HSPB8_HUMAN
Evidence for PS localization
Functions
Displays temperature-dependent chaperone activity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 141 | Lys | Glu | Neuronopathy,distalhereditarymotor,2A(HMN2A) | - |
| 141 | Lys | Asn | Neuronopathy,distalhereditarymotor,2A(HMN2A) | - |
| 90 | Pro | Leu | Neuronopathy,distalhereditarymotor,2A(HMN2A) | - |
| 138 | Asn | Thr | Neuronopathy,distalhereditarymotor,2A(HMN2A) | - |
| 141 | Lys | Met | Neuronopathy,distalhereditarymotor,2A(HMN2A) | - |
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001425 | MOD_PKA_2 | MOD | 54 | 60 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in HSPB8_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 32.6531 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 30.6122 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.6122 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 28.5714 | 5 | no |
| GO:0005524 | ATP binding | 26.5306 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 26.5306 | 5 | no |
| GO:0042803 | protein homodimerization activity | 22.4490 | 4 | yes |
| GO:0003779 | actin binding | 22.4490 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in HSPB8_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 44.8980 | 4 | yes |
| GO:0006996 | organelle organization | 42.8571 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.8163 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 38.7755 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 38.7755 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 36.7347 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.7347 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 34.6939 | 4 | no |
| GO:0010468 | regulation of gene expression | 32.6531 | 5 | no |
| GO:0010646 | regulation of cell communication | 32.6531 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.6122 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.6122 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 30.6122 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.5714 | 5 | no |
| GO:0051049 | regulation of transport | 28.5714 | 4 | no |
| GO:0009966 | regulation of signal transduction | 26.5306 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.5306 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 26.5306 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 26.5306 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 26.5306 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 24.4898 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 24.4898 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 24.4898 | 6 | no |
| GO:0008104 | protein localization | 24.4898 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 24.4898 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 24.4898 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.4898 | 5 | no |
| GO:0010941 | regulation of cell death | 24.4898 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 24.4898 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.4898 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 24.4898 | 5 | no |
| GO:0060341 | regulation of cellular localization | 24.4898 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.4898 | 5 | no |
| GO:0006986 | response to unfolded protein | 24.4898 | 4 | yes |
| GO:0031329 | regulation of cellular catabolic process | 24.4898 | 5 | yes |
| GO:0022607 | cellular component assembly | 24.4898 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 24.4898 | 6 | no |
| GO:0071702 | organic substance transport | 22.4490 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.4490 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.4490 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 22.4490 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.4490 | 5 | yes |
| GO:0015031 | protein transport | 20.4082 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.4082 | 5 | no |
| GO:0043933 | protein-containing complex organization | 20.4082 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.4082 | 4 | no |
| GO:0009896 | positive regulation of catabolic process | 16.3265 | 5 | yes |
| GO:0035967 | cellular response to topologically incorrect protein | 16.3265 | 4 | yes |
| GO:0010506 | regulation of autophagy | 14.2857 | 6 | yes |
| GO:0031331 | positive regulation of cellular catabolic process | 14.2857 | 6 | yes |
| GO:0034620 | cellular response to unfolded protein | 14.2857 | 5 | yes |
| GO:0016241 | regulation of macroautophagy | 8.1633 | 7 | yes |
| GO:0010508 | positive regulation of autophagy | 6.1224 | 7 | yes |
| GO:0016239 | positive regulation of macroautophagy | 6.1224 | 8 | yes |
| GO:1905335 | regulation of aggrephagy | 6.1224 | 8 | yes |
| GO:1905337 | positive regulation of aggrephagy | 6.1224 | 9 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in HSPB8_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 10.2041 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 10.2041 | 5 | no |
| DOID:114 | heart disease | 10.2041 | 3 | no |
| DOID:12930 | dilated cardiomyopathy | 10.2041 | 6 | no |
| DOID:0080000 | muscular disease | 8.1633 | 3 | no |
| DOID:423 | myopathy | 8.1633 | 5 | no |
| DOID:66 | muscle tissue disease | 8.1633 | 4 | no |
| DOID:0111198 | autosomal dominant distal hereditary motor neuronopathy | 6.1224 | 7 | yes |
| DOID:0111206 | distal hereditary motor neuronopathy type 2 | 6.1224 | 8 | yes |
| DOID:12377 | spinal muscular atrophy | 6.1224 | 6 | yes |
| DOID:1289 | neurodegenerative disease | 6.1224 | 4 | yes |
| DOID:231 | motor neuron disease | 6.1224 | 5 | yes |
| DOID:331 | central nervous system disease | 6.1224 | 3 | yes |
| DOID:0111208 | distal hereditary motor neuronopathy type 2A | 4.0816 | 9 | yes |
| DOID:3191 | nemaline myopathy | 4.0816 | 7 | no |
| DOID:422 | congenital structural myopathy | 4.0816 | 6 | no |
| DOID:0080307 | myofibrillar myopathy | 4.0816 | 6 | no |
| DOID:0080326 | familial hypertrophic cardiomyopathy | 4.0816 | 7 | no |
| DOID:11984 | hypertrophic cardiomyopathy | 4.0816 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CRYAB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HSPB3_HUMAN | [view interactions] | Low throughput | no | no |
| HSPB6_HUMAN | [view interactions] | Low throughput | no | no |
| HSPB8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HSPB7_HUMAN | [view interactions] | Low throughput | no | yes |
| HSPB2_HUMAN | [view interactions] | Low throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BAG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NOD1_HUMAN | [view interactions] | Low throughput | no | no |
| NOD2_HUMAN | [view interactions] | Low throughput | no | yes |
| E2AK1_HUMAN | [view interactions] | Low throughput | no | yes |
| DNJB6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| JAK1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG4_HUMAN | [view interactions] | High throughput | no | no |
| TONSL_HUMAN | [view interactions] | High throughput | no | no |
| VPS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXK2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP34_HUMAN | [view interactions] | High throughput | no | yes |
| ARAP3_HUMAN | [view interactions] | High throughput | no | no |
| CD11A_HUMAN | [view interactions] | High throughput | no | yes |
| BIG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAB2_HUMAN | [view interactions] | High throughput | no | yes |
| VIP1_HUMAN | [view interactions] | High throughput | no | yes |
| SUN1_HUMAN | [view interactions] | High throughput | no | yes |
| RHDF2_HUMAN | [view interactions] | High throughput | no | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| GCP6_HUMAN | [view interactions] | High throughput | no | yes |
| TF7L2_HUMAN | [view interactions] | High throughput | no | yes |
| CTF18_HUMAN | [view interactions] | High throughput | no | no |
| IF140_HUMAN | [view interactions] | High throughput | no | yes |
| KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKP2_HUMAN | [view interactions] | High throughput | no | yes |
| CPNE2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN195_HUMAN | [view interactions] | High throughput | no | yes |
| IF122_HUMAN | [view interactions] | High throughput | no | yes |
| DPOE1_HUMAN | [view interactions] | High throughput | no | no |
| RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQEC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKA11_HUMAN | [view interactions] | High throughput | no | yes |
| APAF_HUMAN | [view interactions] | High throughput | no | no |
| SYF1_HUMAN | [view interactions] | High throughput | no | no |
| NACC2_HUMAN | [view interactions] | High throughput | no | yes |
| RGPD8_HUMAN | [view interactions] | High throughput | no | no |
| SAV1_HUMAN | [view interactions] | High throughput | no | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| TBB8_HUMAN | [view interactions] | High throughput | no | no |
| RIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSB10_HUMAN | [view interactions] | High throughput | no | no |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIPK1_HUMAN | [view interactions] | High throughput | no | yes |
| TBD2B_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS5_HUMAN | [view interactions] | High throughput | no | yes |
| PMVK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EHMT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLH34_HUMAN | [view interactions] | High throughput | no | no |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DJC13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIB1_HUMAN | [view interactions] | High throughput | no | no |
| DAAF5_HUMAN | [view interactions] | High throughput | no | no |
| RGL3_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHGA_HUMAN | [view interactions] | High throughput | no | yes |
| MYO9B_HUMAN | [view interactions] | High throughput | no | yes |
| DPOD1_HUMAN | [view interactions] | High throughput | no | yes |
| ERF_HUMAN | [view interactions] | High throughput | no | yes |
| KNL1_HUMAN | [view interactions] | High throughput | no | no |
| K0100_HUMAN | [view interactions] | High throughput | no | yes |
| ESRP2_HUMAN | [view interactions] | High throughput | no | yes |
| APC5_HUMAN | [view interactions] | High throughput | no | yes |
