AT2A2_HUMAN
Evidence for PS localization
Functions
Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AT2A2_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 30.4762 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 23.8095 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 23.8095 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.8571 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 19.0476 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 19.0476 | 5 | yes |
| GO:0005524 | ATP binding | 18.0952 | 5 | yes |
| GO:0008324 | cation transmembrane transporter activity | 18.0952 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 18.0952 | 4 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 15.2381 | 4 | yes |
| GO:0022853 | active ion transmembrane transporter activity | 13.3333 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 13.3333 | 5 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 8.5714 | 6 | yes |
| GO:0005509 | calcium ion binding | 7.6190 | 5 | yes |
| GO:0015662 | P-type ion transporter activity | 5.7143 | 4 | yes |
| GO:0005388 | P-type calcium transporter activity | 2.8571 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AT2A2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.1905 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 49.5238 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 48.5714 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.5714 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 47.6190 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 44.7619 | 4 | no |
| GO:0010646 | regulation of cell communication | 43.8095 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 38.0952 | 4 | no |
| GO:0010468 | regulation of gene expression | 38.0952 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 36.1905 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 35.2381 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.2857 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:0006996 | organelle organization | 32.3810 | 4 | yes |
| GO:0051049 | regulation of transport | 32.3810 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.4762 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 30.4762 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.4762 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.5238 | 5 | no |
| GO:0008104 | protein localization | 28.5714 | 4 | no |
| GO:0071702 | organic substance transport | 28.5714 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 28.5714 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.5714 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.5714 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 27.6190 | 5 | no |
| GO:0023056 | positive regulation of signaling | 27.6190 | 4 | no |
| GO:0031399 | regulation of protein modification process | 27.6190 | 6 | no |
| GO:0071310 | cellular response to organic substance | 27.6190 | 4 | no |
| GO:0022607 | cellular component assembly | 26.6667 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.6667 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.6667 | 5 | no |
| GO:0006811 | ion transport | 25.7143 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 25.7143 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.7143 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.7143 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 24.7619 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 24.7619 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 24.7619 | 7 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 24.7619 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 23.8095 | 5 | no |
| GO:0010941 | regulation of cell death | 23.8095 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 23.8095 | 5 | no |
| GO:0048878 | chemical homeostasis | 22.8571 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 22.8571 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 21.9048 | 7 | no |
| GO:0009894 | regulation of catabolic process | 21.9048 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 21.9048 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.9048 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.9048 | 4 | no |
| GO:0006812 | cation transport | 20.9524 | 5 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 20.9524 | 4 | yes |
| GO:0043269 | regulation of ion transport | 20.9524 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.9524 | 6 | no |
| GO:0009968 | negative regulation of signal transduction | 20.9524 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 20.9524 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.9524 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.9524 | 4 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 20.9524 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.9524 | 6 | no |
| GO:0044057 | regulation of system process | 18.0952 | 4 | yes |
| GO:0050801 | ion homeostasis | 17.1429 | 5 | yes |
| GO:0055080 | cation homeostasis | 17.1429 | 6 | yes |
| GO:0098655 | cation transmembrane transport | 17.1429 | 4 | yes |
| GO:0098771 | inorganic ion homeostasis | 17.1429 | 6 | yes |
| GO:0006873 | cellular ion homeostasis | 16.1905 | 4 | yes |
| GO:0030001 | metal ion transport | 16.1905 | 6 | yes |
| GO:0030003 | cellular cation homeostasis | 16.1905 | 5 | yes |
| GO:0098660 | inorganic ion transmembrane transport | 16.1905 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 16.1905 | 5 | yes |
| GO:0055065 | metal ion homeostasis | 15.2381 | 7 | yes |
| GO:0006875 | cellular metal ion homeostasis | 14.2857 | 6 | yes |
| GO:0090257 | regulation of muscle system process | 13.3333 | 5 | yes |
| GO:0006937 | regulation of muscle contraction | 12.3810 | 6 | yes |
| GO:0061024 | membrane organization | 12.3810 | 4 | yes |
| GO:1903522 | regulation of blood circulation | 12.3810 | 5 | yes |
