HSPB8_HUMAN
Evidence for PS localization
Functions
Displays temperature-dependent chaperone activity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 141 | Lys | Glu | Neuronopathy,distalhereditarymotor,2A(HMN2A) | - |
| 141 | Lys | Asn | Neuronopathy,distalhereditarymotor,2A(HMN2A) | - |
| 90 | Pro | Leu | Neuronopathy,distalhereditarymotor,2A(HMN2A) | - |
| 138 | Asn | Thr | Neuronopathy,distalhereditarymotor,2A(HMN2A) | - |
| 141 | Lys | Met | Neuronopathy,distalhereditarymotor,2A(HMN2A) | - |
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001425 | MOD_PKA_2 | MOD | 54 | 60 | - |
| ELMI001425 | MOD_PKA_2 | MOD | 54 | 60 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in HSPB8_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 28.5714 | 4 | no |
| GO:0043168 | anion binding | 28.5714 | 4 | no |
| GO:0000166 | nucleotide binding | 23.8095 | 4 | no |
| GO:0043169 | cation binding | 23.8095 | 4 | no |
| GO:0046872 | metal ion binding | 23.8095 | 5 | no |
| GO:0017076 | purine nucleotide binding | 21.4286 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 21.4286 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.4286 | 4 | no |
| GO:0042803 | protein homodimerization activity | 19.0476 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in HSPB8_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 42.8571 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 40.4762 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 38.0952 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 28.5714 | 4 | no |
| GO:0010646 | regulation of cell communication | 28.5714 | 4 | no |
| GO:0008104 | protein localization | 26.1905 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 26.1905 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 26.1905 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.8095 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 23.8095 | 4 | no |
| GO:0051049 | regulation of transport | 23.8095 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 23.8095 | 4 | no |
| GO:0010468 | regulation of gene expression | 23.8095 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.8095 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.8095 | 5 | no |
| GO:0022607 | cellular component assembly | 23.8095 | 4 | no |
| GO:0009894 | regulation of catabolic process | 21.4286 | 4 | yes |
| GO:0071702 | organic substance transport | 21.4286 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.4286 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 21.4286 | 5 | no |
| GO:0009966 | regulation of signal transduction | 21.4286 | 4 | no |
| GO:0007010 | cytoskeleton organization | 21.4286 | 5 | no |
| GO:0060341 | regulation of cellular localization | 21.4286 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 19.0476 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 19.0476 | 5 | yes |
| GO:0010506 | regulation of autophagy | 16.6667 | 6 | yes |
| GO:0031329 | regulation of cellular catabolic process | 16.6667 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 11.9048 | 4 | yes |
| GO:0006986 | response to unfolded protein | 9.5238 | 4 | yes |
| GO:0009896 | positive regulation of catabolic process | 9.5238 | 5 | yes |
| GO:0016241 | regulation of macroautophagy | 9.5238 | 7 | yes |
| GO:0031331 | positive regulation of cellular catabolic process | 9.5238 | 6 | yes |
| GO:0010508 | positive regulation of autophagy | 7.1429 | 7 | yes |
| GO:0016239 | positive regulation of macroautophagy | 7.1429 | 8 | yes |
| GO:0034620 | cellular response to unfolded protein | 7.1429 | 5 | yes |
| GO:0035967 | cellular response to topologically incorrect protein | 7.1429 | 4 | yes |
| GO:1905335 | regulation of aggrephagy | 7.1429 | 8 | yes |
| GO:1905337 | positive regulation of aggrephagy | 7.1429 | 9 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CRYAB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HSPB3_HUMAN | [view interactions] | Low throughput | no | no |
| HSPB6_HUMAN | [view interactions] | Low throughput | no | no |
| HSPB8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HSPB7_HUMAN | [view interactions] | Low throughput | no | yes |
| HSPB2_HUMAN | [view interactions] | Low throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BAG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NOD1_HUMAN | [view interactions] | Low throughput | no | no |
| NOD2_HUMAN | [view interactions] | Low throughput | no | yes |
| E2AK1_HUMAN | [view interactions] | Low throughput | no | yes |
| DNJB6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KIF11_HUMAN | [view interactions] | High throughput | no | yes |
| TIM_HUMAN | [view interactions] | High throughput | no | yes |
| TTL12_HUMAN | [view interactions] | High throughput | no | yes |
| SMHD1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| RFX1_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA2_HUMAN | [view interactions] | High throughput | no | no |
| EF1A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LONF2_HUMAN | [view interactions] | High throughput | no | yes |
| FA83H_HUMAN | [view interactions] | High throughput | no | yes |
| ACD11_HUMAN | [view interactions] | High throughput | no | yes |
| NUD12_HUMAN | [view interactions] | High throughput | no | yes |
| SETD2_HUMAN | [view interactions] | High throughput | no | yes |
| BACD1_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| G3PT_HUMAN | [view interactions] | High throughput | no | no |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| P73_HUMAN | [view interactions] | High throughput | no | no |
| CIAO1_HUMAN | [view interactions] | High throughput | no | yes |
| STAT_HUMAN | [view interactions] | High throughput | no | no |
| MYL1_HUMAN | [view interactions] | High throughput | no | no |
| PYGL_HUMAN | [view interactions] | High throughput | no | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH3_HUMAN | [view interactions] | High throughput | no | no |
| PYGB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PYGM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH1_HUMAN | [view interactions] | High throughput | no | no |
| MYH6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH8_HUMAN | [view interactions] | High throughput | no | no |
| ENOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| IQGA2_HUMAN | [view interactions] | High throughput | no | yes |
| MLF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR81_HUMAN | [view interactions] | High throughput | no | no |
