PICAL_HUMAN
Evidence for PS localization
Functions
Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed, PubMed, PubMed). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed, PubMed, PubMed). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001184 | LIG_EH_1 | LIG | 436 | 440 | - |
| ELMI001185 | LIG_EH_1 | LIG | 638 | 642 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PICAL_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 28.2828 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 27.2727 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.2727 | 4 | no |
| GO:0019900 | kinase binding | 24.2424 | 4 | no |
| GO:0019901 | protein kinase binding | 23.2323 | 5 | no |
| GO:0003723 | RNA binding | 20.2020 | 4 | no |
| GO:0045296 | cadherin binding | 18.1818 | 4 | yes |
| GO:0051020 | GTPase binding | 10.1010 | 4 | yes |
| GO:0035091 | phosphatidylinositol binding | 8.0808 | 4 | yes |
| GO:0050750 | low-density lipoprotein particle receptor binding | 8.0808 | 5 | yes |
| GO:0070325 | lipoprotein particle receptor binding | 8.0808 | 4 | yes |
| GO:0048156 | tau protein binding | 7.0707 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 7.0707 | 5 | yes |
| GO:0031267 | small GTPase binding | 6.0606 | 5 | yes |
| GO:1902936 | phosphatidylinositol bisphosphate binding | 6.0606 | 6 | yes |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 5.0505 | 4 | yes |
| GO:0032050 | clathrin heavy chain binding | 5.0505 | 4 | yes |
| GO:0001540 | amyloid-beta binding | 4.0404 | 4 | yes |
| GO:0005545 | 1-phosphatidylinositol binding | 3.0303 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PICAL_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 62.6263 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 50.5051 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 49.4949 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 48.4848 | 4 | yes |
| GO:0008104 | protein localization | 45.4545 | 4 | no |
| GO:0006996 | organelle organization | 44.4444 | 4 | yes |
| GO:0022607 | cellular component assembly | 44.4444 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 44.4444 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 43.4343 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 43.4343 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 43.4343 | 4 | yes |
| GO:0010646 | regulation of cell communication | 41.4141 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.4040 | 4 | yes |
| GO:0071702 | organic substance transport | 40.4040 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.3939 | 5 | yes |
| GO:0071705 | nitrogen compound transport | 39.3939 | 4 | no |
| GO:0010468 | regulation of gene expression | 38.3838 | 5 | yes |
| GO:0051049 | regulation of transport | 38.3838 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 34.3434 | 5 | yes |
| GO:0015031 | protein transport | 34.3434 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | yes |
| GO:0006897 | endocytosis | 32.3232 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 32.3232 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 31.3131 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 31.3131 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.3030 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 30.3030 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 30.3030 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.2828 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 28.2828 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 28.2828 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.2828 | 4 | no |
| GO:0030030 | cell projection organization | 27.2727 | 4 | yes |
| GO:0032880 | regulation of protein localization | 27.2727 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 27.2727 | 4 | yes |
| GO:0051050 | positive regulation of transport | 27.2727 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.2626 | 6 | yes |
| GO:0051246 | regulation of protein metabolic process | 26.2626 | 5 | yes |
| GO:0061024 | membrane organization | 26.2626 | 4 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 26.2626 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 26.2626 | 6 | yes |
| GO:0051130 | positive regulation of cellular component organization | 26.2626 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.2626 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 25.2525 | 6 | yes |
| GO:0043933 | protein-containing complex organization | 24.2424 | 4 | yes |
| GO:0010941 | regulation of cell death | 23.2323 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 23.2323 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 23.2323 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 22.2222 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.2222 | 6 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 22.2222 | 4 | yes |
| GO:0006886 | intracellular protein transport | 22.2222 | 4 | no |
| GO:0007010 | cytoskeleton organization | 22.2222 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.2222 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 21.2121 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.2121 | 6 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.2121 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 21.2121 | 5 | yes |
