Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TPM2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
117 Glu Ala Congenitalmyopathy23(CMYP23) -
147 Gln Pro Congenitalmyopathy23(CMYP23) -
91 Arg Gly Arthrogryposis,distal,1A(DA1A) -
41 Glu Lys Congenitalmyopathy23(CMYP23) -
133 Arg Trp Arthrogryposis,distal,1A(DA1A) -
133 Arg Trp Arthrogryposis,distal,2B4(DA2B4) -
133 Arg Trp Congenitalmyopathy23(CMYP23) -
202 Asn Lys Congenitalmyopathy23(CMYP23) -
2 Asp Val Congenitalmyopathy23(CMYP23) -
3 Ala Gly Congenitalmyopathy23(CMYP23) -
14 Asp Val Congenitalmyopathy23(CMYP23) -
93 Gln His Congenitalmyopathy23(CMYP23) -
93 Gln Arg Arthrogryposis,distal,1A(DA1A) -
117 Glu Lys Arthrogryposis,distal,1A(DA1A) -
117 Glu Lys Congenitalmyopathy23(CMYP23) -
128 Lys Glu Congenitalmyopathy23(CMYP23) -
133 Arg Pro Congenitalmyopathy23(CMYP23) -
143 Leu Pro Congenitalmyopathy23(CMYP23) -
148 Leu Pro Congenitalmyopathy23(CMYP23) -
155 Ala Thr Congenitalmyopathy23(CMYP23) -
261 Tyr Cys Arthrogryposis,distal,1A(DA1A) -
261 Tyr Cys Congenitalmyopathy23(CMYP23) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TPM2_HUMAN
GO:0003779 actin binding 42.6471 4 yes
GO:0043168 anion binding 33.8235 4 no
GO:0043169 cation binding 30.8824 4 no
GO:0046872 metal ion binding 30.8824 5 no
GO:0000166 nucleotide binding 29.4118 4 no
GO:0017076 purine nucleotide binding 29.4118 5 no
GO:0030554 adenyl nucleotide binding 29.4118 6 no
GO:0005524 ATP binding 27.9412 5 no
GO:0032555 purine ribonucleotide binding 27.9412 4 no
GO:0032559 adenyl ribonucleotide binding 27.9412 5 no
GO:0035639 purine ribonucleoside triphosphate binding 27.9412 4 no
GO:0003723 RNA binding 22.0588 4 no
GO:0042803 protein homodimerization activity 17.6471 4 yes
GO:0046982 protein heterodimerization activity 8.8235 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TPM2_HUMAN
GO:0048522 positive regulation of cellular process 60.2941 4 no
GO:0051128 regulation of cellular component organization 54.4118 4 no
GO:0006996 organelle organization 54.4118 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 42.6471 4 no
GO:0031323 regulation of cellular metabolic process 42.6471 4 no
GO:0007010 cytoskeleton organization 41.1765 5 no
GO:0080090 regulation of primary metabolic process 39.7059 4 no
GO:0022607 cellular component assembly 38.2353 4 no
GO:0033043 regulation of organelle organization 36.7647 5 no
GO:0051130 positive regulation of cellular component organization 36.7647 5 no
GO:0044087 regulation of cellular component biogenesis 33.8235 4 no
GO:0009893 positive regulation of metabolic process 33.8235 4 no
GO:0008104 protein localization 33.8235 4 no
GO:0009889 regulation of biosynthetic process 33.8235 4 no
GO:0010646 regulation of cell communication 33.8235 4 no
GO:0010468 regulation of gene expression 32.3529 6 no
GO:0010556 regulation of macromolecule biosynthetic process 32.3529 5 no
GO:0031326 regulation of cellular biosynthetic process 32.3529 5 no
GO:0031325 positive regulation of cellular metabolic process 30.8824 5 no
GO:0009966 regulation of signal transduction 30.8824 4 no
GO:0051246 regulation of protein metabolic process 29.4118 5 no
GO:0051493 regulation of cytoskeleton organization 29.4118 6 no
GO:0097435 supramolecular fiber organization 29.4118 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 29.4118 5 no
GO:0042981 regulation of apoptotic process 27.9412 5 no
GO:0043067 regulation of programmed cell death 27.9412 4 no
GO:0048584 positive regulation of response to stimulus 26.4706 4 no
GO:0051049 regulation of transport 26.4706 4 no
GO:0010647 positive regulation of cell communication 26.4706 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.4706 5 no
GO:0023056 positive regulation of signaling 26.4706 4 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0007015 actin filament organization 25.0000 5 yes
GO:1902531 regulation of intracellular signal transduction 23.5294 5 no
GO:2001141 regulation of RNA biosynthetic process 23.5294 6 no
GO:1902903 regulation of supramolecular fiber organization 23.5294 5 no
GO:0006355 regulation of DNA-templated transcription 23.5294 7 no
GO:0009891 positive regulation of biosynthetic process 23.5294 5 no
GO:0009967 positive regulation of signal transduction 23.5294 5 no
GO:0006796 phosphate-containing compound metabolic process 22.0588 4 no
GO:0009892 negative regulation of metabolic process 22.0588 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.0588 6 no
GO:0031328 positive regulation of cellular biosynthetic process 22.0588 6 no
GO:0045595 regulation of cell differentiation 20.5882 4 no
GO:0010638 positive regulation of organelle organization 20.5882 6 no
GO:0031324 negative regulation of cellular metabolic process 20.5882 5 no
GO:0032970 regulation of actin filament-based process 20.5882 4 no
GO:0051726 regulation of cell cycle 20.5882 4 no
GO:0060341 regulation of cellular localization 20.5882 4 no
GO:0051094 positive regulation of developmental process 20.5882 4 no
GO:0051050 positive regulation of transport 20.5882 4 no
GO:0051240 positive regulation of multicellular organismal process 20.5882 4 no
GO:0010605 negative regulation of macromolecule metabolic process 20.5882 5 no
GO:0031399 regulation of protein modification process 20.5882 6 no
GO:0006936 muscle contraction 11.7647 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TPM1_HUMAN [view entry] [view interactions] Low throughput yes no
TPM2_HUMAN [view entry] [view interactions] Low throughput yes yes
PDLI7_HUMAN [view entry] [view interactions] Low throughput yes no
RAD_HUMAN [view interactions] Low throughput no yes
PDLI5_HUMAN [view entry] [view interactions] Low throughput yes no
ACTS_HUMAN [view interactions] Low throughput no no
NEBU_HUMAN [view interactions] Low throughput no no
SKIL_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
MYO5C_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
ANR16_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
CALR_HUMAN [view entry] [view interactions] High throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
DYRK3_HUMAN [view interactions] High throughput no no
ULK1_HUMAN [view interactions] High throughput no no
PIM3_HUMAN [view interactions] High throughput no no
AAKG2_HUMAN [view interactions] High throughput no yes
HSPB8_HUMAN [view entry] [view interactions] High throughput yes yes
CRCM_HUMAN [view interactions] High throughput no no
EPB41_HUMAN [view entry] [view interactions] High throughput yes no
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
LRRK2_HUMAN [view interactions] High throughput no yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
BMI1_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
ZWINT_HUMAN [view entry] [view interactions] High throughput yes no
POC1B_HUMAN [view interactions] High throughput no no
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
CCD15_HUMAN [view interactions] High throughput no no
CK024_HUMAN [view interactions] High throughput no yes
SUH_HUMAN [view interactions] High throughput no yes
MAST2_HUMAN [view interactions] High throughput no yes
SNAPN_HUMAN [view interactions] High throughput no yes
TFPT_HUMAN [view interactions] High throughput no yes
MESD_HUMAN [view interactions] High throughput no yes
ABI2_HUMAN [view entry] [view interactions] High throughput yes yes
SYFM_HUMAN [view interactions] High throughput no yes
ZN620_HUMAN [view interactions] High throughput no no
MOFA1_HUMAN [view interactions] High throughput no yes
ZN785_HUMAN [view interactions] High throughput no no
ZN229_HUMAN [view interactions] High throughput no no
SP1_HUMAN [view interactions] High throughput no yes
RD23B_HUMAN [view interactions] High throughput no yes
HACE1_HUMAN [view interactions] High throughput no no
RFA3_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
MAGAA_HUMAN [view interactions] High throughput no no
EBP2_HUMAN [view interactions] High throughput no yes
EREP3_HUMAN [view interactions] High throughput no no
CF300_HUMAN [view interactions] High throughput no no
ASPDH_HUMAN [view interactions] High throughput no yes
CD5R1_HUMAN [view entry] [view interactions] High throughput yes no
CIART_HUMAN [view interactions] High throughput no yes
ZN250_HUMAN [view interactions] High throughput no yes
ADDA_HUMAN [view entry] [view interactions] High throughput yes yes
CDK2_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
MYO19_HUMAN [view interactions] High throughput no yes
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
ITA5_HUMAN [view entry] [view interactions] High throughput yes no
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
SAM50_HUMAN [view entry] [view interactions] High throughput yes yes
CALL3_HUMAN [view interactions] High throughput no yes
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
TPM4_HUMAN [view entry] [view interactions] High throughput yes yes
RC3H1_HUMAN [view interactions] High throughput no yes
S2548_HUMAN [view interactions] High throughput no no
TIM44_HUMAN [view interactions] High throughput no yes
PCGF2_HUMAN [view interactions] High throughput no no
FHR3_HUMAN [view interactions] High throughput no no
TM205_HUMAN [view interactions] High throughput no yes
WAC_HUMAN [view interactions] High throughput no yes
ZNF22_HUMAN [view interactions] High throughput no yes
H1T_HUMAN [view interactions] High throughput no no
SHCAF_HUMAN [view interactions] High throughput no yes
AKT2_HUMAN [view entry] [view interactions] High throughput yes yes
CA043_HUMAN [view interactions] High throughput no yes
ZN704_HUMAN [view interactions] High throughput no yes
SEM6D_HUMAN [view interactions] High throughput no no
ATAD1_HUMAN [view entry] [view interactions] High throughput yes yes
RIR2B_HUMAN [view interactions] High throughput no yes
LEG9C_HUMAN [view interactions] High throughput no no
CF97D_HUMAN [view interactions] High throughput no no
STOX1_HUMAN [view interactions] High throughput no yes
ST17B_HUMAN [view interactions] High throughput no yes
HYAS3_HUMAN [view interactions] High throughput no no
POTB3_HUMAN [view interactions] High throughput no no
RHBT2_HUMAN [view interactions] High throughput no no
SEPT2_HUMAN [view interactions] High throughput no no
KANL1_HUMAN [view interactions] High throughput no yes
POF1B_HUMAN [view interactions] High throughput no no
CBPC2_HUMAN [view interactions] High throughput no yes
S47A1_HUMAN [view interactions] High throughput no no
YIPF1_HUMAN [view interactions] High throughput no no
AKAP9_HUMAN [view entry] [view interactions] High throughput yes yes
NINL_HUMAN [view interactions] High throughput no yes
IPKG_HUMAN [view interactions] High throughput no yes
MITOK_HUMAN [view interactions] High throughput no yes
SCG3_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
LAP2A_HUMAN [view interactions] High throughput no yes
TNFA_HUMAN [view interactions] High throughput no no
CDK9_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
TET2_HUMAN [view interactions] High throughput no yes
AGRIN_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
PSB9_HUMAN [view interactions] High throughput no no
SCRB2_HUMAN [view interactions] High throughput no yes
VMP1_HUMAN [view interactions] High throughput no yes
GEM_HUMAN [view interactions] High throughput no yes
RN213_HUMAN [view interactions] High throughput no yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
AURKB_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
MT21E_HUMAN [view interactions] High throughput no no
INSI1_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
ISG15_HUMAN [view interactions] High throughput no no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
CCD96_HUMAN [view interactions] High throughput no no
FAM9C_HUMAN [view interactions] High throughput no no
RSH6A_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
SYCE1_HUMAN [view interactions] High throughput no no
ABTB2_HUMAN [view interactions] High throughput no yes
GOGA7_HUMAN [view interactions] High throughput no yes
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
FBXW7_HUMAN [view interactions] High throughput no yes
SIK2_HUMAN [view interactions] High throughput no yes
MYCN_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
SIR2_HUMAN [view entry] [view interactions] High throughput yes yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
DDX24_HUMAN [view interactions] High throughput no yes
ARC1B_HUMAN [view interactions] High throughput no no
RN207_HUMAN [view interactions] High throughput no no
B3GN2_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
SAHH2_HUMAN [view entry] [view interactions] High throughput yes yes
STMN1_HUMAN [view interactions] High throughput no yes
SRXN1_HUMAN [view interactions] High throughput no no
SF3B2_HUMAN [view interactions] High throughput no yes
DDB1_HUMAN [view interactions] High throughput no yes
NONO_HUMAN [view interactions] High throughput no yes
DEST_HUMAN [view entry] [view interactions] High throughput yes yes
COR1B_HUMAN [view entry] [view interactions] High throughput yes no
ST1A1_HUMAN [view interactions] High throughput no no
STAM1_HUMAN [view interactions] High throughput no yes
CPSF7_HUMAN [view interactions] High throughput no yes
RBP56_HUMAN [view interactions] High throughput no yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
DDX46_HUMAN [view interactions] High throughput no yes
DDX3X_HUMAN [view entry] [view interactions] High throughput yes yes
HECD1_HUMAN [view interactions] High throughput no yes
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
ACTN4_HUMAN [view entry] [view interactions] High throughput yes yes
KCRU_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD5_HUMAN [view interactions] High throughput no yes
ACTN2_HUMAN [view entry] [view interactions] High throughput yes yes
AT5F1_HUMAN [view interactions] High throughput no yes
BAP31_HUMAN [view interactions] High throughput no yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
CCAR1_HUMAN [view interactions] High throughput no yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
MYH3_HUMAN [view interactions] High throughput no no
MYH6_HUMAN [view entry] [view interactions] High throughput yes no
MYH7_HUMAN [view interactions] High throughput no no
MYL6_HUMAN [view entry] [view interactions] High throughput yes no
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
NADAP_HUMAN [view interactions] High throughput no yes
LA_HUMAN [view interactions] High throughput no yes
TCP4_HUMAN [view interactions] High throughput no yes
TNNI1_HUMAN [view interactions] High throughput no no
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
MACD1_HUMAN [view entry] [view interactions] High throughput yes no
NDRG2_HUMAN [view entry] [view interactions] High throughput yes yes
PFKAM_HUMAN [view entry] [view interactions] High throughput yes yes
HMGB1_HUMAN [view interactions] High throughput no yes
PSB6_HUMAN [view entry] [view interactions] High throughput yes yes
TAF6_HUMAN [view interactions] High throughput no no
SQSTM_HUMAN [view interactions] High throughput no yes