Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

EPIPL_HUMAN

GO
G2C
SynGO

Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress (PubMed, PubMed, PubMed). In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture (PubMed, PubMed). However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization . [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in EPIPL_HUMAN
GO:0003723 RNA binding 31.9149 4 yes
GO:0043168 anion binding 31.9149 4 no
GO:0031625 ubiquitin protein ligase binding 27.6596 5 no
GO:0044389 ubiquitin-like protein ligase binding 27.6596 4 no
GO:0000166 nucleotide binding 27.6596 4 no
GO:0017076 purine nucleotide binding 27.6596 5 no
GO:0032555 purine ribonucleotide binding 27.6596 4 no
GO:0035639 purine ribonucleoside triphosphate binding 25.5319 4 no
GO:0043169 cation binding 21.2766 4 no
GO:0046872 metal ion binding 21.2766 5 no
GO:0030554 adenyl nucleotide binding 21.2766 6 no
GO:0032559 adenyl ribonucleotide binding 21.2766 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in EPIPL_HUMAN
GO:0048522 positive regulation of cellular process 63.8298 4 no
GO:0048523 negative regulation of cellular process 59.5745 4 yes
GO:0006996 organelle organization 55.3191 4 yes
GO:0031323 regulation of cellular metabolic process 55.3191 4 no
GO:0060255 regulation of macromolecule metabolic process 51.0638 4 no
GO:0051128 regulation of cellular component organization 51.0638 4 no
GO:0022607 cellular component assembly 48.9362 4 yes
GO:0009889 regulation of biosynthetic process 46.8085 4 no
GO:0080090 regulation of primary metabolic process 46.8085 4 no
GO:0009893 positive regulation of metabolic process 44.6809 4 no
GO:0010468 regulation of gene expression 44.6809 6 no
GO:0010556 regulation of macromolecule biosynthetic process 44.6809 5 no
GO:0031326 regulation of cellular biosynthetic process 44.6809 5 no
GO:0010646 regulation of cell communication 42.5532 4 no
GO:0031325 positive regulation of cellular metabolic process 40.4255 5 no
GO:0010604 positive regulation of macromolecule metabolic process 38.2979 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 38.2979 5 no
GO:0009966 regulation of signal transduction 36.1702 4 no
GO:0051252 regulation of RNA metabolic process 36.1702 5 no
GO:0009891 positive regulation of biosynthetic process 34.0426 5 no
GO:0009892 negative regulation of metabolic process 34.0426 4 no
GO:0051246 regulation of protein metabolic process 34.0426 5 no
GO:0008104 protein localization 34.0426 4 no
GO:0051130 positive regulation of cellular component organization 34.0426 5 no
GO:0006355 regulation of DNA-templated transcription 31.9149 7 no
GO:0010557 positive regulation of macromolecule biosynthetic process 31.9149 6 no
GO:0010605 negative regulation of macromolecule metabolic process 31.9149 5 no
GO:0031328 positive regulation of cellular biosynthetic process 31.9149 6 no
GO:2001141 regulation of RNA biosynthetic process 31.9149 6 no
GO:0033043 regulation of organelle organization 31.9149 5 no
GO:0007010 cytoskeleton organization 29.7872 5 yes
GO:0009890 negative regulation of biosynthetic process 29.7872 5 no
GO:0031324 negative regulation of cellular metabolic process 29.7872 5 no
GO:0042981 regulation of apoptotic process 29.7872 5 no
GO:0043067 regulation of programmed cell death 29.7872 4 no
GO:1902531 regulation of intracellular signal transduction 29.7872 5 no
GO:0044087 regulation of cellular component biogenesis 29.7872 4 no
GO:0048585 negative regulation of response to stimulus 27.6596 4 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 27.6596 6 no
GO:0031327 negative regulation of cellular biosynthetic process 27.6596 6 no
GO:0051247 positive regulation of protein metabolic process 27.6596 6 no
GO:0051049 regulation of transport 27.6596 4 no
GO:0042127 regulation of cell population proliferation 25.5319 4 yes
GO:0010647 positive regulation of cell communication 25.5319 5 no
GO:0023056 positive regulation of signaling 25.5319 4 no
GO:0048584 positive regulation of response to stimulus 25.5319 4 no
GO:0071310 cellular response to organic substance 25.5319 4 no
GO:1901701 cellular response to oxygen-containing compound 25.5319 4 no
GO:0051129 negative regulation of cellular component organization 25.5319 5 no
GO:0051493 regulation of cytoskeleton organization 25.5319 6 no
GO:0009894 regulation of catabolic process 25.5319 4 no
GO:0010638 positive regulation of organelle organization 25.5319 6 no
GO:0051726 regulation of cell cycle 25.5319 4 no
GO:0010648 negative regulation of cell communication 25.5319 5 no
GO:0023057 negative regulation of signaling 25.5319 4 no
GO:0043933 protein-containing complex organization 25.5319 4 no
GO:0006357 regulation of transcription by RNA polymerase II 23.4043 8 no
GO:0009967 positive regulation of signal transduction 23.4043 5 no
GO:0031399 regulation of protein modification process 23.4043 6 no
GO:0051094 positive regulation of developmental process 23.4043 4 no
GO:0071702 organic substance transport 23.4043 4 no
GO:0071705 nitrogen compound transport 23.4043 4 no
GO:0044089 positive regulation of cellular component biogenesis 23.4043 5 no
GO:0009968 negative regulation of signal transduction 23.4043 5 no
GO:0097435 supramolecular fiber organization 21.2766 4 yes
GO:0010628 positive regulation of gene expression 21.2766 7 no
GO:0033993 response to lipid 21.2766 4 no
GO:0036211 protein modification process 21.2766 4 no
GO:0043412 macromolecule modification 21.2766 4 no
GO:0045595 regulation of cell differentiation 21.2766 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 21.2766 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.2766 5 no
GO:0051240 positive regulation of multicellular organismal process 21.2766 4 no
GO:0043066 negative regulation of apoptotic process 21.2766 6 no
GO:0043069 negative regulation of programmed cell death 21.2766 5 no
GO:0010564 regulation of cell cycle process 21.2766 5 no
GO:0032101 regulation of response to external stimulus 19.1489 4 yes
GO:0080134 regulation of response to stress 19.1489 4 yes
GO:0051241 negative regulation of multicellular organismal process 17.0213 4 yes
GO:0030334 regulation of cell migration 12.7660 5 yes
GO:2000145 regulation of cell motility 12.7660 4 yes
GO:0008285 negative regulation of cell population proliferation 10.6383 5 yes
GO:0010632 regulation of epithelial cell migration 10.6383 4 yes
GO:0048638 regulation of developmental growth 10.6383 4 yes
GO:0030336 negative regulation of cell migration 8.5106 6 yes
GO:0040013 negative regulation of locomotion 8.5106 4 yes
GO:0050678 regulation of epithelial cell proliferation 8.5106 5 yes
GO:2000146 negative regulation of cell motility 8.5106 5 yes
GO:0032102 negative regulation of response to external stimulus 6.3830 5 yes
GO:0045109 intermediate filament organization 6.3830 4 yes
GO:0010633 negative regulation of epithelial cell migration 4.2553 5 yes
GO:0042060 wound healing 4.2553 4 yes
GO:0045110 intermediate filament bundle assembly 4.2553 5 yes
GO:0050680 negative regulation of epithelial cell proliferation 4.2553 6 yes
GO:0051547 regulation of keratinocyte migration 4.2553 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GBRL1_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
TRPM7_HUMAN [view interactions] High throughput no no
PCNA_HUMAN [view interactions] High throughput no no
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
ZBTB2_HUMAN [view interactions] High throughput no yes
ZSC12_HUMAN [view interactions] High throughput no yes
TB22B_HUMAN [view interactions] High throughput no no
FGL1_HUMAN [view interactions] High throughput no no
FCF1_HUMAN [view interactions] High throughput no yes
RBM24_HUMAN [view interactions] High throughput no yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
POC5_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
SNF5_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
TP4A3_HUMAN [view interactions] High throughput no no
WRP73_HUMAN [view interactions] High throughput no no
TRDMT_HUMAN [view interactions] High throughput no yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
GSTK1_HUMAN [view entry] [view interactions] High throughput yes yes
PINX1_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
T22D1_HUMAN [view interactions] High throughput no no
CFLAR_HUMAN [view interactions] High throughput no yes
INP5K_HUMAN [view interactions] High throughput no no
TRAF6_HUMAN [view entry] [view interactions] High throughput yes yes
NDKB_HUMAN [view entry] [view interactions] High throughput yes yes
SNW1_HUMAN [view interactions] High throughput no yes
CDC5L_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
M3K8_HUMAN [view interactions] High throughput no yes
NEMO_HUMAN [view interactions] High throughput no yes
M3K1_HUMAN [view interactions] High throughput no yes
M3K3_HUMAN [view interactions] High throughput no no
TNR1A_HUMAN [view interactions] High throughput no yes
TNR1B_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
STK4_HUMAN [view interactions] High throughput no yes
TIFAB_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
FTM_HUMAN [view interactions] High throughput no yes
CNTRB_HUMAN [view interactions] High throughput no yes
CE120_HUMAN [view interactions] High throughput no no
UFO_HUMAN [view interactions] High throughput no no
FLT3_HUMAN [view interactions] High throughput no no
MERTK_HUMAN [view interactions] High throughput no yes
ROR1_HUMAN [view interactions] High throughput no no
ROS1_HUMAN [view interactions] High throughput no no
RGRF2_HUMAN [view entry] [view interactions] High throughput yes yes
SRRM2_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
ISG15_HUMAN [view interactions] High throughput no no
NPHP4_HUMAN [view interactions] High throughput no yes
CDN1A_HUMAN [view interactions] High throughput no no
CP250_HUMAN [view interactions] High throughput no no
GCP3_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
CUL7_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
DD19B_HUMAN [view interactions] High throughput no yes
ZSC20_HUMAN [view interactions] High throughput no yes
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
UBR2_HUMAN [view interactions] High throughput no yes
SKI_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
CDK15_HUMAN [view interactions] High throughput no no
G3BP1_HUMAN [view interactions] High throughput no yes
ZN598_HUMAN [view interactions] High throughput no no
ARMC8_HUMAN [view interactions] High throughput no yes
RMD5A_HUMAN [view interactions] High throughput no yes
PRP8_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
SPDLY_HUMAN [view interactions] High throughput no yes
FGF11_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
CTSL2_HUMAN [view interactions] High throughput no no
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
WDR76_HUMAN [view interactions] High throughput no no
H4_HUMAN [view interactions] High throughput no yes
H2B1B_HUMAN [view interactions] High throughput no yes
H2A1B_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
NHLC2_HUMAN [view interactions] High throughput no yes
BCL9_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
MATR3_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
DEP1B_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
AURKB_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
MD2L2_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CIC_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
RNF17_HUMAN [view interactions] High throughput no yes
RIGI_HUMAN [view interactions] High throughput no yes
ANDR_HUMAN [view interactions] High throughput no no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
WDR5_HUMAN [view interactions] High throughput no no
NUDC2_HUMAN [view entry] [view interactions] High throughput yes yes
K1C27_HUMAN [view interactions] High throughput no no
F227B_HUMAN [view interactions] High throughput no yes
CERS3_HUMAN [view interactions] High throughput no no
ASCL1_HUMAN [view interactions] High throughput no no
K2C3_HUMAN [view interactions] High throughput no no
K1H2_HUMAN [view interactions] High throughput no no
OR2A4_HUMAN [view interactions] High throughput no no
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
K2C73_HUMAN [view interactions] High throughput no no
SIA7F_HUMAN [view interactions] High throughput no yes
KLH11_HUMAN [view interactions] High throughput no yes
STX17_HUMAN [view interactions] High throughput no yes
NFM_HUMAN [view entry] [view interactions] High throughput yes yes
KRT82_HUMAN [view interactions] High throughput no no
K1C14_HUMAN [view interactions] High throughput no no
CERS2_HUMAN [view interactions] High throughput no no
K2C72_HUMAN [view interactions] High throughput no no
2ABB_HUMAN [view interactions] High throughput no yes
K1C23_HUMAN [view interactions] High throughput no no
K2C7_HUMAN [view interactions] High throughput no no
CCD82_HUMAN [view interactions] High throughput no yes
LRC10_HUMAN [view interactions] High throughput no no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
PTSS1_HUMAN [view interactions] High throughput no no
K2C78_HUMAN [view interactions] High throughput no no
GCYA1_HUMAN [view interactions] High throughput no yes
NKAI3_HUMAN [view interactions] High throughput no no
K2C75_HUMAN [view interactions] High throughput no no
ZC3C1_HUMAN [view interactions] High throughput no yes
SARAF_HUMAN [view interactions] High throughput no no
WDR83_HUMAN [view interactions] High throughput no yes
KT33B_HUMAN [view interactions] High throughput no no
KRT86_HUMAN [view interactions] High throughput no no
CR021_HUMAN [view interactions] High throughput no no
CCR1_HUMAN [view interactions] High throughput no no
K1H1_HUMAN [view interactions] High throughput no no
PIGT_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
IFM1_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
CLC4D_HUMAN [view interactions] High throughput no no
CLC4E_HUMAN [view interactions] High throughput no no
KCNA3_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOF_HUMAN [view interactions] High throughput no no
MRCKA_HUMAN [view entry] [view interactions] High throughput yes yes
K1C18_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
UBP53_HUMAN [view interactions] High throughput no yes
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
BAP1_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
PARPT_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
PIAS1_HUMAN [view entry] [view interactions] High throughput yes yes
MOB3C_HUMAN [view interactions] High throughput no no
UBE2H_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
UCHL5_HUMAN [view interactions] High throughput no yes
SUMO2_HUMAN [view entry] [view interactions] High throughput yes yes
SRSF9_HUMAN [view interactions] High throughput no yes
SAFB1_HUMAN [view interactions] High throughput no yes
TSR1_HUMAN [view interactions] High throughput no no
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
DDX3X_HUMAN [view entry] [view interactions] High throughput yes yes
COR1B_HUMAN [view entry] [view interactions] High throughput yes no
RM12_HUMAN [view interactions] High throughput no yes
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
MYLIP_HUMAN [view interactions] High throughput no no
MCES_HUMAN [view interactions] High throughput no yes
CAN1_HUMAN [view entry] [view interactions] High throughput yes yes
TRM61_HUMAN [view interactions] High throughput no no
SPC25_HUMAN [view interactions] High throughput no no
AGR2_HUMAN [view interactions] High throughput no no
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
E41LA_HUMAN [view interactions] High throughput no yes
K2C8_HUMAN [view interactions] High throughput no no
LMNB1_HUMAN [view entry] [view interactions] High throughput yes yes
NU155_HUMAN [view interactions] High throughput no yes
PEX3_HUMAN [view interactions] High throughput no yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
TMPS2_HUMAN [view interactions] High throughput no no
NBR1_HUMAN [view interactions] High throughput no yes
PHLP1_HUMAN [view interactions] High throughput no yes
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no