PTN5_HUMAN
May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI003316 | DOC_MAPK_HePTP_8 | DOC | 239 | 251 | - |
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PTN5_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 30.0000 | 4 | no |
GO:0001784 | phosphotyrosine residue binding | 16.6667 | 5 | yes |
GO:0004725 | protein tyrosine phosphatase activity | 16.6667 | 4 | yes |
GO:0016791 | phosphatase activity | 16.6667 | 5 | yes |
GO:0042578 | phosphoric ester hydrolase activity | 16.6667 | 4 | yes |
GO:0045309 | protein phosphorylated amino acid binding | 16.6667 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PTN5_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 63.3333 | 4 | no |
GO:0010646 | regulation of cell communication | 56.6667 | 4 | no |
GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
GO:0036211 | protein modification process | 46.6667 | 4 | yes |
GO:0043412 | macromolecule modification | 46.6667 | 4 | yes |
GO:0009966 | regulation of signal transduction | 43.3333 | 4 | no |
GO:0010647 | positive regulation of cell communication | 43.3333 | 5 | no |
GO:0023056 | positive regulation of signaling | 43.3333 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 36.6667 | 5 | no |
GO:0031323 | regulation of cellular metabolic process | 36.6667 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 36.6667 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 36.6667 | 5 | no |
GO:0060255 | regulation of macromolecule metabolic process | 36.6667 | 4 | no |
GO:0060341 | regulation of cellular localization | 36.6667 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 36.6667 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 33.3333 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
GO:0051049 | regulation of transport | 33.3333 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | no |
GO:0008104 | protein localization | 33.3333 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 30.0000 | 5 | no |
GO:0006996 | organelle organization | 30.0000 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 30.0000 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 30.0000 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 26.6667 | 5 | no |
GO:0010468 | regulation of gene expression | 26.6667 | 5 | no |
GO:0043085 | positive regulation of catalytic activity | 26.6667 | 4 | no |
GO:0048878 | chemical homeostasis | 26.6667 | 4 | no |
GO:0050890 | cognition | 26.6667 | 4 | no |
GO:0010941 | regulation of cell death | 26.6667 | 4 | no |
GO:0016192 | vesicle-mediated transport | 26.6667 | 4 | no |
GO:0032880 | regulation of protein localization | 26.6667 | 5 | no |
GO:0022607 | cellular component assembly | 23.3333 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 23.3333 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 23.3333 | 4 | no |
GO:0006508 | proteolysis | 23.3333 | 4 | no |
GO:0030030 | cell projection organization | 23.3333 | 4 | no |
GO:0080134 | regulation of response to stress | 23.3333 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 23.3333 | 5 | no |
GO:0009894 | regulation of catabolic process | 23.3333 | 4 | no |
GO:0033043 | regulation of organelle organization | 23.3333 | 5 | no |
GO:0006470 | protein dephosphorylation | 13.3333 | 5 | yes |
GO:0016311 | dephosphorylation | 13.3333 | 5 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in PTN5_HUMAN |
---|---|---|---|---|
DOID:1289 | neurodegenerative disease | 6.6667 | 4 | no |
DOID:331 | central nervous system disease | 6.6667 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
MOB1A_HUMAN | [view interactions] | Low throughput | no | yes |
MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MK14_HUMAN | [view interactions] | Low throughput | no | yes |
NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DCAKD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TOM70_HUMAN | [view interactions] | High throughput | no | yes |
MSPD2_HUMAN | [view interactions] | High throughput | no | yes |
HLAA_HUMAN | [view interactions] | High throughput | no | no |
ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
TERF1_HUMAN | [view interactions] | High throughput | no | no |
MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATPG_HUMAN | [view interactions] | High throughput | no | yes |
PMGT1_HUMAN | [view interactions] | High throughput | no | yes |
RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
S61A2_HUMAN | [view interactions] | High throughput | no | no |
ATPO_HUMAN | [view interactions] | High throughput | no | yes |
AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CERS2_HUMAN | [view interactions] | High throughput | no | no |
2ABD_HUMAN | [view interactions] | High throughput | no | yes |
ATPB_HUMAN | [view interactions] | High throughput | no | yes |
APOA1_HUMAN | [view interactions] | High throughput | no | no |
CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNX4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZBTB5_HUMAN | [view interactions] | High throughput | no | yes |
CCNQ_HUMAN | [view interactions] | High throughput | no | yes |
CXCL9_HUMAN | [view interactions] | High throughput | no | no |
TMM51_HUMAN | [view interactions] | High throughput | no | yes |
VTI1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLC4G_HUMAN | [view interactions] | High throughput | no | no |
S35B1_HUMAN | [view interactions] | High throughput | no | no |
MARH5_HUMAN | [view interactions] | High throughput | no | no |
C56D2_HUMAN | [view interactions] | High throughput | no | yes |
ENTP3_HUMAN | [view interactions] | High throughput | no | no |
TM201_HUMAN | [view interactions] | High throughput | no | no |
PTN5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MISSL_HUMAN | [view interactions] | High throughput | no | yes |
MAPK3_HUMAN | [view interactions] | High throughput | no | no |
A7L3B_HUMAN | [view interactions] | High throughput | no | no |
VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TXND5_HUMAN | [view interactions] | High throughput | no | yes |
VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
5MP2_HUMAN | [view interactions] | High throughput | no | yes |
AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DGKE_HUMAN | [view interactions] | High throughput | no | yes |
DHC24_HUMAN | [view interactions] | High throughput | no | yes |
S61A1_HUMAN | [view interactions] | High throughput | no | no |
TBL2_HUMAN | [view interactions] | High throughput | no | no |
ALG1_HUMAN | [view interactions] | High throughput | no | yes |
ARL1_HUMAN | [view interactions] | High throughput | no | yes |
S27A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DHCR7_HUMAN | [view interactions] | High throughput | no | yes |
FAF2_HUMAN | [view interactions] | High throughput | no | yes |
CDKN3_HUMAN | [view interactions] | High throughput | no | no |
DUS15_HUMAN | [view interactions] | High throughput | no | no |
GHITM_HUMAN | [view interactions] | High throughput | no | yes |
MK11_HUMAN | [view interactions] | High throughput | no | yes |
HACD3_HUMAN | [view interactions] | High throughput | no | yes |
SPTC2_HUMAN | [view interactions] | High throughput | no | no |
DX39A_HUMAN | [view interactions] | High throughput | no | yes |
A20A1_HUMAN | [view interactions] | High throughput | no | no |
VMA21_HUMAN | [view interactions] | High throughput | no | no |
MEF2A_HUMAN | [view interactions] | High throughput | no | yes |
TBX19_HUMAN | [view interactions] | High throughput | no | no |
AT5G1_HUMAN | [view interactions] | High throughput | no | no |
UBIP1_HUMAN | [view interactions] | High throughput | no | no |
REEP4_HUMAN | [view interactions] | High throughput | no | no |
ZN547_HUMAN | [view interactions] | High throughput | no | no |
IKBL1_HUMAN | [view interactions] | High throughput | no | no |
ABCA6_HUMAN | [view interactions] | High throughput | no | no |
PTN2_HUMAN | [view interactions] | High throughput | no | yes |
FIBA_HUMAN | [view interactions] | High throughput | no | no |
TTHY_HUMAN | [view interactions] | High throughput | no | no |
F169A_HUMAN | [view interactions] | High throughput | no | yes |
PTN9_HUMAN | [view interactions] | Computational | no | yes |
PTN13_HUMAN | [view interactions] | Computational | no | yes |
IL37_HUMAN | [view interactions] | Computational | no | no |
PTN7_HUMAN | [view interactions] | Computational | no | no |
PTN18_HUMAN | [view interactions] | Computational | no | yes |
PTN20_HUMAN | [view interactions] | Computational | no | yes |
PTN4_HUMAN | [view interactions] | Computational | no | no |
PTN14_HUMAN | [view interactions] | Computational | no | yes |
SMAD3_HUMAN | [view interactions] | Computational | no | yes |
PTN23_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PTN6_HUMAN | [view interactions] | Computational | no | no |
PTN12_HUMAN | [view interactions] | Computational | no | yes |
DUS3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
PTN11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PTPRR_HUMAN | [view interactions] | Computational | no | yes |