Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RGRF2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RGRF2_HUMAN
GO:0000166 nucleotide binding 46.1538 4 no
GO:0017076 purine nucleotide binding 46.1538 5 no
GO:0032555 purine ribonucleotide binding 46.1538 4 no
GO:0035639 purine ribonucleoside triphosphate binding 46.1538 4 no
GO:0043168 anion binding 46.1538 4 no
GO:0003924 GTPase activity 30.7692 7 no
GO:0005525 GTP binding 30.7692 5 no
GO:0016462 pyrophosphatase activity 30.7692 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 30.7692 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 30.7692 6 no
GO:0019001 guanyl nucleotide binding 30.7692 6 no
GO:0019900 kinase binding 30.7692 4 no
GO:0019901 protein kinase binding 30.7692 5 no
GO:0032561 guanyl ribonucleotide binding 30.7692 5 no
GO:0003723 RNA binding 23.0769 4 no
GO:0005085 guanyl-nucleotide exchange factor activity 15.3846 5 yes
GO:0030695 GTPase regulator activity 15.3846 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RGRF2_HUMAN
GO:0009966 regulation of signal transduction 69.2308 4 yes
GO:0010646 regulation of cell communication 69.2308 4 yes
GO:0048522 positive regulation of cellular process 69.2308 4 yes
GO:0006996 organelle organization 69.2308 4 no
GO:0010647 positive regulation of cell communication 61.5385 5 yes
GO:0023056 positive regulation of signaling 61.5385 4 yes
GO:1902531 regulation of intracellular signal transduction 53.8462 5 yes
GO:0022607 cellular component assembly 53.8462 4 no
GO:0048523 negative regulation of cellular process 53.8462 4 no
GO:0060255 regulation of macromolecule metabolic process 53.8462 4 no
GO:0080090 regulation of primary metabolic process 53.8462 4 no
GO:0007264 small GTPase-mediated signal transduction 46.1538 5 yes
GO:0141124 intracellular signaling cassette 46.1538 4 yes
GO:0007010 cytoskeleton organization 46.1538 5 no
GO:0009893 positive regulation of metabolic process 46.1538 4 no
GO:0009967 positive regulation of signal transduction 46.1538 5 no
GO:0031323 regulation of cellular metabolic process 46.1538 4 no
GO:0042981 regulation of apoptotic process 46.1538 5 no
GO:0043067 regulation of programmed cell death 46.1538 4 no
GO:0048584 positive regulation of response to stimulus 46.1538 4 no
GO:0050804 modulation of chemical synaptic transmission 38.4615 5 yes
GO:0099177 regulation of trans-synaptic signaling 38.4615 4 yes
GO:0009889 regulation of biosynthetic process 38.4615 4 no
GO:0010468 regulation of gene expression 38.4615 6 no
GO:0010556 regulation of macromolecule biosynthetic process 38.4615 5 no
GO:0010604 positive regulation of macromolecule metabolic process 38.4615 5 no
GO:0030334 regulation of cell migration 38.4615 5 no
GO:0031326 regulation of cellular biosynthetic process 38.4615 5 no
GO:0042127 regulation of cell population proliferation 38.4615 4 no
GO:0051128 regulation of cellular component organization 38.4615 4 no
GO:2000145 regulation of cell motility 38.4615 4 no
GO:0051056 regulation of small GTPase mediated signal transduction 30.7692 6 yes
GO:0010810 regulation of cell-substrate adhesion 30.7692 5 no
GO:0016055 Wnt signaling pathway 30.7692 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.7692 5 no
GO:0030155 regulation of cell adhesion 30.7692 4 no
GO:0031325 positive regulation of cellular metabolic process 30.7692 5 no
GO:0031344 regulation of cell projection organization 30.7692 5 no
GO:0043066 negative regulation of apoptotic process 30.7692 6 no
GO:0043069 negative regulation of programmed cell death 30.7692 5 no
GO:0045785 positive regulation of cell adhesion 30.7692 5 no
GO:0050807 regulation of synapse organization 30.7692 5 no
