Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KCTD8_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KCTD8_HUMAN
GO:0003723 RNA binding 38.4615 4 no
GO:0045296 cadherin binding 30.7692 4 no
GO:0019900 kinase binding 30.7692 4 no
GO:0019901 protein kinase binding 30.7692 5 no
GO:0051020 GTPase binding 23.0769 4 no
GO:0023026 MHC class II protein complex binding 23.0769 4 no
GO:0031625 ubiquitin protein ligase binding 23.0769 5 no
GO:0042826 histone deacetylase binding 23.0769 4 no
GO:0044389 ubiquitin-like protein ligase binding 23.0769 4 no
GO:0000166 nucleotide binding 23.0769 4 no
GO:0017076 purine nucleotide binding 23.0769 5 no
GO:0030554 adenyl nucleotide binding 23.0769 6 no
GO:0032555 purine ribonucleotide binding 23.0769 4 no
GO:0032559 adenyl ribonucleotide binding 23.0769 5 no
GO:0043168 anion binding 23.0769 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in KCTD8_HUMAN
GO:0048522 positive regulation of cellular process 69.2308 4 no
GO:0060255 regulation of macromolecule metabolic process 69.2308 4 no
GO:0010646 regulation of cell communication 61.5385 4 yes
GO:0022607 cellular component assembly 61.5385 4 yes
GO:0031323 regulation of cellular metabolic process 61.5385 4 no
GO:0009966 regulation of signal transduction 53.8462 4 yes
GO:0043933 protein-containing complex organization 53.8462 4 yes
GO:0065003 protein-containing complex assembly 53.8462 5 yes
GO:0009893 positive regulation of metabolic process 53.8462 4 no
GO:0010604 positive regulation of macromolecule metabolic process 53.8462 5 no
GO:0080090 regulation of primary metabolic process 53.8462 4 no
GO:0051128 regulation of cellular component organization 46.1538 4 no
GO:0051246 regulation of protein metabolic process 46.1538 5 no
GO:0009889 regulation of biosynthetic process 46.1538 4 no
GO:0010556 regulation of macromolecule biosynthetic process 46.1538 5 no
GO:0031325 positive regulation of cellular metabolic process 46.1538 5 no
GO:0031326 regulation of cellular biosynthetic process 46.1538 5 no
GO:0048523 negative regulation of cellular process 46.1538 4 no
GO:0051049 regulation of transport 46.1538 4 no
GO:0048584 positive regulation of response to stimulus 38.4615 4 no
GO:0009891 positive regulation of biosynthetic process 38.4615 5 no
GO:0009892 negative regulation of metabolic process 38.4615 4 no
GO:0010468 regulation of gene expression 38.4615 6 no
GO:0010557 positive regulation of macromolecule biosynthetic process 38.4615 6 no
GO:0010605 negative regulation of macromolecule metabolic process 38.4615 5 no
GO:0031328 positive regulation of cellular biosynthetic process 38.4615 6 no
GO:0051050 positive regulation of transport 38.4615 4 no
GO:0008104 protein localization 38.4615 4 no
GO:0019220 regulation of phosphate metabolic process 38.4615 6 no
GO:0031399 regulation of protein modification process 38.4615 6 no
GO:0051174 regulation of phosphorus metabolic process 38.4615 5 no
GO:0051259 protein complex oligomerization 30.7692 6 yes
GO:0051260 protein homooligomerization 30.7692 7 yes
GO:0043085 positive regulation of catalytic activity 30.7692 4 no
GO:0051247 positive regulation of protein metabolic process 30.7692 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.7692 5 no
GO:0031324 negative regulation of cellular metabolic process 30.7692 5 no
GO:0042981 regulation of apoptotic process 30.7692 5 no
GO:0043067 regulation of programmed cell death 30.7692 4 no
GO:0032880 regulation of protein localization 30.7692 5 no
GO:0051248 negative regulation of protein metabolic process 30.7692 6 no
GO:0051726 regulation of cell cycle 30.7692 4 no
GO:0060341 regulation of cellular localization 30.7692 4 no
GO:1903829 positive regulation of protein localization 30.7692 5 no
GO:0001932 regulation of protein phosphorylation 30.7692 7 no
GO:0006996 organelle organization 30.7692 4 no
GO:0042325 regulation of phosphorylation 30.7692 7 no
GO:0043549 regulation of kinase activity 30.7692 5 no
GO:0045859 regulation of protein kinase activity 30.7692 6 no
GO:0051338 regulation of transferase activity 30.7692 4 no
GO:0071702 organic substance transport 30.7692 4 no
GO:0071705 nitrogen compound transport 30.7692 4 no
GO:0008277 regulation of G protein-coupled receptor signaling pathway 23.0769 5 yes
GO:0009967 positive regulation of signal transduction 23.0769 5 no
GO:0010647 positive regulation of cell communication 23.0769 5 no
GO:0023056 positive regulation of signaling 23.0769 4 no
GO:0030162 regulation of proteolysis 23.0769 6 no
GO:0051336 regulation of hydrolase activity 23.0769 4 no
GO:0043066 negative regulation of apoptotic process 23.0769 6 no
GO:0043069 negative regulation of programmed cell death 23.0769 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0080134 regulation of response to stress 23.0769 4 no
GO:0090304 nucleic acid metabolic process 23.0769 4 no
GO:0010563 negative regulation of phosphorus metabolic process 23.0769 6 no
GO:0031400 negative regulation of protein modification process 23.0769 7 no
GO:0032386 regulation of intracellular transport 23.0769 5 no
GO:0032388 positive regulation of intracellular transport 23.0769 5 no
GO:0033157 regulation of intracellular protein transport 23.0769 6 no
GO:0034605 cellular response to heat 23.0769 4 no
GO:0044057 regulation of system process 23.0769 4 no
GO:0045936 negative regulation of phosphate metabolic process 23.0769 7 no
GO:0046822 regulation of nucleocytoplasmic transport 23.0769 6 no
GO:0046824 positive regulation of nucleocytoplasmic transport 23.0769 6 no
GO:0051222 positive regulation of protein transport 23.0769 5 no
GO:0051223 regulation of protein transport 23.0769 5 no
GO:0070201 regulation of establishment of protein localization 23.0769 6 no
GO:0090316 positive regulation of intracellular protein transport 23.0769 6 no
GO:1904951 positive regulation of establishment of protein localization 23.0769 6 no
GO:0006886 intracellular protein transport 23.0769 4 no
GO:0015031 protein transport 23.0769 4 no
GO:0045595 regulation of cell differentiation 23.0769 4 no
GO:0051094 positive regulation of developmental process 23.0769 4 no
GO:0010243 response to organonitrogen compound 23.0769 4 no
GO:0014070 response to organic cyclic compound 23.0769 4 no
GO:0071310 cellular response to organic substance 23.0769 4 no
GO:0010628 positive regulation of gene expression 23.0769 7 no
GO:0001934 positive regulation of protein phosphorylation 23.0769 8 no
GO:0010562 positive regulation of phosphorus metabolic process 23.0769 6 no
GO:0031401 positive regulation of protein modification process 23.0769 7 no
GO:0033674 positive regulation of kinase activity 23.0769 6 no
GO:0042327 positive regulation of phosphorylation 23.0769 8 no
GO:0045860 positive regulation of protein kinase activity 23.0769 7 no
GO:0045937 positive regulation of phosphate metabolic process 23.0769 7 no
GO:0051347 positive regulation of transferase activity 23.0769 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KCTD8_HUMAN [view entry] [view interactions] Low throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
CE162_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
KCD16_HUMAN [view entry] [view interactions] High throughput yes yes
PK1L3_HUMAN [view interactions] High throughput no no