Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CADH2_HUMAN

Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells . CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in CADH2_HUMAN
GO:0045296 cadherin binding 30.3797 4 yes
GO:0043168 anion binding 30.3797 4 no
GO:0000166 nucleotide binding 26.5823 4 no
GO:0017076 purine nucleotide binding 26.5823 5 no
GO:0032555 purine ribonucleotide binding 26.5823 4 no
GO:0035639 purine ribonucleoside triphosphate binding 25.3165 4 no
GO:0003723 RNA binding 22.7848 4 yes
GO:0019900 kinase binding 20.2532 4 yes
GO:0019901 protein kinase binding 20.2532 5 yes
GO:0043169 cation binding 17.7215 4 yes
GO:0046872 metal ion binding 17.7215 5 yes
GO:0005509 calcium ion binding 10.1266 6 yes
GO:0019902 phosphatase binding 10.1266 4 yes
GO:0019903 protein phosphatase binding 10.1266 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CADH2_HUMAN
GO:0048522 positive regulation of cellular process 59.4937 4 yes
GO:0010646 regulation of cell communication 54.4304 4 yes
GO:0048523 negative regulation of cellular process 49.3671 4 yes
GO:0051128 regulation of cellular component organization 48.1013 4 yes
GO:0009966 regulation of signal transduction 45.5696 4 yes
GO:0022607 cellular component assembly 44.3038 4 yes
GO:0060255 regulation of macromolecule metabolic process 39.2405 4 no
GO:0031323 regulation of cellular metabolic process 37.9747 4 no
GO:0030030 cell projection organization 36.7089 4 no
GO:0008104 protein localization 35.4430 4 yes
GO:0023056 positive regulation of signaling 34.1772 4 yes
GO:0031344 regulation of cell projection organization 34.1772 5 yes
GO:0010647 positive regulation of cell communication 32.9114 5 yes
GO:0048584 positive regulation of response to stimulus 32.9114 4 yes
GO:0080090 regulation of primary metabolic process 32.9114 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 31.6456 6 yes
GO:0009893 positive regulation of metabolic process 31.6456 4 no
GO:0010604 positive regulation of macromolecule metabolic process 31.6456 5 no
GO:0120036 plasma membrane bounded cell projection organization 31.6456 5 no
GO:0022603 regulation of anatomical structure morphogenesis 30.3797 4 yes
GO:1902531 regulation of intracellular signal transduction 30.3797 5 yes
GO:0009889 regulation of biosynthetic process 30.3797 4 no
GO:0031326 regulation of cellular biosynthetic process 30.3797 5 no
GO:0009967 positive regulation of signal transduction 29.1139 5 yes
GO:0034330 cell junction organization 29.1139 4 yes
GO:0010468 regulation of gene expression 29.1139 6 no
GO:0010556 regulation of macromolecule biosynthetic process 29.1139 5 no
GO:0051049 regulation of transport 27.8481 4 yes
GO:0006996 organelle organization 27.8481 4 no
GO:0031325 positive regulation of cellular metabolic process 27.8481 5 no
GO:0010975 regulation of neuron projection development 25.3165 7 yes
GO:0042127 regulation of cell population proliferation 25.3165 4 yes
GO:0060341 regulation of cellular localization 25.3165 4 yes
GO:0045595 regulation of cell differentiation 25.3165 4 no
GO:2000026 regulation of multicellular organismal development 25.3165 4 no
GO:0051246 regulation of protein metabolic process 24.0506 5 no
GO:0031175 neuron projection development 24.0506 6 no
GO:0051241 negative regulation of multicellular organismal process 24.0506 4 no
GO:0032880 regulation of protein localization 22.7848 5 yes
GO:0048585 negative regulation of response to stimulus 22.7848 4 yes
GO:0034329 cell junction assembly 21.5190 5 yes
GO:0050804 modulation of chemical synaptic transmission 21.5190 5 yes
GO:0099177 regulation of trans-synaptic signaling 21.5190 4 yes
GO:0031399 regulation of protein modification process 21.5190 6 no
GO:0051247 positive regulation of protein metabolic process 21.5190 6 no
GO:0009892 negative regulation of metabolic process 21.5190 4 no
GO:0031324 negative regulation of cellular metabolic process 21.5190 5 no
GO:0060284 regulation of cell development 21.5190 5 no
GO:0010648 negative regulation of cell communication 20.2532 5 yes
GO:0023057 negative regulation of signaling 20.2532 4 yes
GO:0043408 regulation of MAPK cascade 20.2532 6 yes
GO:0045216 cell-cell junction organization 20.2532 5 yes
GO:0051130 positive regulation of cellular component organization 20.2532 5 no
GO:0051240 positive regulation of multicellular organismal process 20.2532 4 no
GO:0010605 negative regulation of macromolecule metabolic process 20.2532 5 no
GO:1902533 positive regulation of intracellular signal transduction 18.9873 6 yes
GO:0007043 cell-cell junction assembly 17.7215 6 yes
GO:0009968 negative regulation of signal transduction 17.7215 5 yes
GO:0050807 regulation of synapse organization 17.7215 5 yes
GO:0051050 positive regulation of transport 16.4557 4 yes
GO:0072657 protein localization to membrane 16.4557 4 yes
GO:0033043 regulation of organelle organization 13.9241 5 yes
GO:0043410 positive regulation of MAPK cascade 13.9241 7 yes
GO:0050808 synapse organization 13.9241 5 yes
GO:1990778 protein localization to cell periphery 13.9241 5 yes
GO:0072659 protein localization to plasma membrane 12.6582 5 yes
GO:0030111 regulation of Wnt signaling pathway 11.3924 5 yes
GO:0050770 regulation of axonogenesis 11.3924 5 yes
GO:0060828 regulation of canonical Wnt signaling pathway 11.3924 6 yes
GO:0099175 regulation of postsynapse organization 11.3924 6 yes
GO:1905475 regulation of protein localization to membrane 10.1266 6 yes
GO:2000177 regulation of neural precursor cell proliferation 10.1266 5 yes
GO:0034332 adherens junction organization 8.8608 6 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 8.8608 6 yes
GO:0044331 cell-cell adhesion mediated by cadherin 7.5949 4 yes
GO:0007416 synapse assembly 6.3291 6 yes
GO:0007420 brain development 6.3291 4 yes
GO:0030178 negative regulation of Wnt signaling pathway 6.3291 6 yes
GO:0043113 receptor clustering 6.3291 5 yes
GO:0048854 brain morphogenesis 6.3291 4 yes
GO:0090090 negative regulation of canonical Wnt signaling pathway 6.3291 7 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 6.3291 4 yes
GO:0002064 epithelial cell development 5.0633 4 yes
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 5.0633 5 yes
GO:0010001 glial cell differentiation 5.0633 4 yes
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 5.0633 5 yes
GO:0030855 epithelial cell differentiation 5.0633 4 yes
GO:0050982 detection of mechanical stimulus 5.0633 4 yes
GO:0097479 synaptic vesicle localization 5.0633 4 yes
GO:0001667 ameboidal-type cell migration 3.7975 4 yes
GO:0002065 columnar/cuboidal epithelial cell differentiation 3.7975 5 yes
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 3.7975 5 yes
GO:0035994 response to muscle stretch 3.7975 4 yes
GO:0035995 detection of muscle stretch 3.7975 5 yes
GO:0042692 muscle cell differentiation 3.7975 4 yes
GO:0048514 blood vessel morphogenesis 3.7975 4 yes
GO:0097091 synaptic vesicle clustering 3.7975 5 yes
GO:0002066 columnar/cuboidal epithelial cell development 2.5316 5 yes
GO:0002068 glandular epithelial cell development 2.5316 6 yes
GO:0003323 type B pancreatic cell development 2.5316 7 yes
GO:0014032 neural crest cell development 2.5316 5 yes
GO:0048864 stem cell development 2.5316 4 yes
GO:0051146 striated muscle cell differentiation 2.5316 5 yes
GO:0060019 radial glial cell differentiation 2.5316 5 yes
GO:0060563 neuroepithelial cell differentiation 2.5316 6 yes
GO:0070445 regulation of oligodendrocyte progenitor proliferation 2.5316 6 yes
GO:0090497 mesenchymal cell migration 2.5316 5 yes
GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly 2.5316 6 yes
GO:1902897 regulation of postsynaptic density protein 95 clustering 2.5316 7 yes
GO:1905874 regulation of postsynaptic density organization 2.5316 6 yes
GO:2000807 regulation of synaptic vesicle clustering 2.5316 4 yes
GO:2000809 positive regulation of synaptic vesicle clustering 2.5316 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
CTND1_HUMAN [view entry] [view interactions] Low throughput yes no
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRM_HUMAN [view interactions] Low throughput no yes
DDR2_HUMAN [view interactions] Low throughput no no
PLAK_HUMAN [view entry] [view interactions] Low throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] Low throughput yes no
NAA25_HUMAN [view interactions] Low throughput no yes
CXA1_HUMAN [view entry] [view interactions] Low throughput yes yes
CDON_HUMAN [view interactions] Low throughput no no
GRIA2_HUMAN [view entry] [view interactions] Low throughput yes yes
CADH2_HUMAN [view entry] [view interactions] Low throughput yes no
RET_HUMAN [view interactions] Low throughput no yes
PKP4_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTS_HUMAN [view interactions] Low throughput no no
CTNA1_HUMAN [view entry] [view interactions] Low throughput yes yes
CAD11_HUMAN [view interactions] Low throughput no no
BOC_HUMAN [view interactions] Low throughput no yes
RHG32_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRC7_HUMAN [view entry] [view interactions] Low throughput yes no
CADH4_HUMAN [view entry] [view interactions] Low throughput yes no
LRP5_HUMAN [view interactions] Low throughput no yes
LRP6_HUMAN [view interactions] Low throughput no yes
AXIN1_HUMAN [view interactions] Low throughput no yes
WNT3A_HUMAN [view entry] [view interactions] Low throughput yes no
CSK_HUMAN [view interactions] Low throughput no yes
P85A_HUMAN [view interactions] Low throughput no yes
NUMB_HUMAN [view entry] [view interactions] Low throughput yes yes
NEO1_HUMAN [view entry] [view interactions] Low throughput yes yes
CBP_HUMAN [view interactions] Low throughput no yes
CCNA2_HUMAN [view interactions] Low throughput no no
DDR1_HUMAN [view interactions] Low throughput no yes
EGFR_HUMAN [view interactions] Low throughput no no
ERBB2_HUMAN [view entry] [view interactions] Low throughput yes no
PSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
FGFR1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRF_HUMAN [view entry] [view interactions] Low throughput yes yes
ARVC_HUMAN [view entry] [view interactions] Low throughput yes yes
HPCL1_HUMAN [view interactions] Low throughput no yes
GNA12_HUMAN [view interactions] Low throughput no no
GNA13_HUMAN [view entry] [view interactions] Low throughput yes yes
NHRF1_HUMAN [view interactions] Low throughput no no
CAD10_HUMAN [view entry] [view interactions] Low throughput yes yes
AKAP5_HUMAN [view entry] [view interactions] Low throughput yes yes
AFAD_HUMAN [view entry] [view interactions] Low throughput yes yes
VANG2_HUMAN [view entry] [view interactions] Low throughput yes no
NPHP4_HUMAN [view interactions] High throughput no yes
KSR1_HUMAN [view interactions] High throughput no yes
CTNA3_HUMAN [view interactions] High throughput no no
ZBT18_HUMAN [view interactions] High throughput no yes
CLC4G_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
HMGA2_HUMAN [view interactions] High throughput no yes
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
TYRO3_HUMAN [view interactions] High throughput no yes
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
PEX5R_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
RYBP_HUMAN [view interactions] High throughput no no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
FA20C_HUMAN [view interactions] High throughput no no
EXOC5_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRC_HUMAN [view interactions] High throughput no no
PTPRK_HUMAN [view interactions] High throughput no no
PTPRG_HUMAN [view interactions] High throughput no no
PTPRB_HUMAN [view interactions] High throughput no yes
PTPRJ_HUMAN [view interactions] High throughput no yes
PTPRO_HUMAN [view entry] [view interactions] High throughput yes no
PTPRR_HUMAN [view interactions] High throughput no yes
PTN7_HUMAN [view interactions] High throughput no no
