EPIPL_HUMAN
Evidence for PS localization
Functions
Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress (PubMed, PubMed, PubMed). In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture (PubMed, PubMed). However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EPIPL_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 30.0000 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 30.0000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 30.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.5000 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 22.5000 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.5000 | 5 | no |
| GO:1990254 | keratin filament binding | 5.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EPIPL_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 57.5000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 57.5000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 55.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 47.5000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 45.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.5000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 42.5000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 42.5000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 37.5000 | 5 | yes |
| GO:0008104 | protein localization | 37.5000 | 4 | no |
| GO:0010468 | regulation of gene expression | 37.5000 | 5 | no |
| GO:0010646 | regulation of cell communication | 37.5000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 32.5000 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.5000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 32.5000 | 5 | no |
| GO:0071702 | organic substance transport | 32.5000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 32.5000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.5000 | 5 | no |
| GO:0033043 | regulation of organelle organization | 32.5000 | 5 | no |
| GO:0051049 | regulation of transport | 30.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.0000 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 30.0000 | 5 | no |
| GO:0009966 | regulation of signal transduction | 30.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 27.5000 | 4 | no |
| GO:0015031 | protein transport | 27.5000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.5000 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.5000 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.5000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 27.5000 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.5000 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 25.0000 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | no |
| GO:0010941 | regulation of cell death | 25.0000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 25.0000 | 6 | no |
| GO:0051726 | regulation of cell cycle | 25.0000 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 25.0000 | 4 | no |
| GO:0043269 | regulation of ion transport | 22.5000 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.5000 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.5000 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 22.5000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.5000 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 22.5000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.5000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 22.5000 | 5 | no |
| GO:0071310 | cellular response to organic substance | 22.5000 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 22.5000 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 20.0000 | 4 | yes |
| GO:0042127 | regulation of cell population proliferation | 17.5000 | 4 | yes |
| GO:0030334 | regulation of cell migration | 15.0000 | 5 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 15.0000 | 4 | yes |
| GO:2000145 | regulation of cell motility | 15.0000 | 4 | yes |
| GO:0010632 | regulation of epithelial cell migration | 12.5000 | 4 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 10.0000 | 5 | yes |
| GO:0030336 | negative regulation of cell migration | 10.0000 | 6 | yes |
| GO:0040013 | negative regulation of locomotion | 10.0000 | 4 | yes |
| GO:0050678 | regulation of epithelial cell proliferation | 10.0000 | 5 | yes |
| GO:2000146 | negative regulation of cell motility | 10.0000 | 5 | yes |
| GO:0032101 | regulation of response to external stimulus | 7.5000 | 4 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 7.5000 | 5 | yes |
| GO:0045109 | intermediate filament organization | 7.5000 | 4 | yes |
| GO:0048638 | regulation of developmental growth | 7.5000 | 4 | yes |
| GO:0010633 | negative regulation of epithelial cell migration | 5.0000 | 5 | yes |
| GO:0042060 | wound healing | 5.0000 | 4 | yes |
| GO:0045110 | intermediate filament bundle assembly | 5.0000 | 5 | yes |
| GO:0050680 | negative regulation of epithelial cell proliferation | 5.0000 | 6 | yes |
| GO:0051547 | regulation of keratinocyte migration | 5.0000 | 5 | yes |
| GO:0080134 | regulation of response to stress | 5.0000 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in EPIPL_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 5.0000 | 3 | no |
| DOID:936 | brain disease | 5.0000 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NFM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KRT82_HUMAN | [view interactions] | High throughput | no | no |
| K1C14_HUMAN | [view interactions] | High throughput | no | no |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| K2C72_HUMAN | [view interactions] | High throughput | no | no |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| K1C23_HUMAN | [view interactions] | High throughput | no | no |
