CYFP2_HUMAN
Evidence for PS localization
Functions
Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CYFP2_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 26.1364 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.1364 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.1364 | 4 | no |
| GO:0003779 | actin binding | 25.0000 | 4 | no |
| GO:0019900 | kinase binding | 25.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 22.7273 | 5 | no |
| GO:0051020 | GTPase binding | 10.2273 | 4 | yes |
| GO:0031267 | small GTPase binding | 6.8182 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CYFP2_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 65.9091 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 64.7727 | 4 | yes |
| GO:0010646 | regulation of cell communication | 54.5455 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 52.2727 | 4 | no |
| GO:0022607 | cellular component assembly | 47.7273 | 4 | no |
| GO:0009966 | regulation of signal transduction | 46.5909 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 45.4545 | 4 | yes |
| GO:0006996 | organelle organization | 45.4545 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 44.3182 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.9091 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 40.9091 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 40.9091 | 4 | yes |
| GO:0030030 | cell projection organization | 39.7727 | 4 | no |
| GO:0033043 | regulation of organelle organization | 38.6364 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 38.6364 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 37.5000 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 37.5000 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 36.3636 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.2273 | 5 | no |
| GO:0007010 | cytoskeleton organization | 35.2273 | 5 | no |
| GO:0008104 | protein localization | 35.2273 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.0909 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 32.9545 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 32.9545 | 6 | yes |
| GO:0051049 | regulation of transport | 32.9545 | 4 | no |
| GO:0010468 | regulation of gene expression | 32.9545 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 31.8182 | 4 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 30.6818 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 30.6818 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 30.6818 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 30.6818 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 30.6818 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 30.6818 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.5455 | 5 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 27.2727 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 27.2727 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 27.2727 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 27.2727 | 4 | no |
| GO:0031399 | regulation of protein modification process | 27.2727 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.2727 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.1364 | 6 | yes |
| GO:0051129 | negative regulation of cellular component organization | 26.1364 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.1364 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 26.1364 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 25.0000 | 6 | yes |
| GO:0010975 | regulation of neuron projection development | 25.0000 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0034330 | cell junction organization | 25.0000 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 23.8636 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 23.8636 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.8636 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 23.8636 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 22.7273 | 7 | no |
| GO:0050807 | regulation of synapse organization | 21.5909 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.5909 | 4 | no |
| GO:0032990 | cell part morphogenesis | 21.5909 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 21.5909 | 4 | no |
| GO:0048858 | cell projection morphogenesis | 21.5909 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 21.5909 | 4 | no |
| GO:0007015 | actin filament organization | 21.5909 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.5909 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 21.5909 | 4 | no |
| GO:0032535 | regulation of cellular component size | 20.4545 | 4 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.4545 | 6 | no |
| GO:0010638 | positive regulation of organelle organization | 20.4545 | 6 | no |
| GO:0010941 | regulation of cell death | 20.4545 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.4545 | 5 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 20.4545 | 5 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.4545 | 7 | no |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 20.4545 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.4545 | 7 | no |
| GO:0071702 | organic substance transport | 20.4545 | 4 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 19.3182 | 5 | yes |
| GO:0043085 | positive regulation of catalytic activity | 18.1818 | 4 | yes |
| GO:0032271 | regulation of protein polymerization | 15.9091 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 14.7727 | 5 | yes |
| GO:0051336 | regulation of hydrolase activity | 14.7727 | 4 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 14.7727 | 6 | yes |
| GO:0030833 | regulation of actin filament polymerization | 13.6364 | 7 | yes |
| GO:0030162 | regulation of proteolysis | 10.2273 | 6 | yes |
| GO:0045862 | positive regulation of proteolysis | 9.0909 | 7 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 9.0909 | 5 | yes |
| GO:0052547 | regulation of peptidase activity | 6.8182 | 5 | yes |
| GO:0052548 | regulation of endopeptidase activity | 6.8182 | 6 | yes |