| GO:0008016 | regulation of heart contraction | 11.4286 | 6 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 11.4286 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 11.4286 | 4 | yes |
| GO:0006874 | cellular calcium ion homeostasis | 10.4762 | 7 | yes |
| GO:0055074 | calcium ion homeostasis | 10.4762 | 8 | yes |
| GO:0072503 | cellular divalent inorganic cation homeostasis | 10.4762 | 6 | yes |
| GO:0072507 | divalent inorganic cation homeostasis | 10.4762 | 7 | yes |
| GO:0006816 | calcium ion transport | 9.5238 | 7 | yes |
| GO:0006942 | regulation of striated muscle contraction | 9.5238 | 7 | yes |
| GO:0034976 | response to endoplasmic reticulum stress | 9.5238 | 4 | yes |
| GO:0051046 | regulation of secretion | 9.5238 | 5 | yes |
| GO:0019932 | second-messenger-mediated signaling | 8.5714 | 4 | yes |
| GO:0055117 | regulation of cardiac muscle contraction | 8.5714 | 7 | yes |
| GO:0070925 | organelle assembly | 8.5714 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 8.5714 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 7.6190 | 4 | yes |
| GO:0019722 | calcium-mediated signaling | 6.6667 | 5 | yes |
| GO:0034599 | cellular response to oxidative stress | 6.6667 | 4 | yes |
| GO:0062197 | cellular response to chemical stress | 6.6667 | 4 | yes |
| GO:0070588 | calcium ion transmembrane transport | 6.6667 | 6 | yes |
| GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling | 5.7143 | 6 | yes |
| GO:0043393 | regulation of protein binding | 5.7143 | 4 | yes |
| GO:0045822 | negative regulation of heart contraction | 5.7143 | 6 | yes |
| GO:0051100 | negative regulation of binding | 5.7143 | 4 | yes |
| GO:0090075 | relaxation of muscle | 5.7143 | 4 | yes |
| GO:1903523 | negative regulation of blood circulation | 5.7143 | 5 | yes |
| GO:0017157 | regulation of exocytosis | 4.7619 | 5 | yes |
| GO:0045823 | positive regulation of heart contraction | 4.7619 | 6 | yes |
| GO:0055119 | relaxation of cardiac muscle | 4.7619 | 5 | yes |
| GO:1903524 | positive regulation of blood circulation | 4.7619 | 5 | yes |
| GO:1903779 | regulation of cardiac conduction | 4.7619 | 4 | yes |
| GO:0007033 | vacuole organization | 3.8095 | 5 | yes |
| GO:0032091 | negative regulation of protein binding | 3.8095 | 5 | yes |
| GO:0032469 | endoplasmic reticulum calcium ion homeostasis | 3.8095 | 8 | yes |
| GO:0000045 | autophagosome assembly | 2.8571 | 6 | yes |
| GO:0010460 | positive regulation of heart rate | 2.8571 | 4 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 2.8571 | 5 | yes |
| GO:0070296 | sarcoplasmic reticulum calcium ion transport | 2.8571 | 8 | yes |
| GO:0098901 | regulation of cardiac muscle cell action potential | 2.8571 | 4 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 2.8571 | 6 | yes |
| GO:1905037 | autophagosome organization | 2.8571 | 6 | yes |
| GO:0003300 | cardiac muscle hypertrophy | 1.9048 | 6 | yes |
| GO:0014896 | muscle hypertrophy | 1.9048 | 4 | yes |
| GO:0014897 | striated muscle hypertrophy | 1.9048 | 5 | yes |
| GO:0032470 | positive regulation of endoplasmic reticulum calcium ion concentration | 1.9048 | 9 | yes |
| GO:0043502 | regulation of muscle adaptation | 1.9048 | 4 | yes |
| GO:0046928 | regulation of neurotransmitter secretion | 1.9048 | 4 | yes |
| GO:1990036 | calcium ion import into sarcoplasmic reticulum | 1.9048 | 4 | yes |
| GO:2000300 | regulation of synaptic vesicle exocytosis | 1.9048 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in AT2A2_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 4.7619 | 4 | no |
| DOID:331 | central nervous system disease | 4.7619 | 3 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 3.8095 | 6 | no |
| DOID:440 | neuromuscular disease | 3.8095 | 5 | no |
| DOID:574 | peripheral nervous system disease | 3.8095 | 3 | no |
| DOID:870 | neuropathy | 3.8095 | 4 | no |
| DOID:12377 | spinal muscular atrophy | 2.8571 | 6 | no |
| DOID:231 | motor neuron disease | 2.8571 | 5 | no |
| DOID:0050542 | Charcot-Marie-Tooth disease type X | 1.9048 | 7 | no |
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 1.9048 | 7 | no |
| DOID:0111198 | autosomal dominant distal hereditary motor neuronopathy | 1.9048 | 7 | no |
| DOID:0111206 | distal hereditary motor neuronopathy type 2 | 1.9048 | 8 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SIR1_HUMAN | [view interactions] | Low throughput | no | yes |
| OPRD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TLR9_HUMAN | [view interactions] | Low throughput | no | no |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| PIEZ1_HUMAN | [view interactions] | Low throughput | no | no |
| PIEZ2_HUMAN | [view interactions] | Low throughput | no | yes |
| WFS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | Low throughput | no | no |
| SORCN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PAR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PPLA_HUMAN | [view interactions] | Low throughput | no | no |
| S10A1_HUMAN | [view interactions] | Low throughput | no | yes |
| SARCO_HUMAN | [view interactions] | Low throughput | no | no |
| TRI13_HUMAN | [view interactions] | Low throughput | no | no |
| AT2B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NOS2_HUMAN | [view interactions] | High throughput | no | yes |
| NAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLN3_HUMAN | [view interactions] | High throughput | no | no |
| CLN5_HUMAN | [view interactions] | High throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ASB1_HUMAN | [view interactions] | High throughput | no | yes |
| ASB5_HUMAN | [view interactions] | High throughput | no | no |
| ASB14_HUMAN | [view interactions] | High throughput | no | no |
| ASB17_HUMAN | [view interactions] | High throughput | no | no |
| ERR2_HUMAN | [view interactions] | High throughput | no | no |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| RIC3_HUMAN | [view interactions] | High throughput | no | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| KTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| TMCO1_HUMAN | [view interactions] | High throughput | no | yes |
| ESYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INT2_HUMAN | [view interactions] | High throughput | no | yes |
| TACAN_HUMAN | [view interactions] | High throughput | no | no |
| SKI_HUMAN | [view interactions] | High throughput | no | yes |
| PODO_HUMAN | [view interactions] | High throughput | no | no |
| RN126_HUMAN | [view interactions] | High throughput | no | yes |
| NEPRO_HUMAN | [view interactions] | High throughput | no | no |
| LNX2_HUMAN | [view interactions] | High throughput | no | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| PTPRK_HUMAN | [view interactions] | High throughput | no | no |
| TPTE_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| DPOD1_HUMAN | [view interactions] | High throughput | no | yes |
| PPP6_HUMAN | [view interactions] | High throughput | no | yes |
| TXTP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MED12_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| ARMC8_HUMAN | [view interactions] | High throughput | no | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| REQU_HUMAN | [view interactions] | High throughput | no | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOCS1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| RBX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| CTCF_HUMAN | [view interactions] | High throughput | no | yes |
| TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| S15A3_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| ANR55_HUMAN | [view interactions] | High throughput | no | yes |
| PDS5A_HUMAN | [view interactions] | High throughput | no | yes |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| RMC1_HUMAN | [view interactions] | High throughput | no | no |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| MT21E_HUMAN | [view interactions] | High throughput | no | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOT1_HUMAN | [view interactions] | High throughput | no | no |
| S61A1_HUMAN | [view interactions] | High throughput | no | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| SEC63_HUMAN | [view interactions] | High throughput | no | yes |
| FA20C_HUMAN | [view interactions] | High throughput | no | no |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| ASXL1_HUMAN | [view interactions] | High throughput | no | no |
| ATF2_HUMAN | [view interactions] | High throughput | no | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| HACD3_HUMAN | [view interactions] | High throughput | no | yes |
| APR_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NICA_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YIPF5_HUMAN | [view interactions] | High throughput | no | yes |
| VTCN1_HUMAN | [view interactions] | High throughput | no | yes |
| PTSS1_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| S43A3_HUMAN | [view interactions] | High throughput | no | yes |
| VMP1_HUMAN | [view interactions] | High throughput | no | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RABL3_HUMAN | [view interactions] | High throughput | no | yes |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| DPOLQ_HUMAN | [view interactions] | High throughput | no | no |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| CLCN7_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| T161A_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| AAAT_HUMAN | [view interactions] | High throughput | no | no |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| PON2_HUMAN | [view interactions] | High throughput | no | yes |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| VTI1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| TMM33_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| S35F6_HUMAN | [view interactions] | High throughput | no | yes |
| ZN363_HUMAN | [view interactions] | High throughput | no | yes |
| ALG8_HUMAN | [view interactions] | High throughput | no | yes |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S35E1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| STT3A_HUMAN | [view interactions] | High throughput | no | yes |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| ATPO_HUMAN | [view interactions] | High throughput | no | yes |
| OST48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHCR7_HUMAN | [view interactions] | High throughput | no | yes |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| TAP2_HUMAN | [view interactions] | High throughput | no | no |
| EMC8_HUMAN | [view interactions] | High throughput | no | no |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSDHL_HUMAN | [view interactions] | High throughput | no | yes |
| DHC24_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKN2_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC2_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| TMED2_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MBOA1_HUMAN | [view interactions] | High throughput | no | no |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XRCC3_HUMAN | [view interactions] | High throughput | no | no |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| ACATN_HUMAN | [view interactions] | High throughput | no | yes |
| NCLN_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| TBCD7_HUMAN | [view interactions] | High throughput | no | no |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| MDM2_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| 4F2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMAN1_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| QCR8_HUMAN | [view interactions] | High throughput | no | yes |
