WIF1_HUMAN
Evidence for PS localization
Functions
Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in WIF1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 26.8293 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.8293 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.8293 | 4 | no |
| GO:0045296 | cadherin binding | 24.3902 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in WIF1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 48.7805 | 4 | yes |
| GO:0008104 | protein localization | 43.9024 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 41.4634 | 4 | no |
| GO:0051049 | regulation of transport | 39.0244 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.0244 | 4 | no |
| GO:0006996 | organelle organization | 36.5854 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 36.5854 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 36.5854 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.5854 | 4 | no |
| GO:0010646 | regulation of cell communication | 34.1463 | 4 | yes |
| GO:0071702 | organic substance transport | 34.1463 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 34.1463 | 4 | no |
| GO:0022607 | cellular component assembly | 34.1463 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 34.1463 | 4 | no |
| GO:0071705 | nitrogen compound transport | 31.7073 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 31.7073 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.7073 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 31.7073 | 5 | no |
| GO:0009966 | regulation of signal transduction | 29.2683 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 29.2683 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.2683 | 5 | no |
| GO:0010468 | regulation of gene expression | 29.2683 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 26.8293 | 4 | yes |
| GO:0015031 | protein transport | 26.8293 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.8293 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.8293 | 6 | no |
| GO:0060341 | regulation of cellular localization | 26.8293 | 4 | no |
| GO:0061024 | membrane organization | 24.3902 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.3902 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.3902 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 21.9512 | 4 | yes |
| GO:0048878 | chemical homeostasis | 21.9512 | 4 | no |
| GO:0006886 | intracellular protein transport | 21.9512 | 4 | no |
| GO:0043933 | protein-containing complex organization | 21.9512 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 21.9512 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.9512 | 6 | no |
| GO:0030030 | cell projection organization | 21.9512 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.9512 | 5 | no |
| GO:0071310 | cellular response to organic substance | 21.9512 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.9512 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 21.9512 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.9512 | 5 | no |
| GO:0010941 | regulation of cell death | 21.9512 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.9512 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.9512 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 21.9512 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.9512 | 6 | no |
| GO:0033043 | regulation of organelle organization | 21.9512 | 5 | no |
| GO:0045597 | positive regulation of cell differentiation | 17.0732 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 12.1951 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 9.7561 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 9.7561 | 5 | yes |
| GO:0016055 | Wnt signaling pathway | 9.7561 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 9.7561 | 4 | yes |
| GO:0030111 | regulation of Wnt signaling pathway | 9.7561 | 5 | yes |
| GO:1905114 | cell surface receptor signaling pathway involved in cell-cell signaling | 9.7561 | 4 | yes |
| GO:0045598 | regulation of fat cell differentiation | 7.3171 | 5 | yes |
| GO:0030178 | negative regulation of Wnt signaling pathway | 4.8780 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in WIF1_HUMAN |
|---|---|---|---|---|
| DOID:574 | peripheral nervous system disease | 4.8780 | 3 | no |
| DOID:870 | neuropathy | 4.8780 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| WNT3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WNT5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WNT7A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WNT4_HUMAN | [view interactions] | Low throughput | no | no |
| WNT9B_HUMAN | [view interactions] | Low throughput | no | no |
| WNT11_HUMAN | [view interactions] | Low throughput | no | no |
| WNT1_HUMAN | [view interactions] | Low throughput | no | no |
| RL37_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ICOS_HUMAN | [view interactions] | High throughput | no | no |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| KR108_HUMAN | [view interactions] | High throughput | no | no |
| CRTP1_HUMAN | [view interactions] | High throughput | no | yes |
| CRADD_HUMAN | [view interactions] | High throughput | no | yes |
| KR103_HUMAN | [view interactions] | High throughput | no | no |
| IP6K1_HUMAN | [view interactions] | High throughput | no | yes |
| CATL2_HUMAN | [view interactions] | High throughput | no | yes |
| SMHD1_HUMAN | [view interactions] | High throughput | no | yes |
| NDRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMD3_HUMAN | [view interactions] | High throughput | no | no |
| MAP1S_HUMAN | [view interactions] | High throughput | no | no |
| ZFR_HUMAN | [view interactions] | High throughput | no | yes |
| SGPL1_HUMAN | [view interactions] | High throughput | no | yes |
| NUP35_HUMAN | [view interactions] | High throughput | no | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| GSH0_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP3_HUMAN | [view interactions] | High throughput | no | yes |
| CCHL_HUMAN | [view interactions] | High throughput | no | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFS1_HUMAN | [view interactions] | High throughput | no | yes |
| PPME1_HUMAN | [view interactions] | High throughput | no | yes |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYRIB_HUMAN | [view interactions] | High throughput | no | yes |
| BRE1B_HUMAN | [view interactions] | High throughput | no | yes |
| STK24_HUMAN | [view interactions] | High throughput | no | yes |
| UBF1_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC2_HUMAN | [view interactions] | High throughput | no | yes |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FACE1_HUMAN | [view interactions] | High throughput | no | yes |
