Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AUHM_HUMAN

Catalyzes the conversion of 3-methylglutaconyl-CoA to 3-hydroxy-3-methylglutaryl-CoA (PubMed, PubMed, PubMed). Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5-dicarboxylate catabolism pathway (PubMed). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed). Has very low enoyl-CoA hydratase activity (PubMed). Was originally identified as RNA-binding protein that binds in vitro to clustered 5-AUUUA-3 motifs (PubMed). [View more on UniProt]

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in AUHM_HUMAN
GO:0003723 RNA binding 26.0870 4 yes
GO:0046872 metal ion binding 24.6377 4 no
GO:0017076 purine nucleotide binding 23.1884 4 no
GO:0030554 adenyl nucleotide binding 23.1884 5 no
GO:0032555 purine ribonucleotide binding 23.1884 4 no
GO:0032559 adenyl ribonucleotide binding 23.1884 5 no
GO:0015399 primary active transmembrane transporter activity 23.1884 4 no
GO:0015453 oxidoreduction-driven active transmembrane transporter activity 23.1884 5 no
GO:0003729 mRNA binding 4.3478 5 yes
GO:0004300 enoyl-CoA hydratase activity 4.3478 5 yes
GO:0016836 hydro-lyase activity 4.3478 4 yes
GO:0003730 mRNA 3-UTR binding 2.8986 6 yes
GO:0004490 methylglutaconyl-CoA hydratase activity 2.8986 5 yes
GO:0050011 itaconyl-CoA hydratase activity 2.8986 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AUHM_HUMAN
GO:0019752 carboxylic acid metabolic process 40.5797 5 yes
GO:0043436 oxoacid metabolic process 40.5797 4 yes
GO:0022607 cellular component assembly 31.8841 4 no
GO:0043933 protein-containing complex organization 28.9855 4 no
GO:0065003 protein-containing complex assembly 28.9855 5 no
GO:0022900 electron transport chain 26.0870 4 no
GO:0022904 respiratory electron transport chain 26.0870 5 no
GO:0009060 aerobic respiration 24.6377 6 no
GO:0015980 energy derivation by oxidation of organic compounds 24.6377 4 no
GO:0045333 cellular respiration 24.6377 5 no
GO:0016054 organic acid catabolic process 23.1884 4 yes
GO:0046395 carboxylic acid catabolic process 23.1884 5 yes
GO:0019646 aerobic electron transport chain 23.1884 6 no
GO:1901565 organonitrogen compound catabolic process 21.7391 4 yes
GO:1901566 organonitrogen compound biosynthetic process 20.2899 4 no
GO:0032787 monocarboxylic acid metabolic process 18.8406 6 yes
GO:0009063 cellular amino acid catabolic process 18.8406 4 yes
GO:1901605 alpha-amino acid metabolic process 17.3913 4 yes
GO:1901606 alpha-amino acid catabolic process 15.9420 5 yes
GO:0016042 lipid catabolic process 13.0435 4 yes
GO:0019395 fatty acid oxidation 11.5942 5 yes
GO:0030258 lipid modification 11.5942 4 yes
GO:0034440 lipid oxidation 11.5942 5 yes
GO:0044242 cellular lipid catabolic process 11.5942 4 yes
GO:0072329 monocarboxylic acid catabolic process 11.5942 6 yes
GO:0006631 fatty acid metabolic process 11.5942 4 yes
GO:0006635 fatty acid beta-oxidation 11.5942 6 yes
GO:0009062 fatty acid catabolic process 11.5942 5 yes
GO:0009081 branched-chain amino acid metabolic process 10.1449 4 yes
GO:0009083 branched-chain amino acid catabolic process 10.1449 5 yes
GO:0006551 leucine metabolic process 5.7971 5 yes
GO:0006552 leucine catabolic process 5.7971 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AUHM_HUMAN [view entry] [view interactions] Low throughput yes yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
PDK1_HUMAN [view interactions] High throughput no yes
PDK3_HUMAN [view entry] [view interactions] High throughput yes yes
PDPR_HUMAN [view interactions] High throughput no yes
PLOD1_HUMAN [view interactions] High throughput no yes
PNPT1_HUMAN [view interactions] High throughput no yes
PDIP2_HUMAN [view interactions] High throughput no no
DPOG1_HUMAN [view interactions] High throughput no yes
RPOM_HUMAN [view interactions] High throughput no yes
IPYR2_HUMAN [view interactions] High throughput no yes
CPLN1_HUMAN [view interactions] High throughput no yes
PPIF_HUMAN [view interactions] High throughput no no
GARE1_HUMAN [view interactions] High throughput no yes
PRDX3_HUMAN [view interactions] High throughput no yes
GAB2_HUMAN [view interactions] High throughput no yes
PPCEL_HUMAN [view interactions] High throughput no yes
SHC2_HUMAN [view interactions] High throughput no yes
PTCD3_HUMAN [view interactions] High throughput no yes
SHF_HUMAN [view interactions] High throughput no no
TRUA_HUMAN [view interactions] High throughput no yes
SHIP2_HUMAN [view interactions] High throughput no yes
P5CR1_HUMAN [view entry] [view interactions] High throughput yes yes
STAP2_HUMAN [view interactions] High throughput no yes
P5CR2_HUMAN [view interactions] High throughput no yes
HSPB2_HUMAN [view interactions] High throughput no yes
GATA_HUMAN [view interactions] High throughput no yes
CAV3_HUMAN [view interactions] High throughput no no
RAD21_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
RBFA_HUMAN [view interactions] High throughput no yes
F107A_HUMAN [view entry] [view interactions] High throughput yes no
RCC1L_HUMAN [view interactions] High throughput no yes
ECHD2_HUMAN [view interactions] High throughput no no
RS15A_HUMAN [view entry] [view interactions] High throughput yes yes
OXLD1_HUMAN [view interactions] High throughput no no
RT4I1_HUMAN [view interactions] High throughput no yes
ATPD_HUMAN [view interactions] High throughput no yes
SYSM_HUMAN [view interactions] High throughput no yes
RM21_HUMAN [view interactions] High throughput no no
SDHA_HUMAN [view interactions] High throughput no yes
BPNT1_HUMAN [view interactions] High throughput no yes
SDHF3_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
SDHB_HUMAN [view interactions] High throughput no yes
FNDC5_HUMAN [view interactions] High throughput no no
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
DX39A_HUMAN [view interactions] High throughput no yes
ZNT9_HUMAN [view interactions] High throughput no yes
HINT2_HUMAN [view interactions] High throughput no yes
SLIRP_HUMAN [view interactions] High throughput no yes
UCRI_HUMAN [view entry] [view interactions] High throughput yes yes
SSRP1_HUMAN [view interactions] High throughput no yes
FOSB_HUMAN [view interactions] High throughput no no
STML2_HUMAN [view entry] [view interactions] High throughput yes yes
COX5B_HUMAN [view entry] [view interactions] High throughput yes yes
SUCB1_HUMAN [view entry] [view interactions] High throughput yes yes
SUCA_HUMAN [view entry] [view interactions] High throughput yes yes
RCAF1_HUMAN [view interactions] High throughput no yes
SUV3_HUMAN [view interactions] High throughput no yes
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
TACO1_HUMAN [view interactions] High throughput no yes
NIPS1_HUMAN [view entry] [view interactions] High throughput yes yes
SYTM_HUMAN [view interactions] High throughput no yes
ODBA_HUMAN [view interactions] High throughput no yes
TEFM_HUMAN [view interactions] High throughput no no
COX6C_HUMAN [view entry] [view interactions] High throughput yes yes
TFAM_HUMAN [view entry] [view interactions] High throughput yes yes
COX7B_HUMAN [view interactions] High throughput no yes
THEM4_HUMAN [view interactions] High throughput no no
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
THG1_HUMAN [view interactions] High throughput no yes
NIPS2_HUMAN [view interactions] High throughput no yes
THNS1_HUMAN [view interactions] High throughput no no
ENPL_HUMAN [view entry] [view interactions] High throughput yes yes
TIM44_HUMAN [view interactions] High throughput no yes
LACTB_HUMAN [view interactions] High throughput no yes
TM9S3_HUMAN [view interactions] High throughput no yes
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
P4HA1_HUMAN [view interactions] High throughput no yes
TM10C_HUMAN [view interactions] High throughput no yes
ODPB_HUMAN [view entry] [view interactions] High throughput yes yes
TRM5_HUMAN [view interactions] High throughput no no
SYAM_HUMAN [view interactions] High throughput no yes
TR61B_HUMAN [view interactions] High throughput no yes
AASS_HUMAN [view interactions] High throughput no yes
TRUB2_HUMAN [view interactions] High throughput no yes
ABCB7_HUMAN [view interactions] High throughput no yes
EFTS_HUMAN [view interactions] High throughput no no
ACAD9_HUMAN [view interactions] High throughput no yes
PEO1_HUMAN [view interactions] High throughput no yes
THIL_HUMAN [view entry] [view interactions] High throughput yes yes
UQCC1_HUMAN [view interactions] High throughput no yes
ACOT1_HUMAN [view interactions] High throughput no yes
SYVM_HUMAN [view interactions] High throughput no yes
ACOT2_HUMAN [view interactions] High throughput no yes
VWA8_HUMAN [view interactions] High throughput no yes
AFG32_HUMAN [view entry] [view interactions] High throughput yes yes
SYYM_HUMAN [view interactions] High throughput no no
KAD4_HUMAN [view interactions] High throughput no yes
HEM1_HUMAN [view interactions] High throughput no yes
ALDH2_HUMAN [view entry] [view interactions] High throughput yes no
AL4A1_HUMAN [view entry] [view interactions] High throughput yes yes
THOC4_HUMAN [view interactions] High throughput no no
ANGE2_HUMAN [view interactions] High throughput no yes
ATPB_HUMAN [view interactions] High throughput no yes
ATP5L_HUMAN [view interactions] High throughput no yes
AT5F1_HUMAN [view interactions] High throughput no yes
ATP5H_HUMAN [view interactions] High throughput no yes
ATP5J_HUMAN [view interactions] High throughput no yes
ATPO_HUMAN [view interactions] High throughput no yes
ATPF1_HUMAN [view interactions] High throughput no yes
BCS1_HUMAN [view interactions] High throughput no yes
CQ080_HUMAN [view interactions] High throughput no yes
SYCM_HUMAN [view interactions] High throughput no yes
CK5P1_HUMAN [view interactions] High throughput no no
CENPV_HUMAN [view interactions] High throughput no yes
CLPP_HUMAN [view interactions] High throughput no yes
CLPX_HUMAN [view interactions] High throughput no yes
COQ5_HUMAN [view interactions] High throughput no yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
COX5A_HUMAN [view entry] [view interactions] High throughput yes yes
CISY_HUMAN [view entry] [view interactions] High throughput yes yes
RT29_HUMAN [view interactions] High throughput no yes
SYDM_HUMAN [view interactions] High throughput no yes
ODB2_HUMAN [view entry] [view interactions] High throughput yes yes
DDX24_HUMAN [view interactions] High throughput no yes
DDX28_HUMAN [view interactions] High throughput no yes
DDX50_HUMAN [view interactions] High throughput no yes
DDX54_HUMAN [view interactions] High throughput no yes
DHTK1_HUMAN [view interactions] High throughput no no
DHX30_HUMAN [view entry] [view interactions] High throughput yes yes
ODP2_HUMAN [view entry] [view interactions] High throughput yes yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
SYEM_HUMAN [view interactions] High throughput no yes
ECH1_HUMAN [view interactions] High throughput no yes
ECHM_HUMAN [view interactions] High throughput no yes
ECI2_HUMAN [view entry] [view interactions] High throughput yes yes
ECSIT_HUMAN [view interactions] High throughput no yes
RNZ2_HUMAN [view interactions] High throughput no yes
ERAL1_HUMAN [view interactions] High throughput no yes
ETFA_HUMAN [view interactions] High throughput no yes
ETFB_HUMAN [view entry] [view interactions] High throughput yes yes
FAKD2_HUMAN [view interactions] High throughput no no
FAKD5_HUMAN [view interactions] High throughput no yes
HEMH_HUMAN [view interactions] High throughput no yes
FAD1_HUMAN [view interactions] High throughput no yes
FXRD1_HUMAN [view interactions] High throughput no no
G45IP_HUMAN [view interactions] High throughput no yes
GARS_HUMAN [view interactions] High throughput no yes
GATB_HUMAN [view interactions] High throughput no yes
GATC_HUMAN [view interactions] High throughput no no
GCDH_HUMAN [view interactions] High throughput no yes
EFGM_HUMAN [view interactions] High throughput no yes
GLSK_HUMAN [view entry] [view interactions] High throughput yes yes
DHE3_HUMAN [view entry] [view interactions] High throughput yes yes
GRPE1_HUMAN [view interactions] High throughput no yes
GRSF1_HUMAN [view interactions] High throughput no yes
GTPBA_HUMAN [view interactions] High throughput no yes
GTPB3_HUMAN [view interactions] High throughput no yes
GTPB6_HUMAN [view interactions] High throughput no no
GUF1_HUMAN [view interactions] High throughput no yes
HCDH_HUMAN [view entry] [view interactions] High throughput yes yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
SYHM_HUMAN [view entry] [view interactions] High throughput yes yes
ROAA_HUMAN [view interactions] High throughput no yes
HNRDL_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
HSDL2_HUMAN [view entry] [view interactions] High throughput yes yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
CH10_HUMAN [view interactions] High throughput no yes
SYIM_HUMAN [view entry] [view interactions] High throughput yes yes
CAF17_HUMAN [view interactions] High throughput no no
IDH3B_HUMAN [view entry] [view interactions] High throughput yes yes
MIC60_HUMAN [view entry] [view interactions] High throughput yes yes
MRPP3_HUMAN [view interactions] High throughput no yes
SYLM_HUMAN [view interactions] High throughput no yes
LETM1_HUMAN [view entry] [view interactions] High throughput yes yes
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
LUC7L_HUMAN [view interactions] High throughput no yes
LYRM4_HUMAN [view interactions] High throughput no yes
LYRM7_HUMAN [view interactions] High throughput no yes
MDHM_HUMAN [view entry] [view interactions] High throughput yes yes
MAOM_HUMAN [view interactions] High throughput no yes
MET15_HUMAN [view interactions] High throughput no no
MGME1_HUMAN [view interactions] High throughput no yes
MMAB_HUMAN [view interactions] High throughput no yes
MUTA_HUMAN [view interactions] High throughput no yes
MRM3_HUMAN [view interactions] High throughput no yes
RM01_HUMAN [view interactions] High throughput no yes
RM10_HUMAN [view interactions] High throughput no yes
RM12_HUMAN [view interactions] High throughput no yes
RM13_HUMAN [view interactions] High throughput no yes
RM14_HUMAN [view interactions] High throughput no yes
RM15_HUMAN [view interactions] High throughput no yes
RM16_HUMAN [view interactions] High throughput no yes
RM17_HUMAN [view interactions] High throughput no yes
RM18_HUMAN [view interactions] High throughput no yes
RM19_HUMAN [view interactions] High throughput no yes
RM02_HUMAN [view interactions] High throughput no yes
RM20_HUMAN [view interactions] High throughput no yes
RM22_HUMAN [view interactions] High throughput no yes
RM23_HUMAN [view interactions] High throughput no yes
RM24_HUMAN [view interactions] High throughput no yes
RM27_HUMAN [view interactions] High throughput no yes
RM28_HUMAN [view interactions] High throughput no yes
RM03_HUMAN [view interactions] High throughput no yes
RM32_HUMAN [view interactions] High throughput no yes
RM37_HUMAN [view interactions] High throughput no yes
RM38_HUMAN [view interactions] High throughput no yes
RM39_HUMAN [view interactions] High throughput no yes
RM04_HUMAN [view interactions] High throughput no yes
RM40_HUMAN [view interactions] High throughput no yes
RM41_HUMAN [view interactions] High throughput no yes
RM42_HUMAN [view interactions] High throughput no yes
RM43_HUMAN [view interactions] High throughput no no
RM44_HUMAN [view interactions] High throughput no yes
RM46_HUMAN [view interactions] High throughput no yes
RM47_HUMAN [view interactions] High throughput no yes
RM48_HUMAN [view interactions] High throughput no yes
RM49_HUMAN [view interactions] High throughput no yes
RM50_HUMAN [view interactions] High throughput no yes
RM51_HUMAN [view interactions] High throughput no yes
RM53_HUMAN [view interactions] High throughput no yes
RM55_HUMAN [view interactions] High throughput no yes
ICT1_HUMAN [view interactions] High throughput no yes
RM09_HUMAN [view interactions] High throughput no yes
RT10_HUMAN [view interactions] High throughput no yes
RT11_HUMAN [view interactions] High throughput no yes
RT14_HUMAN [view interactions] High throughput no yes
RT16_HUMAN [view interactions] High throughput no yes
RT17_HUMAN [view interactions] High throughput no yes