| GO:0065003 | protein-containing complex assembly | 21.2121 | 5 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 20.2020 | 7 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 20.2020 | 6 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 20.2020 | 7 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 20.2020 | 8 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 20.2020 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.2020 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 20.2020 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 19.1919 | 5 | yes |
| GO:0006898 | receptor-mediated endocytosis | 18.1818 | 6 | yes |
| GO:0030100 | regulation of endocytosis | 18.1818 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 18.1818 | 6 | yes |
| GO:0043085 | positive regulation of catalytic activity | 16.1616 | 4 | yes |
| GO:0010942 | positive regulation of cell death | 14.1414 | 5 | yes |
| GO:0016050 | vesicle organization | 14.1414 | 5 | yes |
| GO:0030162 | regulation of proteolysis | 13.1313 | 6 | yes |
| GO:0032535 | regulation of cellular component size | 13.1313 | 4 | yes |
| GO:0048878 | chemical homeostasis | 13.1313 | 4 | yes |
| GO:1905475 | regulation of protein localization to membrane | 13.1313 | 6 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 12.1212 | 6 | yes |
| GO:0051051 | negative regulation of transport | 12.1212 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 12.1212 | 4 | yes |
| GO:0072583 | clathrin-dependent endocytosis | 12.1212 | 7 | yes |
| GO:0016197 | endosomal transport | 11.1111 | 4 | yes |
| GO:0032990 | cell part morphogenesis | 11.1111 | 4 | yes |
| GO:0048858 | cell projection morphogenesis | 11.1111 | 5 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 11.1111 | 6 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 11.1111 | 6 | yes |
| GO:0010629 | negative regulation of gene expression | 10.1010 | 6 | yes |
| GO:0034248 | regulation of cellular amide metabolic process | 10.1010 | 5 | yes |
| GO:0045862 | positive regulation of proteolysis | 10.1010 | 7 | yes |
| GO:0048812 | neuron projection morphogenesis | 10.1010 | 7 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 10.1010 | 5 | yes |
| GO:1901214 | regulation of neuron death | 10.1010 | 5 | yes |
| GO:1903076 | regulation of protein localization to plasma membrane | 10.1010 | 7 | yes |
| GO:1904375 | regulation of protein localization to cell periphery | 10.1010 | 6 | yes |
| GO:0048268 | clathrin coat assembly | 9.0909 | 6 | yes |
| GO:0006900 | vesicle budding from membrane | 8.0808 | 5 | yes |
| GO:0031623 | receptor internalization | 8.0808 | 7 | yes |
| GO:0043086 | negative regulation of catalytic activity | 8.0808 | 4 | yes |
| GO:0043087 | regulation of GTPase activity | 8.0808 | 5 | yes |
| GO:0050801 | ion homeostasis | 8.0808 | 5 | yes |
| GO:0050890 | cognition | 8.0808 | 4 | yes |
| GO:0055080 | cation homeostasis | 8.0808 | 6 | yes |
| GO:1903828 | negative regulation of protein localization | 8.0808 | 5 | yes |
| GO:0043547 | positive regulation of GTPase activity | 7.0707 | 6 | yes |
| GO:0052547 | regulation of peptidase activity | 7.0707 | 5 | yes |
| GO:0052548 | regulation of endopeptidase activity | 7.0707 | 6 | yes |
| GO:0055065 | metal ion homeostasis | 7.0707 | 7 | yes |
| GO:0098771 | inorganic ion homeostasis | 7.0707 | 6 | yes |
| GO:1901216 | positive regulation of neuron death | 7.0707 | 6 | yes |
| GO:0007409 | axonogenesis | 6.0606 | 8 | yes |
| GO:0034250 | positive regulation of cellular amide metabolic process | 6.0606 | 6 | yes |
| GO:0045861 | negative regulation of proteolysis | 6.0606 | 7 | yes |
| GO:0051346 | negative regulation of hydrolase activity | 6.0606 | 5 | yes |
| GO:1902991 | regulation of amyloid precursor protein catabolic process | 6.0606 | 6 | yes |
| GO:0010466 | negative regulation of peptidase activity | 5.0505 | 6 | yes |
| GO:0010950 | positive regulation of endopeptidase activity | 5.0505 | 7 | yes |
| GO:0010951 | negative regulation of endopeptidase activity | 5.0505 | 7 | yes |
| GO:0010952 | positive regulation of peptidase activity | 5.0505 | 6 | yes |
| GO:0070142 | synaptic vesicle budding | 5.0505 | 6 | yes |
| GO:0071709 | membrane assembly | 5.0505 | 5 | yes |
| GO:1902003 | regulation of amyloid-beta formation | 5.0505 | 6 | yes |
| GO:1902992 | negative regulation of amyloid precursor protein catabolic process | 5.0505 | 7 | yes |
| GO:1902993 | positive regulation of amyloid precursor protein catabolic process | 5.0505 | 7 | yes |
| GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane | 4.0404 | 7 | yes |
| GO:0035459 | vesicle cargo loading | 4.0404 | 4 | yes |
| GO:0045806 | negative regulation of endocytosis | 4.0404 | 5 | yes |
| GO:0048261 | negative regulation of receptor-mediated endocytosis | 4.0404 | 6 | yes |
| GO:0055076 | transition metal ion homeostasis | 4.0404 | 8 | yes |
| GO:1902004 | positive regulation of amyloid-beta formation | 4.0404 | 7 | yes |
| GO:1902959 | regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process | 4.0404 | 7 | yes |
| GO:1903077 | negative regulation of protein localization to plasma membrane | 4.0404 | 7 | yes |
| GO:1904376 | negative regulation of protein localization to cell periphery | 4.0404 | 6 | yes |
| GO:1905245 | regulation of aspartic-type peptidase activity | 4.0404 | 6 | yes |
| GO:1905476 | negative regulation of protein localization to membrane | 4.0404 | 6 | yes |
