Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PJA2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PJA2_HUMAN
GO:0019900 kinase binding 47.0588 4 yes
GO:0019901 protein kinase binding 47.0588 5 yes
GO:0017076 purine nucleotide binding 41.1765 4 no
GO:0030554 adenyl nucleotide binding 41.1765 5 no
GO:0032555 purine ribonucleotide binding 41.1765 4 no
GO:0032559 adenyl ribonucleotide binding 41.1765 5 no
GO:0046872 metal ion binding 29.4118 4 yes
GO:0031625 ubiquitin protein ligase binding 29.4118 5 no
GO:0044389 ubiquitin-like protein ligase binding 29.4118 4 no
GO:0004842 ubiquitin-protein transferase activity 23.5294 4 yes
GO:0034236 protein kinase A catalytic subunit binding 23.5294 4 yes
GO:0003723 RNA binding 23.5294 4 no
GO:0005524 ATP binding 23.5294 5 no
GO:0035639 purine ribonucleoside triphosphate binding 23.5294 4 no
GO:0034237 protein kinase A regulatory subunit binding 11.7647 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PJA2_HUMAN
GO:0048522 positive regulation of cellular process 58.8235 4 yes
GO:0010646 regulation of cell communication 47.0588 4 yes
GO:0031323 regulation of cellular metabolic process 47.0588 4 no
GO:0051171 regulation of nitrogen compound metabolic process 47.0588 4 no
GO:0051246 regulation of protein metabolic process 47.0588 5 no
GO:0060255 regulation of macromolecule metabolic process 47.0588 4 no
GO:0080090 regulation of primary metabolic process 47.0588 4 no
GO:0048523 negative regulation of cellular process 41.1765 4 no
GO:0006996 organelle organization 41.1765 4 no
GO:0009966 regulation of signal transduction 41.1765 4 yes
GO:0036211 protein modification process 41.1765 4 yes
GO:0043412 macromolecule modification 41.1765 4 yes
GO:0009892 negative regulation of metabolic process 35.2941 4 no
GO:0010605 negative regulation of macromolecule metabolic process 35.2941 5 no
GO:0031324 negative regulation of cellular metabolic process 35.2941 5 no
GO:0051128 regulation of cellular component organization 35.2941 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 35.2941 5 no
GO:0007010 cytoskeleton organization 35.2941 5 no
GO:0070647 protein modification by small protein conjugation or removal 35.2941 5 yes
GO:1902531 regulation of intracellular signal transduction 35.2941 5 yes
GO:0009889 regulation of biosynthetic process 35.2941 4 no
GO:0010468 regulation of gene expression 35.2941 5 no
GO:0010556 regulation of macromolecule biosynthetic process 35.2941 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 35.2941 5 no
GO:0031326 regulation of cellular biosynthetic process 35.2941 5 no
GO:0031399 regulation of protein modification process 35.2941 6 no
GO:0051252 regulation of RNA metabolic process 35.2941 5 no
GO:0009967 positive regulation of signal transduction 29.4118 5 yes
GO:0010647 positive regulation of cell communication 29.4118 5 yes
GO:0016567 protein ubiquitination 29.4118 7 yes
GO:0023056 positive regulation of signaling 29.4118 4 yes
GO:0032446 protein modification by small protein conjugation 29.4118 6 yes
GO:0048584 positive regulation of response to stimulus 29.4118 4 yes
GO:1902533 positive regulation of intracellular signal transduction 29.4118 6 yes
GO:0006355 regulation of DNA-templated transcription 29.4118 6 no
GO:0009893 positive regulation of metabolic process 29.4118 4 no
GO:0010604 positive regulation of macromolecule metabolic process 29.4118 5 no
GO:1903506 regulation of nucleic acid-templated transcription 29.4118 7 no
GO:2001141 regulation of RNA biosynthetic process 29.4118 6 no
GO:0008104 protein localization 29.4118 4 no
GO:0015031 protein transport 23.5294 4 no
GO:0019220 regulation of phosphate metabolic process 23.5294 6 no
GO:0033043 regulation of organelle organization 23.5294 5 no
GO:0042325 regulation of phosphorylation 23.5294 7 no
GO:0051049 regulation of transport 23.5294 4 no
GO:0051130 positive regulation of cellular component organization 23.5294 5 no
GO:0051174 regulation of phosphorus metabolic process 23.5294 5 no
GO:0071702 organic substance transport 23.5294 4 no
GO:0071705 nitrogen compound transport 23.5294 4 no
GO:0051726 regulation of cell cycle 23.5294 4 no
GO:0050776 regulation of immune response 23.5294 4 yes
GO:0080134 regulation of response to stress 23.5294 4 yes
GO:0006508 proteolysis 23.5294 4 no
GO:0006511 ubiquitin-dependent protein catabolic process 23.5294 7 no
GO:0009057 macromolecule catabolic process 23.5294 4 no
GO:0019941 modification-dependent protein catabolic process 23.5294 6 no
GO:0043632 modification-dependent macromolecule catabolic process 23.5294 5 no
GO:0044265 cellular macromolecule catabolic process 23.5294 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 23.5294 5 no
GO:0051247 positive regulation of protein metabolic process 23.5294 6 no
GO:0051338 regulation of transferase activity 23.5294 4 no
GO:0051603 proteolysis involved in protein catabolic process 23.5294 5 no
GO:0001932 regulation of protein phosphorylation 23.5294 7 no
GO:0002694 regulation of leukocyte activation 17.6471 4 yes
GO:0034121 regulation of toll-like receptor signaling pathway 17.6471 6 yes
GO:0043408 regulation of MAPK cascade 17.6471 6 yes
GO:0043410 positive regulation of MAPK cascade 17.6471 7 yes
GO:0050865 regulation of cell activation 17.6471 4 yes
GO:0062207 regulation of pattern recognition receptor signaling pathway 17.6471 5 yes
GO:0080135 regulation of cellular response to stress 17.6471 4 yes
GO:0006954 inflammatory response 11.7647 4 yes
GO:0007613 memory 11.7647 4 yes
GO:0007616 long-term memory 11.7647 5 yes
GO:0010738 regulation of protein kinase A signaling 11.7647 6 yes
GO:0032872 regulation of stress-activated MAPK cascade 11.7647 6 yes
GO:0032874 positive regulation of stress-activated MAPK cascade 11.7647 7 yes
GO:0034123 positive regulation of toll-like receptor signaling pathway 11.7647 7 yes
GO:0034135 regulation of toll-like receptor 2 signaling pathway 11.7647 7 yes
GO:0034137 positive regulation of toll-like receptor 2 signaling pathway 11.7647 8 yes
GO:0035329 hippo signaling 11.7647 4 yes
GO:0043030 regulation of macrophage activation 11.7647 5 yes
GO:0046328 regulation of JNK cascade 11.7647 7 yes
GO:0046330 positive regulation of JNK cascade 11.7647 8 yes
GO:0050890 cognition 11.7647 4 yes
GO:0062208 positive regulation of pattern recognition receptor signaling pathway 11.7647 6 yes
GO:0070302 regulation of stress-activated protein kinase signaling cascade 11.7647 5 yes
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 11.7647 6 yes
GO:1900744 regulation of p38MAPK cascade 11.7647 7 yes
GO:1900745 positive regulation of p38MAPK cascade 11.7647 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MAGD1_HUMAN [view interactions] Low throughput no no
CD5R1_HUMAN [view entry] [view interactions] Low throughput yes no
KAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
UB2D2_HUMAN [view interactions] Low throughput no yes
UB2D3_HUMAN [view interactions] Low throughput no yes
MOB1A_HUMAN [view interactions] Low throughput no yes
KAP0_HUMAN [view entry] [view interactions] Low throughput yes yes
KSR1_HUMAN [view interactions] Low throughput no yes
MFHA1_HUMAN [view interactions] Low throughput no yes
CCNT1_HUMAN [view interactions] Low throughput no yes
CDK9_HUMAN [view interactions] Low throughput no yes
LATS1_HUMAN [view interactions] Low throughput no yes
LEF1_HUMAN [view interactions] Low throughput no no
TCF7_HUMAN [view interactions] Low throughput no no
TF7L1_HUMAN [view interactions] Low throughput no no
PJA2_HUMAN [view entry] [view interactions] Low throughput yes yes
DCTN2_HUMAN [view entry] [view interactions] High throughput yes yes
K2C8_HUMAN [view interactions] High throughput no no
PXMP2_HUMAN [view interactions] High throughput no no
SQSTM_HUMAN [view interactions] High throughput no yes
UBXN7_HUMAN [view interactions] High throughput no yes
FAF2_HUMAN [view interactions] High throughput no yes
FAF1_HUMAN [view interactions] High throughput no yes
UBXN1_HUMAN [view interactions] High throughput no no
UBP46_HUMAN [view entry] [view interactions] High throughput yes yes
EGLN3_HUMAN [view interactions] High throughput no no
RIPK4_HUMAN [view interactions] High throughput no no
KSR2_HUMAN [view interactions] High throughput no yes
MOT11_HUMAN [view interactions] High throughput no no
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
UB2D1_HUMAN [view interactions] High throughput no yes
UB2D4_HUMAN [view interactions] High throughput no yes
UB2J1_HUMAN [view interactions] High throughput no yes
UB2L6_HUMAN [view interactions] High throughput no no
UBE2N_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2W_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
AKP8L_HUMAN [view interactions] High throughput no yes
HOOK2_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
MAGD2_HUMAN [view interactions] High throughput no yes
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
UNK_HUMAN [view interactions] High throughput no yes
APC13_HUMAN [view interactions] High throughput no no
CNOT2_HUMAN [view interactions] High throughput no yes
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
FXL17_HUMAN [view interactions] High throughput no yes
RHG36_HUMAN [view interactions] High throughput no yes
IQCN_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
TNIP2_HUMAN [view interactions] High throughput no yes
MINY4_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
AMRA1_HUMAN [view interactions] High throughput no yes
LMBRL_HUMAN [view interactions] High throughput no no
BRD1_HUMAN [view interactions] High throughput no yes
SP110_HUMAN [view interactions] High throughput no no
TRI33_HUMAN [view interactions] High throughput no yes
DJC15_HUMAN [view interactions] High throughput no no
DNJC1_HUMAN [view interactions] High throughput no yes
AGO2_HUMAN [view interactions] High throughput no yes
TULP3_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
NSE3_HUMAN [view interactions] High throughput no no
NPAS1_HUMAN [view interactions] High throughput no no
SPSB4_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
AMFR_HUMAN [view interactions] High throughput no yes
BRWD3_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
CUL4B_HUMAN [view interactions] High throughput no yes
UBR1_HUMAN [view interactions] High throughput no yes
WDR11_HUMAN [view interactions] High throughput no yes
MOONR_HUMAN [view interactions] High throughput no yes
DC1L2_HUMAN [view entry] [view interactions] High throughput yes yes
HOOK1_HUMAN [view interactions] High throughput no no
CNOT9_HUMAN [view interactions] High throughput no yes
F120C_HUMAN [view interactions] High throughput no yes
PRP19_HUMAN [view interactions] High throughput no yes
PRC2A_HUMAN [view interactions] High throughput no yes
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC2_HUMAN [view interactions] High throughput no yes
ACBD5_HUMAN [view entry] [view interactions] High throughput yes yes