VATE1_HUMAN
Evidence for PS localization
Functions
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VATE1_HUMAN |
|---|---|---|---|---|
| GO:0008324 | monoatomic cation transmembrane transporter activity | 31.4815 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 31.4815 | 4 | yes |
| GO:0015078 | proton transmembrane transporter activity | 29.6296 | 5 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 29.6296 | 4 | yes |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 29.6296 | 4 | yes |
| GO:0003723 | RNA binding | 22.2222 | 4 | no |
| GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism | 20.3704 | 4 | yes |
| GO:0046961 | proton-transporting ATPase activity, rotational mechanism | 20.3704 | 4 | yes |
| GO:0043168 | anion binding | 20.3704 | 4 | no |
| GO:0000166 | nucleotide binding | 20.3704 | 4 | no |
| GO:0017076 | purine nucleotide binding | 20.3704 | 5 | no |
| GO:0051117 | ATPase binding | 9.2593 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VATE1_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 57.4074 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 40.7407 | 4 | no |
| GO:0009894 | regulation of catabolic process | 37.0370 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 37.0370 | 4 | no |
| GO:0010646 | regulation of cell communication | 37.0370 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 35.1852 | 4 | no |
| GO:0022607 | cellular component assembly | 35.1852 | 4 | no |
| GO:0009966 | regulation of signal transduction | 35.1852 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0006811 | monoatomic ion transport | 31.4815 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 31.4815 | 5 | yes |
| GO:0006996 | organelle organization | 31.4815 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 29.6296 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 27.7778 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 27.7778 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 27.7778 | 5 | no |
| GO:0098655 | monoatomic cation transmembrane transport | 27.7778 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 27.7778 | 4 | yes |
| GO:1902600 | proton transmembrane transport | 27.7778 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 27.7778 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.9259 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.9259 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.9259 | 5 | no |
| GO:0010506 | regulation of autophagy | 25.9259 | 6 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.9259 | 5 | no |
| GO:0006873 | intracellular monoatomic ion homeostasis | 25.9259 | 4 | no |
| GO:0030003 | intracellular monoatomic cation homeostasis | 25.9259 | 5 | no |
| GO:0055080 | monoatomic cation homeostasis | 25.9259 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.0741 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.0741 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.0741 | 4 | no |
| GO:0031399 | regulation of protein modification process | 24.0741 | 6 | no |
| GO:0097401 | synaptic vesicle lumen acidification | 22.2222 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 22.2222 | 4 | no |
| GO:0008104 | protein localization | 22.2222 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 20.3704 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.3704 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 20.3704 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 20.3704 | 5 | no |
| GO:0023056 | positive regulation of signaling | 20.3704 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.3704 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.3704 | 5 | no |
| GO:0016241 | regulation of macroautophagy | 20.3704 | 7 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.3704 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 20.3704 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 20.3704 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VATG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ALDOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ALDOB_HUMAN | [view interactions] | Low throughput | no | no |
| ALDOC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MESD_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| RMD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| VATC2_HUMAN | [view interactions] | High throughput | no | yes |
| PSG9_HUMAN | [view interactions] | High throughput | no | no |
| VPP2_HUMAN | [view interactions] | High throughput | no | yes |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| TLDC2_HUMAN | [view interactions] | High throughput | no | no |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| MED20_HUMAN | [view interactions] | High throughput | no | no |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX4_HUMAN | [view interactions] | High throughput | no | yes |
| DEDD_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTP_HUMAN | [view interactions] | High throughput | no | yes |
| TGFB1_HUMAN | [view interactions] | High throughput | no | no |
| SOCS2_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| VPP3_HUMAN | [view interactions] | High throughput | no | no |
| VPP4_HUMAN | [view interactions] | High throughput | no | no |
| TRI26_HUMAN | [view interactions] | High throughput | no | yes |
| TM192_HUMAN | [view interactions] | High throughput | no | yes |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROGDI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DMXL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DMXL1_HUMAN | [view interactions] | High throughput | no | yes |
| VATF_HUMAN | [view interactions] | High throughput | no | yes |
| PYRG1_HUMAN | [view interactions] | High throughput | no | no |
| DRG1_HUMAN | [view interactions] | High throughput | no | yes |
| SCYL1_HUMAN | [view interactions] | High throughput | no | yes |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| PJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| ARI1A_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIF_HUMAN | [view interactions] | High throughput | no | no |
| LTOR3_HUMAN | [view interactions] | High throughput | no | yes |
| SCAM3_HUMAN | [view interactions] | High throughput | no | no |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| XPP1_HUMAN | [view interactions] | High throughput | no | yes |
| ZFR_HUMAN | [view interactions] | High throughput | no | yes |
| MRP2_HUMAN | [view interactions] | High throughput | no | no |
| SCO2_HUMAN | [view interactions] | High throughput | no | no |
| SRSF3_HUMAN | [view interactions] | High throughput | no | yes |
| ZN827_HUMAN | [view interactions] | High throughput | no | yes |
| THOC4_HUMAN | [view interactions] | High throughput | no | no |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10AA_HUMAN | [view interactions] | High throughput | no | no |
| TYSY_HUMAN | [view interactions] | High throughput | no | yes |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNT5_HUMAN | [view interactions] | High throughput | no | yes |
| THY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUGP1_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAF_HUMAN | [view interactions] | High throughput | no | no |
| TMM43_HUMAN | [view interactions] | High throughput | no | no |
| SAMH1_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
| HMCS1_HUMAN | [view interactions] | High throughput | no | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS8_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODBA_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| EMC8_HUMAN | [view interactions] | High throughput | no | no |
| P4HA1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCN2_HUMAN | [view interactions] | High throughput | no | yes |
| NCPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NNTM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS5_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCMC1_HUMAN | [view interactions] | High throughput | no | no |
| TFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| TP4A2_HUMAN | [view interactions] | High throughput | no | yes |