High throughput no no
CYBP_HUMAN [view entry] [view interactions] High throughput yes yes
ANKY2_HUMAN [view interactions] High throughput no no
SNX4_HUMAN [view entry] [view interactions] High throughput yes yes
SNX7_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
VPP1_HUMAN [view entry] [view interactions] High throughput yes yes
SPT5H_HUMAN [view interactions] High throughput no yes
PTN5_HUMAN [view entry] [view interactions] High throughput yes yes
MAGA6_HUMAN [view interactions] High throughput no no
AR6P1_HUMAN [view interactions] High throughput no yes
SHLB1_HUMAN [view interactions] High throughput no yes
DG2L6_HUMAN [view interactions] High throughput no no
CSN6_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
SCLT1_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view interactions] High throughput no yes
DUS18_HUMAN [view interactions] High throughput no yes
FHI1A_HUMAN [view interactions] High throughput no yes
SNX6_HUMAN [view entry] [view interactions] High throughput yes no
SNX2_HUMAN [view entry] [view interactions] High throughput yes no
PGFRA_HUMAN [view interactions] High throughput no no
SNP25_HUMAN [view entry] [view interactions] Computational yes yes
VAMP7_HUMAN [view interactions] Computational no yes
STX17_HUMAN [view interactions] Computational no yes
DYLT3_HUMAN [view interactions] Computational no yes
STX16_HUMAN [view interactions] Computational no yes
VTI1B_HUMAN [view entry] [view interactions] Computational yes yes
SNX5_HUMAN [view entry] [view interactions] Computational yes yes
VAMP3_HUMAN [view entry] [view interactions] Computational yes no
SNP23_HUMAN [view entry] [view interactions] Computational yes no
DYL1_HUMAN [view entry] [view interactions] Computational yes no
VAMP8_HUMAN [view interactions] Computational no no
TPR_HUMAN [view interactions] Computational no yes
SNP29_HUMAN [view interactions] Computational no yes
STX6_HUMAN [view interactions] Computational no yes
STX4_HUMAN [view entry] [view interactions] Computational yes no
VAMP2_HUMAN [view entry] [view interactions] Computational yes no
VP26A_HUMAN [view entry] [view interactions] Computational yes no
VPS35_HUMAN [view entry] [view interactions] Computational yes yes