| DJC10_HUMAN | [view interactions] | High throughput | no | yes |
| EXPH5_HUMAN | [view interactions] | High throughput | no | no |
| TITIN_HUMAN | [view interactions] | High throughput | no | no |
| MYL11_HUMAN | [view interactions] | High throughput | no | no |
| ZCHC3_HUMAN | [view interactions] | High throughput | no | no |
| MYH2_HUMAN | [view interactions] | High throughput | no | yes |
| AKP8L_HUMAN | [view interactions] | High throughput | no | yes |
| MYH4_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| QRIC1_HUMAN | [view interactions] | High throughput | no | yes |
| DUS12_HUMAN | [view interactions] | High throughput | no | no |
| SOCS7_HUMAN | [view interactions] | High throughput | no | yes |
| ATOSB_HUMAN | [view interactions] | High throughput | no | yes |
| MOT6_HUMAN | [view interactions] | High throughput | no | no |
| MISP_HUMAN | [view interactions] | High throughput | no | no |
| RPIA_HUMAN | [view interactions] | High throughput | no | yes |
| CTSRT_HUMAN | [view interactions] | High throughput | no | no |
| TPC6A_HUMAN | [view interactions] | High throughput | no | yes |
| AT7L2_HUMAN | [view interactions] | High throughput | no | yes |
| ASB4_HUMAN | [view interactions] | High throughput | no | no |
| ZNF92_HUMAN | [view interactions] | High throughput | no | no |
| ALMS1_HUMAN | [view interactions] | High throughput | no | no |
| WDR20_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
| DLGP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP12_HUMAN | [view interactions] | High throughput | no | yes |
| TF2L1_HUMAN | [view interactions] | High throughput | no | yes |
| IRAK3_HUMAN | [view interactions] | High throughput | no | yes |
| JAK1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG4_HUMAN | [view interactions] | High throughput | no | no |
| TONSL_HUMAN | [view interactions] | High throughput | no | no |
| VPS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXK2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP34_HUMAN | [view interactions] | High throughput | no | yes |
| ARAP3_HUMAN | [view interactions] | High throughput | no | no |
| CD11A_HUMAN | [view interactions] | High throughput | no | yes |
| BIG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAB2_HUMAN | [view interactions] | High throughput | no | yes |
| VIP1_HUMAN | [view interactions] | High throughput | no | yes |
| SUN1_HUMAN | [view interactions] | High throughput | no | yes |
| RHDF2_HUMAN | [view interactions] | High throughput | no | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| GCP6_HUMAN | [view interactions] | High throughput | no | yes |
| TF7L2_HUMAN | [view interactions] | High throughput | no | yes |
| CTF18_HUMAN | [view interactions] | High throughput | no | no |
| IF140_HUMAN | [view interactions] | High throughput | no | yes |
| KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKP2_HUMAN | [view interactions] | High throughput | no | yes |
| CPNE2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN195_HUMAN | [view interactions] | High throughput | no | yes |
| IF122_HUMAN | [view interactions] | High throughput | no | yes |
| DPOE1_HUMAN | [view interactions] | High throughput | no | no |
| RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQEC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKA11_HUMAN | [view interactions] | High throughput | no | yes |
| APAF_HUMAN | [view interactions] | High throughput | no | no |
| SYF1_HUMAN | [view interactions] | High throughput | no | no |
| NACC2_HUMAN | [view interactions] | High throughput | no | yes |
| RGPD8_HUMAN | [view interactions] | High throughput | no | no |
| SAV1_HUMAN | [view interactions] | High throughput | no | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| TBB8_HUMAN | [view interactions] | High throughput | no | no |
| RIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSB10_HUMAN | [view interactions] | High throughput | no | no |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIPK1_HUMAN | [view interactions] | High throughput | no | yes |
| TBD2B_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS5_HUMAN | [view interactions] | High throughput | no | yes |
| PMVK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EHMT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLH34_HUMAN | [view interactions] | High throughput | no | no |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DJC13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIB1_HUMAN | [view interactions] | High throughput | no | no |
| DAAF5_HUMAN | [view interactions] | High throughput | no | no |
| RGL3_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHGA_HUMAN | [view interactions] | High throughput | no | yes |
| MYO9B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPOD1_HUMAN | [view interactions] | High throughput | no | yes |
| ERF_HUMAN | [view interactions] | High throughput | no | yes |
| KNL1_HUMAN | [view interactions] | High throughput | no | no |
| BLTP2_HUMAN | [view interactions] | High throughput | no | yes |
| ESRP2_HUMAN | [view interactions] | High throughput | no | yes |
| APC5_HUMAN | [view interactions] | High throughput | no | yes |
| ZER1_HUMAN | [view interactions] | High throughput | no | no |
| MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETV3_HUMAN | [view interactions] | High throughput | no | yes |
| ASCC3_HUMAN | [view interactions] | High throughput | no | yes |
| TF2H2_HUMAN | [view interactions] | High throughput | no | no |
| DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KLD10_HUMAN | [view interactions] | High throughput | no | yes |
| AHR_HUMAN | [view interactions] | High throughput | no | yes |
| FRMD5_HUMAN | [view interactions] | High throughput | no | no |
| ZBT20_HUMAN | [view interactions] | High throughput | no | yes |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| ABCF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCA10_HUMAN | [view interactions] | High throughput | no | no |
| RGPD5_HUMAN | [view interactions] | High throughput | no | no |
| FOXA1_HUMAN | [view interactions] | High throughput | no | no |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN207_HUMAN | [view interactions] | High throughput | no | no |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| CPIN1_HUMAN | [view interactions] | High throughput | no | no |
| DEST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHLB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| R113A_HUMAN | [view interactions] | High throughput | no | yes |