NNTM_HUMAN
Evidence for PS localization
Functions
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane . May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NNTM_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 36.3636 | 4 | no |
| GO:0003723 | RNA binding | 27.2727 | 4 | no |
| GO:0015399 | primary active transmembrane transporter activity | 25.7576 | 4 | no |
| GO:0017076 | purine nucleotide binding | 24.2424 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 24.2424 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.7273 | 4 | no |
| GO:0008324 | cation transmembrane transporter activity | 13.6364 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 13.6364 | 4 | yes |
| GO:0015078 | proton transmembrane transporter activity | 12.1212 | 5 | yes |
| GO:0051287 | NAD binding | 9.0909 | 4 | yes |
| GO:0050661 | NADP binding | 4.5455 | 4 | yes |
| GO:0003957 | NAD(P)+ transhydrogenase (B-specific) activity | 3.0303 | 6 | yes |
| GO:0008746 | NAD(P)+ transhydrogenase activity | 3.0303 | 5 | yes |
| GO:0016652 | oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor | 3.0303 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NNTM_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 42.4242 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.9091 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 39.3939 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 39.3939 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 36.3636 | 4 | no |
| GO:0022607 | cellular component assembly | 34.8485 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 34.8485 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.3030 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.3030 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 30.3030 | 5 | no |
| GO:0006996 | organelle organization | 27.2727 | 4 | no |
| GO:0010646 | regulation of cell communication | 27.2727 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 27.2727 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 27.2727 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.2727 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 27.2727 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.7576 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 25.7576 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.2424 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.2424 | 5 | no |
| GO:0009966 | regulation of signal transduction | 24.2424 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.7273 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 22.7273 | 5 | no |
| GO:0015980 | energy derivation by oxidation of organic compounds | 22.7273 | 4 | no |
| GO:0045333 | cellular respiration | 22.7273 | 5 | no |
| GO:0010941 | regulation of cell death | 21.2121 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.2121 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.2121 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 21.2121 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 21.2121 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.2121 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.2121 | 4 | no |
| GO:0009060 | aerobic respiration | 21.2121 | 6 | no |
| GO:0008104 | protein localization | 21.2121 | 4 | no |
| GO:0043933 | protein-containing complex organization | 21.2121 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 19.6970 | 4 | yes |
| GO:0006811 | ion transport | 18.1818 | 4 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 16.6667 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 16.6667 | 5 | yes |
| GO:0006812 | cation transport | 12.1212 | 5 | yes |
| GO:0098655 | cation transmembrane transport | 10.6061 | 4 | yes |
| GO:0098660 | inorganic ion transmembrane transport | 10.6061 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 10.6061 | 5 | yes |
| GO:1902600 | proton transmembrane transport | 9.0909 | 6 | yes |
| GO:0006739 | NADP metabolic process | 4.5455 | 7 | yes |
| GO:0019362 | pyridine nucleotide metabolic process | 4.5455 | 5 | yes |
| GO:0046496 | nicotinamide nucleotide metabolic process | 4.5455 | 6 | yes |
| GO:0072524 | pyridine-containing compound metabolic process | 4.5455 | 4 | yes |
| GO:0006740 | NADPH regeneration | 3.0303 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in NNTM_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 6.0606 | 4 | no |
| DOID:331 | central nervous system disease | 6.0606 | 3 | no |
| DOID:0111198 | autosomal dominant distal hereditary motor neuronopathy | 3.0303 | 7 | no |
| DOID:12377 | spinal muscular atrophy | 3.0303 | 6 | no |
| DOID:231 | motor neuron disease | 3.0303 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NNTM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MVP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAPS1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC26_HUMAN | [view interactions] | High throughput | no | yes |
| MKLN1_HUMAN | [view interactions] | High throughput | no | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| SLAI2_HUMAN | [view interactions] | High throughput | no | no |
| WIZ_HUMAN | [view interactions] | High throughput | no | yes |
| MIS12_HUMAN | [view interactions] | High throughput | no | yes |
| ATLA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEIL3_HUMAN | [view interactions] | High throughput | no | no |
| JUNB_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| GATA3_HUMAN | [view interactions] | High throughput | no | no |
| NEP_HUMAN | [view interactions] | High throughput | no | no |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| OSMR_HUMAN | [view interactions] | High throughput | no | yes |
| NPHP1_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
| FBF1_HUMAN | [view interactions] | High throughput | no | no |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| SUSD4_HUMAN | [view interactions] | High throughput | no | yes |
| IPYR2_HUMAN | [view interactions] | High throughput | no | yes |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| ECSIT_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PAPD5_HUMAN | [view interactions] | High throughput | no | no |
| AGRE5_HUMAN | [view interactions] | High throughput | no | no |
| GPC5C_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLD7_HUMAN | [view interactions] | High throughput | no | no |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDE2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LTOR3_HUMAN | [view interactions] | High throughput | no | yes |
| QCR10_HUMAN | [view interactions] | High throughput | no | no |
| TIM10_HUMAN | [view interactions] | High throughput | no | yes |
| OFUT1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTCD1_HUMAN | [view interactions] | High throughput | no | yes |
| ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATF_HUMAN | [view interactions] | High throughput | no | yes |
| SF01_HUMAN | [view interactions] | High throughput | no | yes |
| S26A2_HUMAN | [view interactions] | High throughput | no | no |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| P4HA1_HUMAN | [view interactions] | High throughput | no | yes |
| NCPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS8_HUMAN | [view interactions] | High throughput | no | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODBB_HUMAN | [view interactions] | High throughput | no | yes |
| ARMX3_HUMAN | [view interactions] | High throughput | no | no |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODBA_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| PON2_HUMAN | [view interactions] | High throughput | no | yes |
| ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMC8_HUMAN | [view interactions] | High throughput | no | no |
| APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LACTB_HUMAN | [view interactions] | High throughput | no | yes |
| RCN2_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CMC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| CAVN1_HUMAN | [view interactions] | High throughput | no | no |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR2_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADAS_HUMAN | [view interactions] | High throughput | no | yes |
| VATE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRXR1_HUMAN | [view interactions] | High throughput | no | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CMC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CQ080_HUMAN | [view interactions] | High throughput | no | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| MCUR1_HUMAN | [view interactions] | High throughput | no | no |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD5_HUMAN | [view interactions] | High throughput | no | yes |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| MCU_HUMAN | [view interactions] | High throughput | no | yes |
| MCUB_HUMAN | [view interactions] | High throughput | no | no |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD4_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SURF1_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| TMM70_HUMAN | [view interactions] | High throughput | no | yes |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMNA3_HUMAN | [view interactions] | Computational | no | yes |
| NMNA2_HUMAN | [view interactions] | Computational | no | no |
| SIR6_HUMAN | [view interactions] | Computational | no | yes |
| SIR3_HUMAN | [view interactions] | Computational | no | yes |
| NAKD2_HUMAN | [view interactions] | Computational | no | yes |
| NMNA1_HUMAN | [view interactions] | Computational | no | yes |
| SIR2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SIR5_HUMAN | [view interactions] | Computational | no | yes |
| ENPP3_HUMAN | [view interactions] | Computational | no | no |
| BST1_HUMAN | [view interactions] | Computational | no | no |
| SIR1_HUMAN | [view interactions] | Computational | no | yes |
| IDHP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NADK_HUMAN | [view interactions] | Computational | no | yes |
| NUD12_HUMAN | [view interactions] | Computational | no | yes |
| SIR4_HUMAN | [view interactions] | Computational | no | yes |
| NADE_HUMAN | [view interactions] | Computational | no | yes |
| CD38_HUMAN | [view interactions] | Computational | no | no |