GO:0051130 positive regulation of cellular component organization 30.7692 5 no
GO:0051246 regulation of protein metabolic process 30.7692 5 no
GO:0051247 positive regulation of protein metabolic process 30.7692 6 no
GO:0061024 membrane organization 30.7692 4 no
GO:0071310 cellular response to organic substance 30.7692 4 no
GO:0097435 supramolecular fiber organization 30.7692 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 30.7692 6 no
GO:1902533 positive regulation of intracellular signal transduction 30.7692 6 no
GO:0051049 regulation of transport 30.7692 4 no
GO:0007265 Ras protein signal transduction 23.0769 6 yes
GO:0001764 neuron migration 23.0769 4 no
GO:0001932 regulation of protein phosphorylation 23.0769 7 no
GO:0001934 positive regulation of protein phosphorylation 23.0769 8 no
GO:0001952 regulation of cell-matrix adhesion 23.0769 6 no
GO:0006355 regulation of DNA-templated transcription 23.0769 7 no
GO:0006915 apoptotic process 23.0769 4 no
GO:0007015 actin filament organization 23.0769 5 no
GO:0009890 negative regulation of biosynthetic process 23.0769 5 no
GO:0009892 negative regulation of metabolic process 23.0769 4 no
GO:0010324 membrane invagination 23.0769 5 no
GO:0010562 positive regulation of phosphorus metabolic process 23.0769 6 no
GO:0010632 regulation of epithelial cell migration 23.0769 4 no
GO:0010638 positive regulation of organelle organization 23.0769 6 no
GO:0010720 positive regulation of cell development 23.0769 6 no
GO:0019220 regulation of phosphate metabolic process 23.0769 6 no
GO:0030335 positive regulation of cell migration 23.0769 6 no
GO:0030336 negative regulation of cell migration 23.0769 6 no
GO:0030855 epithelial cell differentiation 23.0769 4 no
GO:0031324 negative regulation of cellular metabolic process 23.0769 5 no
GO:0031399 regulation of protein modification process 23.0769 6 no
GO:0031401 positive regulation of protein modification process 23.0769 7 no
GO:0032231 regulation of actin filament bundle assembly 23.0769 5 no
GO:0032233 positive regulation of actin filament bundle assembly 23.0769 6 no
GO:0032956 regulation of actin cytoskeleton organization 23.0769 5 no
GO:0032970 regulation of actin filament-based process 23.0769 4 no
GO:0033043 regulation of organelle organization 23.0769 5 no
GO:0034097 response to cytokine 23.0769 4 no
GO:0035567 non-canonical Wnt signaling pathway 23.0769 5 no
GO:0040013 negative regulation of locomotion 23.0769 4 no
GO:0040017 positive regulation of locomotion 23.0769 4 no
GO:0042325 regulation of phosphorylation 23.0769 7 no
GO:0042327 positive regulation of phosphorylation 23.0769 8 no
GO:0043254 regulation of protein-containing complex assembly 23.0769 5 no
GO:0043523 regulation of neuron apoptotic process 23.0769 6 no
GO:0044087 regulation of cellular component biogenesis 23.0769 4 no
GO:0044089 positive regulation of cellular component biogenesis 23.0769 5 no
GO:0045595 regulation of cell differentiation 23.0769 4 no
GO:0045597 positive regulation of cell differentiation 23.0769 5 no
GO:0045937 positive regulation of phosphate metabolic process 23.0769 7 no
GO:0048585 negative regulation of response to stimulus 23.0769 4 no
GO:0051094 positive regulation of developmental process 23.0769 4 no
GO:0051174 regulation of phosphorus metabolic process 23.0769 5 no
GO:0051240 positive regulation of multicellular organismal process 23.0769 4 no
GO:0051241 negative regulation of multicellular organismal process 23.0769 4 no
GO:0051252 regulation of RNA metabolic process 23.0769 5 no
GO:0051492 regulation of stress fiber assembly 23.0769 6 no
GO:0051493 regulation of cytoskeleton organization 23.0769 6 no
GO:0051495 positive regulation of cytoskeleton organization 23.0769 7 no
GO:0051496 positive regulation of stress fiber assembly 23.0769 7 no
GO:0060071 Wnt signaling pathway, planar cell polarity pathway 23.0769 6 no
GO:0060284 regulation of cell development 23.0769 5 no
GO:0070925 organelle assembly 23.0769 5 no
GO:0071345 cellular response to cytokine stimulus 23.0769 5 no
GO:0099024 plasma membrane invagination 23.0769 6 no
GO:0110020 regulation of actomyosin structure organization 23.0769 6 no
GO:0110053 regulation of actin filament organization 23.0769 6 no
GO:1902903 regulation of supramolecular fiber organization 23.0769 5 no
GO:1902905 positive regulation of supramolecular fiber organization 23.0769 6 no
GO:2000026 regulation of multicellular organismal development 23.0769 4 no
GO:2000146 negative regulation of cell motility 23.0769 5 no
GO:2000147 positive regulation of cell motility 23.0769 5 no
GO:2001141 regulation of RNA biosynthetic process 23.0769 6 no
GO:0009057 macromolecule catabolic process 23.0769 4 no
GO:0036211 protein modification process 23.0769 4 no
GO:0043412 macromolecule modification 23.0769 4 no
GO:0006796 phosphate-containing compound metabolic process 23.0769 4 no
GO:0016310 phosphorylation 23.0769 5 no
GO:0032101 regulation of response to external stimulus 23.0769 4 no
GO:0032880 regulation of protein localization 23.0769 5 no
GO:0060341 regulation of cellular localization 23.0769 4 no
GO:0010811 positive regulation of cell-substrate adhesion 23.0769 6 no
GO:0030030 cell projection organization 23.0769 4 no
GO:0030031 cell projection assembly 23.0769 5 no
GO:0031346 positive regulation of cell projection organization 23.0769 6 no
GO:0120031 plasma membrane bounded cell projection assembly 23.0769 6 no
GO:0120036 plasma membrane bounded cell projection organization 23.0769 5 no
GO:0051050 positive regulation of transport 23.0769 4 no
GO:0008104 protein localization 23.0769 4 no
GO:0008284 positive regulation of cell population proliferation 23.0769 5 no
GO:0034976 response to endoplasmic reticulum stress 15.3846 4 yes
GO:0050806 positive regulation of synaptic transmission 15.3846 5 yes
GO:0060291 long-term synaptic potentiation 15.3846 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RASK_HUMAN [view entry] [view interactions] Low throughput yes no
ZFR_HUMAN [view interactions] High throughput no yes
GLRX5_HUMAN [view interactions] High throughput no yes
SETB1_HUMAN [view interactions] High throughput no yes
CSTF2_HUMAN [view interactions] High throughput no yes
CTBP2_HUMAN [view interactions] High throughput no no
FGD3_HUMAN [view interactions] High throughput no yes
NOSIP_HUMAN [view interactions] High throughput no yes
RLP24_HUMAN [view interactions] High throughput no yes
SF3A2_HUMAN [view interactions] High throughput no yes
UTP11_HUMAN [view interactions] High throughput no yes
SNRPA_HUMAN [view interactions] High throughput no yes
DNMBP_HUMAN [view interactions] High throughput no no
PANK2_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
AKTIP_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
RGRF2_HUMAN [view entry] [view interactions] High throughput yes yes
PMVK_HUMAN [view entry] [view interactions] High throughput yes yes
EPIPL_HUMAN [view entry] [view interactions] High throughput yes no
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
CCD86_HUMAN [view interactions] High throughput no yes
GAR1_HUMAN [view interactions] High throughput no yes
RS27A_HUMAN [view entry] [view interactions] High throughput yes yes
ZYX_HUMAN [view interactions] High throughput no no
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes