PMVK_HUMAN
Evidence for PS localization
Functions
Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PMVK_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 30.4348 | 4 | yes |
| GO:0000166 | nucleotide binding | 21.7391 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 21.7391 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 21.7391 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.7391 | 4 | yes |
| GO:0043169 | cation binding | 21.7391 | 4 | no |
| GO:0005524 | ATP binding | 13.0435 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 13.0435 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 13.0435 | 5 | yes |
| GO:0004631 | phosphomevalonate kinase activity | 8.6957 | 5 | yes |
| GO:0016301 | kinase activity | 8.6957 | 4 | yes |
| GO:0016776 | phosphotransferase activity, phosphate group as acceptor | 8.6957 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PMVK_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 39.1304 | 4 | no |
| GO:0006996 | organelle organization | 34.7826 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 30.4348 | 4 | no |
| GO:0010646 | regulation of cell communication | 30.4348 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 26.0870 | 4 | no |
| GO:0014070 | response to organic cyclic compound | 26.0870 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 26.0870 | 4 | no |
| GO:0071702 | organic substance transport | 26.0870 | 4 | no |
| GO:0009966 | regulation of signal transduction | 26.0870 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 26.0870 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.0870 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.0870 | 5 | no |
| GO:0008104 | protein localization | 26.0870 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 26.0870 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.0870 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.0870 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.0870 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 26.0870 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 21.7391 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 21.7391 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.7391 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 21.7391 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 21.7391 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 17.3913 | 4 | yes |
| GO:0033993 | response to lipid | 17.3913 | 4 | yes |
| GO:0046165 | alcohol biosynthetic process | 17.3913 | 4 | yes |
| GO:1901617 | organic hydroxy compound biosynthetic process | 17.3913 | 4 | yes |
| GO:0006644 | phospholipid metabolic process | 13.0435 | 4 | yes |
| GO:0006694 | steroid biosynthetic process | 13.0435 | 5 | yes |
| GO:0006695 | cholesterol biosynthetic process | 13.0435 | 6 | yes |
| GO:0008202 | steroid metabolic process | 13.0435 | 4 | yes |
| GO:0008203 | cholesterol metabolic process | 13.0435 | 5 | yes |
| GO:0008610 | lipid biosynthetic process | 13.0435 | 4 | yes |
| GO:0008654 | phospholipid biosynthetic process | 13.0435 | 5 | yes |
| GO:0016125 | sterol metabolic process | 13.0435 | 4 | yes |
| GO:0016126 | sterol biosynthetic process | 13.0435 | 5 | yes |
| GO:0090407 | organophosphate biosynthetic process | 13.0435 | 4 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 13.0435 | 4 | yes |
| GO:1902652 | secondary alcohol metabolic process | 13.0435 | 4 | yes |
| GO:1902653 | secondary alcohol biosynthetic process | 13.0435 | 5 | yes |
| GO:0006084 | acetyl-CoA metabolic process | 8.6957 | 4 | yes |
| GO:0006163 | purine nucleotide metabolic process | 8.6957 | 5 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 8.6957 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 8.6957 | 5 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 8.6957 | 6 | yes |
| GO:0009240 | isopentenyl diphosphate biosynthetic process | 8.6957 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 8.6957 | 5 | yes |
| GO:0016310 | phosphorylation | 8.6957 | 5 | yes |
| GO:0019287 | isopentenyl diphosphate biosynthetic process, mevalonate pathway | 8.6957 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 8.6957 | 4 | yes |
| GO:0033865 | nucleoside bisphosphate metabolic process | 8.6957 | 5 | yes |
| GO:0033875 | ribonucleoside bisphosphate metabolic process | 8.6957 | 6 | yes |
| GO:0034032 | purine nucleoside bisphosphate metabolic process | 8.6957 | 5 | yes |
| GO:0036314 | response to sterol | 8.6957 | 4 | yes |
| GO:0046490 | isopentenyl diphosphate metabolic process | 8.6957 | 5 | yes |
| GO:0070723 | response to cholesterol | 8.6957 | 5 | yes |
| GO:0072521 | purine-containing compound metabolic process | 8.6957 | 4 | yes |
