Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

WNT3A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed, PubMed, PubMed, PubMed). Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube . Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in WNT3A_HUMAN
GO:0031625 ubiquitin protein ligase binding 25.9259 5 no
GO:0044389 ubiquitin-like protein ligase binding 25.9259 4 no
GO:0001664 G protein-coupled receptor binding 22.2222 4 yes
GO:0005109 frizzled binding 22.2222 5 yes
GO:0046872 metal ion binding 22.2222 4 no
GO:0019900 kinase binding 22.2222 4 no
GO:0019901 protein kinase binding 22.2222 5 no
GO:0005125 cytokine activity 14.8148 5 yes
GO:0048018 receptor ligand activity 14.8148 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in WNT3A_HUMAN
GO:0010646 regulation of cell communication 74.0741 4 yes
GO:0009966 regulation of signal transduction 70.3704 4 yes
GO:0048522 positive regulation of cellular process 70.3704 4 yes
GO:0048523 negative regulation of cellular process 59.2593 4 yes
GO:0051128 regulation of cellular component organization 55.5556 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 55.5556 4 yes
GO:0051246 regulation of protein metabolic process 55.5556 5 yes
GO:0060255 regulation of macromolecule metabolic process 55.5556 4 yes
GO:0080090 regulation of primary metabolic process 55.5556 4 yes
GO:0030111 regulation of Wnt signaling pathway 55.5556 5 yes
GO:0048585 negative regulation of response to stimulus 55.5556 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 48.1481 5 yes
GO:0051247 positive regulation of protein metabolic process 48.1481 6 yes
GO:0009893 positive regulation of metabolic process 48.1481 4 yes
GO:0009967 positive regulation of signal transduction 48.1481 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 48.1481 5 yes
GO:0010647 positive regulation of cell communication 48.1481 5 yes
GO:0023056 positive regulation of signaling 48.1481 4 yes
GO:0036211 protein modification process 48.1481 4 no
GO:0043412 macromolecule modification 48.1481 4 no
GO:0031323 regulation of cellular metabolic process 48.1481 4 yes
GO:0031399 regulation of protein modification process 48.1481 6 yes
GO:0048584 positive regulation of response to stimulus 48.1481 4 yes
GO:0060341 regulation of cellular localization 44.4444 4 yes
GO:0060828 regulation of canonical Wnt signaling pathway 44.4444 6 yes
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 44.4444 4 yes
GO:0016055 Wnt signaling pathway 44.4444 5 yes
GO:0009968 negative regulation of signal transduction 44.4444 5 no
GO:0010648 negative regulation of cell communication 44.4444 5 no
GO:0023057 negative regulation of signaling 44.4444 4 no
GO:0032880 regulation of protein localization 44.4444 5 yes
GO:0051049 regulation of transport 40.7407 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 40.7407 6 yes
GO:0008104 protein localization 40.7407 4 yes
GO:0009889 regulation of biosynthetic process 40.7407 4 yes
GO:0010468 regulation of gene expression 40.7407 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 40.7407 5 yes
GO:0010941 regulation of cell death 40.7407 4 yes
GO:0031325 positive regulation of cellular metabolic process 40.7407 5 yes
GO:0031326 regulation of cellular biosynthetic process 40.7407 5 yes
GO:0031344 regulation of cell projection organization 40.7407 5 yes
GO:0045595 regulation of cell differentiation 40.7407 4 yes
GO:0051094 positive regulation of developmental process 37.0370 4 yes
GO:0051130 positive regulation of cellular component organization 37.0370 5 yes
GO:0051174 regulation of phosphorus metabolic process 37.0370 5 yes
GO:0051252 regulation of RNA metabolic process 37.0370 5 yes
GO:0006355 regulation of DNA-templated transcription 37.0370 6 yes
GO:1903506 regulation of nucleic acid-templated transcription 37.0370 7 yes
GO:0010975 regulation of neuron projection development 37.0370 7 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.0370 5 yes
GO:0019220 regulation of phosphate metabolic process 37.0370 6 yes
GO:2001141 regulation of RNA biosynthetic process 37.0370 6 yes
GO:0022607 cellular component assembly 37.0370 4 yes
GO:1902531 regulation of intracellular signal transduction 37.0370 5 no
GO:0031401 positive regulation of protein modification process 37.0370 7 yes
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 yes
GO:0051338 regulation of transferase activity 33.3333 4 yes
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 yes
GO:0006508 proteolysis 33.3333 4 no
GO:0042981 regulation of apoptotic process 33.3333 6 no
GO:0043067 regulation of programmed cell death 33.3333 5 no
GO:0042127 regulation of cell population proliferation 33.3333 4 yes
GO:0051129 negative regulation of cellular component organization 29.6296 5 yes
GO:0051240 positive regulation of multicellular organismal process 29.6296 4 yes
GO:0051241 negative regulation of multicellular organismal process 29.6296 4 yes
GO:0051254 positive regulation of RNA metabolic process 29.6296 6 yes
GO:0060070 canonical Wnt signaling pathway 29.6296 6 yes
GO:0060548 negative regulation of cell death 29.6296 5 yes
GO:0071310 cellular response to organic substance 29.6296 4 yes
GO:0001932 regulation of protein phosphorylation 29.6296 7 yes
GO:1902680 positive regulation of RNA biosynthetic process 29.6296 7 yes
GO:0009891 positive regulation of biosynthetic process 29.6296 5 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 29.6296 8 yes
GO:1903829 positive regulation of protein localization 29.6296 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 29.6296 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 29.6296 4 yes
GO:0030030 cell projection organization 29.6296 4 yes
GO:0009057 macromolecule catabolic process 29.6296 4 no
GO:0019941 modification-dependent protein catabolic process 29.6296 6 no
GO:0043632 modification-dependent macromolecule catabolic process 29.6296 5 no
GO:0044265 cellular macromolecule catabolic process 29.6296 4 no
GO:0051603 proteolysis involved in protein catabolic process 29.6296 5 no
GO:0031328 positive regulation of cellular biosynthetic process 29.6296 6 yes
GO:0031346 positive regulation of cell projection organization 29.6296 6 yes
GO:0030178 negative regulation of Wnt signaling pathway 29.6296 6 no
GO:0033043 regulation of organelle organization 29.6296 5 yes
GO:0042325 regulation of phosphorylation 29.6296 7 yes
GO:0045893 positive regulation of DNA-templated transcription 29.6296 7 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 29.6296 6 yes
GO:0051093 negative regulation of developmental process 25.9259 4 yes
GO:0060627 regulation of vesicle-mediated transport 25.9259 4 yes
GO:0120036 plasma membrane bounded cell projection organization 25.9259 5 yes
GO:1901214 regulation of neuron death 25.9259 5 yes
GO:0006357 regulation of transcription by RNA polymerase II 25.9259 7 yes
GO:1901701 cellular response to oxygen-containing compound 25.9259 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 25.9259 6 yes
GO:2000026 regulation of multicellular organismal development 25.9259 4 yes
GO:0009892 negative regulation of metabolic process 25.9259 4 no
GO:0010605 negative regulation of macromolecule metabolic process 25.9259 5 no
GO:0031324 negative regulation of cellular metabolic process 25.9259 5 no
GO:0030155 regulation of cell adhesion 25.9259 4 yes
GO:0030177 positive regulation of Wnt signaling pathway 25.9259 6 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 25.9259 5 no
GO:0031175 neuron projection development 25.9259 6 yes
GO:0010942 positive regulation of cell death 25.9259 5 no
GO:1902533 positive regulation of intracellular signal transduction 25.9259 6 no