| GO:0048813 | dendrite morphogenesis | 3.0303 | 8 | yes |
| GO:0097494 | regulation of vesicle size | 3.0303 | 5 | yes |
| GO:1902961 | positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process | 3.0303 | 8 | yes |
| GO:1905224 | clathrin-coated pit assembly | 3.0303 | 6 | yes |
| GO:1905247 | positive regulation of aspartic-type peptidase activity | 3.0303 | 7 | yes |
| GO:2000008 | regulation of protein localization to cell surface | 3.0303 | 6 | yes |
| GO:2000009 | negative regulation of protein localization to cell surface | 3.0303 | 6 | yes |
| GO:0030097 | hemopoiesis | 2.0202 | 5 | yes |
| GO:0048534 | hematopoietic or lymphoid organ development | 2.0202 | 4 | yes |
| GO:0055072 | iron ion homeostasis | 2.0202 | 9 | yes |
| GO:0097753 | membrane bending | 2.0202 | 5 | yes |
| GO:1902962 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process | 2.0202 | 7 | yes |
| GO:1902963 | negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process | 2.0202 | 8 | yes |
| GO:1904683 | regulation of metalloendopeptidase activity | 2.0202 | 7 | yes |
| GO:1904684 | negative regulation of metalloendopeptidase activity | 2.0202 | 8 | yes |
| GO:1905048 | regulation of metallopeptidase activity | 2.0202 | 6 | yes |
| GO:1905049 | negative regulation of metallopeptidase activity | 2.0202 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PICAL_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 2.0202 | 4 | no |
| DOID:331 | central nervous system disease | 2.0202 | 3 | no |
| DOID:114 | heart disease | 2.0202 | 3 | no |
| DOID:0050155 | sensory system disease | 2.0202 | 3 | no |
| DOID:0050563 | nonsyndromic deafness | 2.0202 | 5 | no |
| DOID:0050564 | autosomal dominant nonsyndromic deafness | 2.0202 | 6 | no |
| DOID:2742 | auditory system disease | 2.0202 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EHD2_HUMAN | [view interactions] | Low throughput | no | no |
| PLCG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FHL2_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VAMP8_HUMAN | [view interactions] | Low throughput | no | no |
| VAMP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VAMP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PICAL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EPHA5_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROR1_HUMAN | [view interactions] | High throughput | no | no |
| ROR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STYK1_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBPMS_HUMAN | [view interactions] | High throughput | no | no |
| CRX_HUMAN | [view interactions] | High throughput | no | no |
| TEN1_HUMAN | [view interactions] | High throughput | no | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| ZC3HA_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1L_HUMAN | [view interactions] | High throughput | no | no |
| SIR1_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| KLH20_HUMAN | [view interactions] | High throughput | no | yes |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| ITLN1_HUMAN | [view interactions] | High throughput | no | no |
| ATF6B_HUMAN | [view interactions] | High throughput | no | yes |
| MFTC_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| PIMRE_HUMAN | [view interactions] | High throughput | no | no |
| CP1A1_HUMAN | [view interactions] | High throughput | no | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPN4_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
| WNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| STALP_HUMAN | [view interactions] | High throughput | no | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNR27_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR4_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| WDR76_HUMAN | [view interactions] | High throughput | no | no |
| FA20C_HUMAN | [view interactions] | High throughput | no | no |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| PIP_HUMAN | [view interactions] | High throughput | no | no |
| AP180_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTSS2_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDX3Y_HUMAN | [view interactions] | High throughput | no | yes |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| WIF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZN444_HUMAN | [view interactions] | High throughput | no | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| CENPQ_HUMAN | [view interactions] | High throughput | no | yes |
| DOK4_HUMAN | [view interactions] | High throughput | no | yes |
| SIAT9_HUMAN | [view interactions] | High throughput | no | no |
| BBS1_HUMAN | [view interactions] | High throughput | no | no |
| RBM47_HUMAN | [view interactions] | High throughput | no | yes |
| PAAT_HUMAN | [view interactions] | High throughput | no | yes |
| NTNG1_HUMAN | [view interactions] | High throughput | no | no |
| CK049_HUMAN | [view interactions] | High throughput | no | yes |
| AUXI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
| RDH11_HUMAN | [view interactions] | High throughput | no | no |
| MED17_HUMAN | [view interactions] | High throughput | no | no |
| POGZ_HUMAN | [view interactions] | High throughput | no | yes |
| PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
| RBM38_HUMAN | [view interactions] | High throughput | no | yes |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHG18_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OST48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KTAP2_HUMAN | [view interactions] | High throughput | no | no |
| OST4_HUMAN | [view interactions] | High throughput | no | no |
| OSTC_HUMAN | [view interactions] | High throughput | no | no |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HXA11_HUMAN | [view interactions] | High throughput | no | no |
| CCSE2_HUMAN | [view interactions] | High throughput | no | yes |
| STT3B_HUMAN | [view interactions] | High throughput | no | yes |
| MLEC_HUMAN | [view interactions] | High throughput | no | no |
| H2A2A_HUMAN | [view interactions] | High throughput | no | yes |
| RPAC2_HUMAN | [view interactions] | High throughput | no | no |
| FCHO1_HUMAN | [view interactions] | High throughput | no | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR3_HUMAN | [view interactions] | High throughput | no | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC24D_HUMAN | [view interactions] | High throughput | no | yes |
| DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC24C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| HNRDL_HUMAN | [view interactions] | High throughput | no | yes |
| SHLB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MRP2_HUMAN | [view interactions] | High throughput | no | no |
| VATF_HUMAN | [view interactions] | High throughput | no | yes |
| DAF_HUMAN | [view interactions] | High throughput | no | no |
| RTRAF_HUMAN | [view interactions] | High throughput | no | yes |
| SYCC_HUMAN | [view interactions] | High throughput | no | yes |
| CPPED_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HACL2_HUMAN | [view interactions] | High throughput | no | yes |
| ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LPP_HUMAN | [view interactions] | High throughput | no | yes |
| PAPOA_HUMAN | [view interactions] | High throughput | no | yes |
| DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| FERM2_HUMAN | [view interactions] | High throughput | no | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| NPL4_HUMAN | [view interactions] | High throughput | no | yes |
| PFKAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| UN13D_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| GGA2_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PELI2_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| FCHO2_HUMAN | [view interactions] | High throughput | no | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAB2_HUMAN | [view interactions] | High throughput | no | yes |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| STON2_HUMAN | [view interactions] | High throughput | no | yes |
| SEC13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| MICA3_HUMAN | [view interactions] | High throughput | no | yes |
| PRC2B_HUMAN | [view interactions] | High throughput | no | no |
| DEN1A_HUMAN | [view interactions] | High throughput | no | no |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P3C2A_HUMAN | [view interactions] | High throughput | no | yes |
| BMP2K_HUMAN | [view interactions] | High throughput | no | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| NECP1_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
| VMP1_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| ANGI_HUMAN | [view interactions] | High throughput | no | no |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| SCG1_HUMAN | [view interactions] | High throughput | no | no |
| EPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX33_HUMAN | [view interactions] | High throughput | no | yes |
| ZN521_HUMAN | [view interactions] | High throughput | no | yes |
| ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAZ2B_HUMAN | [view interactions] | High throughput | no | yes |
| EPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NECA1_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| AP4E1_HUMAN | [view interactions] | Computational | no | no |
| SNX5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ABCA7_HUMAN | [view interactions] | Computational | no | yes |
| SORL_HUMAN | [view interactions] | Computational | no | yes |
| BIN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SYNJ2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| M4A6A_HUMAN | [view interactions] | Computational | no | yes |
| YIPF6_HUMAN | [view interactions] | Computational | no | yes |
| SORT_HUMAN | [view interactions] | Computational | no | yes |
| AP3B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PP2BC_HUMAN | [view interactions] | Computational | no | yes |
| PP2BB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP4B1_HUMAN | [view interactions] | Computational | no | yes |
| SNX2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| DYN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SNAPN_HUMAN | [view interactions] | Computational | no | yes |
| APOE_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PP2BA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CD2AP_HUMAN | [view interactions] | Computational | no | no |
| AP3S1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CBPD_HUMAN | [view interactions] | Computational | no | yes |
| A4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CLUS_HUMAN | [view entry] [view interactions] | Computational | yes | yes |