1433F_HUMAN
Evidence for PS localization
Functions
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
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1433F_HUMAN has binary interactions with 50 proteins
Isoforms
Interacting regions
Canonical [1433F_HUMAN]
Isoform [F8WEB6] alignment
Isoform [A2IDB2] alignment
Isoform [A2IDB1] alignment
LOADING 89%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
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Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in 1433F_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 26.3852 | 4 | no |
| GO:0000166 | nucleotide binding | 25.3298 | 4 | no |
| GO:0017076 | purine nucleotide binding | 24.8021 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 23.7467 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.2190 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 21.1082 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 20.0528 | 5 | no |
| GO:0003779 | actin binding | 12.6649 | 4 | yes |
| GO:0140297 | DNA-binding transcription factor binding | 4.2216 | 4 | yes |
| GO:0046982 | protein heterodimerization activity | 2.9024 | 4 | yes |
| GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | 2.6385 | 5 | yes |
| GO:0099106 | ion channel regulator activity | 2.1108 | 4 | yes |
| GO:0005159 | insulin-like growth factor receptor binding | 1.5831 | 4 | yes |
| GO:0017080 | sodium channel regulator activity | 1.0554 | 5 | yes |
| GO:0016922 | nuclear receptor binding | 0.7916 | 6 | yes |
| GO:0035259 | nuclear glucocorticoid receptor binding | 0.5277 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in 1433F_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 49.0765 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 41.1609 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 40.8971 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 40.6332 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 38.7863 | 4 | yes |
| GO:0010646 | regulation of cell communication | 38.5224 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 38.5224 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 35.0923 | 4 | no |
| GO:0006996 | organelle organization | 35.0923 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 31.9261 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 30.8707 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.6069 | 5 | yes |
| GO:0022607 | cellular component assembly | 28.7599 | 4 | no |
| GO:0008104 | protein localization | 28.7599 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 28.7599 | 4 | yes |
| GO:0010468 | regulation of gene expression | 28.7599 | 6 | yes |
| GO:0051246 | regulation of protein metabolic process | 27.4406 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.6491 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 25.3298 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.8021 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.4828 | 5 | yes |
| GO:0007010 | cytoskeleton organization | 23.2190 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 22.4274 | 4 | no |
| GO:0023056 | positive regulation of signaling | 22.1636 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 21.6359 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 3BP5L_HUMAN | [view interactions] | High throughput | no | yes |
| 5NTC_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAAT_HUMAN | [view interactions] | High throughput | no | no |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
| AASS_HUMAN | [view interactions] | High throughput | no | yes |
| AATM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCA2_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| ABCF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABRAL_HUMAN | [view interactions] | High throughput | no | yes |