PTN5_HUMAN
Evidence for PS localization
Functions
May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003316 | DOC_MAPK_HePTP_8 | DOC | 239 | 251 | - |
| ELMI003316 | DOC_MAPK_HePTP_8 | DOC | 239 | 251 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PTN5_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 35.7143 | 4 | no |
| GO:0046872 | metal ion binding | 35.7143 | 5 | no |
| GO:0043168 | anion binding | 28.5714 | 4 | no |
| GO:0000166 | nucleotide binding | 25.0000 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 21.4286 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 21.4286 | 4 | no |
| GO:0017076 | purine nucleotide binding | 21.4286 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 21.4286 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.4286 | 4 | no |
| GO:0019900 | kinase binding | 17.8571 | 4 | yes |
| GO:0001784 | phosphotyrosine residue binding | 14.2857 | 5 | yes |
| GO:0019901 | protein kinase binding | 14.2857 | 5 | yes |
| GO:0045309 | protein phosphorylated amino acid binding | 14.2857 | 4 | yes |
| GO:0004725 | protein tyrosine phosphatase activity | 7.1429 | 4 | yes |
| GO:0016791 | phosphatase activity | 7.1429 | 5 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 7.1429 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PTN5_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.7143 | 4 | no |
| GO:0010646 | regulation of cell communication | 53.5714 | 4 | no |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
| GO:0036211 | protein modification process | 42.8571 | 4 | yes |
| GO:0043412 | macromolecule modification | 42.8571 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 42.8571 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 42.8571 | 5 | no |
| GO:0023056 | positive regulation of signaling | 42.8571 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 42.8571 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 42.8571 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.2857 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.2857 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 39.2857 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.7143 | 4 | no |
| GO:0051049 | regulation of transport | 35.7143 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 35.7143 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 35.7143 | 4 | no |
| GO:0008104 | protein localization | 32.1429 | 4 | no |
| GO:0006996 | organelle organization | 32.1429 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 32.1429 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 32.1429 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 32.1429 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 28.5714 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 28.5714 | 5 | no |
| GO:0006508 | proteolysis | 28.5714 | 4 | no |
| GO:0009057 | macromolecule catabolic process | 28.5714 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 28.5714 | 4 | no |
| GO:0050890 | cognition | 28.5714 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 28.5714 | 6 | no |
| GO:0060341 | regulation of cellular localization | 28.5714 | 4 | no |
| GO:0009894 | regulation of catabolic process | 25.0000 | 4 | no |
| GO:0033043 | regulation of organelle organization | 25.0000 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0071702 | organic substance transport | 25.0000 | 4 | no |
| GO:0030030 | cell projection organization | 25.0000 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.0000 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 25.0000 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 25.0000 | 4 | no |
| GO:0080134 | regulation of response to stress | 21.4286 | 4 | no |
| GO:0031175 | neuron projection development | 21.4286 | 6 | no |
| GO:0033365 | protein localization to organelle | 21.4286 | 5 | no |
| GO:0061024 | membrane organization | 21.4286 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 21.4286 | 7 | no |
| GO:0030162 | regulation of proteolysis | 21.4286 | 6 | no |
| GO:0034762 | regulation of transmembrane transport | 21.4286 | 4 | no |
| GO:0045862 | positive regulation of proteolysis | 21.4286 | 7 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.4286 | 5 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 21.4286 | 6 | no |
| GO:0099536 | synaptic signaling | 21.4286 | 4 | no |
| GO:0099537 | trans-synaptic signaling | 21.4286 | 5 | no |
| GO:0007612 | learning | 21.4286 | 4 | no |
| GO:0010468 | regulation of gene expression | 21.4286 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.4286 | 4 | no |
| GO:0006470 | protein dephosphorylation | 7.1429 | 5 | yes |
| GO:0016311 | dephosphorylation | 7.1429 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MOB1A_HUMAN | [view interactions] | Low throughput | no | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK14_HUMAN | [view interactions] | Low throughput | no | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
| DCAKD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HLAA_HUMAN | [view interactions] | High throughput | no | no |
| MSPD2_HUMAN | [view interactions] | High throughput | no | yes |
| TOM70_HUMAN | [view interactions] | High throughput | no | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABD_HUMAN | [view interactions] | High throughput | no | yes |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| ATPO_HUMAN | [view interactions] | High throughput | no | yes |
| S61A2_HUMAN | [view interactions] | High throughput | no | no |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PMGT1_HUMAN | [view interactions] | High throughput | no | yes |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APOA1_HUMAN | [view interactions] | High throughput | no | no |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBTB5_HUMAN | [view interactions] | High throughput | no | yes |
| CCNQ_HUMAN | [view interactions] | High throughput | no | yes |
| CXCL9_HUMAN | [view interactions] | High throughput | no | no |
| TMM51_HUMAN | [view interactions] | High throughput | no | yes |
| VTI1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLC4G_HUMAN | [view interactions] | High throughput | no | no |
| S35B1_HUMAN | [view interactions] | High throughput | no | no |
| MARH5_HUMAN | [view interactions] | High throughput | no | no |
| C56D2_HUMAN | [view interactions] | High throughput | no | yes |
| ENTP3_HUMAN | [view interactions] | High throughput | no | no |
| TM201_HUMAN | [view interactions] | High throughput | no | no |
| PTN5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MISSL_HUMAN | [view interactions] | High throughput | no | yes |
| MAPK3_HUMAN | [view interactions] | High throughput | no | no |
| A7L3B_HUMAN | [view interactions] | High throughput | no | no |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXND5_HUMAN | [view interactions] | High throughput | no | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 5MP2_HUMAN | [view interactions] | High throughput | no | yes |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DGKE_HUMAN | [view interactions] | High throughput | no | yes |
| DHC24_HUMAN | [view interactions] | High throughput | no | yes |
| S61A1_HUMAN | [view interactions] | High throughput | no | no |
| TBL2_HUMAN | [view interactions] | High throughput | no | no |
| ALG1_HUMAN | [view interactions] | High throughput | no | yes |
| ARL1_HUMAN | [view interactions] | High throughput | no | yes |
| S27A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHCR7_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| CDKN3_HUMAN | [view interactions] | High throughput | no | no |
| DUS15_HUMAN | [view interactions] | High throughput | no | no |
| GHITM_HUMAN | [view interactions] | High throughput | no | yes |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| HACD3_HUMAN | [view interactions] | High throughput | no | yes |
| SPTC2_HUMAN | [view interactions] | High throughput | no | no |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| A20A1_HUMAN | [view interactions] | High throughput | no | no |
| VMA21_HUMAN | [view interactions] | High throughput | no | no |
| MEF2A_HUMAN | [view interactions] | High throughput | no | yes |
| TBX19_HUMAN | [view interactions] | High throughput | no | no |
| AT5G1_HUMAN | [view interactions] | High throughput | no | no |
| UBIP1_HUMAN | [view interactions] | High throughput | no | no |
| REEP4_HUMAN | [view interactions] | High throughput | no | no |
| ZN547_HUMAN | [view interactions] | High throughput | no | no |
| IKBL1_HUMAN | [view interactions] | High throughput | no | no |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCA6_HUMAN | [view interactions] | High throughput | no | no |
| PTN2_HUMAN | [view interactions] | High throughput | no | yes |
| FIBA_HUMAN | [view interactions] | High throughput | no | no |
| TTHY_HUMAN | [view interactions] | High throughput | no | no |
| F169A_HUMAN | [view interactions] | High throughput | no | yes |