RT18A_HUMAN [view interactions] High throughput no yes
RT18B_HUMAN [view interactions] High throughput no yes
RT18C_HUMAN [view interactions] High throughput no yes
RT02_HUMAN [view interactions] High throughput no no
RT22_HUMAN [view interactions] High throughput no yes
RT23_HUMAN [view interactions] High throughput no yes
RT24_HUMAN [view interactions] High throughput no yes
RT25_HUMAN [view interactions] High throughput no yes
RT26_HUMAN [view interactions] High throughput no yes
RT27_HUMAN [view interactions] High throughput no yes
RT28_HUMAN [view interactions] High throughput no yes
RT30_HUMAN [view interactions] High throughput no yes
RT31_HUMAN [view interactions] High throughput no yes
RT33_HUMAN [view interactions] High throughput no no
RT34_HUMAN [view interactions] High throughput no yes
RT35_HUMAN [view interactions] High throughput no yes
KGD4_HUMAN [view entry] [view interactions] High throughput yes yes
RT05_HUMAN [view interactions] High throughput no yes
RT06_HUMAN [view interactions] High throughput no yes
RT07_HUMAN [view interactions] High throughput no yes
RT09_HUMAN [view interactions] High throughput no yes
RRFM_HUMAN [view interactions] High throughput no yes
MTEF3_HUMAN [view interactions] High throughput no no
MTG2_HUMAN [view interactions] High throughput no yes
MTDC_HUMAN [view interactions] High throughput no yes
IF2M_HUMAN [view interactions] High throughput no yes
SYNM_HUMAN [view interactions] High throughput no yes
NDUAC_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA2_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA5_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA6_HUMAN [view interactions] High throughput no no
NDUA7_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA9_HUMAN [view entry] [view interactions] High throughput yes yes
ACPM_HUMAN [view interactions] High throughput no yes
CIA30_HUMAN [view interactions] High throughput no yes
NDUF2_HUMAN [view interactions] High throughput no yes
NDUF3_HUMAN [view interactions] High throughput no yes
NDUF4_HUMAN [view interactions] High throughput no yes
NDUF5_HUMAN [view interactions] High throughput no yes
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
NDUS2_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS4_HUMAN [view interactions] High throughput no yes
NDUS6_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
NDUS8_HUMAN [view interactions] High throughput no yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV2_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV3_HUMAN [view interactions] High throughput no yes
NFS1_HUMAN [view interactions] High throughput no yes
NFU1_HUMAN [view interactions] High throughput no yes
NGRN_HUMAN [view interactions] High throughput no yes
NDKM_HUMAN [view interactions] High throughput no yes
NNTM_HUMAN [view entry] [view interactions] High throughput yes yes
NOA1_HUMAN [view interactions] High throughput no yes
NSA2_HUMAN [view interactions] High throughput no yes
NT5D2_HUMAN [view interactions] High throughput no yes
NTPCR_HUMAN [view interactions] High throughput no yes
NUBPL_HUMAN [view interactions] High throughput no no
NUD19_HUMAN [view interactions] High throughput no no
OAT_HUMAN [view interactions] High throughput no yes
ODO1_HUMAN [view entry] [view interactions] High throughput yes yes
OXA1L_HUMAN [view interactions] High throughput no yes
SCOT1_HUMAN [view entry] [view interactions] High throughput yes yes
TIM16_HUMAN [view entry] [view interactions] High throughput yes no
RRP5_HUMAN [view interactions] High throughput no yes
PDE12_HUMAN [view interactions] High throughput no yes
HMGC2_HUMAN [view interactions] Computational no no
HMCS2_HUMAN [view interactions] Computational no no
HMCS1_HUMAN [view interactions] Computational no yes
MCCB_HUMAN [view entry] [view interactions] Computational yes yes
MCCA_HUMAN [view entry] [view interactions] Computational yes yes
HMGCL_HUMAN [view interactions] Computational no yes
TIM14_HUMAN [view entry] [view interactions] Computational yes yes