GO:0034330 cell junction organization 25.9259 4 no
GO:0090090 negative regulation of canonical Wnt signaling pathway 25.9259 7 no
GO:0033993 response to lipid 25.9259 4 yes
GO:0043085 positive regulation of catalytic activity 25.9259 4 yes
GO:0043549 regulation of kinase activity 25.9259 5 yes
GO:0044087 regulation of cellular component biogenesis 25.9259 4 yes
GO:0045596 negative regulation of cell differentiation 25.9259 5 yes
GO:0045859 regulation of protein kinase activity 25.9259 6 yes
GO:0045937 positive regulation of phosphate metabolic process 25.9259 7 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 25.9259 8 yes
GO:0050770 regulation of axonogenesis 22.2222 5 yes
GO:0050807 regulation of synapse organization 22.2222 5 yes
GO:0051050 positive regulation of transport 22.2222 4 yes
GO:0051099 positive regulation of binding 22.2222 4 yes
GO:0051347 positive regulation of transferase activity 22.2222 5 yes
GO:0060284 regulation of cell development 22.2222 5 yes
GO:0001558 regulation of cell growth 22.2222 4 yes
GO:0090263 positive regulation of canonical Wnt signaling pathway 22.2222 7 yes
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 yes
GO:0008284 positive regulation of cell population proliferation 22.2222 5 yes
GO:0010628 positive regulation of gene expression 22.2222 6 yes
GO:2000027 regulation of animal organ morphogenesis 22.2222 5 yes
GO:0010721 negative regulation of cell development 22.2222 6 yes
GO:2000177 regulation of neural precursor cell proliferation 22.2222 5 yes
GO:0006796 phosphate-containing compound metabolic process 22.2222 4 no
GO:0031400 negative regulation of protein modification process 22.2222 7 no
GO:0030182 neuron differentiation 22.2222 4 yes
GO:0051248 negative regulation of protein metabolic process 22.2222 6 no
GO:0051726 regulation of cell cycle 22.2222 4 no
GO:0070647 protein modification by small protein conjugation or removal 22.2222 5 no
GO:0043066 negative regulation of apoptotic process 22.2222 7 no
GO:0043069 negative regulation of programmed cell death 22.2222 6 no
GO:0006996 organelle organization 22.2222 4 no
GO:0009894 regulation of catabolic process 22.2222 4 no
GO:0042176 regulation of protein catabolic process 22.2222 5 no
GO:0043065 positive regulation of apoptotic process 22.2222 7 no
GO:0043068 positive regulation of programmed cell death 22.2222 6 no
GO:0043408 regulation of MAPK cascade 22.2222 6 no
GO:0034329 cell junction assembly 22.2222 5 no
GO:0042327 positive regulation of phosphorylation 22.2222 8 yes
GO:0043393 regulation of protein binding 22.2222 4 yes
GO:0045597 positive regulation of cell differentiation 22.2222 5 yes
GO:0050767 regulation of neurogenesis 18.5185 6 yes
GO:0050768 negative regulation of neurogenesis 18.5185 6 yes
GO:0051960 regulation of nervous system development 18.5185 5 yes
GO:0051961 negative regulation of nervous system development 18.5185 5 yes
GO:0071396 cellular response to lipid 18.5185 5 yes
GO:0097485 neuron projection guidance 18.5185 7 yes
GO:0002009 morphogenesis of an epithelium 18.5185 4 yes
GO:0099054 presynapse assembly 18.5185 5 yes
GO:0099172 presynapse organization 18.5185 4 yes
GO:1901215 negative regulation of neuron death 18.5185 6 yes
GO:0007411 axon guidance 18.5185 8 yes
GO:0030162 regulation of proteolysis 18.5185 6 yes
GO:0030308 negative regulation of cell growth 18.5185 5 yes
GO:0032092 positive regulation of protein binding 18.5185 5 yes
GO:0032101 regulation of response to external stimulus 18.5185 4 yes
GO:0032102 negative regulation of response to external stimulus 18.5185 5 yes
GO:0033674 positive regulation of kinase activity 18.5185 6 yes
GO:0043933 protein-containing complex organization 18.5185 4 yes
GO:0045860 positive regulation of protein kinase activity 18.5185 7 yes
GO:0045926 negative regulation of growth 18.5185 4 yes
GO:0050678 regulation of epithelial cell proliferation 18.5185 5 yes
GO:0050679 positive regulation of epithelial cell proliferation 18.5185 6 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 14.8148 8 yes
GO:0050865 regulation of cell activation 14.8148 4 yes
GO:0050920 regulation of chemotaxis 14.8148 4 yes
GO:0050922 negative regulation of chemotaxis 14.8148 5 yes
GO:0051091 positive regulation of DNA-binding transcription factor activity 14.8148 4 yes
GO:0051336 regulation of hydrolase activity 14.8148 4 yes
GO:0051345 positive regulation of hydrolase activity 14.8148 5 yes
GO:0051493 regulation of cytoskeleton organization 14.8148 6 yes
GO:0051962 positive regulation of nervous system development 14.8148 5 yes
GO:0051963 regulation of synapse assembly 14.8148 6 yes
GO:0060562 epithelial tube morphogenesis 14.8148 4 yes
GO:0061311 cell surface receptor signaling pathway involved in heart development 14.8148 4 yes
GO:0061387 regulation of extent of cell growth 14.8148 5 yes
GO:0062009 secondary palate development 14.8148 4 yes
GO:0065003 protein-containing complex assembly 14.8148 5 yes
GO:0070507 regulation of microtubule cytoskeleton organization 14.8148 5 yes
GO:0071300 cellular response to retinoic acid 14.8148 5 yes
GO:0002684 positive regulation of immune system process 14.8148 4 yes
GO:0002694 regulation of leukocyte activation 14.8148 4 yes
GO:0003156 regulation of animal organ formation 14.8148 6 yes
GO:0003306 Wnt signaling pathway involved in heart development 14.8148 5 yes
GO:1901888 regulation of cell junction assembly 14.8148 5 yes
GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation 14.8148 6 yes
GO:1905475 regulation of protein localization to membrane 14.8148 6 yes
GO:0010977 negative regulation of neuron projection development 14.8148 7 yes
GO:2000179 positive regulation of neural precursor cell proliferation 14.8148 6 yes
GO:0030516 regulation of axon extension 14.8148 5 yes
GO:0031345 negative regulation of cell projection organization 14.8148 6 yes
GO:0032526 response to retinoic acid 14.8148 4 yes
GO:0032886 regulation of microtubule-based process 14.8148 4 yes
GO:0040013 negative regulation of locomotion 14.8148 4 yes
GO:0045598 regulation of fat cell differentiation 14.8148 5 yes
GO:0045785 positive regulation of cell adhesion 14.8148 5 yes
GO:0045862 positive regulation of proteolysis 14.8148 7 yes
GO:0048638 regulation of developmental growth 14.8148 4 yes
GO:0048732 gland development 14.8148 4 yes
GO:0050769 positive regulation of neurogenesis 11.1111 6 yes
GO:0050771 negative regulation of axonogenesis 11.1111 6 yes
GO:0050867 positive regulation of cell activation 11.1111 5 yes
GO:0051249 regulation of lymphocyte activation 11.1111 5 yes
GO:0060795 cell fate commitment involved in formation of primary germ layer 11.1111 4 yes
GO:0061316 canonical Wnt signaling pathway involved in heart development 11.1111 6 yes
GO:0070663 regulation of leukocyte proliferation 11.1111 5 yes
GO:0001701 in utero embryonic development 11.1111 6 yes
GO:0001817 regulation of cytokine production 11.1111 4 yes
GO:0001819 positive regulation of cytokine production 11.1111 5 yes
GO:0090381 regulation of heart induction 11.1111 4 yes
GO:0001947 heart looping 11.1111 5 yes
GO:0002696 positive regulation of leukocyte activation 11.1111 5 yes
GO:0099174 regulation of presynapse organization 11.1111 6 yes
GO:0003143 embryonic heart tube morphogenesis 11.1111 4 yes
GO:0006811 ion transport 11.1111 4 yes
GO:1901861 regulation of muscle tissue development 11.1111 4 yes
GO:1901863 positive regulation of muscle tissue development 11.1111 5 yes
GO:0009792 embryo development ending in birth or egg hatching 11.1111 4 yes
GO:0009953 dorsal/ventral pattern formation 11.1111 4 yes
GO:1904338 regulation of dopaminergic neuron differentiation 11.1111 6 yes
GO:1904339 negative regulation of dopaminergic neuron differentiation 11.1111 7 yes
GO:0010453 regulation of cell fate commitment 11.1111 4 yes
GO:1905606 regulation of presynapse assembly 11.1111 7 yes
GO:0010720 positive regulation of cell development 11.1111 6 yes
GO:2000047 regulation of cell-cell adhesion mediated by cadherin 11.1111 6 yes
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin 11.1111 7 yes
GO:0021846 cell proliferation in forebrain 11.1111 4 yes
GO:2000736 regulation of stem cell differentiation 11.1111 5 yes
GO:2000737 negative regulation of stem cell differentiation 11.1111 6 yes
GO:0021953 central nervous system neuron differentiation 11.1111 5 yes
GO:2000826 regulation of heart morphogenesis 11.1111 6 yes
GO:0022407 regulation of cell-cell adhesion 11.1111 5 yes
GO:0022409 positive regulation of cell-cell adhesion 11.1111 6 yes
GO:0030100 regulation of endocytosis 11.1111 5 yes
GO:0030517 negative regulation of axon extension 11.1111 6 yes
GO:0032944 regulation of mononuclear cell proliferation 11.1111 6 yes
GO:0033135 regulation of peptidyl-serine phosphorylation 11.1111 8 yes
GO:0033138 positive regulation of peptidyl-serine phosphorylation 11.1111 9 yes
GO:0036465 synaptic vesicle recycling 11.1111 4 yes
GO:0042472 inner ear morphogenesis 11.1111 4 yes
GO:0042659 regulation of cell fate specification 11.1111 5 yes
GO:0043009 chordate embryonic development 11.1111 5 yes
GO:0045599 negative regulation of fat cell differentiation 11.1111 6 yes
GO:0045664 regulation of neuron differentiation 11.1111 5 yes
GO:0045665 negative regulation of neuron differentiation 11.1111 6 yes
GO:0045807 positive regulation of endocytosis 11.1111 5 yes
GO:0045995 regulation of embryonic development 11.1111 5 yes
GO:0048103 somatic stem cell division 11.1111 4 yes
GO:0048534 hematopoietic or lymphoid organ development 11.1111 4 yes
GO:0048640 negative regulation of developmental growth 11.1111 5 yes
GO:0048641 regulation of skeletal muscle tissue development 11.1111 5 yes
GO:0048643 positive regulation of skeletal muscle tissue development 11.1111 6 yes
GO:0048841 regulation of axon extension involved in axon guidance 11.1111 6 yes
GO:0048843 negative regulation of axon extension involved in axon guidance 11.1111 6 yes
GO:0050670 regulation of lymphocyte proliferation 11.1111 6 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 7.4074 9 yes
GO:0050772 positive regulation of axonogenesis 7.4074 6 yes
GO:0050864 regulation of B cell activation 7.4074 6 yes
GO:0050871 positive regulation of B cell activation 7.4074 7 yes
GO:0051147 regulation of muscle cell differentiation 7.4074 5 yes
GO:0051149 positive regulation of muscle cell differentiation 7.4074 6 yes
GO:0051153 regulation of striated muscle cell differentiation 7.4074 6 yes
GO:0051155 positive regulation of striated muscle cell differentiation 7.4074 7 yes
GO:0051251 positive regulation of lymphocyte activation 7.4074 6 yes
GO:0051890 regulation of cardioblast differentiation 7.4074 6 yes
GO:0051892 negative regulation of cardioblast differentiation 7.4074 6 yes
GO:0052547 regulation of peptidase activity 7.4074 5 yes
GO:0052548 regulation of endopeptidase activity 7.4074 6 yes
GO:0061097 regulation of protein tyrosine kinase activity 7.4074 7 yes
GO:0061098 positive regulation of protein tyrosine kinase activity 7.4074 8 yes
GO:0061183 regulation of dermatome development 7.4074 4 yes
GO:0061184 positive regulation of dermatome development 7.4074 5 yes
GO:0061317 canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment 7.4074 7 yes
GO:0070527 platelet aggregation 7.4074 5 yes
GO:0070588 calcium ion transmembrane transport 7.4074 6 yes
GO:0070665 positive regulation of leukocyte proliferation 7.4074 6 yes
GO:0001649 osteoblast differentiation 7.4074 4 yes
GO:0001710 mesodermal cell fate commitment 7.4074 5 yes
GO:0090245 axis elongation involved in somitogenesis 7.4074 5 yes
GO:0090676 calcium ion transmembrane transport via low voltage-gated calcium channel 7.4074 7 yes
GO:0098655 cation transmembrane transport 7.4074 4 yes
GO:0002090 regulation of receptor internalization 7.4074 7 yes
GO:0098660 inorganic ion transmembrane transport 7.4074 4 yes
GO:0002092 positive regulation of receptor internalization 7.4074 7 yes
GO:0098662 inorganic cation transmembrane transport 7.4074 5 yes
GO:0003136 negative regulation of heart induction by canonical Wnt signaling pathway 7.4074 6 yes
GO:0099527 postsynapse to nucleus signaling pathway 7.4074 4 yes
GO:0100012 regulation of heart induction by canonical Wnt signaling pathway 7.4074 5 yes
GO:0003401 axis elongation 7.4074 4 yes
GO:1901320 negative regulation of heart induction 7.4074 5 yes
GO:0006812 cation transport 7.4074 5 yes
GO:0006816 calcium ion transport 7.4074 7 yes
GO:1903076 regulation of protein localization to plasma membrane 7.4074 7 yes
GO:1903078 positive regulation of protein localization to plasma membrane 7.4074 7 yes
GO:0009996 negative regulation of cell fate specification 7.4074 6 yes
GO:1904375 regulation of protein localization to cell periphery 7.4074 6 yes
GO:0009997 negative regulation of cardioblast cell fate specification 7.4074 7 yes
GO:1904377 positive regulation of protein localization to cell periphery 7.4074 6 yes
GO:0010387 COP9 signalosome assembly 7.4074 6 yes
GO:0010454 negative regulation of cell fate commitment 7.4074 5 yes
GO:1905207 regulation of cardiocyte differentiation 7.4074 5 yes
GO:0010455 positive regulation of cell fate commitment 7.4074 5 yes
GO:1905208 negative regulation of cardiocyte differentiation 7.4074 5 yes
GO:1905209 positive regulation of cardiocyte differentiation 7.4074 5 yes
GO:1905477 positive regulation of protein localization to membrane 7.4074 6 yes
GO:1905770 regulation of mesodermal cell differentiation 7.4074 5 yes
GO:1905772 positive regulation of mesodermal cell differentiation 7.4074 6 yes
GO:2000043 regulation of cardiac cell fate specification 7.4074 6 yes
GO:2000044 negative regulation of cardiac cell fate specification 7.4074 6 yes
GO:0010950 positive regulation of endopeptidase activity 7.4074 7 yes
GO:0010952 positive regulation of peptidase activity 7.4074 6 yes
GO:2000079 regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation 7.4074 7 yes
GO:2000081 positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation 7.4074 8 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 7.4074 7 yes
GO:2000345 regulation of hepatocyte proliferation 7.4074 6 yes
GO:0021515 cell differentiation in spinal cord 7.4074 4 yes
GO:2000347 positive regulation of hepatocyte proliferation 7.4074 7 yes
GO:0021527 spinal cord association neuron differentiation 7.4074 5 yes
GO:2000725 regulation of cardiac muscle cell differentiation 7.4074 6 yes
GO:2000727 positive regulation of cardiac muscle cell differentiation 7.4074 6 yes
GO:0021874 Wnt signaling pathway involved in forebrain neuroblast division 7.4074 6 yes
GO:0021904 dorsal/ventral neural tube patterning 7.4074 5 yes
GO:2001056 positive regulation of cysteine-type endopeptidase activity 7.4074 8 yes
GO:0030001 metal ion transport 7.4074 6 yes
GO:0030097 hemopoiesis 7.4074 5 yes
GO:0030198 extracellular matrix organization 7.4074 5 yes
GO:0030307 positive regulation of cell growth 7.4074 5 yes
GO:0030879 mammary gland development 7.4074 5 yes
GO:0030888 regulation of B cell proliferation 7.4074 7 yes
GO:0030890 positive regulation of B cell proliferation 7.4074 8 yes
GO:0032946 positive regulation of mononuclear cell proliferation 7.4074 7 yes
GO:0033278 cell proliferation in midbrain 7.4074 4 yes
GO:0034109 homotypic cell-cell adhesion 7.4074 4 yes
GO:0035914 skeletal muscle cell differentiation 7.4074 4 yes
GO:0040019 positive regulation of embryonic development 7.4074 5 yes
GO:0042660 positive regulation of cell fate specification 7.4074 6 yes
GO:0042661 regulation of mesodermal cell fate specification 7.4074 6 yes
GO:0042686 regulation of cardioblast cell fate specification 7.4074 7 yes
GO:0043062 extracellular structure organization 7.4074 4 yes
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 7.4074 9 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 7.4074 8 yes
GO:0045229 external encapsulating structure organization 7.4074 4 yes
GO:0045927 positive regulation of growth 7.4074 4 yes
GO:0048259 regulation of receptor-mediated endocytosis 7.4074 6 yes
GO:0048260 positive regulation of receptor-mediated endocytosis 7.4074 6 yes
GO:0048337 positive regulation of mesodermal cell fate specification 7.4074 7 yes
GO:0048343 paraxial mesodermal cell fate commitment 7.4074 6 yes
GO:0048639 positive regulation of developmental growth 7.4074 5 yes
GO:0048670 regulation of collateral sprouting 7.4074 5 yes
GO:0048672 positive regulation of collateral sprouting 7.4074 6 yes
GO:0048696 regulation of collateral sprouting in absence of injury 7.4074 6 yes
GO:0048697 positive regulation of collateral sprouting in absence of injury 7.4074 7 yes
GO:0050671 positive regulation of lymphocyte proliferation 7.4074 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SFRP4_HUMAN [view interactions] Low throughput no no
PTPRO_HUMAN [view entry] [view interactions] Low throughput yes no
LRP6_HUMAN [view interactions] Low throughput no yes
FZD8_HUMAN [view interactions] Low throughput no yes
TIKI2_HUMAN [view interactions] Low throughput no yes
APCD1_HUMAN [view interactions] Low throughput no no
WNT3A_HUMAN [view entry] [view interactions] Low throughput yes no
AFAM_HUMAN [view interactions] Low throughput no no
WLS_HUMAN [view entry] [view interactions] Low throughput yes no
FZD5_HUMAN [view interactions] Low throughput no yes
WIF1_HUMAN [view entry] [view interactions] Low throughput yes no
NOTUM_HUMAN [view interactions] Low throughput no no
FZD2_HUMAN [view interactions] Low throughput no no
FZD1_HUMAN [view interactions] Low throughput no yes
CADH2_HUMAN [view entry] [view interactions] Low throughput yes no
RYK_HUMAN [view interactions] Low throughput no no
PORCN_HUMAN [view entry] [view interactions] Low throughput yes yes
LG3BP_HUMAN [view interactions] Low throughput no no
DKK1_HUMAN [view interactions] Low throughput no no
WNT1_HUMAN [view interactions] Low throughput no no
KCTD1_HUMAN [view interactions] Low throughput no no
SFRP3_HUMAN [view interactions] Low throughput no no
SFRP1_HUMAN [view interactions] Low throughput no no
SFRP2_HUMAN [view interactions] Low throughput no no
WNT3_HUMAN [view interactions] High throughput no no
FEM1B_HUMAN [view interactions] High throughput no yes
SDF2L_HUMAN [view interactions] High throughput no yes
2ABD_HUMAN [view interactions] High throughput no yes
2A5E_HUMAN [view interactions] High throughput no yes
2A5A_HUMAN [view interactions] High throughput no yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
2AAB_HUMAN [view interactions] High throughput no yes
2A5D_HUMAN [view entry] [view interactions] High throughput yes yes
2A5B_HUMAN [view interactions] High throughput no yes
TRAF2_HUMAN [view interactions] High throughput no yes
2A5G_HUMAN [view interactions] High throughput no yes
ST14_HUMAN [view entry] [view interactions] High throughput yes yes
ACHA5_HUMAN [view entry] [view interactions] High throughput yes yes
WNT16_HUMAN [view interactions] High throughput no no
LAMC1_HUMAN [view interactions] High throughput no yes
KLHL9_HUMAN [view interactions] High throughput no no
DNJC3_HUMAN [view interactions] High throughput no yes
TM9S2_HUMAN [view interactions] High throughput no yes
GLT18_HUMAN [view interactions] High throughput no yes
NOTC2_HUMAN [view interactions] High throughput no yes
NOTC1_HUMAN [view interactions] High throughput no yes
MANBA_HUMAN [view interactions] High throughput no yes
JAG2_HUMAN [view interactions] High throughput no yes
TIMP2_HUMAN [view interactions] High throughput no no
LDLR_HUMAN [view interactions] High throughput no yes
INSR_HUMAN [view interactions] High throughput no yes
DVL1_HUMAN [view entry] [view interactions] Computational yes yes
LRP5_HUMAN [view interactions] Computational no yes
WNT4_HUMAN [view interactions] Computational no no
FZD4_HUMAN [view interactions] Computational no yes
WNT7A_HUMAN [view entry] [view interactions] Computational yes no
CTNB1_HUMAN [view entry] [view interactions] Computational yes yes
WNT2B_HUMAN [view interactions] Computational no no
RSPO2_HUMAN [view interactions] Computational no no
APC_HUMAN [view entry] [view interactions] Computational yes no
WNT11_HUMAN [view interactions] Computational no no
P4K2A_HUMAN [view interactions] Computational no yes
WNT2_HUMAN [view interactions] Computational no no
RL40_HUMAN [view entry] [view interactions] Computational yes yes
UBB_HUMAN [view entry] [view interactions] Computational yes yes
UBC_HUMAN [view entry] [view interactions] Computational yes yes
RS27A_HUMAN [view entry] [view interactions] Computational yes yes
BMP4_HUMAN [view interactions] Computational no no
AXIN1_HUMAN [view interactions] Computational no yes
PTK7_HUMAN [view interactions] Computational no yes
CTHR1_HUMAN [view interactions] Computational no yes
DKK4_HUMAN [view interactions] Computational no no
AXIN2_HUMAN [view interactions] Computational no yes
2AAA_HUMAN [view entry] [view interactions] Computational yes no
PP2AA_HUMAN [view entry] [view interactions] Computational yes yes
WNT9A_HUMAN [view interactions] Computational no no
HNF4A_HUMAN [view interactions] Computational no no
TMED5_HUMAN [view interactions] Computational no yes
GRK5_HUMAN [view interactions] Computational no yes
DVL3_HUMAN [view interactions] Computational no yes
CAV1_HUMAN [view interactions] Computational no no
FZD6_HUMAN [view interactions] Computational no yes
WNT6_HUMAN [view interactions] Computational no yes
FZD7_HUMAN [view interactions] Computational no yes
WNT5B_HUMAN [view interactions] Computational no no
DKK2_HUMAN [view interactions] Computational no no
KREM2_HUMAN [view interactions] Computational no no
WNT7B_HUMAN [view interactions] Computational no no
KC1G1_HUMAN [view interactions] Computational no no
KREM1_HUMAN [view interactions] Computational no no
FZD3_HUMAN [view interactions] Computational no yes
GSK3B_HUMAN [view entry] [view interactions] Computational yes yes
FGF8_HUMAN [view interactions] Computational no no
FZD9_HUMAN [view entry] [view interactions] Computational yes no
WN10A_HUMAN [view interactions] Computational no no
RSPO1_HUMAN [view interactions] Computational no yes
ROR2_HUMAN [view entry] [view interactions] Computational yes yes
WNT8B_HUMAN [view interactions] Computational no no
DVL2_HUMAN [view interactions] Computational no yes
WN10B_HUMAN [view interactions] Computational no yes
GPC3_HUMAN [view interactions] Computational no no
UBP8_HUMAN [view entry] [view interactions] Computational yes no
GSK3A_HUMAN [view interactions] Computational no yes
FZD10_HUMAN [view interactions] Computational no no
KC1G2_HUMAN [view interactions] Computational no yes
IBP4_HUMAN [view interactions] Computational no no
SOST_HUMAN [view interactions] Computational no no
SFRP5_HUMAN [view interactions] Computational no no
WNT9B_HUMAN [view interactions] Computational no no
LEF1_HUMAN [view interactions] Computational no no
PP2AB_HUMAN [view interactions] Computational no yes
WNT5A_HUMAN [view entry] [view interactions] Computational yes no