Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PMVK_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PMVK_HUMAN
GO:0017076 purine nucleotide binding 25.0000 4 yes
GO:0032555 purine ribonucleotide binding 25.0000 4 yes
GO:0030554 adenyl nucleotide binding 18.7500 5 yes
GO:0032559 adenyl ribonucleotide binding 18.7500 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 18.7500 4 yes
GO:0004631 phosphomevalonate kinase activity 12.5000 5 yes
GO:0005524 ATP binding 12.5000 5 yes
GO:0016301 kinase activity 12.5000 4 yes
GO:0016776 phosphotransferase activity, phosphate group as acceptor 12.5000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PMVK_HUMAN
GO:0048522 positive regulation of cellular process 37.5000 4 no
GO:0010646 regulation of cell communication 25.0000 4 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0014070 response to organic cyclic compound 25.0000 4 yes
GO:0033993 response to lipid 25.0000 4 yes
GO:0046165 alcohol biosynthetic process 25.0000 4 yes
GO:1901617 organic hydroxy compound biosynthetic process 25.0000 4 yes
GO:0006996 organelle organization 25.0000 4 no
GO:0031323 regulation of cellular metabolic process 25.0000 4 no
GO:0006644 phospholipid metabolic process 18.7500 4 yes
GO:0006694 steroid biosynthetic process 18.7500 5 yes
GO:0006695 cholesterol biosynthetic process 18.7500 6 yes
GO:0006796 phosphate-containing compound metabolic process 18.7500 4 yes
GO:0008202 steroid metabolic process 18.7500 4 yes
GO:0008203 cholesterol metabolic process 18.7500 5 yes
GO:0008610 lipid biosynthetic process 18.7500 4 yes
GO:0008654 phospholipid biosynthetic process 18.7500 4 yes
GO:0016125 sterol metabolic process 18.7500 4 yes
GO:0016126 sterol biosynthetic process 18.7500 5 yes
GO:0090407 organophosphate biosynthetic process 18.7500 4 yes
GO:1901362 organic cyclic compound biosynthetic process 18.7500 4 yes
GO:1902652 secondary alcohol metabolic process 18.7500 4 yes
GO:1902653 secondary alcohol biosynthetic process 18.7500 5 yes
GO:0006084 acetyl-CoA metabolic process 12.5000 5 yes
GO:0006163 purine nucleotide metabolic process 12.5000 5 yes
GO:0006637 acyl-CoA metabolic process 12.5000 4 yes
GO:0006753 nucleoside phosphate metabolic process 12.5000 4 yes
GO:0009117 nucleotide metabolic process 12.5000 5 yes
GO:0009150 purine ribonucleotide metabolic process 12.5000 6 yes
GO:0009240 isopentenyl diphosphate biosynthetic process 12.5000 5 yes
GO:0009259 ribonucleotide metabolic process 12.5000 5 yes
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway 12.5000 6 yes
GO:0019693 ribose phosphate metabolic process 12.5000 4 yes
GO:0033865 nucleoside bisphosphate metabolic process 12.5000 5 yes
GO:0033875 ribonucleoside bisphosphate metabolic process 12.5000 6 yes
GO:0034032 purine nucleoside bisphosphate metabolic process 12.5000 5 yes
GO:0036314 response to sterol 12.5000 4 yes
GO:0043603 cellular amide metabolic process 12.5000 4 yes
GO:0046490 isopentenyl diphosphate metabolic process 12.5000 5 yes
GO:0070723 response to cholesterol 12.5000 5 yes
GO:0072521 purine-containing compound metabolic process 12.5000 4 yes
GO:0097305 response to alcohol 12.5000 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in PMVK_HUMAN
DOID:161 keratosis 12.5000 4 yes
DOID:37 skin disease 12.5000 3 yes
DOID:3805 porokeratosis 12.5000 5 yes
DOID:331 central nervous system disease 12.5000 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
T2EB_HUMAN [view interactions] High throughput no yes
SNR27_HUMAN [view interactions] High throughput no yes
UIF_HUMAN [view interactions] High throughput no yes
ODAPH_HUMAN [view interactions] High throughput no no
ANF_HUMAN [view interactions] High throughput no no
MFTC_HUMAN [view interactions] High throughput no yes
FIBB_HUMAN [view entry] [view interactions] High throughput yes no
FSD1_HUMAN [view entry] [view interactions] High throughput yes no
AR6P6_HUMAN [view interactions] High throughput no yes
RDH12_HUMAN [view interactions] High throughput no no
SETD3_HUMAN [view interactions] High throughput no yes
SCNM1_HUMAN [view interactions] High throughput no no
KI67_HUMAN [view interactions] High throughput no no
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
VCAM1_HUMAN [view interactions] High throughput no no
SDHA_HUMAN [view interactions] High throughput no yes
RGS20_HUMAN [view interactions] High throughput no no
TBPL1_HUMAN [view interactions] High throughput no yes
LA_HUMAN [view interactions] High throughput no yes
MPU1_HUMAN [view interactions] High throughput no yes
MLF2_HUMAN [view entry] [view interactions] High throughput yes yes
CENPH_HUMAN [view interactions] High throughput no yes
PIPNA_HUMAN [view entry] [view interactions] High throughput yes no
HSC20_HUMAN [view interactions] High throughput no yes
DDT4L_HUMAN [view interactions] High throughput no no
MCPH1_HUMAN [view interactions] High throughput no yes
ZN177_HUMAN [view interactions] High throughput no no
RGRF2_HUMAN [view entry] [view interactions] High throughput yes yes
EED_HUMAN [view interactions] High throughput no yes
MBD5_HUMAN [view interactions] High throughput no no
S2535_HUMAN [view interactions] High throughput no no
NKD2_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
DX39A_HUMAN [view interactions] High throughput no yes
HNRC2_HUMAN [view interactions] High throughput no no
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
GSX1_HUMAN [view interactions] High throughput no no
CENPW_HUMAN [view interactions] High throughput no no
TCPQM_HUMAN [view interactions] High throughput no no
LGI1_HUMAN [view entry] [view interactions] High throughput yes no
G6PT1_HUMAN [view interactions] High throughput no no
PINK1_HUMAN [view interactions] High throughput no yes
EFMT3_HUMAN [view interactions] High throughput no no
HSPB8_HUMAN [view entry] [view interactions] High throughput yes yes
NIPA_HUMAN [view interactions] High throughput no yes
LRC29_HUMAN [view interactions] High throughput no no
CCR1_HUMAN [view interactions] High throughput no no
PLBL1_HUMAN [view interactions] High throughput no no
SARAF_HUMAN [view interactions] High throughput no no
UBXN6_HUMAN [view entry] [view interactions] High throughput yes yes
KCD14_HUMAN [view interactions] High throughput no no
PSG11_HUMAN [view interactions] High throughput no no
UPK1A_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
MABP1_HUMAN [view interactions] High throughput no yes
CATL2_HUMAN [view interactions] High throughput no yes
DUS14_HUMAN [view interactions] High throughput no yes
LTOR5_HUMAN [view interactions] High throughput no yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
S10A7_HUMAN [view interactions] High throughput no no
PIP_HUMAN [view interactions] High throughput no no
SAP_HUMAN [view interactions] High throughput no yes
CND2_HUMAN [view interactions] High throughput no no
VPS25_HUMAN [view interactions] High throughput no yes
NUP88_HUMAN [view interactions] High throughput no yes
KRA32_HUMAN [view interactions] High throughput no no
COG3_HUMAN [view entry] [view interactions] High throughput yes yes
LSM7_HUMAN [view interactions] High throughput no yes
DSC1_HUMAN [view interactions] High throughput no no
PKP1_HUMAN [view interactions] High throughput no no
BLMH_HUMAN [view interactions] High throughput no yes
DSG1_HUMAN [view entry] [view interactions] High throughput yes no
FPPS_HUMAN [view entry] [view interactions] High throughput yes yes
PMVK_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
DAA10_HUMAN [view interactions] High throughput no yes
FDFT_HUMAN [view interactions] Computational no yes
SRBP2_HUMAN [view interactions] Computational no yes
GGPPS_HUMAN [view interactions] Computational no yes
NFYC_HUMAN [view interactions] Computational no no
HMGA1_HUMAN [view interactions] Computational no yes
NFYB_HUMAN [view interactions] Computational no yes
MVD1_HUMAN [view interactions] Computational no yes
SP1_HUMAN [view interactions] Computational no yes
NFYA_HUMAN [view interactions] Computational no yes
KIME_HUMAN [view interactions] Computational no yes
SRBP1_HUMAN [view interactions] Computational no yes