PTN6_HUMAN [view interactions] High throughput no no
PTN12_HUMAN [view interactions] High throughput no yes
PTN22_HUMAN [view interactions] High throughput no yes
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
MET_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
NECD_HUMAN [view interactions] High throughput no no
RAB8B_HUMAN [view entry] [view interactions] High throughput yes no
PTPRQ_HUMAN [view interactions] High throughput no no
KIFA3_HUMAN [view entry] [view interactions] High throughput yes yes
KIF3B_HUMAN [view entry] [view interactions] High throughput yes no
KIF5C_HUMAN [view entry] [view interactions] High throughput yes yes
RYK_HUMAN [view entry] [view interactions] High throughput yes no
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
FBSP1_HUMAN [view entry] [view interactions] High throughput yes no
SKP1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
BAP31_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
FBX6_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
TX1B3_HUMAN [view interactions] High throughput no no
SPSB4_HUMAN [view interactions] High throughput no no
SAPC1_HUMAN [view interactions] High throughput no no
HECD1_HUMAN [view interactions] High throughput no yes
TMPS2_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
CLC4D_HUMAN [view interactions] High throughput no no
TMPS4_HUMAN [view interactions] High throughput no yes
RHOJ_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
BPNT1_HUMAN [view interactions] High throughput no yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
MIDN_HUMAN [view interactions] High throughput no no
RN207_HUMAN [view interactions] High throughput no no
EGR2_HUMAN [view interactions] High throughput no no
PERI_HUMAN [view entry] [view interactions] High throughput yes no
RL32_HUMAN [view entry] [view interactions] High throughput yes yes
CAVN3_HUMAN [view interactions] High throughput no no
RM23_HUMAN [view interactions] High throughput no yes
C1TC_HUMAN [view entry] [view interactions] High throughput yes yes
PYC_HUMAN [view entry] [view interactions] High throughput yes yes
SPT5H_HUMAN [view interactions] High throughput no yes
SSRD_HUMAN [view interactions] High throughput no yes
RL21_HUMAN [view entry] [view interactions] High throughput yes yes
RL3_HUMAN [view entry] [view interactions] High throughput yes yes
RL8_HUMAN [view entry] [view interactions] High throughput yes yes
ICT1_HUMAN [view interactions] High throughput no yes
RS26_HUMAN [view entry] [view interactions] High throughput yes yes
RL14_HUMAN [view entry] [view interactions] High throughput yes yes
RS16_HUMAN [view entry] [view interactions] High throughput yes yes
KTN1_HUMAN [view entry] [view interactions] High throughput yes yes
LYAG_HUMAN [view interactions] High throughput no yes
TPM4_HUMAN [view entry] [view interactions] High throughput yes yes
RM49_HUMAN [view interactions] High throughput no yes
PTBP3_HUMAN [view interactions] High throughput no no
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
TM256_HUMAN [view interactions] High throughput no no
NENF_HUMAN [view interactions] High throughput no yes
SYSM_HUMAN [view interactions] High throughput no yes
PPT2_HUMAN [view interactions] High throughput no no
SYIM_HUMAN [view entry] [view interactions] High throughput yes yes
NACA2_HUMAN [view interactions] High throughput no no
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA4_HUMAN [view interactions] High throughput no yes
CTND2_HUMAN [view entry] [view interactions] High throughput yes no
PTPRA_HUMAN [view interactions] High throughput no yes
LEG9_HUMAN [view interactions] High throughput no yes
PARD3_HUMAN [view interactions] High throughput no yes
SC61B_HUMAN [view interactions] High throughput no yes
TM11B_HUMAN [view interactions] High throughput no no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
ACE2_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no