| ULA1_HUMAN | [view interactions] | High throughput | no | yes |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JAM1_HUMAN | [view interactions] | High throughput | no | yes |
| ADK_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| NAA50_HUMAN | [view interactions] | High throughput | no | yes |
| PNPT1_HUMAN | [view interactions] | High throughput | no | yes |
| NAA15_HUMAN | [view interactions] | High throughput | no | yes |
| MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX52_HUMAN | [view interactions] | High throughput | no | no |
| CTBP2_HUMAN | [view interactions] | High throughput | no | no |
| GAMT_HUMAN | [view interactions] | High throughput | no | no |
| CIP4_HUMAN | [view interactions] | High throughput | no | no |
| STAM1_HUMAN | [view interactions] | High throughput | no | yes |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| QCR8_HUMAN | [view interactions] | High throughput | no | yes |
| TXLNA_HUMAN | [view interactions] | High throughput | no | yes |
| RFC1_HUMAN | [view interactions] | High throughput | no | yes |
| PR40A_HUMAN | [view interactions] | High throughput | no | yes |
| CYB5_HUMAN | [view interactions] | High throughput | no | no |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPR1B_HUMAN | [view interactions] | High throughput | no | yes |
| SYJ2B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SF3A1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ1_HUMAN | [view interactions] | High throughput | no | yes |
| RPA49_HUMAN | [view interactions] | High throughput | no | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OXSR1_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF7_HUMAN | [view interactions] | High throughput | no | yes |
| SYLM_HUMAN | [view interactions] | High throughput | no | yes |
| MGME1_HUMAN | [view interactions] | High throughput | no | yes |
| TBL2_HUMAN | [view interactions] | High throughput | no | no |
| TOPK_HUMAN | [view interactions] | High throughput | no | no |
| GSTK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 3BP1_HUMAN | [view interactions] | High throughput | no | no |
| PUR8_HUMAN | [view interactions] | High throughput | no | yes |
| RRP5_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN7_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| SYUG_HUMAN | [view interactions] | High throughput | no | yes |
| SR140_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPAS2_HUMAN | [view interactions] | High throughput | no | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2A5D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPRB_HUMAN | [view interactions] | High throughput | no | yes |
| NAA10_HUMAN | [view interactions] | High throughput | no | yes |
| GALE_HUMAN | [view interactions] | High throughput | no | no |
| HSP7E_HUMAN | [view interactions] | High throughput | no | yes |
| RED_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 5NTC_HUMAN | [view interactions] | High throughput | no | yes |
| EHD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| C19L1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDS5A_HUMAN | [view interactions] | High throughput | no | yes |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1R8_HUMAN | [view interactions] | High throughput | no | yes |
| RBM26_HUMAN | [view interactions] | High throughput | no | yes |
| RPA34_HUMAN | [view interactions] | High throughput | no | yes |
| HDGR2_HUMAN | [view interactions] | High throughput | no | yes |
| ARMT1_HUMAN | [view interactions] | High throughput | no | yes |
| SYMPK_HUMAN | [view interactions] | High throughput | no | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| IL27A_HUMAN | [view interactions] | High throughput | no | no |
| TTL12_HUMAN | [view interactions] | High throughput | no | yes |
| SNX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBCP1_HUMAN | [view interactions] | High throughput | no | yes |
| T2FA_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| RRP44_HUMAN | [view interactions] | High throughput | no | yes |
| TBL3_HUMAN | [view interactions] | High throughput | no | yes |
| SNX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRM1_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EHD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| EDC4_HUMAN | [view interactions] | High throughput | no | yes |
| CSTF3_HUMAN | [view interactions] | High throughput | no | yes |
| PRPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBM15_HUMAN | [view interactions] | High throughput | no | yes |
| NEP1_HUMAN | [view interactions] | High throughput | no | yes |
| SUV3_HUMAN | [view interactions] | High throughput | no | yes |
| RBM25_HUMAN | [view interactions] | High throughput | no | yes |
| RDH11_HUMAN | [view interactions] | High throughput | no | no |
| PTH2_HUMAN | [view interactions] | High throughput | no | yes |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCDC6_HUMAN | [view interactions] | High throughput | no | yes |
| RMD1_HUMAN | [view interactions] | High throughput | no | no |
| TERF2_HUMAN | [view interactions] | High throughput | no | yes |
| SPT5H_HUMAN | [view interactions] | High throughput | no | yes |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LETM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WNT8B_HUMAN | [view interactions] | Computational | no | no |
| LRP6_HUMAN | [view interactions] | Computational | no | yes |
| WN10B_HUMAN | [view interactions] | Computational | no | yes |
| NOE1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| WNT6_HUMAN | [view interactions] | Computational | no | yes |
| FZD1_HUMAN | [view interactions] | Computational | no | yes |
| WNT2B_HUMAN | [view interactions] | Computational | no | no |
| WNT7B_HUMAN | [view interactions] | Computational | no | no |
| WNT5B_HUMAN | [view interactions] | Computational | no | no |
| FZD2_HUMAN | [view interactions] | Computational | no | no |
| MAN1_HUMAN | [view interactions] | Computational | no | yes |
| LRP5_HUMAN | [view interactions] | Computational | no | yes |
| WN10A_HUMAN | [view interactions] | Computational | no | no |
| SFRP1_HUMAN | [view interactions] | Computational | no | no |
| WNT2_HUMAN | [view interactions] | Computational | no | no |
| WNT3_HUMAN | [view interactions] | Computational | no | no |
| GDF11_HUMAN | [view interactions] | Computational | no | yes |
| DKK1_HUMAN | [view interactions] | Computational | no | no |
| WNT9A_HUMAN | [view interactions] | Computational | no | no |