PDK3_HUMAN
Evidence for PS localization
Functions
Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 158 | Arg | His | Charcot-Marie-Toothdisease,X-linkeddominant,6(CMTX6) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PDK3_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 50.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 43.1818 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 43.1818 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 43.1818 | 4 | yes |
| GO:0005524 | ATP binding | 40.9091 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 40.9091 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 40.9091 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 36.3636 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 36.3636 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 36.3636 | 6 | no |
| GO:0016887 | ATP hydrolysis activity | 34.0909 | 7 | no |
| GO:0004674 | protein serine/threonine kinase activity | 4.5455 | 4 | yes |
| GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity | 4.5455 | 4 | yes |
| GO:0016301 | kinase activity | 4.5455 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 4.5455 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PDK3_HUMAN |
|---|---|---|---|---|
| GO:0051171 | regulation of nitrogen compound metabolic process | 54.5455 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 54.5455 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 52.2727 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 52.2727 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 52.2727 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 45.4545 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 43.1818 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 43.1818 | 5 | yes |
| GO:0022607 | cellular component assembly | 43.1818 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 43.1818 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 43.1818 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 40.9091 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.6364 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.3636 | 5 | no |
| GO:0043933 | protein-containing complex organization | 36.3636 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 36.3636 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 34.0909 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 31.8182 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 31.8182 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 31.8182 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 31.8182 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 29.5455 | 6 | no |
| GO:0032880 | regulation of protein localization | 29.5455 | 5 | no |
| GO:0060341 | regulation of cellular localization | 29.5455 | 4 | no |
| GO:0033043 | regulation of organelle organization | 27.2727 | 5 | no |
| GO:0010468 | regulation of gene expression | 27.2727 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 27.2727 | 4 | no |
| GO:0010646 | regulation of cell communication | 25.0000 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
| GO:0050821 | protein stabilization | 25.0000 | 4 | no |
| GO:0051052 | regulation of DNA metabolic process | 25.0000 | 5 | no |
| GO:0051054 | positive regulation of DNA metabolic process | 25.0000 | 6 | no |
| GO:1903829 | positive regulation of protein localization | 25.0000 | 5 | no |
| GO:0090304 | nucleic acid metabolic process | 25.0000 | 4 | no |
| GO:0006996 | organelle organization | 22.7273 | 4 | no |
| GO:0010638 | positive regulation of organelle organization | 22.7273 | 6 | no |
| GO:0070201 | regulation of establishment of protein localization | 22.7273 | 6 | no |
| GO:1900180 | regulation of protein localization to nucleus | 22.7273 | 6 | no |
| GO:1904951 | positive regulation of establishment of protein localization | 22.7273 | 6 | no |
| GO:2000278 | regulation of DNA biosynthetic process | 22.7273 | 6 | no |
| GO:2000573 | positive regulation of DNA biosynthetic process | 22.7273 | 7 | no |
| GO:0010941 | regulation of cell death | 22.7273 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.7273 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 22.7273 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 22.7273 | 5 | no |
| GO:0019752 | carboxylic acid metabolic process | 22.7273 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 22.7273 | 4 | no |
| GO:0018130 | heterocycle biosynthetic process | 22.7273 | 4 | no |
| GO:0019438 | aromatic compound biosynthetic process | 22.7273 | 4 | no |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 22.7273 | 4 | no |
| GO:1901362 | organic cyclic compound biosynthetic process | 22.7273 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 20.4545 | 4 | yes |
| GO:0033044 | regulation of chromosome organization | 20.4545 | 6 | no |
| GO:1900182 | positive regulation of protein localization to nucleus | 20.4545 | 6 | no |
| GO:2001252 | positive regulation of chromosome organization | 20.4545 | 7 | no |
| GO:0009966 | regulation of signal transduction | 20.4545 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 20.4545 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.4545 | 4 | no |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 20.4545 | 4 | no |
| GO:0071310 | cellular response to organic substance | 18.1818 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 15.9091 | 6 | yes |
| GO:0036211 | protein modification process | 15.9091 | 4 | yes |
| GO:0043412 | macromolecule modification | 15.9091 | 4 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 15.9091 | 5 | yes |
| GO:0034248 | regulation of cellular amide metabolic process | 13.6364 | 5 | yes |
| GO:0019318 | hexose metabolic process | 11.3636 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 11.3636 | 4 | yes |
