Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

OPRD_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in OPRD_HUMAN
GO:0043168 anion binding 33.3333 4 no
GO:0043169 cation binding 33.3333 4 no
GO:0046872 metal ion binding 28.5714 5 no
GO:0000166 nucleotide binding 28.5714 4 no
GO:0016462 pyrophosphatase activity 28.5714 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 28.5714 4 no
GO:0017076 purine nucleotide binding 28.5714 5 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 28.5714 6 no
GO:0032555 purine ribonucleotide binding 28.5714 4 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no
GO:0003924 GTPase activity 23.8095 7 no
GO:0001664 G protein-coupled receptor binding 23.8095 4 no
GO:0004930 G protein-coupled receptor activity 19.0476 4 yes
GO:0004985 G protein-coupled opioid receptor activity 14.2857 5 yes
GO:0008528 G protein-coupled peptide receptor activity 14.2857 4 yes
GO:0033612 receptor serine/threonine kinase binding 9.5238 4 yes
GO:0038046 G protein-coupled enkephalin receptor activity 9.5238 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in OPRD_HUMAN
GO:0048522 positive regulation of cellular process 76.1905 4 yes
GO:0010646 regulation of cell communication 57.1429 4 no
GO:0051049 regulation of transport 52.3810 4 yes
GO:0009966 regulation of signal transduction 52.3810 4 no
GO:0048523 negative regulation of cellular process 47.6190 4 yes
GO:0051128 regulation of cellular component organization 47.6190 4 yes
GO:0009967 positive regulation of signal transduction 47.6190 5 no
GO:0010647 positive regulation of cell communication 47.6190 5 no
GO:0023056 positive regulation of signaling 47.6190 4 no
GO:0048584 positive regulation of response to stimulus 47.6190 4 no
GO:1902531 regulation of intracellular signal transduction 47.6190 5 no
GO:0009889 regulation of biosynthetic process 42.8571 4 yes
GO:0009893 positive regulation of metabolic process 42.8571 4 yes
GO:0031323 regulation of cellular metabolic process 42.8571 4 yes
GO:0008104 protein localization 42.8571 4 no
GO:0098657 import into cell 42.8571 4 no
GO:1902533 positive regulation of intracellular signal transduction 42.8571 6 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 38.0952 4 yes
GO:0010468 regulation of gene expression 38.0952 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 38.0952 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 38.0952 5 yes
GO:0031325 positive regulation of cellular metabolic process 38.0952 5 yes
GO:0031326 regulation of cellular biosynthetic process 38.0952 5 yes
GO:0060255 regulation of macromolecule metabolic process 38.0952 4 yes
GO:0080090 regulation of primary metabolic process 38.0952 4 yes
GO:0071702 organic substance transport 38.0952 4 no
GO:0071705 nitrogen compound transport 38.0952 4 no
GO:0006355 regulation of DNA-templated transcription 33.3333 7 yes
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 yes
GO:0019220 regulation of phosphate metabolic process 33.3333 6 yes
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 yes
GO:0051246 regulation of protein metabolic process 33.3333 5 yes
GO:0051247 positive regulation of protein metabolic process 33.3333 6 yes
GO:0051252 regulation of RNA metabolic process 33.3333 5 yes
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 yes
GO:0015031 protein transport 33.3333 4 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0006898 receptor-mediated endocytosis 33.3333 4 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 yes
GO:0001934 positive regulation of protein phosphorylation 28.5714 8 yes
GO:0009890 negative regulation of biosynthetic process 28.5714 5 yes
GO:0009892 negative regulation of metabolic process 28.5714 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 28.5714 6 yes
GO:0031399 regulation of protein modification process 28.5714 6 yes
GO:0031401 positive regulation of protein modification process 28.5714 7 yes
GO:0042325 regulation of phosphorylation 28.5714 7 yes
GO:0042327 positive regulation of phosphorylation 28.5714 8 yes
GO:0045937 positive regulation of phosphate metabolic process 28.5714 7 yes
GO:0061024 membrane organization 28.5714 4 no
GO:0006996 organelle organization 28.5714 4 no
GO:0009891 positive regulation of biosynthetic process 28.5714 5 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:0051094 positive regulation of developmental process 28.5714 4 no
GO:0009968 negative regulation of signal transduction 28.5714 5 no
GO:0010648 negative regulation of cell communication 28.5714 5 no
GO:0023057 negative regulation of signaling 28.5714 4 no
GO:0048585 negative regulation of response to stimulus 28.5714 4 no
GO:0051241 negative regulation of multicellular organismal process 28.5714 4 no
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 23.8095 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 23.8095 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 23.8095 5 yes
GO:0010629 negative regulation of gene expression 23.8095 7 yes
