VATE1_HUMAN
Evidence for PS localization
Functions
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VATE1_HUMAN |
|---|---|---|---|---|
| GO:0008324 | cation transmembrane transporter activity | 33.3333 | 4 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 33.3333 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 31.2500 | 4 | yes |
| GO:0015078 | proton transmembrane transporter activity | 29.1667 | 5 | yes |
| GO:0022853 | active ion transmembrane transporter activity | 27.0833 | 4 | yes |
| GO:0009678 | pyrophosphate hydrolysis-driven proton transmembrane transporter activity | 20.8333 | 5 | yes |
| GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism | 20.8333 | 4 | yes |
| GO:0046961 | proton-transporting ATPase activity, rotational mechanism | 20.8333 | 4 | yes |
| GO:0051117 | ATPase binding | 10.4167 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VATE1_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 52.0833 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 37.5000 | 4 | no |
| GO:0009894 | regulation of catabolic process | 33.3333 | 4 | yes |
| GO:0031329 | regulation of cellular catabolic process | 33.3333 | 5 | yes |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
| GO:0009966 | regulation of signal transduction | 31.2500 | 4 | no |
| GO:0010506 | regulation of autophagy | 29.1667 | 6 | yes |
| GO:0006996 | organelle organization | 29.1667 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 29.1667 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 29.1667 | 4 | no |
| GO:0016241 | regulation of macroautophagy | 27.0833 | 7 | yes |
| GO:0006811 | ion transport | 25.0000 | 4 | yes |
| GO:0006812 | cation transport | 25.0000 | 5 | yes |
| GO:0098655 | cation transmembrane transport | 25.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 25.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 25.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:0098660 | inorganic ion transmembrane transport | 22.9167 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 22.9167 | 5 | yes |
| GO:0048878 | chemical homeostasis | 22.9167 | 4 | no |
| GO:0050801 | ion homeostasis | 22.9167 | 5 | no |
| GO:0055080 | cation homeostasis | 22.9167 | 6 | no |
| GO:0098771 | inorganic ion homeostasis | 22.9167 | 6 | no |
| GO:0043933 | protein-containing complex organization | 22.9167 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.9167 | 4 | no |
| GO:0008104 | protein localization | 22.9167 | 4 | no |
| GO:1902600 | proton transmembrane transport | 20.8333 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 20.8333 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.8333 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 20.8333 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VATG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ALDOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ALDOB_HUMAN | [view interactions] | Low throughput | no | no |
| ALDOC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MESD_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| VATC2_HUMAN | [view interactions] | High throughput | no | yes |
| PSG9_HUMAN | [view interactions] | High throughput | no | no |
| VPP2_HUMAN | [view interactions] | High throughput | no | yes |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLDC2_HUMAN | [view interactions] | High throughput | no | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| MED20_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| VATG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEDD_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| VATO_HUMAN | [view interactions] | High throughput | no | no |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTP_HUMAN | [view interactions] | High throughput | no | yes |
| TGFB1_HUMAN | [view interactions] | High throughput | no | no |
| SOCS2_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| VPP3_HUMAN | [view interactions] | High throughput | no | no |
| VPP4_HUMAN | [view interactions] | High throughput | no | no |
| TRI26_HUMAN | [view interactions] | High throughput | no | yes |
| TM192_HUMAN | [view interactions] | High throughput | no | yes |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROGDI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DMXL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DMXL1_HUMAN | [view interactions] | High throughput | no | yes |
| VATF_HUMAN | [view interactions] | High throughput | no | yes |
| PYRG1_HUMAN | [view interactions] | High throughput | no | no |
| DRG1_HUMAN | [view interactions] | High throughput | no | yes |
| SCYL1_HUMAN | [view interactions] | High throughput | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIF_HUMAN | [view interactions] | High throughput | no | no |
| LTOR3_HUMAN | [view interactions] | High throughput | no | yes |
| SCAM3_HUMAN | [view interactions] | High throughput | no | no |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| XPP1_HUMAN | [view interactions] | High throughput | no | yes |
| ZFR_HUMAN | [view interactions] | High throughput | no | yes |
| MRP2_HUMAN | [view interactions] | High throughput | no | no |
| SCO2_HUMAN | [view interactions] | High throughput | no | no |
| SRSF3_HUMAN | [view interactions] | High throughput | no | yes |
| ZN827_HUMAN | [view interactions] | High throughput | no | yes |
| THOC4_HUMAN | [view interactions] | High throughput | no | no |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10AA_HUMAN | [view interactions] | High throughput | no | no |
| TYSY_HUMAN | [view interactions] | High throughput | no | yes |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNT5_HUMAN | [view interactions] | High throughput | no | yes |
| THY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUGP1_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAF_HUMAN | [view interactions] | High throughput | no | no |
| TMM43_HUMAN | [view interactions] | High throughput | no | no |
| SAMH1_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
| HMCS1_HUMAN | [view interactions] | High throughput | no | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS8_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODBA_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| EMC8_HUMAN | [view interactions] | High throughput | no | no |
| P4HA1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCN2_HUMAN | [view interactions] | High throughput | no | yes |
| NCPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NNTM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS5_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCMC1_HUMAN | [view interactions] | High throughput | no | no |
| TFR1_HUMAN | [view interactions] | High throughput | no | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| SAMTR_HUMAN | [view interactions] | Computational | no | yes |
| NPRL2_HUMAN | [view interactions] | Computational | no | yes |
| VATL_HUMAN | [view interactions] | Computational | no | no |
| ITFG2_HUMAN | [view interactions] | Computational | no | yes |
| AT5G3_HUMAN | [view interactions] | Computational | no | no |
| VATG3_HUMAN | [view interactions] | Computational | no | no |
| TM199_HUMAN | [view interactions] | Computational | no | yes |
| ATP5E_HUMAN | [view interactions] | Computational | no | no |
| CAST2_HUMAN | [view interactions] | Computational | no | no |
| VA0E2_HUMAN | [view interactions] | Computational | no | no |
| SH3B4_HUMAN | [view interactions] | Computational | no | yes |
| ATPO_HUMAN | [view interactions] | Computational | no | yes |
| CAST1_HUMAN | [view interactions] | Computational | no | yes |
| ATPB_HUMAN | [view interactions] | Computational | no | yes |
| ATPA_HUMAN | [view interactions] | Computational | no | yes |
| FLCN_HUMAN | [view interactions] | Computational | no | yes |
| VA0D2_HUMAN | [view interactions] | Computational | no | no |
| SESN2_HUMAN | [view interactions] | Computational | no | no |
| MIO_HUMAN | [view interactions] | Computational | no | yes |
| ATP5J_HUMAN | [view interactions] | Computational | no | yes |
| SZT2_HUMAN | [view interactions] | Computational | no | yes |
| AT5F1_HUMAN | [view interactions] | Computational | no | yes |
| SESN1_HUMAN | [view interactions] | Computational | no | no |
| FNIP2_HUMAN | [view interactions] | Computational | no | yes |
| SEH1_HUMAN | [view interactions] | Computational | no | no |
| WDR24_HUMAN | [view interactions] | Computational | no | yes |
| ATPK_HUMAN | [view interactions] | Computational | no | yes |
| ATPG_HUMAN | [view interactions] | Computational | no | yes |
| AT5G2_HUMAN | [view interactions] | Computational | no | yes |
| SEC13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VATE2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ATP5I_HUMAN | [view interactions] | Computational | no | yes |
| WDR59_HUMAN | [view interactions] | Computational | no | yes |
| VA0E1_HUMAN | [view interactions] | Computational | no | no |
| TFG_HUMAN | [view interactions] | Computational | no | yes |
| AT5G1_HUMAN | [view interactions] | Computational | no | no |
| VAS1_HUMAN | [view interactions] | Computational | no | yes |
| FNIP1_HUMAN | [view interactions] | Computational | no | yes |
| KPTN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ATP5L_HUMAN | [view interactions] | Computational | no | yes |
| CC115_HUMAN | [view interactions] | Computational | no | no |