Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CD5R1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at Thr-451 and Thr-461 and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004683 DEG_Cend_FEM1B_2 DEG 304 307 -
ELMI003228 MOD_CDK_SPxxK_3 MOD 5 12 -
ELMI002324 MOD_NMyristoyl MOD 1 7 -
ELMI004683 DEG_Cend_FEM1B_2 DEG 304 307 -
ELMI003228 MOD_CDK_SPxxK_3 MOD 5 12 -
ELMI002324 MOD_NMyristoyl MOD 1 7 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CD5R1_HUMAN
GO:0019900 kinase binding 34.4828 4 yes
GO:0019901 protein kinase binding 27.5862 5 yes
GO:0044389 ubiquitin-like protein ligase binding 27.5862 4 no
GO:0016301 kinase activity 24.1379 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 24.1379 4 yes
GO:0043169 cation binding 24.1379 4 yes
GO:0046872 metal ion binding 24.1379 5 yes
GO:0000166 nucleotide binding 24.1379 4 no
GO:0017076 purine nucleotide binding 24.1379 5 no
GO:0031625 ubiquitin protein ligase binding 24.1379 5 no
GO:0032555 purine ribonucleotide binding 24.1379 4 no
GO:0035639 purine ribonucleoside triphosphate binding 24.1379 4 no
GO:0043168 anion binding 24.1379 4 no
GO:0003723 RNA binding 24.1379 4 no
GO:0003779 actin binding 20.6897 4 yes
GO:0005524 ATP binding 20.6897 5 no
GO:0030554 adenyl nucleotide binding 20.6897 6 no
GO:0032559 adenyl ribonucleotide binding 20.6897 5 no
GO:0042803 protein homodimerization activity 20.6897 4 no
GO:0002020 protease binding 13.7931 4 yes
GO:0005509 calcium ion binding 10.3448 6 yes
GO:0035254 glutamate receptor binding 10.3448 4 yes
GO:0045296 cadherin binding 10.3448 4 yes
GO:0015631 tubulin binding 6.8966 4 yes
GO:0035255 ionotropic glutamate receptor binding 6.8966 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CD5R1_HUMAN
GO:0048522 positive regulation of cellular process 65.5172 4 yes
GO:0060255 regulation of macromolecule metabolic process 58.6207 4 yes
GO:0080090 regulation of primary metabolic process 58.6207 4 yes
GO:0031323 regulation of cellular metabolic process 55.1724 4 yes
GO:0036211 protein modification process 55.1724 4 yes
GO:0043412 macromolecule modification 55.1724 4 yes
GO:0048523 negative regulation of cellular process 55.1724 4 yes
GO:0051246 regulation of protein metabolic process 51.7241 5 yes
GO:0010646 regulation of cell communication 51.7241 4 no
GO:0031326 regulation of cellular biosynthetic process 48.2759 5 yes
GO:0051128 regulation of cellular component organization 48.2759 4 yes
GO:0009889 regulation of biosynthetic process 48.2759 4 yes
GO:0010468 regulation of gene expression 48.2759 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 48.2759 5 yes
GO:0031399 regulation of protein modification process 44.8276 6 yes
GO:0051049 regulation of transport 44.8276 4 yes
GO:0009966 regulation of signal transduction 44.8276 4 no
GO:0030030 cell projection organization 41.3793 4 yes
GO:0009893 positive regulation of metabolic process 41.3793 4 no
GO:0010604 positive regulation of macromolecule metabolic process 41.3793 5 no
GO:0042981 regulation of apoptotic process 37.9310 5 yes
GO:0043067 regulation of programmed cell death 37.9310 4 yes
GO:0051247 positive regulation of protein metabolic process 37.9310 6 no
GO:0048584 positive regulation of response to stimulus 37.9310 4 no
GO:0009892 negative regulation of metabolic process 37.9310 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 37.9310 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 34.4828 5 yes
GO:0019220 regulation of phosphate metabolic process 34.4828 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 34.4828 4 yes
GO:0031324 negative regulation of cellular metabolic process 34.4828 5 yes
GO:0031344 regulation of cell projection organization 34.4828 5 yes
GO:0045595 regulation of cell differentiation 34.4828 4 yes
GO:0051174 regulation of phosphorus metabolic process 34.4828 5 yes
GO:0060341 regulation of cellular localization 34.4828 4 yes
GO:0120036 plasma membrane bounded cell projection organization 34.4828 5 yes
GO:0009057 macromolecule catabolic process 34.4828 4 no
GO:0031325 positive regulation of cellular metabolic process 34.4828 5 no
GO:1902531 regulation of intracellular signal transduction 34.4828 5 no
GO:0022607 cellular component assembly 34.4828 4 no
GO:0009967 positive regulation of signal transduction 34.4828 5 no
GO:0010647 positive regulation of cell communication 34.4828 5 no
GO:0023056 positive regulation of signaling 34.4828 4 no
GO:0006996 organelle organization 34.4828 4 yes
GO:0009894 regulation of catabolic process 34.4828 4 yes
GO:0031175 neuron projection development 31.0345 6 yes
GO:0032880 regulation of protein localization 31.0345 5 yes
GO:0042325 regulation of phosphorylation 31.0345 7 yes
GO:0051130 positive regulation of cellular component organization 31.0345 5 yes
GO:0051252 regulation of RNA metabolic process 31.0345 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 31.0345 6 yes
GO:2001141 regulation of RNA biosynthetic process 31.0345 6 yes
GO:0006508 proteolysis 31.0345 4 no
GO:0006355 regulation of DNA-templated transcription 31.0345 7 yes
GO:0031327 negative regulation of cellular biosynthetic process 27.5862 6 yes
GO:0044087 regulation of cellular component biogenesis 27.5862 4 yes
GO:0051338 regulation of transferase activity 27.5862 4 yes
GO:1903829 positive regulation of protein localization 27.5862 5 yes
GO:0009891 positive regulation of biosynthetic process 27.5862 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 27.5862 6 no
GO:0019941 modification-dependent protein catabolic process 27.5862 6 no
GO:0031328 positive regulation of cellular biosynthetic process 27.5862 6 no
GO:0031401 positive regulation of protein modification process 27.5862 7 no
GO:0043632 modification-dependent macromolecule catabolic process 27.5862 5 no
GO:0050804 modulation of chemical synaptic transmission 27.5862 5 no
GO:0051603 proteolysis involved in protein catabolic process 27.5862 5 no
GO:0071310 cellular response to organic substance 27.5862 4 no
GO:0099177 regulation of trans-synaptic signaling 27.5862 4 no
GO:0050890 cognition 27.5862 4 no
GO:0008104 protein localization 27.5862 4 no
GO:0032446 protein modification by small protein conjugation 27.5862 7 no
GO:0043687 post-translational protein modification 27.5862 5 no
GO:0070647 protein modification by small protein conjugation or removal 27.5862 6 no
GO:1902533 positive regulation of intracellular signal transduction 27.5862 6 no
GO:0001932 regulation of protein phosphorylation 27.5862 7 yes
GO:0006796 phosphate-containing compound metabolic process 27.5862 4 yes
GO:0009890 negative regulation of biosynthetic process 27.5862 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 27.5862 6 yes
GO:0010975 regulation of neuron projection development 27.5862 7 yes
GO:0043523 regulation of neuron apoptotic process 24.1379 6 yes
GO:0043549 regulation of kinase activity 24.1379 5 yes
GO:0010243 response to organonitrogen compound 24.1379 4 no
GO:0051248 negative regulation of protein metabolic process 24.1379 6 no
GO:0060284 regulation of cell development 24.1379 5 no
GO:1901701 cellular response to oxygen-containing compound 24.1379 4 no
GO:0042127 regulation of cell population proliferation 24.1379 4 no
GO:0051240 positive regulation of multicellular organismal process 24.1379 4 no
GO:0034330 cell junction organization 24.1379 4 no
GO:0016567 protein ubiquitination 24.1379 8 no
GO:0016310 phosphorylation 24.1379 5 yes
GO:0031329 regulation of cellular catabolic process 20.6897 5 yes
GO:0045859 regulation of protein kinase activity 20.6897 6 yes
GO:0050807 regulation of synapse organization 20.6897 5 yes
GO:0051726 regulation of cell cycle 20.6897 4 yes
GO:0060627 regulation of vesicle-mediated transport 20.6897 4 yes
GO:0070201 regulation of establishment of protein localization 20.6897 6 yes
GO:0010628 positive regulation of gene expression 20.6897 7 no
GO:0031346 positive regulation of cell projection organization 20.6897 6 no
GO:0031396 regulation of protein ubiquitination 20.6897 9 no
GO:0031400 negative regulation of protein modification process 20.6897 7 no
GO:0042176 regulation of protein catabolic process 20.6897 5 no
GO:0051050 positive regulation of transport 20.6897 4 no
GO:0051093 negative regulation of developmental process 20.6897 4 no
GO:0051094 positive regulation of developmental process 20.6897 4 no
GO:0051129 negative regulation of cellular component organization 20.6897 5 no
GO:0051336 regulation of hydrolase activity 20.6897 4 no
GO:0071417 cellular response to organonitrogen compound 20.6897 4 no
GO:1901699 cellular response to nitrogen compound 20.6897 4 no
GO:1901873 regulation of post-translational protein modification 20.6897 7 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 20.6897 8 no
GO:0050767 regulation of neurogenesis 20.6897 6 no
GO:0051960 regulation of nervous system development 20.6897 5 no
GO:2000026 regulation of multicellular organismal development 20.6897 4 no
GO:0030334 regulation of cell migration 20.6897 5 no
GO:0034329 cell junction assembly 20.6897 5 no
GO:0050808 synapse organization 20.6897 5 no
GO:0071702 organic substance transport 20.6897 4 no
GO:2000145 regulation of cell motility 20.6897 4 no
GO:0010562 positive regulation of phosphorus metabolic process 20.6897 6 no
GO:0042327 positive regulation of phosphorylation 20.6897 8 no
GO:0045937 positive regulation of phosphate metabolic process 20.6897 7 no
GO:0043408 regulation of MAPK cascade 20.6897 6 no
GO:0097435 supramolecular fiber organization 20.6897 4 no
GO:0006468 protein phosphorylation 20.6897 5 yes
GO:0033043 regulation of organelle organization 17.2414 5 yes
GO:0043065 positive regulation of apoptotic process 17.2414 6 yes
GO:0043068 positive regulation of programmed cell death 17.2414 5 yes
GO:0043254 regulation of protein-containing complex assembly 17.2414 5 yes
GO:0044089 positive regulation of cellular component biogenesis 17.2414 5 yes
GO:0045892 negative regulation of DNA-templated transcription 17.2414 8 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 17.2414 5 yes
GO:0051253 negative regulation of RNA metabolic process 17.2414 6 yes
GO:1902679 negative regulation of RNA biosynthetic process 17.2414 7 yes
GO:1904951 positive regulation of establishment of protein localization 17.2414 6 yes
GO:0001764 neuron migration 17.2414 4 yes
GO:0007010 cytoskeleton organization 17.2414 5 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 17.2414 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 17.2414 5 yes
GO:0010506 regulation of autophagy 17.2414 6 yes
GO:0018193 peptidyl-amino acid modification 13.7931 5 yes
GO:0018209 peptidyl-serine modification 13.7931 6 yes
GO:0018210 peptidyl-threonine modification 13.7931 6 yes
GO:0030182 neuron differentiation 13.7931 4 yes
GO:0031334 positive regulation of protein-containing complex assembly 13.7931 6 yes
GO:0032271 regulation of protein polymerization 13.7931 6 yes
GO:0045664 regulation of neuron differentiation 13.7931 5 yes
GO:0051493 regulation of cytoskeleton organization 13.7931 6 yes
GO:1902903 regulation of supramolecular fiber organization 13.7931 5 yes
GO:0010638 positive regulation of organelle organization 13.7931 6 yes
GO:0018105 peptidyl-serine phosphorylation 13.7931 6 yes
GO:0018107 peptidyl-threonine phosphorylation 13.7931 6 yes
GO:0032273 positive regulation of protein polymerization 10.3448 7 yes
GO:0032886 regulation of microtubule-based process 10.3448 4 yes
GO:0043525 positive regulation of neuron apoptotic process 10.3448 7 yes
GO:0070507 regulation of microtubule cytoskeleton organization 10.3448 5 yes
GO:0071900 regulation of protein serine/threonine kinase activity 10.3448 7 yes
GO:1902905 positive regulation of supramolecular fiber organization 10.3448 6 yes
GO:1905475 regulation of protein localization to membrane 10.3448 6 yes
GO:1905477 positive regulation of protein localization to membrane 10.3448 6 yes
GO:0016241 regulation of macroautophagy 10.3448 7 yes
GO:0031110 regulation of microtubule polymerization or depolymerization 6.8966 6 yes
GO:0031112 positive regulation of microtubule polymerization or depolymerization 6.8966 7 yes
GO:0031113 regulation of microtubule polymerization 6.8966 6 yes
GO:0031116 positive regulation of microtubule polymerization 6.8966 7 yes
GO:0032956 regulation of actin cytoskeleton organization 6.8966 5 yes
GO:0032970 regulation of actin filament-based process 6.8966 4 yes
GO:0035235 ionotropic glutamate receptor signaling pathway 6.8966 4 yes
GO:0051495 positive regulation of cytoskeleton organization 6.8966 7 yes
GO:0061001 regulation of dendritic spine morphogenesis 6.8966 5 yes
GO:0090313 regulation of protein targeting to membrane 6.8966 7 yes
GO:0090314 positive regulation of protein targeting to membrane 6.8966 7 yes
GO:0097485 neuron projection guidance 6.8966 7 yes
GO:0098693 regulation of synaptic vesicle cycle 6.8966 5 yes
GO:0099175 regulation of postsynapse organization 6.8966 6 yes
GO:1903533 regulation of protein targeting 6.8966 7 yes
GO:1904029 regulation of cyclin-dependent protein kinase activity 6.8966 5 yes