| GO:0097305 | response to alcohol | 8.6957 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| HSPB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZC3C1_HUMAN | [view interactions] | High throughput | no | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| PLBL1_HUMAN | [view interactions] | High throughput | no | no |
| SARAF_HUMAN | [view interactions] | High throughput | no | no |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCD14_HUMAN | [view interactions] | High throughput | no | no |
| PSG11_HUMAN | [view interactions] | High throughput | no | no |
| UPK1A_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| MABP1_HUMAN | [view interactions] | High throughput | no | yes |
| CATL2_HUMAN | [view interactions] | High throughput | no | yes |
| DUS14_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR5_HUMAN | [view interactions] | High throughput | no | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10A7_HUMAN | [view interactions] | High throughput | no | no |
| PIP_HUMAN | [view interactions] | High throughput | no | no |
| SAP_HUMAN | [view interactions] | High throughput | no | yes |
| CND2_HUMAN | [view interactions] | High throughput | no | no |
| VPS25_HUMAN | [view interactions] | High throughput | no | yes |
| NUP88_HUMAN | [view interactions] | High throughput | no | yes |
| KRA32_HUMAN | [view interactions] | High throughput | no | no |
| COG3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSM7_HUMAN | [view interactions] | High throughput | no | yes |
| DSC1_HUMAN | [view interactions] | High throughput | no | no |
| PKP1_HUMAN | [view interactions] | High throughput | no | no |
| BLMH_HUMAN | [view interactions] | High throughput | no | yes |
| DSG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FPPS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PMVK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| DAA10_HUMAN | [view interactions] | High throughput | no | yes |
| UBFD1_HUMAN | [view interactions] | High throughput | no | no |
| PTPRF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THOP1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR4_HUMAN | [view interactions] | High throughput | no | no |
| KIME_HUMAN | [view interactions] | High throughput | no | yes |
| TRI29_HUMAN | [view interactions] | High throughput | no | no |
| LSM12_HUMAN | [view interactions] | High throughput | no | yes |
| PREP_HUMAN | [view interactions] | High throughput | no | yes |
| RAB12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTNA_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| SNR27_HUMAN | [view interactions] | High throughput | no | yes |
| UIF_HUMAN | [view interactions] | High throughput | no | yes |
| ODAPH_HUMAN | [view interactions] | High throughput | no | no |
| ANF_HUMAN | [view interactions] | High throughput | no | no |
| S2532_HUMAN | [view interactions] | High throughput | no | yes |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FSD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AR6P6_HUMAN | [view interactions] | High throughput | no | yes |
| RDH12_HUMAN | [view interactions] | High throughput | no | no |
| SCNM1_HUMAN | [view interactions] | High throughput | no | no |
| SETD3_HUMAN | [view interactions] | High throughput | no | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| RGS20_HUMAN | [view interactions] | High throughput | no | no |
| TBPL1_HUMAN | [view interactions] | High throughput | no | yes |
| LA_HUMAN | [view interactions] | High throughput | no | yes |
| MPU1_HUMAN | [view interactions] | High throughput | no | yes |
| MLF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CENPH_HUMAN | [view interactions] | High throughput | no | yes |
| PIPNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| DDT4L_HUMAN | [view interactions] | High throughput | no | no |
| MCPH1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN177_HUMAN | [view interactions] | High throughput | no | no |
| RGRF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| MBD5_HUMAN | [view interactions] | High throughput | no | no |
| S2535_HUMAN | [view interactions] | High throughput | no | no |
| NKD2_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| HNRC2_HUMAN | [view interactions] | High throughput | no | no |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSX1_HUMAN | [view interactions] | High throughput | no | no |
| CENPW_HUMAN | [view interactions] | High throughput | no | no |
| TCPQM_HUMAN | [view interactions] | High throughput | no | no |
| LGI1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| G6PT1_HUMAN | [view interactions] | High throughput | no | no |