Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

OPRD_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004294 TRG_DiLeu_BaLyEn_6 TRG 241 246 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in OPRD_HUMAN
GO:0001664 G protein-coupled receptor binding 43.7500 4 no
GO:0017076 purine nucleotide binding 37.5000 4 no
GO:0032555 purine ribonucleotide binding 37.5000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.5000 4 no
GO:0046872 metal ion binding 37.5000 4 no
GO:0004930 G protein-coupled receptor activity 31.2500 4 yes
GO:0016462 pyrophosphatase activity 31.2500 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 31.2500 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 31.2500 6 no
GO:0003924 GTPase activity 25.0000 7 no
GO:0005525 GTP binding 25.0000 5 no
GO:0019001 guanyl nucleotide binding 25.0000 5 no
GO:0031821 G protein-coupled serotonin receptor binding 25.0000 5 no
GO:0032561 guanyl ribonucleotide binding 25.0000 5 no
GO:0004985 G protein-coupled opioid receptor activity 18.7500 5 yes
GO:0008528 G protein-coupled peptide receptor activity 18.7500 4 yes
GO:0042923 neuropeptide binding 18.7500 4 yes
GO:0033612 receptor serine/threonine kinase binding 12.5000 4 yes
GO:0038046 G protein-coupled enkephalin receptor activity 12.5000 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in OPRD_HUMAN
GO:0048522 positive regulation of cellular process 75.0000 4 yes
GO:0010646 regulation of cell communication 68.7500 4 no
GO:0051049 regulation of transport 62.5000 4 yes
GO:0009966 regulation of signal transduction 62.5000 4 no
GO:1902531 regulation of intracellular signal transduction 56.2500 5 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 56.2500 4 yes
GO:0009893 positive regulation of metabolic process 56.2500 4 yes
GO:0031323 regulation of cellular metabolic process 56.2500 4 yes
GO:0031325 positive regulation of cellular metabolic process 56.2500 5 yes
GO:0048523 negative regulation of cellular process 56.2500 4 yes
GO:0048584 positive regulation of response to stimulus 50.0000 4 no
GO:1902533 positive regulation of intracellular signal transduction 50.0000 6 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 yes
GO:0009967 positive regulation of signal transduction 50.0000 5 no
GO:0010647 positive regulation of cell communication 50.0000 5 no
GO:0023056 positive regulation of signaling 50.0000 4 no
GO:0048585 negative regulation of response to stimulus 43.7500 4 no
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 43.7500 5 yes
GO:0009892 negative regulation of metabolic process 43.7500 4 yes
GO:0019220 regulation of phosphate metabolic process 43.7500 6 yes
GO:0031399 regulation of protein modification process 43.7500 6 yes
GO:0043269 regulation of ion transport 43.7500 5 yes
GO:0044057 regulation of system process 43.7500 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 43.7500 5 yes
GO:0051174 regulation of phosphorus metabolic process 43.7500 5 yes
GO:0051246 regulation of protein metabolic process 43.7500 5 yes
GO:0060255 regulation of macromolecule metabolic process 43.7500 4 yes
GO:0080090 regulation of primary metabolic process 43.7500 4 yes
GO:0008104 protein localization 43.7500 4 no
GO:0071702 organic substance transport 43.7500 4 no
GO:0071705 nitrogen compound transport 43.7500 4 no
GO:0010648 negative regulation of cell communication 43.7500 5 no
GO:0023057 negative regulation of signaling 43.7500 4 no
GO:0043410 positive regulation of MAPK cascade 37.5000 7 no
GO:0051050 positive regulation of transport 37.5000 4 no
GO:0001932 regulation of protein phosphorylation 37.5000 7 yes
GO:0001934 positive regulation of protein phosphorylation 37.5000 8 yes
GO:0009889 regulation of biosynthetic process 37.5000 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 37.5000 6 yes
GO:0010604 positive regulation of macromolecule metabolic process 37.5000 5 yes
GO:0010959 regulation of metal ion transport 37.5000 6 yes
GO:0031326 regulation of cellular biosynthetic process 37.5000 5 yes
GO:0031401 positive regulation of protein modification process 37.5000 7 yes
GO:0042325 regulation of phosphorylation 37.5000 7 yes
GO:0042327 positive regulation of phosphorylation 37.5000 8 yes
GO:0045937 positive regulation of phosphate metabolic process 37.5000 7 yes
GO:0051128 regulation of cellular component organization 37.5000 4 yes
GO:0051247 positive regulation of protein metabolic process 37.5000 6 yes
GO:0051241 negative regulation of multicellular organismal process 37.5000 4 no
GO:0015031 protein transport 37.5000 4 no
GO:0009968 negative regulation of signal transduction 37.5000 5 no
GO:0016192 vesicle-mediated transport 37.5000 4 no
GO:0043408 regulation of MAPK cascade 37.5000 6 no
GO:0006355 regulation of DNA-templated transcription 31.2500 6 yes
GO:0010468 regulation of gene expression 31.2500 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 31.2500 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 31.2500 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.2500 5 yes
GO:0031644 regulation of nervous system process 31.2500 5 yes
GO:0051252 regulation of RNA metabolic process 31.2500 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 31.2500 7 yes
GO:2001141 regulation of RNA biosynthetic process 31.2500 6 yes
GO:0006996 organelle organization 31.2500 4 no
GO:0050804 modulation of chemical synaptic transmission 31.2500 5 no
GO:0051046 regulation of secretion 31.2500 5 no
GO:0051240 positive regulation of multicellular organismal process 31.2500 4 no
GO:0099177 regulation of trans-synaptic signaling 31.2500 4 no
GO:1903530 regulation of secretion by cell 31.2500 4 no
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 25.0000 6 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0070372 regulation of ERK1 and ERK2 cascade 25.0000 7 no
GO:0070374 positive regulation of ERK1 and ERK2 cascade 25.0000 8 no
GO:0010941 regulation of cell death 25.0000 4 no
GO:0042981 regulation of apoptotic process 25.0000 6 no
GO:0043066 negative regulation of apoptotic process 25.0000 7 no
GO:0043067 regulation of programmed cell death 25.0000 5 no
GO:0043069 negative regulation of programmed cell death 25.0000 6 no
GO:0060548 negative regulation of cell death 25.0000 5 no
GO:0010629 negative regulation of gene expression 25.0000 6 yes
GO:0051924 regulation of calcium ion transport 25.0000 7 yes
GO:0051930 regulation of sensory perception of pain 25.0000 7 yes
GO:0051931 regulation of sensory perception 25.0000 6 yes
GO:0071310 cellular response to organic substance 25.0000 4 yes
GO:0022607 cellular component assembly 25.0000 4 no
GO:0060627 regulation of vesicle-mediated transport 25.0000 4 no
GO:0061024 membrane organization 25.0000 4 no
GO:0006897 endocytosis 25.0000 5 no
GO:0006898 receptor-mediated endocytosis 25.0000 6 no
GO:0008277 regulation of G protein-coupled receptor signaling pathway 25.0000 5 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 18.7500 4 yes
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 18.7500 4 yes
GO:0007218 neuropeptide signaling pathway 18.7500 4 yes
GO:0008344 adult locomotory behavior 18.7500 4 yes
GO:0033135 regulation of peptidyl-serine phosphorylation 18.7500 8 yes
GO:0033138 positive regulation of peptidyl-serine phosphorylation 18.7500 9 yes
GO:0036293 response to decreased oxygen levels 18.7500 4 yes
GO:0038003 G protein-coupled opioid receptor signaling pathway 18.7500 4 yes
GO:0042755 eating behavior 18.7500 4 yes
GO:0051129 negative regulation of cellular component organization 18.7500 5 yes
GO:0070848 response to growth factor 18.7500 4 yes
GO:0031333 negative regulation of protein-containing complex assembly 12.5000 6 yes
GO:0032793 positive regulation of CREB transcription factor activity 12.5000 5 yes
GO:0036294 cellular response to decreased oxygen levels 12.5000 5 yes
GO:0043254 regulation of protein-containing complex assembly 12.5000 5 yes
GO:0044087 regulation of cellular component biogenesis 12.5000 4 yes
GO:0051091 positive regulation of DNA-binding transcription factor activity 12.5000 4 yes
GO:0051881 regulation of mitochondrial membrane potential 12.5000 4 yes
GO:0071363 cellular response to growth factor stimulus 12.5000 5 yes
GO:0071453 cellular response to oxygen levels 12.5000 4 yes
GO:0071456 cellular response to hypoxia 12.5000 4 yes
GO:0097237 cellular response to toxic substance 12.5000 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GASP1_HUMAN [view interactions] Low throughput no yes
AT2A2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALX_HUMAN [view entry] [view interactions] Low throughput yes yes
RTP4_HUMAN [view interactions] Low throughput no no
OPRM_HUMAN [view entry] [view interactions] Low throughput yes no
OPRD_HUMAN [view entry] [view interactions] Low throughput yes no
ADRB2_HUMAN [view entry] [view interactions] Low throughput yes no
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
S61A1_HUMAN [view interactions] Low throughput no no
SSR4_HUMAN [view interactions] Low throughput no no
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
HSP74_HUMAN [view entry] [view interactions] Low throughput yes yes
AUP1_HUMAN [view interactions] High throughput no yes
CXA4_HUMAN [view interactions] High throughput no yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
SIAH2_HUMAN [view interactions] High throughput no no
WLS_HUMAN [view entry] [view interactions] High throughput yes no
SIAH1_HUMAN [view interactions] High throughput no yes
S13A4_HUMAN [view interactions] High throughput no no
SMAGP_HUMAN [view interactions] High throughput no yes
CTXN3_HUMAN [view interactions] High throughput no no
RPRM_HUMAN [view interactions] High throughput no no
S12A7_HUMAN [view interactions] High throughput no yes
TM237_HUMAN [view interactions] High throughput no no
DOK4_HUMAN [view interactions] High throughput no yes
FCER2_HUMAN [view interactions] Computational no no
AA1R_HUMAN [view entry] [view interactions] Computational yes no
IL4RA_HUMAN [view interactions] Computational no no
PENK_HUMAN [view interactions] Computational no yes
BKRB2_HUMAN [view interactions] Computational no yes
GNAI2_HUMAN [view entry] [view interactions] Computational yes yes
STAT6_HUMAN [view interactions] Computational no yes
GNAI3_HUMAN [view entry] [view interactions] Computational yes yes
PDYN_HUMAN [view interactions] Computational no yes
GNAI1_HUMAN [view entry] [view interactions] Computational yes yes