| GO:1990138 | neuron projection extension | 5.6818 | 4 | yes |
| GO:2000116 | regulation of cysteine-type endopeptidase activity | 5.6818 | 7 | yes |
| GO:0006915 | apoptotic process | 5.6818 | 4 | yes |
| GO:0010950 | positive regulation of endopeptidase activity | 5.6818 | 7 | yes |
| GO:0010952 | positive regulation of peptidase activity | 5.6818 | 6 | yes |
| GO:0090287 | regulation of cellular response to growth factor stimulus | 4.5455 | 4 | yes |
| GO:2001056 | positive regulation of cysteine-type endopeptidase activity | 4.5455 | 8 | yes |
| GO:0006508 | proteolysis | 4.5455 | 4 | yes |
| GO:0051386 | regulation of neurotrophin TRK receptor signaling pathway | 3.4091 | 5 | yes |
| GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway | 3.4091 | 6 | yes |
| GO:0097484 | dendrite extension | 3.4091 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| FMR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FXR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABI3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| PLMN_HUMAN | [view interactions] | High throughput | no | no |
| ZC12A_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRK1_HUMAN | [view interactions] | High throughput | no | no |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHSL1_HUMAN | [view interactions] | High throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDIPT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLSL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P3C2A_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| WASF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| GAS7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MP2K7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K13_HUMAN | [view interactions] | High throughput | no | yes |
| BUB1B_HUMAN | [view interactions] | High throughput | no | no |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DMXL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANGI_HUMAN | [view interactions] | High throughput | no | no |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPP2_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NLGN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRGP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX5R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHSL2_HUMAN | [view interactions] | High throughput | no | yes |
| NEK9_HUMAN | [view interactions] | High throughput | no | yes |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K5_HUMAN | [view interactions] | High throughput | no | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FYCO1_HUMAN | [view interactions] | High throughput | no | no |
| DYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAD10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSKI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OXYR_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ITF2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRE_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNMBP_HUMAN | [view interactions] | High throughput | no | no |
| PACN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PACN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PACN3_HUMAN | [view interactions] | High throughput | no | yes |
| MARK4_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN511_HUMAN | [view interactions] | High throughput | no | yes |
| UBX11_HUMAN | [view interactions] | High throughput | no | yes |
| VASP_HUMAN | [view interactions] | High throughput | no | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LHX4_HUMAN | [view interactions] | High throughput | no | no |
| BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSPB9_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| AMZ1_HUMAN | [view interactions] | High throughput | no | no |
| IKIP_HUMAN | [view interactions] | High throughput | no | no |
| CBLC_HUMAN | [view interactions] | High throughput | no | yes |
| HOME3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NYAP1_HUMAN | [view interactions] | High throughput | no | no |
| NYAP2_HUMAN | [view interactions] | High throughput | no | no |
| MYO16_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| PAAT_HUMAN | [view interactions] | High throughput | no | yes |
| ES8L1_HUMAN | [view interactions] | High throughput | no | no |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| FGOP2_HUMAN | [view interactions] | High throughput | no | yes |
| HIDE1_HUMAN | [view interactions] | High throughput | no | no |
| CD6_HUMAN | [view interactions] | High throughput | no | no |
| K1522_HUMAN | [view interactions] | High throughput | no | yes |
| RHG12_HUMAN | [view interactions] | High throughput | no | yes |
| HACL2_HUMAN | [view interactions] | High throughput | no | yes |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| TSN8_HUMAN | [view interactions] | High throughput | no | no |
| HS2ST_HUMAN | [view interactions] | High throughput | no | yes |
| VIPR2_HUMAN | [view interactions] | High throughput | no | no |
| F167A_HUMAN | [view interactions] | High throughput | no | yes |
| TYOBP_HUMAN | [view interactions] | High throughput | no | no |
| CMTD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| P2RY8_HUMAN | [view interactions] | High throughput | no | no |
| SPTCS_HUMAN | [view interactions] | High throughput | no | yes |
| VIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX43_HUMAN | [view interactions] | High throughput | no | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCRG1_HUMAN | [view interactions] | High throughput | no | yes |
| PR40A_HUMAN | [view interactions] | High throughput | no | yes |
| APBB1_HUMAN | [view interactions] | High throughput | no | yes |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCKPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX7B_HUMAN | [view interactions] | High throughput | no | yes |
| EMRE_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| MIB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |