Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TPM2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
117 Glu Ala Nemalinemyopathy4(NEM4) -
147 Gln Pro Nemalinemyopathy4(NEM4) -
91 Arg Gly Arthrogryposis,distal,1A(DA1A) -
41 Glu Lys Nemalinemyopathy4(NEM4) -
133 Arg Trp Arthrogryposis,distal,1A(DA1A) -
133 Arg Trp Arthrogryposis,distal,2B4(DA2B4) -
133 Arg Trp Nemalinemyopathy4(NEM4) -
202 Asn Lys Capmyopathy2(CAPM2) -
2 Asp Val - -
3 Ala Gly Nemalinemyopathy4(NEM4) -
14 Asp Val Nemalinemyopathy4(NEM4) -
93 Gln His - -
93 Gln Arg Arthrogryposis,distal,1A(DA1A) -
117 Glu Lys Arthrogryposis,distal,1A(DA1A) -
128 Lys Glu - -
133 Arg Pro - -
143 Leu Pro Nemalinemyopathy4(NEM4) -
148 Leu Pro Nemalinemyopathy4(NEM4) -
155 Ala Thr - -
261 Tyr Cys Arthrogryposis,distal,1A(DA1A) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TPM2_HUMAN
GO:0003779 actin binding 53.0303 4 yes
GO:0046872 metal ion binding 30.3030 4 no
GO:0005524 ATP binding 24.2424 5 no
GO:0017076 purine nucleotide binding 24.2424 4 no
GO:0030554 adenyl nucleotide binding 24.2424 5 no
GO:0032555 purine ribonucleotide binding 24.2424 4 no
GO:0032559 adenyl ribonucleotide binding 24.2424 5 no
GO:0035639 purine ribonucleoside triphosphate binding 24.2424 4 no
GO:0042803 protein homodimerization activity 18.1818 4 yes
GO:0046982 protein heterodimerization activity 9.0909 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TPM2_HUMAN
GO:0048522 positive regulation of cellular process 54.5455 4 no
GO:0006996 organelle organization 51.5152 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0007010 cytoskeleton organization 42.4242 5 no
GO:0048523 negative regulation of cellular process 40.9091 4 no
GO:0022607 cellular component assembly 39.3939 4 no
GO:0033043 regulation of organelle organization 36.3636 5 no
GO:0097435 supramolecular fiber organization 34.8485 4 yes
GO:0031323 regulation of cellular metabolic process 34.8485 4 no
GO:0060255 regulation of macromolecule metabolic process 34.8485 4 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0051171 regulation of nitrogen compound metabolic process 31.8182 4 no
GO:0051493 regulation of cytoskeleton organization 31.8182 6 no
GO:0051130 positive regulation of cellular component organization 30.3030 5 no
GO:0044087 regulation of cellular component biogenesis 30.3030 4 no
GO:0007015 actin filament organization 28.7879 5 yes
GO:0008104 protein localization 28.7879 4 no
GO:0010646 regulation of cell communication 27.2727 4 no
GO:0051049 regulation of transport 27.2727 4 no
GO:0009893 positive regulation of metabolic process 25.7576 4 no
GO:0032970 regulation of actin filament-based process 25.7576 4 no
GO:0009966 regulation of signal transduction 24.2424 4 no
GO:0010468 regulation of gene expression 24.2424 5 no
GO:0032956 regulation of actin cytoskeleton organization 24.2424 5 no
GO:1902903 regulation of supramolecular fiber organization 24.2424 5 no
GO:0006936 muscle contraction 22.7273 4 yes
GO:0051050 positive regulation of transport 22.7273 4 no
GO:0051129 negative regulation of cellular component organization 22.7273 5 no
GO:0051246 regulation of protein metabolic process 22.7273 5 no
GO:0022603 regulation of anatomical structure morphogenesis 22.7273 4 no
GO:0009889 regulation of biosynthetic process 21.2121 4 no
GO:0010556 regulation of macromolecule biosynthetic process 21.2121 5 no
GO:0010604 positive regulation of macromolecule metabolic process 21.2121 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.2121 5 no
GO:0031325 positive regulation of cellular metabolic process 21.2121 5 no
GO:0031326 regulation of cellular biosynthetic process 21.2121 5 no
GO:0060341 regulation of cellular localization 21.2121 4 no
GO:0110053 regulation of actin filament organization 21.2121 6 no

Disease

Term Name % Distance from top the of the tree Annotated in TPM2_HUMAN
DOID:114 heart disease 7.5758 3 no
DOID:0050700 cardiomyopathy 6.0606 4 no
DOID:0060036 intrinsic cardiomyopathy 6.0606 5 no
DOID:3191 nemaline myopathy 4.5455 7 yes
DOID:422 congenital structural myopathy 4.5455 6 yes
DOID:423 myopathy 4.5455 5 yes
DOID:66 muscle tissue disease 4.5455 4 yes
DOID:12930 dilated cardiomyopathy 4.5455 6 no
DOID:0080000 muscular disease 4.5455 3 yes
DOID:0110932 nemaline myopathy 4 3.0303 8 yes
DOID:0111596 distal arthrogryposis type 1 3.0303 6 yes
DOID:0111597 distal arthrogryposis type 1A 3.0303 7 yes
DOID:0080326 familial hypertrophic cardiomyopathy 3.0303 7 no
DOID:11984 hypertrophic cardiomyopathy 3.0303 6 no
DOID:1247 blood coagulation disease 3.0303 3 no
DOID:2218 blood platelet disease 3.0303 4 no
DOID:0050646 distal arthrogryposis 3.0303 5 yes

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACTS_HUMAN [view interactions] Low throughput no no
NEBU_HUMAN [view interactions] Low throughput no no
TPM1_HUMAN [view entry] [view interactions] Low throughput yes no
TPM2_HUMAN [view entry] [view interactions] Low throughput yes yes
PDLI7_HUMAN [view entry] [view interactions] Low throughput yes no
RAD_HUMAN [view interactions] Low throughput no yes
PDLI5_HUMAN [view entry] [view interactions] Low throughput yes no
RIR2B_HUMAN [view interactions] High throughput no yes
LEG9C_HUMAN [view interactions] High throughput no no
CF97D_HUMAN [view interactions] High throughput no no
STOX1_HUMAN [view interactions] High throughput no yes
ST17B_HUMAN [view interactions] High throughput no yes
HYAS3_HUMAN [view interactions] High throughput no no
POTB3_HUMAN [view interactions] High throughput no no
RHBT2_HUMAN [view interactions] High throughput no no
SEPT2_HUMAN [view interactions] High throughput no no
KANL1_HUMAN [view interactions] High throughput no yes
POF1B_HUMAN [view interactions] High throughput no no
CBPC2_HUMAN [view interactions] High throughput no yes
S47A1_HUMAN [view interactions] High throughput no no
YIPF1_HUMAN [view interactions] High throughput no no
AKAP9_HUMAN [view entry] [view interactions] High throughput yes yes
NINL_HUMAN [view interactions] High throughput no yes
IPKG_HUMAN [view interactions] High throughput no yes
MITOK_HUMAN [view interactions] High throughput no yes
SCG3_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
LAP2A_HUMAN [view interactions] High throughput no yes
TNFA_HUMAN [view interactions] High throughput no no
CDK9_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
TET2_HUMAN [view interactions] High throughput no yes
AGRIN_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
PSB9_HUMAN [view interactions] High throughput no no
SCRB2_HUMAN [view interactions] High throughput no yes
VMP1_HUMAN [view interactions] High throughput no yes
GEM_HUMAN [view interactions] High throughput no yes
RN213_HUMAN [view interactions] High throughput no yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
AURKB_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
MT21E_HUMAN [view interactions] High throughput no no
INSI1_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
ISG15_HUMAN [view interactions] High throughput no no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
CCD96_HUMAN [view interactions] High throughput no no
FAM9C_HUMAN [view interactions] High throughput no no
RSH6A_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
SYCE1_HUMAN [view interactions] High throughput no no
ABTB2_HUMAN [view interactions] High throughput no yes
CF201_HUMAN [view interactions] High throughput no no
GOGA7_HUMAN [view interactions] High throughput no yes
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
FBXW7_HUMAN [view interactions] High throughput no yes
SIK2_HUMAN [view interactions] High throughput no yes
SAHH2_HUMAN [view entry] [view interactions] High throughput yes yes
STMN1_HUMAN [view interactions] High throughput no yes
SRXN1_HUMAN [view interactions] High throughput no no
SF3B2_HUMAN [view interactions] High throughput no yes
DDB1_HUMAN [view interactions] High throughput no yes
NONO_HUMAN [view interactions] High throughput no yes
DEST_HUMAN [view entry] [view interactions] High throughput yes yes
COR1B_HUMAN [view entry] [view interactions] High throughput yes no
ST1A1_HUMAN [view interactions] High throughput no no
STAM1_HUMAN [view interactions] High throughput no yes
CPSF7_HUMAN [view interactions] High throughput no yes
RBP56_HUMAN [view interactions] High throughput no yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
DDX46_HUMAN [view interactions] High throughput no yes
DDX3X_HUMAN [view entry] [view interactions] High throughput yes yes
HECD1_HUMAN [view interactions] High throughput no yes
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
ACTN4_HUMAN [view entry] [view interactions] High throughput yes yes
KCRU_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD5_HUMAN [view interactions] High throughput no yes
ACTN2_HUMAN [view entry] [view interactions] High throughput yes yes
AT5F1_HUMAN [view interactions] High throughput no yes
BAP31_HUMAN [view interactions] High throughput no yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
CCAR1_HUMAN [view interactions] High throughput no yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
MYH3_HUMAN [view interactions] High throughput no no
MYH6_HUMAN [view entry] [view interactions] High throughput yes no
MYH7_HUMAN [view interactions] High throughput no no
MYL6_HUMAN [view entry] [view interactions] High throughput yes no
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
NADAP_HUMAN [view interactions] High throughput no yes
LA_HUMAN [view interactions] High throughput no yes
TCP4_HUMAN [view interactions] High throughput no yes
TNNI1_HUMAN [view interactions] High throughput no no
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
MACD1_HUMAN [view entry] [view interactions] High throughput yes no
NDRG2_HUMAN [view entry] [view interactions] High throughput yes yes
PFKAM_HUMAN [view entry] [view interactions] High throughput yes yes
SQSTM_HUMAN [view interactions] High throughput no yes
SKIL_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
MYO5C_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
PP1B_HUMAN [view entry] [view interactions] High throughput yes yes
ANR16_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
CALR_HUMAN [view interactions] High throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
DYRK3_HUMAN [view interactions] High throughput no no
ULK1_HUMAN [view interactions] High throughput no no
PIM3_HUMAN [view interactions] High throughput no no
AAKG2_HUMAN [view interactions] High throughput no yes
HSPB8_HUMAN [view entry] [view interactions] High throughput yes yes
CRCM_HUMAN [view interactions] High throughput no no
EPB41_HUMAN [view entry] [view interactions] High throughput yes no
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
LRRK2_HUMAN [view interactions] High throughput no yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
BMI1_HUMAN [view interactions] High throughput no yes
ZWINT_HUMAN [view entry] [view interactions] High throughput yes no
POC1B_HUMAN [view interactions] High throughput no no
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
CCD15_HUMAN [view interactions] High throughput no no
CK024_HUMAN [view interactions] High throughput no yes
SUH_HUMAN [view interactions] High throughput no yes
MAST2_HUMAN [view interactions] High throughput no yes
SNAPN_HUMAN [view interactions] High throughput no yes
TFPT_HUMAN [view interactions] High throughput no yes
MESD_HUMAN [view interactions] High throughput no yes
ABI2_HUMAN [view entry] [view interactions] High throughput yes yes
SYFM_HUMAN [view interactions] High throughput no yes
ZN620_HUMAN [view interactions] High throughput no no
MOFA1_HUMAN [view interactions] High throughput no yes
