PDK3_HUMAN
Evidence for PS localization
Functions
Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 158 | Arg | His | Charcot-Marie-Toothdisease,X-linkeddominant,6(CMTX6) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PDK3_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 48.9362 | 4 | no |
| GO:0000166 | nucleotide binding | 42.5532 | 4 | yes |
| GO:0043168 | anion binding | 42.5532 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 40.4255 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 40.4255 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 40.4255 | 4 | yes |
| GO:0005524 | ATP binding | 38.2979 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 38.2979 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 38.2979 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 36.1702 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 36.1702 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 36.1702 | 6 | no |
| GO:0016887 | ATP hydrolysis activity | 34.0426 | 7 | no |
| GO:0031625 | ubiquitin protein ligase binding | 21.2766 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 21.2766 | 4 | no |
| GO:0004674 | protein serine/threonine kinase activity | 4.2553 | 4 | yes |
| GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity | 4.2553 | 4 | yes |
| GO:0016301 | kinase activity | 4.2553 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 4.2553 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PDK3_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 55.3191 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 55.3191 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 55.3191 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 53.1915 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 51.0638 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 48.9362 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 44.6809 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 44.6809 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 44.6809 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 44.6809 | 5 | no |
| GO:0022607 | cellular component assembly | 42.5532 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 38.2979 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.2979 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 38.2979 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 36.1702 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 36.1702 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 34.0426 | 5 | no |
| GO:0043933 | protein-containing complex organization | 34.0426 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 31.9149 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 31.9149 | 5 | no |
| GO:0032880 | regulation of protein localization | 29.7872 | 5 | no |
| GO:0060341 | regulation of cellular localization | 29.7872 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 29.7872 | 4 | no |
| GO:0033043 | regulation of organelle organization | 27.6596 | 5 | no |
| GO:0050821 | protein stabilization | 27.6596 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 27.6596 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 27.6596 | 5 | no |
| GO:0010646 | regulation of cell communication | 27.6596 | 4 | no |
| GO:0010638 | positive regulation of organelle organization | 25.5319 | 6 | no |
| GO:0010468 | regulation of gene expression | 25.5319 | 6 | no |
| GO:0090304 | nucleic acid metabolic process | 25.5319 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 23.4043 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 23.4043 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 23.4043 | 4 | no |
| GO:0051052 | regulation of DNA metabolic process | 23.4043 | 5 | no |
| GO:0051054 | positive regulation of DNA metabolic process | 23.4043 | 6 | no |
| GO:0009966 | regulation of signal transduction | 23.4043 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.4043 | 4 | no |
| GO:0006996 | organelle organization | 23.4043 | 4 | no |
| GO:1901362 | organic cyclic compound biosynthetic process | 23.4043 | 4 | no |
| GO:0070201 | regulation of establishment of protein localization | 21.2766 | 6 | no |
| GO:2000278 | regulation of DNA biosynthetic process | 21.2766 | 6 | no |
| GO:2000573 | positive regulation of DNA biosynthetic process | 21.2766 | 7 | no |
| GO:0010648 | negative regulation of cell communication | 21.2766 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.2766 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 21.2766 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.2766 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.2766 | 6 | no |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 21.2766 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 19.1489 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 19.1489 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 19.1489 | 4 | yes |
| GO:0036211 | protein modification process | 17.0213 | 4 | yes |
| GO:0043412 | macromolecule modification | 17.0213 | 4 | yes |
| GO:0006006 | glucose metabolic process | 12.7660 | 5 | yes |
| GO:0019318 | hexose metabolic process | 12.7660 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 12.7660 | 4 | yes |
| GO:0062012 | regulation of small molecule metabolic process | 10.6383 | 4 | yes |
| GO:0006109 | regulation of carbohydrate metabolic process | 8.5106 | 5 | yes |
| GO:0006140 | regulation of nucleotide metabolic process | 8.5106 | 5 | yes |
| GO:1900542 | regulation of purine nucleotide metabolic process | 8.5106 | 6 | yes |
| GO:2000377 | regulation of reactive oxygen species metabolic process | 8.5106 | 5 | yes |
| GO:0006468 | protein phosphorylation | 6.3830 | 5 | yes |
| GO:0010906 | regulation of glucose metabolic process | 6.3830 | 5 | yes |
| GO:0016310 | phosphorylation | 6.3830 | 5 | yes |
| GO:0019216 | regulation of lipid metabolic process | 6.3830 | 5 | yes |
| GO:0030808 | regulation of nucleotide biosynthetic process | 6.3830 | 5 | yes |
| GO:0033993 | response to lipid | 6.3830 | 4 | yes |
| GO:0071396 | cellular response to lipid | 6.3830 | 5 | yes |
| GO:1900371 | regulation of purine nucleotide biosynthetic process | 6.3830 | 6 | yes |
| GO:0001678 | intracellular glucose homeostasis | 4.2553 | 4 | yes |
| GO:0009743 | response to carbohydrate | 4.2553 | 4 | yes |
| GO:0009746 | response to hexose | 4.2553 | 6 | yes |
| GO:0009749 | response to glucose | 4.2553 | 7 | yes |
| GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate | 4.2553 | 6 | yes |
| GO:0010565 | regulation of cellular ketone metabolic process | 4.2553 | 5 | yes |
| GO:0018105 | peptidyl-serine phosphorylation | 4.2553 | 6 | yes |
| GO:0018193 | peptidyl-amino acid modification | 4.2553 | 5 | yes |
| GO:0018209 | peptidyl-serine modification | 4.2553 | 6 | yes |
| GO:0019217 | regulation of fatty acid metabolic process | 4.2553 | 6 | yes |
| GO:0034248 | regulation of amide metabolic process | 4.2553 | 4 | yes |
| GO:0034284 | response to monosaccharide | 4.2553 | 5 | yes |
| GO:0035357 | peroxisome proliferator activated receptor signaling pathway | 4.2553 | 4 | yes |
| GO:0042593 | glucose homeostasis | 4.2553 | 4 | yes |
| GO:0042762 | regulation of sulfur metabolic process | 4.2553 | 5 | yes |
| GO:0050812 | regulation of acyl-CoA biosynthetic process | 4.2553 | 5 | yes |
| GO:0070542 | response to fatty acid | 4.2553 | 4 | yes |
| GO:0071322 | cellular response to carbohydrate stimulus | 4.2553 | 5 | yes |
| GO:0071326 | cellular response to monosaccharide stimulus | 4.2553 | 6 | yes |
| GO:0071331 | cellular response to hexose stimulus | 4.2553 | 7 | yes |
| GO:0071333 | cellular response to glucose stimulus | 4.2553 | 5 | yes |
| GO:0071398 | cellular response to fatty acid | 4.2553 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PDK3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ODP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HSF1_HUMAN | [view interactions] | Low throughput | no | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBR7_HUMAN | [view interactions] | High throughput | no | yes |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HLTF_HUMAN | [view interactions] | High throughput | no | no |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UTRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECD_HUMAN | [view interactions] | High throughput | no | yes |
| ACAP2_HUMAN | [view interactions] | High throughput | no | yes |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| FOXD4_HUMAN | [view interactions] | High throughput | no | no |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDK4_HUMAN | [view interactions] | High throughput | no | yes |
| ODPX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPAT_HUMAN | [view interactions] | High throughput | no | no |
| IF1AX_HUMAN | [view interactions] | High throughput | no | yes |
| PDK2_HUMAN | [view interactions] | High throughput | no | yes |
| DNLZ_HUMAN | [view interactions] | High throughput | no | no |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYT12_HUMAN | [view interactions] | High throughput | no | yes |
| STA5A_HUMAN | [view interactions] | High throughput | no | no |
| HDHD5_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| SIM26_HUMAN | [view interactions] | High throughput | no | no |
| AICDA_HUMAN | [view interactions] | High throughput | no | no |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FDFT_HUMAN | [view interactions] | High throughput | no | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| ACPM_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| YBEY_HUMAN | [view interactions] | High throughput | no | yes |
| FPR1_HUMAN | [view interactions] | High throughput | no | no |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPS3B_HUMAN | [view interactions] | High throughput | no | yes |
| HERC5_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CASP7_HUMAN | [view interactions] | High throughput | no | no |
| ZC3HE_HUMAN | [view interactions] | High throughput | no | yes |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | no |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD2_HUMAN | [view interactions] | High throughput | no | no |
| FAKD5_HUMAN | [view interactions] | High throughput | no | yes |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| RRF2M_HUMAN | [view interactions] | High throughput | no | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET15_HUMAN | [view interactions] | High throughput | no | no |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| RMND1_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD4_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |