Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RGRF2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RGRF2_HUMAN
GO:0017076 purine nucleotide binding 61.1111 4 no
GO:0032555 purine ribonucleotide binding 55.5556 4 no
GO:0035639 purine ribonucleoside triphosphate binding 55.5556 4 no
GO:0003924 GTPase activity 33.3333 7 no
GO:0005525 GTP binding 33.3333 5 no
GO:0016462 pyrophosphatase activity 33.3333 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 33.3333 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 33.3333 6 no
GO:0019001 guanyl nucleotide binding 33.3333 5 no
GO:0032561 guanyl ribonucleotide binding 33.3333 5 no
GO:0019900 kinase binding 27.7778 4 no
GO:0019901 protein kinase binding 27.7778 5 no
GO:0046872 metal ion binding 27.7778 4 no
GO:0030554 adenyl nucleotide binding 27.7778 5 no
GO:0019003 GDP binding 22.2222 4 no
GO:0031625 ubiquitin protein ligase binding 22.2222 5 no
GO:0044389 ubiquitin-like protein ligase binding 22.2222 4 no
GO:0005524 ATP binding 22.2222 5 no
GO:0016301 kinase activity 22.2222 4 no
GO:0032559 adenyl ribonucleotide binding 22.2222 5 no
GO:0005085 guanyl-nucleotide exchange factor activity 11.1111 5 yes
GO:0030695 GTPase regulator activity 11.1111 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RGRF2_HUMAN
GO:0010646 regulation of cell communication 72.2222 4 yes
GO:0048522 positive regulation of cellular process 72.2222 4 yes
GO:0009966 regulation of signal transduction 66.6667 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 66.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 no
GO:0080090 regulation of primary metabolic process 66.6667 4 no
GO:0031323 regulation of cellular metabolic process 55.5556 4 no
GO:0048523 negative regulation of cellular process 55.5556 4 no
GO:0022607 cellular component assembly 50.0000 4 no
GO:0010647 positive regulation of cell communication 50.0000 5 yes
GO:0023056 positive regulation of signaling 50.0000 4 yes
GO:0051049 regulation of transport 50.0000 4 yes
GO:0010468 regulation of gene expression 50.0000 5 no
GO:0006996 organelle organization 50.0000 4 no
GO:0007264 small GTPase mediated signal transduction 44.4444 4 yes
GO:0050804 modulation of chemical synaptic transmission 44.4444 5 yes
GO:0099177 regulation of trans-synaptic signaling 44.4444 4 yes
GO:1902531 regulation of intracellular signal transduction 44.4444 5 yes
GO:0009893 positive regulation of metabolic process 44.4444 4 no
GO:0010941 regulation of cell death 44.4444 4 no
GO:0042981 regulation of apoptotic process 44.4444 6 no
GO:0043067 regulation of programmed cell death 44.4444 5 no
GO:0051246 regulation of protein metabolic process 44.4444 5 no
GO:0006796 phosphate-containing compound metabolic process 38.8889 4 no
GO:0042127 regulation of cell population proliferation 38.8889 4 no
GO:0010604 positive regulation of macromolecule metabolic process 38.8889 5 no
GO:0031325 positive regulation of cellular metabolic process 38.8889 5 no
GO:0051128 regulation of cellular component organization 38.8889 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 38.8889 5 no
GO:0007010 cytoskeleton organization 33.3333 5 no
GO:0045595 regulation of cell differentiation 33.3333 4 no
GO:0008104 protein localization 33.3333 4 no
GO:0036211 protein modification process 33.3333 4 no
GO:0043412 macromolecule modification 33.3333 4 no
GO:0007265 Ras protein signal transduction 33.3333 5 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0030162 regulation of proteolysis 27.7778 6 no
GO:0006468 protein phosphorylation 27.7778 5 no
GO:0016310 phosphorylation 27.7778 5 no
GO:0043269 regulation of ion transport 27.7778 5 yes
GO:0008284 positive regulation of cell population proliferation 27.7778 5 no
GO:0006355 regulation of DNA-templated transcription 27.7778 6 no
GO:0010556 regulation of macromolecule biosynthetic process 27.7778 5 no
GO:0010562 positive regulation of phosphorus metabolic process 27.7778 6 no
GO:0010605 negative regulation of macromolecule metabolic process 27.7778 5 no
GO:0019220 regulation of phosphate metabolic process 27.7778 6 no
GO:0030334 regulation of cell migration 27.7778 5 no
GO:0031344 regulation of cell projection organization 27.7778 5 no
GO:0042325 regulation of phosphorylation 27.7778 7 no
GO:0042327 positive regulation of phosphorylation 27.7778 8 no
GO:0043066 negative regulation of apoptotic process 27.7778 7 no
GO:0043069 negative regulation of programmed cell death 27.7778 6 no
GO:0044087 regulation of cellular component biogenesis 27.7778 4 no
GO:0045937 positive regulation of phosphate metabolic process 27.7778 7 no
GO:0051050 positive regulation of transport 27.7778 4 no
GO:0051130 positive regulation of cellular component organization 27.7778 5 no
GO:0051174 regulation of phosphorus metabolic process 27.7778 5 no
GO:0051252 regulation of RNA metabolic process 27.7778 5 no
GO:0060548 negative regulation of cell death 27.7778 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 27.7778 6 no
GO:1902533 positive regulation of intracellular signal transduction 27.7778 6 no
GO:1903506 regulation of nucleic acid-templated transcription 27.7778 7 no
GO:2000145 regulation of cell motility 27.7778 4 no
GO:2001141 regulation of RNA biosynthetic process 27.7778 6 no
GO:0010810 regulation of cell-substrate adhesion 22.2222 5 no
GO:0016055 Wnt signaling pathway 22.2222 5 no
GO:0022603 regulation of anatomical structure morphogenesis 22.2222 4 no
GO:0030030 cell projection organization 22.2222 4 no
GO:0030155 regulation of cell adhesion 22.2222 4 no
GO:0045597 positive regulation of cell differentiation 22.2222 5 no
GO:0045785 positive regulation of cell adhesion 22.2222 5 no
GO:0051094 positive regulation of developmental process 22.2222 4 no
GO:0061024 membrane organization 22.2222 4 no
GO:0097435 supramolecular fiber organization 22.2222 4 no
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 22.2222 4 no
GO:0009894 regulation of catabolic process 22.2222 4 no
GO:0050807 regulation of synapse organization 22.2222 5 no
GO:0010942 positive regulation of cell death 22.2222 5 no
GO:0043065 positive regulation of apoptotic process 22.2222 7 no
GO:0043068 positive regulation of programmed cell death 22.2222 6 no
GO:0048585 negative regulation of response to stimulus 22.2222 4 no
GO:0071310 cellular response to organic substance 22.2222 4 no
GO:0046578 regulation of Ras protein signal transduction 22.2222 7 yes
GO:0051056 regulation of small GTPase mediated signal transduction 22.2222 6 yes
GO:0000165 MAPK cascade 22.2222 4 no
GO:0050678 regulation of epithelial cell proliferation 22.2222 5 no
GO:0001932 regulation of protein phosphorylation 22.2222 7 no
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 no
GO:0006357 regulation of transcription by RNA polymerase II 22.2222 7 no
GO:0010638 positive regulation of organelle organization 22.2222 6 no
GO:0031346 positive regulation of cell projection organization 22.2222 6 no
GO:0031399 regulation of protein modification process 22.2222 6 no
GO:0031401 positive regulation of protein modification process 22.2222 7 no
GO:0032386 regulation of intracellular transport 22.2222 5 no
GO:0032388 positive regulation of intracellular transport 22.2222 5 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0032956 regulation of actin cytoskeleton organization 22.2222 5 no
GO:0032970 regulation of actin filament-based process 22.2222 4 no
GO:0033043 regulation of organelle organization 22.2222 5 no
GO:0033157 regulation of intracellular protein transport 22.2222 6 no
GO:0043085 positive regulation of catalytic activity 22.2222 4 no
GO:0043523 regulation of neuron apoptotic process 22.2222 6 no
GO:0044089 positive regulation of cellular component biogenesis 22.2222 5 no
GO:0051222 positive regulation of protein transport 22.2222 5 no
GO:0051223 regulation of protein transport 22.2222 5 no
GO:0051336 regulation of hydrolase activity 22.2222 4 no
GO:0051493 regulation of cytoskeleton organization 22.2222 6 no
GO:0051495 positive regulation of cytoskeleton organization 22.2222 7 no
GO:0051726 regulation of cell cycle 22.2222 4 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:0070201 regulation of establishment of protein localization 22.2222 6 no
GO:0090316 positive regulation of intracellular protein transport 22.2222 6 no
GO:1901214 regulation of neuron death 22.2222 5 no
GO:1903829 positive regulation of protein localization 22.2222 5 no
GO:1904951 positive regulation of establishment of protein localization 22.2222 6 no
GO:0022898 regulation of transmembrane transporter activity 16.6667 4 yes
GO:0032412 regulation of ion transmembrane transporter activity 16.6667 5 yes
GO:0034762 regulation of transmembrane transport 16.6667 4 yes
GO:0034765 regulation of ion transmembrane transport 16.6667 5 yes
GO:0035023 regulation of Rho protein signal transduction 16.6667 8 yes
GO:0050806 positive regulation of synaptic transmission 16.6667 5 yes
GO:0060291 long-term synaptic potentiation 16.6667 4 yes
GO:1904062 regulation of cation transmembrane transport 16.6667 6 yes
GO:2001257 regulation of cation channel activity 16.6667 6 yes
GO:0034976 response to endoplasmic reticulum stress 11.1111 4 yes
GO:0099601 regulation of neurotransmitter receptor activity 11.1111 4 yes
GO:2000310 regulation of NMDA receptor activity 11.1111 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RASK_HUMAN [view entry] [view interactions] Low throughput yes no
ZFR_HUMAN [view interactions] High throughput no yes
GLRX5_HUMAN [view interactions] High throughput no yes
SETB1_HUMAN [view interactions] High throughput no yes
SNRPA_HUMAN [view interactions] High throughput no yes
UTP11_HUMAN [view interactions] High throughput no yes
SF3A2_HUMAN [view interactions] High throughput no yes
RLP24_HUMAN [view interactions] High throughput no yes
NOSIP_HUMAN [view interactions] High throughput no yes
FGD3_HUMAN [view interactions] High throughput no yes
CTBP2_HUMAN [view interactions] High throughput no no
CSTF2_HUMAN [view interactions] High throughput no yes
DNMBP_HUMAN [view interactions] High throughput no no
PANK2_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
AKTIP_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
RGRF2_HUMAN [view entry] [view interactions] High throughput yes yes
PMVK_HUMAN [view entry] [view interactions] High throughput yes yes
EPIPL_HUMAN [view entry] [view interactions] High throughput yes no
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
CCD86_HUMAN [view interactions] High throughput no yes
GAR1_HUMAN [view interactions] High throughput no yes
RS27A_HUMAN [view entry] [view interactions] High throughput yes yes
ZYX_HUMAN [view interactions] High throughput no no
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RGRF1_HUMAN [view interactions] Computational no yes
KAPCG_HUMAN [view interactions] Computational no no
KAPCA_HUMAN [view entry] [view interactions] Computational yes yes
RASN_HUMAN [view entry] [view interactions] Computational yes no
RASH_HUMAN [view entry] [view interactions] Computational yes no
NMDE1_HUMAN [view entry] [view interactions] Computational yes yes
KAPCB_HUMAN [view entry] [view interactions] Computational yes yes