| ZER1_HUMAN | [view interactions] | High throughput | no | no |
| MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETV3_HUMAN | [view interactions] | High throughput | no | yes |
| ASCC3_HUMAN | [view interactions] | High throughput | no | yes |
| TF2H2_HUMAN | [view interactions] | High throughput | no | no |
| DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KLD10_HUMAN | [view interactions] | High throughput | no | yes |
| AHR_HUMAN | [view interactions] | High throughput | no | yes |
| FRMD5_HUMAN | [view interactions] | High throughput | no | no |
| ZBT20_HUMAN | [view interactions] | High throughput | no | yes |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| ABCF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCA10_HUMAN | [view interactions] | High throughput | no | no |
| RGPD5_HUMAN | [view interactions] | High throughput | no | no |
| CPIN1_HUMAN | [view interactions] | High throughput | no | no |
| DEST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHLB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF11_HUMAN | [view interactions] | High throughput | no | yes |
| TIM_HUMAN | [view interactions] | High throughput | no | yes |
| TTL12_HUMAN | [view interactions] | High throughput | no | yes |
| SMHD1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| SETD2_HUMAN | [view interactions] | High throughput | no | yes |
| NUD12_HUMAN | [view interactions] | High throughput | no | yes |
| ACD11_HUMAN | [view interactions] | High throughput | no | yes |
| FA83H_HUMAN | [view interactions] | High throughput | no | yes |
| LONF2_HUMAN | [view interactions] | High throughput | no | yes |
| EF1A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRCA2_HUMAN | [view interactions] | High throughput | no | no |
| RFX1_HUMAN | [view interactions] | High throughput | no | yes |
| BACD1_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH4_HUMAN | [view interactions] | High throughput | no | no |
| AKP8L_HUMAN | [view interactions] | High throughput | no | yes |
| MYH2_HUMAN | [view interactions] | High throughput | no | yes |
| ZCHC3_HUMAN | [view interactions] | High throughput | no | no |
| MLRS_HUMAN | [view interactions] | High throughput | no | no |
| TITIN_HUMAN | [view interactions] | High throughput | no | no |
| EXPH5_HUMAN | [view interactions] | High throughput | no | no |
| DJC10_HUMAN | [view interactions] | High throughput | no | yes |
| WDR81_HUMAN | [view interactions] | High throughput | no | no |
| MLF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH8_HUMAN | [view interactions] | High throughput | no | no |
| MYH6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH1_HUMAN | [view interactions] | High throughput | no | no |
| PYGM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PYGB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH3_HUMAN | [view interactions] | High throughput | no | no |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYGL_HUMAN | [view interactions] | High throughput | no | yes |
| MYL1_HUMAN | [view interactions] | High throughput | no | no |
| STAT_HUMAN | [view interactions] | High throughput | no | no |
| CIAO1_HUMAN | [view interactions] | High throughput | no | yes |
| P73_HUMAN | [view interactions] | High throughput | no | no |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| G3PT_HUMAN | [view interactions] | High throughput | no | no |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| QRIC1_HUMAN | [view interactions] | High throughput | no | yes |
| DUS12_HUMAN | [view interactions] | High throughput | no | no |
| SOCS7_HUMAN | [view interactions] | High throughput | no | yes |
| F214B_HUMAN | [view interactions] | High throughput | no | yes |
| MOT6_HUMAN | [view interactions] | High throughput | no | no |
| MISP_HUMAN | [view interactions] | High throughput | no | no |
| RPIA_HUMAN | [view interactions] | High throughput | no | yes |
| C2CD6_HUMAN | [view interactions] | High throughput | no | no |
| TPC6A_HUMAN | [view interactions] | High throughput | no | yes |
| AT7L2_HUMAN | [view interactions] | High throughput | no | yes |
| ASB4_HUMAN | [view interactions] | High throughput | no | no |
| ZNF92_HUMAN | [view interactions] | High throughput | no | no |
| ALMS1_HUMAN | [view interactions] | High throughput | no | no |
| WDR20_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
| DLGP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP12_HUMAN | [view interactions] | High throughput | no | yes |
| TF2L1_HUMAN | [view interactions] | High throughput | no | yes |
| IRAK3_HUMAN | [view interactions] | High throughput | no | yes |
| DDX20_HUMAN | [view interactions] | Computational | no | no |
| DNJB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HSBP1_HUMAN | [view interactions] | Computational | no | no |
| HS71L_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| HSF1_HUMAN | [view interactions] | Computational | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CHIP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HSP74_HUMAN | [view entry] [view interactions] | Computational | yes | yes |