ZN785_HUMAN [view interactions] High throughput no no
ZN229_HUMAN [view interactions] High throughput no no
SP1_HUMAN [view interactions] High throughput no yes
RD23B_HUMAN [view interactions] High throughput no yes
HACE1_HUMAN [view interactions] High throughput no no
RFA3_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
MAGAA_HUMAN [view interactions] High throughput no no
EBP2_HUMAN [view interactions] High throughput no yes
F189B_HUMAN [view interactions] High throughput no no
CF300_HUMAN [view interactions] High throughput no no
ASPD_HUMAN [view interactions] High throughput no yes
CD5R1_HUMAN [view entry] [view interactions] High throughput yes no
CIART_HUMAN [view interactions] High throughput no yes
ZN250_HUMAN [view interactions] High throughput no yes
ADDA_HUMAN [view entry] [view interactions] High throughput yes yes
CDK2_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
MYO19_HUMAN [view interactions] High throughput no yes
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
ITA5_HUMAN [view entry] [view interactions] High throughput yes no
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
SAM50_HUMAN [view entry] [view interactions] High throughput yes yes
CALL3_HUMAN [view interactions] High throughput no yes
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
TPM4_HUMAN [view entry] [view interactions] High throughput yes yes
RC3H1_HUMAN [view interactions] High throughput no yes
S2548_HUMAN [view interactions] High throughput no no
TIM44_HUMAN [view interactions] High throughput no yes
PCGF2_HUMAN [view interactions] High throughput no no
FHR3_HUMAN [view interactions] High throughput no no
TM205_HUMAN [view interactions] High throughput no yes
WAC_HUMAN [view interactions] High throughput no yes
ZNF22_HUMAN [view interactions] High throughput no yes
H1T_HUMAN [view interactions] High throughput no no
SHCAF_HUMAN [view interactions] High throughput no yes
AKT2_HUMAN [view entry] [view interactions] High throughput yes yes
CA043_HUMAN [view interactions] High throughput no yes
ZN704_HUMAN [view interactions] High throughput no yes
SEM6D_HUMAN [view interactions] High throughput no no
ATAD1_HUMAN [view entry] [view interactions] High throughput yes yes
MYL6B_HUMAN [view entry] [view interactions] Computational yes no
MYL10_HUMAN [view interactions] Computational no no
TNNT3_HUMAN [view interactions] Computational no no
MYL9_HUMAN [view interactions] Computational no no
MLRS_HUMAN [view interactions] Computational no no
TMOD4_HUMAN [view interactions] Computational no no
ACTC_HUMAN [view interactions] Computational no no
TNNT1_HUMAN [view interactions] Computational no no
ML12B_HUMAN [view interactions] Computational no no
MYL1_HUMAN [view interactions] Computational no no
TNNI3_HUMAN [view interactions] Computational no no
ACTH_HUMAN [view interactions] Computational no no
MLRV_HUMAN [view interactions] Computational no no
MYL4_HUMAN [view entry] [view interactions] Computational yes no
TNNT2_HUMAN [view interactions] Computational no no
TNNC2_HUMAN [view interactions] Computational no no
VINC_HUMAN [view entry] [view interactions] Computational yes no
MYL3_HUMAN [view interactions] Computational no no
MYH8_HUMAN [view interactions] Computational no no
TMOD2_HUMAN [view entry] [view interactions] Computational yes yes
MYL5_HUMAN [view interactions] Computational no no
CALD1_HUMAN [view entry] [view interactions] Computational yes no
ML12A_HUMAN [view interactions] Computational no no
MYLK_HUMAN [view interactions] Computational no no
TMOD3_HUMAN [view interactions] Computational no yes
MLRA_HUMAN [view interactions] Computational no no
MYPC1_HUMAN [view interactions] Computational no no
TMOD1_HUMAN [view entry] [view interactions] Computational yes yes
TNNI2_HUMAN [view interactions] Computational no no
MYH11_HUMAN [view entry] [view interactions] Computational yes no