| CLN6_HUMAN | [view interactions] | High throughput | no | no |
| NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| NOTC2_HUMAN | [view interactions] | High throughput | no | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| NNTM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK07_HUMAN | [view interactions] | High throughput | no | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P4HA1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNR2_HUMAN | [view interactions] | High throughput | no | yes |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| ODBB_HUMAN | [view interactions] | High throughput | no | yes |
| CNEP1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPE2_HUMAN | [view interactions] | High throughput | no | no |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS8_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSA2_HUMAN | [view interactions] | High throughput | no | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPTX_HUMAN | [view interactions] | High throughput | no | no |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S4A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PALMD_HUMAN | [view interactions] | High throughput | no | no |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E2F3_HUMAN | [view interactions] | High throughput | no | no |
| ODBA_HUMAN | [view interactions] | High throughput | no | yes |
| HACD1_HUMAN | [view interactions] | High throughput | no | no |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPE1_HUMAN | [view interactions] | High throughput | no | no |
| CMC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAP1_HUMAN | [view interactions] | High throughput | no | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APBB1_HUMAN | [view interactions] | High throughput | no | yes |
| Z3H7A_HUMAN | [view interactions] | High throughput | no | no |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| MP2K7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELP4_HUMAN | [view interactions] | High throughput | no | yes |
| PDK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARH5_HUMAN | [view interactions] | High throughput | no | no |
| ADCK2_HUMAN | [view interactions] | High throughput | no | yes |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| ST32C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| COQ8A_HUMAN | [view interactions] | High throughput | no | no |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPA34_HUMAN | [view interactions] | High throughput | no | yes |
| SG196_HUMAN | [view interactions] | High throughput | no | yes |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| KLF16_HUMAN | [view interactions] | High throughput | no | yes |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| TYRO3_HUMAN | [view interactions] | High throughput | no | yes |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| MK67I_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| PEX3_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN330_HUMAN | [view interactions] | High throughput | no | yes |
| TMX1_HUMAN | [view interactions] | High throughput | no | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| CALR_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SELN_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCR4_HUMAN | [view interactions] | High throughput | no | yes |
| ACM5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNR1A_HUMAN | [view interactions] | High throughput | no | yes |
| TNR1B_HUMAN | [view interactions] | High throughput | no | no |
| TRADD_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LMBL1_HUMAN | [view interactions] | High throughput | no | no |
| TFDP1_HUMAN | [view interactions] | High throughput | no | yes |
| ERLN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JMY_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| JMJD4_HUMAN | [view interactions] | High throughput | no | no |
| TIFAB_HUMAN | [view interactions] | High throughput | no | no |
| ITPR3_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AKIP_HUMAN | [view interactions] | High throughput | no | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLF8_HUMAN | [view interactions] | High throughput | no | no |
| KLF9_HUMAN | [view interactions] | High throughput | no | no |
| SP7_HUMAN | [view interactions] | High throughput | no | no |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSTP_HUMAN | [view interactions] | High throughput | no | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| AMFR_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| FBX25_HUMAN | [view interactions] | High throughput | no | no |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| MDC1_HUMAN | [view interactions] | High throughput | no | yes |
| RORA_HUMAN | [view interactions] | Computational | no | yes |
| PDE3A_HUMAN | [view interactions] | Computational | no | no |
| RYR2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PDE4D_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CALU_HUMAN | [view interactions] | Computational | no | yes |
| SRCH_HUMAN | [view interactions] | Computational | no | no |
| AT1A1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AT1A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SL9A1_HUMAN | [view interactions] | Computational | no | no |
| NOTC4_HUMAN | [view interactions] | Computational | no | no |
| AT1B2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RYR1_HUMAN | [view interactions] | Computational | no | no |
| NOTC3_HUMAN | [view interactions] | Computational | no | yes |
| SRCA_HUMAN | [view interactions] | Computational | no | no |
| AT1B3_HUMAN | [view interactions] | Computational | no | yes |
| PLM_HUMAN | [view interactions] | Computational | no | no |
| KAT5_HUMAN | [view interactions] | Computational | no | yes |