| K2C7_HUMAN | [view interactions] | High throughput | no | no |
| CCD82_HUMAN | [view interactions] | High throughput | no | yes |
| LRC10_HUMAN | [view interactions] | High throughput | no | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTSS1_HUMAN | [view interactions] | High throughput | no | no |
| K2C78_HUMAN | [view interactions] | High throughput | no | no |
| GCYA1_HUMAN | [view interactions] | High throughput | no | yes |
| NKAI3_HUMAN | [view interactions] | High throughput | no | no |
| K2C75_HUMAN | [view interactions] | High throughput | no | no |
| NIPA_HUMAN | [view interactions] | High throughput | no | yes |
| SARAF_HUMAN | [view interactions] | High throughput | no | no |
| WDR83_HUMAN | [view interactions] | High throughput | no | yes |
| KT33B_HUMAN | [view interactions] | High throughput | no | no |
| KRT86_HUMAN | [view interactions] | High throughput | no | no |
| CR021_HUMAN | [view interactions] | High throughput | no | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| PIGT_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| MRCKA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF9_HUMAN | [view interactions] | High throughput | no | yes |
| SAFB1_HUMAN | [view interactions] | High throughput | no | yes |
| TSR1_HUMAN | [view interactions] | High throughput | no | no |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RM12_HUMAN | [view interactions] | High throughput | no | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYLIP_HUMAN | [view interactions] | High throughput | no | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| PEX3_HUMAN | [view interactions] | High throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| TRPM7_HUMAN | [view interactions] | High throughput | no | no |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| ZSC12_HUMAN | [view interactions] | High throughput | no | yes |
| TB22B_HUMAN | [view interactions] | High throughput | no | no |
| FGL1_HUMAN | [view interactions] | High throughput | no | no |
| FCF1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM24_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| POC5_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| WRP73_HUMAN | [view interactions] | High throughput | no | no |
| TRDMT_HUMAN | [view interactions] | High throughput | no | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSTK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PINX1_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| CFLAR_HUMAN | [view interactions] | High throughput | no | yes |
| INP5K_HUMAN | [view interactions] | High throughput | no | no |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| M3K8_HUMAN | [view interactions] | High throughput | no | yes |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| M3K1_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| TNR1A_HUMAN | [view interactions] | High throughput | no | yes |
| TNR1B_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK4_HUMAN | [view interactions] | High throughput | no | yes |
| TIFAB_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| CNTRB_HUMAN | [view interactions] | High throughput | no | yes |
| CE120_HUMAN | [view interactions] | High throughput | no | no |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| MERTK_HUMAN | [view interactions] | High throughput | no | yes |
| ROR1_HUMAN | [view interactions] | High throughput | no | no |
| ROS1_HUMAN | [view interactions] | High throughput | no | no |
| RGRF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRRM2_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| NPHP4_HUMAN | [view interactions] | High throughput | no | yes |
| CDN1A_HUMAN | [view interactions] | High throughput | no | no |
| CP250_HUMAN | [view interactions] | High throughput | no | no |
| GCP3_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| DD19B_HUMAN | [view interactions] | High throughput | no | yes |
| ZSC20_HUMAN | [view interactions] | High throughput | no | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBR2_HUMAN | [view interactions] | High throughput | no | yes |
| SKI_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| CDK15_HUMAN | [view interactions] | High throughput | no | no |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| ARMC8_HUMAN | [view interactions] | High throughput | no | yes |
| RMD5A_HUMAN | [view interactions] | High throughput | no | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
| FGF11_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| CTSL2_HUMAN | [view interactions] | High throughput | no | no |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR76_HUMAN | [view interactions] | High throughput | no | no |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1B_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| BCL9_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| RNF17_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C27_HUMAN | [view interactions] | High throughput | no | no |
| F227B_HUMAN | [view interactions] | High throughput | no | yes |
| CERS3_HUMAN | [view interactions] | High throughput | no | no |
| ASCL1_HUMAN | [view interactions] | High throughput | no | no |
| K2C3_HUMAN | [view interactions] | High throughput | no | no |
| K1H2_HUMAN | [view interactions] | High throughput | no | no |
| OR2A4_HUMAN | [view interactions] | High throughput | no | no |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K2C73_HUMAN | [view interactions] | High throughput | no | no |
| SIA7F_HUMAN | [view interactions] | High throughput | no | yes |
| KLH11_HUMAN | [view interactions] | High throughput | no | yes |
| STX17_HUMAN | [view interactions] | High throughput | no | yes |