PJA2_HUMAN
Evidence for PS localization
Functions
Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PJA2_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 33.9623 | 4 | no |
| GO:0017076 | purine nucleotide binding | 33.9623 | 5 | no |
| GO:0043168 | anion binding | 32.0755 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 30.1887 | 4 | no |
| GO:0043169 | cation binding | 28.3019 | 4 | yes |
| GO:0046872 | metal ion binding | 28.3019 | 5 | yes |
| GO:0019900 | kinase binding | 26.4151 | 4 | yes |
| GO:0019901 | protein kinase binding | 26.4151 | 5 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 26.4151 | 4 | no |
| GO:0015078 | proton transmembrane transporter activity | 26.4151 | 5 | no |
| GO:0015399 | primary active transmembrane transporter activity | 26.4151 | 4 | no |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 26.4151 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 26.4151 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 24.5283 | 6 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.5283 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 20.7547 | 5 | no |
| GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 20.7547 | 5 | no |
| GO:0004842 | ubiquitin-protein transferase activity | 7.5472 | 4 | yes |
| GO:0016755 | aminoacyltransferase activity | 7.5472 | 4 | yes |
| GO:0034236 | protein kinase A catalytic subunit binding | 7.5472 | 4 | yes |
| GO:0061630 | ubiquitin protein ligase activity | 5.6604 | 5 | yes |
| GO:0061659 | ubiquitin-like protein ligase activity | 5.6604 | 4 | yes |
| GO:0034237 | protein kinase A regulatory subunit binding | 3.7736 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PJA2_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 45.2830 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 39.6226 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 35.8491 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 35.8491 | 4 | no |
| GO:0010646 | regulation of cell communication | 35.8491 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 32.0755 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 30.1887 | 4 | no |
| GO:0009894 | regulation of catabolic process | 30.1887 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.1887 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 28.3019 | 4 | no |
| GO:0006996 | organelle organization | 26.4151 | 4 | no |
| GO:0008104 | protein localization | 26.4151 | 4 | no |
| GO:0051049 | regulation of transport | 26.4151 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 26.4151 | 4 | no |
| GO:0015980 | energy derivation by oxidation of organic compounds | 26.4151 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.4151 | 5 | no |
| GO:0022607 | cellular component assembly | 26.4151 | 4 | no |
| GO:0071702 | organic substance transport | 24.5283 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 24.5283 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.5283 | 5 | no |
| GO:0009060 | aerobic respiration | 24.5283 | 6 | no |
| GO:0045333 | cellular respiration | 24.5283 | 5 | no |
| GO:0009966 | regulation of signal transduction | 24.5283 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 22.6415 | 5 | yes |
| GO:0015031 | protein transport | 22.6415 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.6415 | 4 | no |
| GO:0032880 | regulation of protein localization | 22.6415 | 5 | no |
| GO:0060341 | regulation of cellular localization | 22.6415 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.6415 | 5 | no |
| GO:0031399 | regulation of protein modification process | 22.6415 | 6 | no |
| GO:0006163 | purine nucleotide metabolic process | 22.6415 | 5 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 22.6415 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 22.6415 | 5 | no |
| GO:0009150 | purine ribonucleotide metabolic process | 22.6415 | 6 | no |
| GO:0009259 | ribonucleotide metabolic process | 22.6415 | 5 | no |
| GO:0019693 | ribose phosphate metabolic process | 22.6415 | 4 | no |
| GO:0072521 | purine-containing compound metabolic process | 22.6415 | 4 | no |
| GO:0019646 | aerobic electron transport chain | 22.6415 | 6 | no |
| GO:0022900 | electron transport chain | 22.6415 | 4 | no |
| GO:0022904 | respiratory electron transport chain | 22.6415 | 5 | no |
| GO:0043933 | protein-containing complex organization | 22.6415 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 22.6415 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 20.7547 | 4 | no |
| GO:0010468 | regulation of gene expression | 20.7547 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 20.7547 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.7547 | 6 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.7547 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.7547 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.7547 | 5 | no |
| GO:1901362 | organic cyclic compound biosynthetic process | 20.7547 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 20.7547 | 4 | no |
| GO:0036211 | protein modification process | 18.8679 | 4 | yes |
| GO:0043412 | macromolecule modification | 18.8679 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 16.9811 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 16.9811 | 4 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 15.0943 | 4 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 15.0943 | 6 | yes |
| GO:0009967 | positive regulation of signal transduction | 15.0943 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 15.0943 | 4 | yes |
| GO:0006508 | proteolysis | 13.2075 | 4 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 11.3208 | 6 | yes |
| GO:0009057 | macromolecule catabolic process | 11.3208 | 4 | yes |
| GO:0030163 | protein catabolic process | 11.3208 | 4 | yes |
| GO:0043687 | post-translational protein modification | 11.3208 | 5 | yes |
| GO:0080134 | regulation of response to stress | 9.4340 | 4 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 9.4340 | 7 | yes |
| GO:0010498 | proteasomal protein catabolic process | 9.4340 | 5 | yes |
| GO:0016567 | protein ubiquitination | 9.4340 | 8 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 9.4340 | 6 | yes |
| GO:0032446 | protein modification by small protein conjugation | 9.4340 | 7 | yes |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 9.4340 | 6 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 9.4340 | 5 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 9.4340 | 5 | yes |
| GO:0002684 | positive regulation of immune system process | 7.5472 | 4 | yes |
| GO:0002694 | regulation of leukocyte activation | 7.5472 | 4 | yes |
| GO:0006954 | inflammatory response | 7.5472 | 4 | yes |
| GO:0050776 | regulation of immune response | 7.5472 | 4 | yes |
| GO:0050865 | regulation of cell activation | 7.5472 | 4 | yes |
| GO:0140546 | defense response to symbiont | 5.6604 | 4 | yes |
| GO:0002831 | regulation of response to biotic stimulus | 5.6604 | 4 | yes |
| GO:0031347 | regulation of defense response | 5.6604 | 5 | yes |
| GO:0032101 | regulation of response to external stimulus | 5.6604 | 4 | yes |
| GO:0043408 | regulation of MAPK cascade | 5.6604 | 6 | yes |
| GO:0043410 | positive regulation of MAPK cascade | 5.6604 | 7 | yes |
| GO:0045088 | regulation of innate immune response | 5.6604 | 5 | yes |
| GO:0050778 | positive regulation of immune response | 5.6604 | 5 | yes |
| GO:0062207 | regulation of pattern recognition receptor signaling pathway | 5.6604 | 5 | yes |
| GO:1900744 | regulation of p38MAPK cascade | 3.7736 | 7 | yes |
| GO:1900745 | positive regulation of p38MAPK cascade | 3.7736 | 8 | yes |
| GO:0002833 | positive regulation of response to biotic stimulus | 3.7736 | 5 | yes |
| GO:0007613 | memory | 3.7736 | 4 | yes |
| GO:0007616 | long-term memory | 3.7736 | 5 | yes |
| GO:0010738 | regulation of protein kinase A signaling | 3.7736 | 6 | yes |
| GO:0031349 | positive regulation of defense response | 3.7736 | 5 | yes |
| GO:0032103 | positive regulation of response to external stimulus | 3.7736 | 5 | yes |
| GO:0034135 | regulation of toll-like receptor 2 signaling pathway | 3.7736 | 6 | yes |
| GO:0034137 | positive regulation of toll-like receptor 2 signaling pathway | 3.7736 | 7 | yes |
| GO:0043030 | regulation of macrophage activation | 3.7736 | 5 | yes |
| GO:0045089 | positive regulation of innate immune response | 3.7736 | 6 | yes |
| GO:0046328 | regulation of JNK cascade | 3.7736 | 7 | yes |
| GO:0046330 | positive regulation of JNK cascade | 3.7736 | 8 | yes |
| GO:0050890 | cognition | 3.7736 | 4 | yes |
| GO:0062208 | positive regulation of pattern recognition receptor signaling pathway | 3.7736 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MAGD1_HUMAN | [view interactions] | Low throughput | no | no |
| KSR2_HUMAN | [view interactions] | Low throughput | no | yes |
| CD5R1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UB2D2_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2D3_HUMAN | [view interactions] | Low throughput | no | yes |
| MOB1A_HUMAN | [view interactions] | Low throughput | no | yes |
| BBS2_HUMAN | [view interactions] | Low throughput | no | no |
| KAP0_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KSR1_HUMAN | [view interactions] | Low throughput | no | yes |
| MFHA1_HUMAN | [view interactions] | Low throughput | no | yes |
| CCNT1_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK9_HUMAN | [view interactions] | Low throughput | no | yes |
| LATS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LEF1_HUMAN | [view interactions] | Low throughput | no | no |
| TCF7_HUMAN | [view interactions] | Low throughput | no | no |
| TF7L1_HUMAN | [view interactions] | Low throughput | no | no |
| PJA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BBS1_HUMAN | [view interactions] | Low throughput | no | no |
| BBS4_HUMAN | [view interactions] | Low throughput | no | no |
| BBS5_HUMAN | [view interactions] | Low throughput | no | yes |
| BBS7_HUMAN | [view interactions] | Low throughput | no | no |
| TTC8_HUMAN | [view interactions] | Low throughput | no | no |
| UBXN7_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| FAF1_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN1_HUMAN | [view interactions] | High throughput | no | no |
| UBP46_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| UB2D1_HUMAN | [view interactions] | High throughput | no | yes |
| UB2D4_HUMAN | [view interactions] | High throughput | no | yes |
| UB2J1_HUMAN | [view interactions] | High throughput | no | yes |
| UB2L6_HUMAN | [view interactions] | High throughput | no | no |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2W_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKP8L_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAGD2_HUMAN | [view interactions] | High throughput | no | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| APC13_HUMAN | [view interactions] | High throughput | no | no |
| CNOT2_HUMAN | [view interactions] | High throughput | no | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXL17_HUMAN | [view interactions] | High throughput | no | yes |
| RHG36_HUMAN | [view interactions] | High throughput | no | yes |
| IQCN_HUMAN | [view interactions] | High throughput | no | no |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| MINY4_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| AMRA1_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| SP110_HUMAN | [view interactions] | High throughput | no | no |
| TRI33_HUMAN | [view interactions] | High throughput | no | yes |
| DJC15_HUMAN | [view interactions] | High throughput | no | no |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| AGO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| NSE3_HUMAN | [view interactions] | High throughput | no | no |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| SPSB4_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PLD1_HUMAN | [view interactions] | High throughput | no | no |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| MYO10_HUMAN | [view interactions] | High throughput | no | no |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| ACDSB_HUMAN | [view interactions] | High throughput | no | yes |
| THIC_HUMAN | [view interactions] | High throughput | no | yes |
| ACSL1_HUMAN | [view interactions] | High throughput | no | no |
| AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPD_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5I_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
| ATPO_HUMAN | [view interactions] | High throughput | no | yes |
| VAS1_HUMAN | [view interactions] | High throughput | no | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX11_HUMAN | [view interactions] | High throughput | no | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| COX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPT1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| HACD3_HUMAN | [view interactions] | High throughput | no | yes |
| HCDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IRS2_HUMAN | [view interactions] | High throughput | no | yes |
| MTOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA6_HUMAN | [view interactions] | High throughput | no | no |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPYR2_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABD_HUMAN | [view interactions] | High throughput | no | yes |
| 2A5D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| AAKG1_HUMAN | [view interactions] | High throughput | no | no |
| RAB10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| TECR_HUMAN | [view interactions] | High throughput | no | yes |
| TSC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| AMFR_HUMAN | [view interactions] | High throughput | no | yes |
| BRWD3_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| UBR1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR11_HUMAN | [view interactions] | High throughput | no | yes |
| MOONR_HUMAN | [view interactions] | High throughput | no | yes |
| DC1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| CNOT9_HUMAN | [view interactions] | High throughput | no | yes |
| F120C_HUMAN | [view interactions] | High throughput | no | yes |
| PRP19_HUMAN | [view interactions] | High throughput | no | yes |
| PRC2A_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC2_HUMAN | [view interactions] | High throughput | no | yes |
| ACBD5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| BACD1_HUMAN | [view interactions] | High throughput | no | no |