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 6.8966 6 yes
GO:0007215 glutamate receptor signaling pathway 6.8966 4 yes
GO:0007411 axon guidance 6.8966 8 yes
GO:0007420 brain development 6.8966 4 yes
GO:0009792 embryo development ending in birth or egg hatching 6.8966 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
UBB_HUMAN [view entry] [view interactions] Low throughput yes yes
RS27A_HUMAN [view entry] [view interactions] Low throughput yes yes
RL40_HUMAN [view entry] [view interactions] Low throughput yes yes
CADH1_HUMAN [view entry] [view interactions] Low throughput yes no
CDK5_HUMAN [view entry] [view interactions] Low throughput yes yes
CDK2_HUMAN [view interactions] Low throughput no yes
PJA2_HUMAN [view entry] [view interactions] Low throughput yes yes
NEST_HUMAN [view interactions] Low throughput no no
LMTK1_HUMAN [view interactions] Low throughput no yes
FZR1_HUMAN [view interactions] Low throughput no no
SIK2_HUMAN [view interactions] Low throughput no yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
COR1A_HUMAN [view entry] [view interactions] Low throughput yes no
CDK16_HUMAN [view interactions] Low throughput no yes
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SDS3_HUMAN [view interactions] Low throughput no yes
SEPT5_HUMAN [view interactions] Low throughput no no
SET_HUMAN [view interactions] Low throughput no yes
AMPH_HUMAN [view entry] [view interactions] Low throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
HDAC1_HUMAN [view interactions] Low throughput no no
CDK3_HUMAN [view interactions] Low throughput no no
CDK4_HUMAN [view interactions] Low throughput no no
CDK6_HUMAN [view interactions] Low throughput no yes
CDK9_HUMAN [view interactions] Low throughput no yes
ODFP1_HUMAN [view interactions] Low throughput no no
GSK3B_HUMAN [view entry] [view interactions] Low throughput yes yes
DNMT1_HUMAN [view interactions] Low throughput no no
PTPRZ_HUMAN [view entry] [view interactions] Low throughput yes yes
VLDLR_HUMAN [view interactions] Low throughput no yes
CK5P2_HUMAN [view interactions] Low throughput no yes
CK5P1_HUMAN [view interactions] Low throughput no no
CK5P3_HUMAN [view entry] [view interactions] Low throughput yes yes
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
FEM1B_HUMAN [view interactions] Low throughput no yes
FEM1C_HUMAN [view interactions] Low throughput no yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DENR_HUMAN [view interactions] High throughput no yes
PLPHP_HUMAN [view interactions] High throughput no yes
HMCS1_HUMAN [view interactions] High throughput no yes
RSPRY_HUMAN [view interactions] High throughput no yes
MB12A_HUMAN [view interactions] High throughput no yes
MMAB_HUMAN [view interactions] High throughput no yes
UBE2T_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
NTRK2_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
MTUS2_HUMAN [view interactions] High throughput no yes
NT2NA_HUMAN [view interactions] High throughput no no
DNSL1_HUMAN [view interactions] High throughput no yes
NKG2A_HUMAN [view interactions] High throughput no no
EPCAM_HUMAN [view interactions] High throughput no no
MAGA2_HUMAN [view interactions] High throughput no no
M2OM_HUMAN [view entry] [view interactions] High throughput yes yes
TPX2_HUMAN [view interactions] High throughput no yes
PIAS4_HUMAN [view interactions] High throughput no yes
MYNN_HUMAN [view interactions] High throughput no no
THAP7_HUMAN [view interactions] High throughput no no
PRAM_HUMAN [view interactions] High throughput no no
RAB3C_HUMAN [view entry] [view interactions] High throughput yes yes
MFI_HUMAN [view interactions] High throughput no no
MBPHL_HUMAN [view interactions] High throughput no no
T22D4_HUMAN [view entry] [view interactions] High throughput yes no
SIAH1_HUMAN [view interactions] High throughput no yes
BL1S6_HUMAN [view interactions] High throughput no yes
K1C40_HUMAN [view interactions] High throughput no no
KR103_HUMAN [view interactions] High throughput no no
B2L13_HUMAN [view interactions] High throughput no no
TPM2_HUMAN [view entry] [view interactions] High throughput yes yes
UBXN1_HUMAN [view interactions] High throughput no no
TNIP2_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
SCRN1_HUMAN [view entry] [view interactions] High throughput yes yes
CDCA3_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes