Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KCTD8_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KCTD8_HUMAN
GO:0019900 kinase binding 37.5000 4 no
GO:0019901 protein kinase binding 37.5000 5 no
GO:0003723 RNA binding 37.5000 4 no
GO:0005524 ATP binding 25.0000 5 no
GO:0016462 pyrophosphatase activity 25.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.0000 4 no
GO:0016887 ATP hydrolysis activity 25.0000 7 no
GO:0017076 purine nucleotide binding 25.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.0000 6 no
GO:0023026 MHC class II protein complex binding 25.0000 4 no
GO:0030554 adenyl nucleotide binding 25.0000 5 no
GO:0030911 TPR domain binding 25.0000 4 no
GO:0031625 ubiquitin protein ligase binding 25.0000 5 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0042803 protein homodimerization activity 25.0000 4 no
GO:0042826 histone deacetylase binding 25.0000 4 no
GO:0044389 ubiquitin-like protein ligase binding 25.0000 4 no
GO:0045296 cadherin binding 25.0000 4 no
GO:0048156 tau protein binding 25.0000 4 no
GO:0070182 DNA polymerase binding 25.0000 4 no
GO:0097718 disordered domain specific binding 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in KCTD8_HUMAN
GO:0010646 regulation of cell communication 87.5000 4 yes
GO:0009966 regulation of signal transduction 75.0000 4 yes
GO:0022607 cellular component assembly 62.5000 4 yes
GO:0043933 protein-containing complex organization 62.5000 4 yes
GO:0065003 protein-containing complex assembly 62.5000 5 yes
GO:0009893 positive regulation of metabolic process 62.5000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 62.5000 5 no
GO:0048522 positive regulation of cellular process 62.5000 4 no
GO:0060255 regulation of macromolecule metabolic process 62.5000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0051049 regulation of transport 50.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 50.0000 5 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0010468 regulation of gene expression 50.0000 5 no
GO:0008277 regulation of G protein-coupled receptor signaling pathway 37.5000 5 yes
GO:0051259 protein complex oligomerization 37.5000 6 yes
GO:0051260 protein homooligomerization 37.5000 7 yes
GO:0001932 regulation of protein phosphorylation 37.5000 7 no
GO:0001934 positive regulation of protein phosphorylation 37.5000 8 no
GO:0009892 negative regulation of metabolic process 37.5000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 37.5000 6 no
GO:0010605 negative regulation of macromolecule metabolic process 37.5000 5 no
GO:0019220 regulation of phosphate metabolic process 37.5000 6 no
GO:0031324 negative regulation of cellular metabolic process 37.5000 5 no
GO:0031399 regulation of protein modification process 37.5000 6 no
GO:0031401 positive regulation of protein modification process 37.5000 7 no
GO:0032880 regulation of protein localization 37.5000 5 no
GO:0033674 positive regulation of kinase activity 37.5000 6 no
GO:0042325 regulation of phosphorylation 37.5000 7 no
GO:0042327 positive regulation of phosphorylation 37.5000 8 no
GO:0043085 positive regulation of catalytic activity 37.5000 4 no
GO:0043549 regulation of kinase activity 37.5000 5 no
GO:0045859 regulation of protein kinase activity 37.5000 6 no
GO:0045860 positive regulation of protein kinase activity 37.5000 7 no
GO:0045937 positive regulation of phosphate metabolic process 37.5000 7 no
GO:0051128 regulation of cellular component organization 37.5000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 37.5000 5 no
GO:0051174 regulation of phosphorus metabolic process 37.5000 5 no
GO:0051246 regulation of protein metabolic process 37.5000 5 no
GO:0051247 positive regulation of protein metabolic process 37.5000 6 no
GO:0051338 regulation of transferase activity 37.5000 4 no
GO:0051347 positive regulation of transferase activity 37.5000 5 no
GO:0060341 regulation of cellular localization 37.5000 4 no
GO:0051050 positive regulation of transport 37.5000 4 no
GO:0009889 regulation of biosynthetic process 37.5000 4 no
GO:0009891 positive regulation of biosynthetic process 37.5000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 37.5000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 37.5000 6 no
GO:0010941 regulation of cell death 37.5000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.5000 5 no
GO:0031326 regulation of cellular biosynthetic process 37.5000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 37.5000 6 no
GO:0042981 regulation of apoptotic process 37.5000 6 no
GO:0043067 regulation of programmed cell death 37.5000 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 37.5000 6 no
GO:0080134 regulation of response to stress 37.5000 4 no
GO:0090304 nucleic acid metabolic process 37.5000 4 no
GO:1902531 regulation of intracellular signal transduction 37.5000 5 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:1902947 regulation of tau-protein kinase activity 25.0000 7 no
GO:1902949 positive regulation of tau-protein kinase activity 25.0000 8 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 25.0000 7 no
GO:1904407 positive regulation of nitric oxide metabolic process 25.0000 6 no
GO:1905323 telomerase holoenzyme complex assembly 25.0000 7 no
GO:1990138 neuron projection extension 25.0000 4 no
GO:2000278 regulation of DNA biosynthetic process 25.0000 6 no
GO:2000573 positive regulation of DNA biosynthetic process 25.0000 7 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0051046 regulation of secretion 25.0000 5 no
GO:0051223 regulation of protein transport 25.0000 5 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0070201 regulation of establishment of protein localization 25.0000 6 no
GO:1903530 regulation of secretion by cell 25.0000 4 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0010628 positive regulation of gene expression 25.0000 6 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0014070 response to organic cyclic compound 25.0000 4 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0051241 negative regulation of multicellular organismal process 25.0000 4 no
GO:0051726 regulation of cell cycle 25.0000 4 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0071407 cellular response to organic cyclic compound 25.0000 5 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0000723 telomere maintenance 25.0000 5 no
GO:0001817 regulation of cytokine production 25.0000 4 no
GO:0002831 regulation of response to biotic stimulus 25.0000 4 no
GO:0006259 DNA metabolic process 25.0000 4 no
GO:0006278 RNA-templated DNA biosynthetic process 25.0000 6 no
GO:0006986 response to unfolded protein 25.0000 4 no
GO:0006996 organelle organization 25.0000 4 no
GO:0007004 telomere maintenance via telomerase 25.0000 7 no
GO:0007409 axonogenesis 25.0000 8 no
GO:0009059 macromolecule biosynthetic process 25.0000 4 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010629 negative regulation of gene expression 25.0000 6 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0010833 telomere maintenance via telomere lengthening 25.0000 6 no
GO:0018130 heterocycle biosynthetic process 25.0000 4 no
GO:0019438 aromatic compound biosynthetic process 25.0000 4 no
GO:0021955 central nervous system neuron axonogenesis 25.0000 9 no
GO:0022618 ribonucleoprotein complex assembly 25.0000 6 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0031347 regulation of defense response 25.0000 5 no
GO:0031396 regulation of protein ubiquitination 25.0000 8 no
GO:0032101 regulation of response to external stimulus 25.0000 4 no
GO:0032200 telomere organization 25.0000 6 no
GO:0032990 cell part morphogenesis 25.0000 4 no
GO:0033135 regulation of peptidyl-serine phosphorylation 25.0000 8 no
GO:0033138 positive regulation of peptidyl-serine phosphorylation 25.0000 9 no
GO:0034605 cellular response to heat 25.0000 4 no
GO:0034654 nucleobase-containing compound biosynthetic process 25.0000 4 no
GO:0042176 regulation of protein catabolic process 25.0000 5 no
GO:0043066 negative regulation of apoptotic process 25.0000 7 no
GO:0043069 negative regulation of programmed cell death 25.0000 6 no
GO:0044271 cellular nitrogen compound biosynthetic process 25.0000 4 no
GO:0045088 regulation of innate immune response 25.0000 5 no
GO:0045428 regulation of nitric oxide biosynthetic process 25.0000 6 no
GO:0045429 positive regulation of nitric oxide biosynthetic process 25.0000 7 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0048675 axon extension 25.0000 5 no
GO:0048812 neuron projection morphogenesis 25.0000 7 no
GO:0048858 cell projection morphogenesis 25.0000 5 no
GO:0050776 regulation of immune response 25.0000 4 no
GO:0050821 protein stabilization 25.0000 4 no
GO:0051052 regulation of DNA metabolic process 25.0000 5 no
GO:0051054 positive regulation of DNA metabolic process 25.0000 6 no
GO:0051131 chaperone-mediated protein complex assembly 25.0000 6 no
GO:0051276 chromosome organization 25.0000 5 no
GO:0051896 regulation of protein kinase B signaling 25.0000 6 no
GO:0051897 positive regulation of protein kinase B signaling 25.0000 7 no
GO:0051972 regulation of telomerase activity 25.0000 5 no
GO:0051973 positive regulation of telomerase activity 25.0000 6 no
GO:0060548 negative regulation of cell death 25.0000 5 no
GO:0071826 ribonucleoprotein complex subunit organization 25.0000 5 no
GO:0071897 DNA biosynthetic process 25.0000 5 no
GO:0080164 regulation of nitric oxide metabolic process 25.0000 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 25.0000 6 no
GO:1901362 organic cyclic compound biosynthetic process 25.0000 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KCTD8_HUMAN [view entry] [view interactions] Low throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
CE162_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
KCD16_HUMAN [view entry] [view interactions] High throughput yes yes
PK1L3_HUMAN [view interactions] High throughput no no