GO:0031324 negative regulation of cellular metabolic process 23.8095 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 23.8095 6 yes
GO:0043933 protein-containing complex organization 23.8095 4 no
GO:0065003 protein-containing complex assembly 23.8095 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.8095 6 no
GO:0031328 positive regulation of cellular biosynthetic process 23.8095 6 no
GO:0060627 regulation of vesicle-mediated transport 23.8095 4 no
GO:0051046 regulation of secretion 23.8095 5 no
GO:0051050 positive regulation of transport 23.8095 4 no
GO:0051130 positive regulation of cellular component organization 23.8095 5 no
GO:1903530 regulation of secretion by cell 23.8095 4 no
GO:0043408 regulation of MAPK cascade 23.8095 6 no
GO:0043410 positive regulation of MAPK cascade 23.8095 7 no
GO:0051240 positive regulation of multicellular organismal process 23.8095 4 no
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 19.0476 4 yes
GO:0010959 regulation of metal ion transport 19.0476 6 yes
GO:0043269 regulation of monoatomic ion transport 19.0476 5 yes
GO:0051129 negative regulation of cellular component organization 19.0476 5 yes
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 14.2857 4 yes
GO:0007218 neuropeptide signaling pathway 14.2857 4 yes
GO:0008344 adult locomotory behavior 14.2857 4 yes
GO:0033135 regulation of peptidyl-serine phosphorylation 14.2857 8 yes
GO:0033138 positive regulation of peptidyl-serine phosphorylation 14.2857 9 yes
GO:0036293 response to decreased oxygen levels 14.2857 4 yes
GO:0038003 G protein-coupled opioid receptor signaling pathway 14.2857 4 yes
GO:0043254 regulation of protein-containing complex assembly 14.2857 5 yes
GO:0044087 regulation of cellular component biogenesis 14.2857 4 yes
GO:0051091 positive regulation of DNA-binding transcription factor activity 14.2857 4 yes
GO:0051924 regulation of calcium ion transport 14.2857 7 yes
GO:0031333 negative regulation of protein-containing complex assembly 9.5238 6 yes
GO:0032793 positive regulation of CREB transcription factor activity 9.5238 5 yes
GO:0036294 cellular response to decreased oxygen levels 9.5238 5 yes
GO:0042755 eating behavior 9.5238 4 yes
GO:0051881 regulation of mitochondrial membrane potential 9.5238 4 yes
GO:0071363 cellular response to growth factor stimulus 9.5238 4 yes
GO:0071453 cellular response to oxygen levels 9.5238 4 yes
GO:0071456 cellular response to hypoxia 9.5238 4 yes
GO:0097237 cellular response to toxic substance 9.5238 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GASP1_HUMAN [view interactions] Low throughput no yes
AT2A2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALX_HUMAN [view entry] [view interactions] Low throughput yes yes
RTP4_HUMAN [view interactions] Low throughput no no
OPRM_HUMAN [view entry] [view interactions] Low throughput yes no
OPRD_HUMAN [view entry] [view interactions] Low throughput yes no
ADRB2_HUMAN [view entry] [view interactions] Low throughput yes no
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
S61A1_HUMAN [view interactions] Low throughput no no
SSR4_HUMAN [view interactions] Low throughput no no
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
HSP74_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
CXA4_HUMAN [view interactions] High throughput no yes
AUP1_HUMAN [view interactions] High throughput no yes
SIAH2_HUMAN [view interactions] High throughput no no
SIAH1_HUMAN [view interactions] High throughput no yes
WLS_HUMAN [view entry] [view interactions] High throughput yes no
S13A4_HUMAN [view interactions] High throughput no no
SMAGP_HUMAN [view interactions] High throughput no yes
CTXN3_HUMAN [view interactions] High throughput no no
RPRM_HUMAN [view interactions] High throughput no no
S12A7_HUMAN [view interactions] High throughput no yes
TM237_HUMAN [view interactions] High throughput no no
DOK4_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
GNAI2_HUMAN [view entry] [view interactions] High throughput yes yes
AGFG1_HUMAN [view interactions] High throughput no yes
DNM1L_HUMAN [view entry] [view interactions] High throughput yes yes
EPN2_HUMAN [view entry] [view interactions] High throughput yes yes
ITSN2_HUMAN [view entry] [view interactions] High throughput yes yes
MYOF_HUMAN [view interactions] High throughput no yes
SNAG_HUMAN [view entry] [view interactions] High throughput yes yes
PICAL_HUMAN [view entry] [view interactions] High throughput yes yes
SCAM3_HUMAN [view interactions] High throughput no no
SORT_HUMAN [view interactions] High throughput no yes
SPCS2_HUMAN [view interactions] High throughput no yes
ZNRD2_HUMAN [view interactions] High throughput no yes
TFR1_HUMAN [view entry] [view interactions] High throughput yes yes
TGFA1_HUMAN [view interactions] High throughput no no
TOM1_HUMAN [view interactions] High throughput no yes
RBNS5_HUMAN [view interactions] High throughput no yes
WWP2_HUMAN [view interactions] High throughput no no