| GO:0006006 | glucose metabolic process | 11.3636 | 5 | yes |
| GO:0019216 | regulation of lipid metabolic process | 9.0909 | 5 | yes |
| GO:0048878 | chemical homeostasis | 9.0909 | 4 | yes |
| GO:0062012 | regulation of small molecule metabolic process | 9.0909 | 4 | yes |
| GO:1900542 | regulation of purine nucleotide metabolic process | 9.0909 | 6 | yes |
| GO:2000377 | regulation of reactive oxygen species metabolic process | 9.0909 | 5 | yes |
| GO:0006140 | regulation of nucleotide metabolic process | 9.0909 | 5 | yes |
| GO:0006468 | protein phosphorylation | 6.8182 | 5 | yes |
| GO:0016310 | phosphorylation | 6.8182 | 5 | yes |
| GO:0030808 | regulation of nucleotide biosynthetic process | 6.8182 | 6 | yes |
| GO:0033993 | response to lipid | 6.8182 | 4 | yes |
| GO:0071396 | cellular response to lipid | 6.8182 | 5 | yes |
| GO:1900371 | regulation of purine nucleotide biosynthetic process | 6.8182 | 7 | yes |
| GO:0006109 | regulation of carbohydrate metabolic process | 6.8182 | 5 | yes |
| GO:0009743 | response to carbohydrate | 4.5455 | 4 | yes |
| GO:0009746 | response to hexose | 4.5455 | 6 | yes |
| GO:0009749 | response to glucose | 4.5455 | 7 | yes |
| GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate | 4.5455 | 7 | yes |
| GO:0010565 | regulation of cellular ketone metabolic process | 4.5455 | 5 | yes |
| GO:0010675 | regulation of cellular carbohydrate metabolic process | 4.5455 | 5 | yes |
| GO:0010906 | regulation of glucose metabolic process | 4.5455 | 5 | yes |
| GO:0018105 | peptidyl-serine phosphorylation | 4.5455 | 6 | yes |
| GO:0018193 | peptidyl-amino acid modification | 4.5455 | 5 | yes |
| GO:0018209 | peptidyl-serine modification | 4.5455 | 6 | yes |
| GO:0019217 | regulation of fatty acid metabolic process | 4.5455 | 6 | yes |
| GO:0033500 | carbohydrate homeostasis | 4.5455 | 5 | yes |
| GO:0034284 | response to monosaccharide | 4.5455 | 5 | yes |
| GO:0035357 | peroxisome proliferator activated receptor signaling pathway | 4.5455 | 4 | yes |
| GO:0042593 | glucose homeostasis | 4.5455 | 6 | yes |
| GO:0042762 | regulation of sulfur metabolic process | 4.5455 | 5 | yes |
| GO:0050812 | regulation of acyl-CoA biosynthetic process | 4.5455 | 6 | yes |
| GO:0070542 | response to fatty acid | 4.5455 | 4 | yes |
| GO:0071322 | cellular response to carbohydrate stimulus | 4.5455 | 5 | yes |
| GO:0071326 | cellular response to monosaccharide stimulus | 4.5455 | 6 | yes |
| GO:0071331 | cellular response to hexose stimulus | 4.5455 | 7 | yes |
| GO:0071333 | cellular response to glucose stimulus | 4.5455 | 5 | yes |
| GO:0071398 | cellular response to fatty acid | 4.5455 | 5 | yes |
| GO:0001678 | cellular glucose homeostasis | 4.5455 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PDK3_HUMAN |
|---|---|---|---|---|
| DOID:0050542 | Charcot-Marie-Tooth disease type X | 4.5455 | 7 | yes |
| DOID:0110207 | Charcot-Marie-Tooth disease X-linked dominant 6 | 4.5455 | 8 | yes |
| DOID:10595 | Charcot-Marie-Tooth disease | 4.5455 | 6 | yes |
| DOID:440 | neuromuscular disease | 4.5455 | 5 | yes |
| DOID:574 | peripheral nervous system disease | 4.5455 | 3 | yes |
| DOID:870 | neuropathy | 4.5455 | 4 | yes |
| DOID:700 | mitochondrial metabolism disease | 4.5455 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ODP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HSF1_HUMAN | [view interactions] | Low throughput | no | yes |
| PDK3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACAP2_HUMAN | [view interactions] | High throughput | no | yes |
| ECD_HUMAN | [view interactions] | High throughput | no | yes |
| UTRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HLTF_HUMAN | [view interactions] | High throughput | no | no |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBR7_HUMAN | [view interactions] | High throughput | no | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| FOXD4_HUMAN | [view interactions] | High throughput | no | no |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDK4_HUMAN | [view interactions] | High throughput | no | yes |
| DNLZ_HUMAN | [view interactions] | High throughput | no | no |
| PDK2_HUMAN | [view interactions] | High throughput | no | yes |
| IF1AX_HUMAN | [view interactions] | High throughput | no | yes |
| ODPAT_HUMAN | [view interactions] | High throughput | no | no |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYT12_HUMAN | [view interactions] | High throughput | no | yes |
| STA5A_HUMAN | [view interactions] | High throughput | no | no |
| HDHD5_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| AICDA_HUMAN | [view interactions] | High throughput | no | no |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FDFT_HUMAN | [view interactions] | High throughput | no | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| ACPM_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| YBEY_HUMAN | [view interactions] | High throughput | no | yes |
| FPR1_HUMAN | [view interactions] | High throughput | no | no |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPS3B_HUMAN | [view interactions] | High throughput | no | yes |
| HERC5_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD2_HUMAN | [view interactions] | High throughput | no | no |
| FAKD5_HUMAN | [view interactions] | High throughput | no | yes |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| RRF2M_HUMAN | [view interactions] | High throughput | no | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET15_HUMAN | [view interactions] | High throughput | no | no |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| RMND1_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD4_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |